-
1
-
-
84859644590
-
Clinical spectrum and pathogenesis of nephronophthisis
-
Benzing, T. and Schermer, B. (2012) Clinical spectrum and pathogenesis of nephronophthisis. Curr. Opin. Nephrol. Hypertens., 21, 272-278.
-
(2012)
Curr. Opin. Nephrol. Hypertens.
, vol.21
, pp. 272-278
-
-
Benzing, T.1
Schermer, B.2
-
2
-
-
58149504281
-
Nephronophthisis: disease mechanisms of a ciliopathy
-
Hildebrandt, F., Attanasio, M. and Otto, E. (2009) Nephronophthisis: disease mechanisms of a ciliopathy. J. Am. Soc. Nephrol., 20, 23-35.
-
(2009)
J. Am. Soc. Nephrol.
, vol.20
, pp. 23-35
-
-
Hildebrandt, F.1
Attanasio, M.2
Otto, E.3
-
3
-
-
79955808192
-
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways
-
Sang, L., Miller, J.J., Corbit, K.C., Giles, R.H., Brauer, M.J., Otto, E.A., Baye, L.M., Wen, X., Scales, S.J., Kwong, M. et al. (2011) Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell, 145, 513-528.
-
(2011)
Cell
, vol.145
, pp. 513-528
-
-
Sang, L.1
Miller, J.J.2
Corbit, K.C.3
Giles, R.H.4
Brauer, M.J.5
Otto, E.A.6
Baye, L.M.7
Wen, X.8
Scales, S.J.9
Kwong, M.10
-
5
-
-
79958182034
-
NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway
-
Habbig, S., Bartram, M.P., Muller, R.U., Schwarz, R., Andriopoulos, N., Chen, S., Sagmuller, J.G., Hoehne, M., Burst, V., Liebau, M.C. et al. (2011) NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway. J. Cell Biol., 193, 633-642.
-
(2011)
J. Cell Biol.
, vol.193
, pp. 633-642
-
-
Habbig, S.1
Bartram, M.P.2
Muller, R.U.3
Schwarz, R.4
Andriopoulos, N.5
Chen, S.6
Sagmuller, J.G.7
Hoehne, M.8
Burst, V.9
Liebau, M.C.10
-
6
-
-
34247191134
-
Hippo signaling in organ size control
-
Pan, D. (2007) Hippo signaling in organ size control. Genes Dev., 21, 886-897.
-
(2007)
Genes Dev
, vol.21
, pp. 886-897
-
-
Pan, D.1
-
7
-
-
84856514914
-
Coordinating developmental signaling: novel roles for the Hippo pathway
-
Varelas, X. and Wrana, J.L. (2012) Coordinating developmental signaling: novel roles for the Hippo pathway. Trends Cell Biol., 22, 88-96.
-
(2012)
Trends Cell Biol
, vol.22
, pp. 88-96
-
-
Varelas, X.1
Wrana, J.L.2
-
8
-
-
77957883342
-
The hippo signaling pathway in development and cancer
-
Pan, D. (2010) The hippo signaling pathway in development and cancer. Dev. Cell, 19, 491-505.
-
(2010)
Dev. Cell
, vol.19
, pp. 491-505
-
-
Pan, D.1
-
9
-
-
77955868800
-
Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver
-
Benhamouche, S., Curto, M., Saotome, I., Gladden, A.B., Liu, C.H., Giovannini, M. and McClatchey, A.I. (2010) Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver. Genes Dev., 24, 1718-1730.
-
(2010)
Genes Dev
, vol.24
, pp. 1718-1730
-
-
Benhamouche, S.1
Curto, M.2
Saotome, I.3
Gladden, A.B.4
Liu, C.H.5
Giovannini, M.6
McClatchey, A.I.7
-
10
-
-
79955638768
-
TAZ is a novel oncogene in non-small cell lung cancer
-
Zhou, Z., Hao, Y., Liu, N., Raptis, L., Tsao, M.S. and Yang, X. (2011) TAZ is a novel oncogene in non-small cell lung cancer. Oncogene, 30, 2181-2186.
-
(2011)
Oncogene
, vol.30
, pp. 2181-2186
-
-
Zhou, Z.1
Hao, Y.2
Liu, N.3
Raptis, L.4
Tsao, M.S.5
Yang, X.6
-
11
-
-
42349088170
-
A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells
-
Chan, S.W., Lim, C.J., Guo, K., Ng, C.P., Lee, I., Hunziker, W., Zeng, Q. and Hong, W. (2008) A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. Cancer Res., 68, 2592-2598.
-
(2008)
Cancer Res
, vol.68
, pp. 2592-2598
-
-
Chan, S.W.1
Lim, C.J.2
Guo, K.3
Ng, C.P.4
Lee, I.5
Hunziker, W.6
Zeng, Q.7
Hong, W.8
-
12
-
-
67649770134
-
TEADs mediate nuclear retention of TAZ to promote oncogenic transformation
-
Chan, S.W., Lim, C.J., Loo, L.S., Chong, Y.F., Huang, C. and Hong, W. (2009) TEADs mediate nuclear retention of TAZ to promote oncogenic transformation. J. Biol. Chem., 284, 14347-14358.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 14347-14358
-
-
Chan, S.W.1
Lim, C.J.2
Loo, L.S.3
Chong, Y.F.4
Huang, C.5
Hong, W.6
-
13
-
-
81055140859
-
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells
-
Cordenonsi, M., Zanconato, F., Azzolin, L., Forcato, M., Rosato, A., Frasson, C., Inui, M., Montagner, M., Parenti, A.R., Poletti, A. et al. (2011) The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell, 147, 759-772.
-
(2011)
Cell
, vol.147
, pp. 759-772
-
-
Cordenonsi, M.1
Zanconato, F.2
Azzolin, L.3
Forcato, M.4
Rosato, A.5
Frasson, C.6
Inui, M.7
Montagner, M.8
Parenti, A.R.9
Poletti, A.10
-
14
-
-
33846805976
-
Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1
-
Hossain, Z., Ali, S.M., Ko, H.L., Xu, J., Ng, C.P., Guo, K., Qi, Z., Ponniah, S., Hong, W. and Hunziker, W. (2007) Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1. Proc. Natl Acad. Sci. USA, 104, 1631-1636.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 1631-1636
-
-
Hossain, Z.1
Ali, S.M.2
Ko, H.L.3
Xu, J.4
Ng, C.P.5
Guo, K.6
Qi, Z.7
Ponniah, S.8
Hong, W.9
Hunziker, W.10
-
15
-
-
34548719323
-
TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex
-
Tian, Y., Kolb, R., Hong, J.H., Carroll, J., Li, D., You, J., Bronson, R., Yaffe, M.B., Zhou, J. and Benjamin, T. (2007) TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol. Cell. Biol., 27, 6383-6395.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 6383-6395
-
-
Tian, Y.1
Kolb, R.2
Hong, J.H.3
Carroll, J.4
Li, D.5
You, J.6
Bronson, R.7
Yaffe, M.B.8
Zhou, J.9
Benjamin, T.10
-
16
-
-
40449102218
-
NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis
-
Otto, E.A., Trapp, M.L., Schultheiss, U.T., Helou, J., Quarmby, L.M. and Hildebrandt, F. (2008) NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis. J. Am. Soc. Nephrol., 19, 587-592.
-
(2008)
J. Am. Soc. Nephrol.
, vol.19
, pp. 587-592
-
-
Otto, E.A.1
Trapp, M.L.2
Schultheiss, U.T.3
Helou, J.4
Quarmby, L.M.5
Hildebrandt, F.6
-
17
-
-
0036931712
-
A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish
-
Liu, S., Lu, W., Obara, T., Kuida, S., Lehoczky, J., Dewar, K., Drummond, I.A. and Beier, D.R. (2002) A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. Development, 129, 5839-5846.
-
(2002)
Development
, vol.129
, pp. 5839-5846
-
-
Liu, S.1
Lu, W.2
Obara, T.3
Kuida, S.4
Lehoczky, J.5
Dewar, K.6
Drummond, I.A.7
Beier, D.R.8
-
18
-
-
1542395668
-
Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors
-
Bowers, A.J. and Boylan, J.F. (2004) Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors. Gene, 328, 135-142.
-
(2004)
Gene
, vol.328
, pp. 135-142
-
-
Bowers, A.J.1
Boylan, J.F.2
-
19
-
-
67649510223
-
The basal body gene, RPGRIP1L, is a candidate tumour suppressor gene in human hepatocellular carcinoma
-
Lin, Y.W., Yan, M.D., Shih, Y.L. and Hsieh, C.B. (2009) The basal body gene, RPGRIP1L, is a candidate tumour suppressor gene in human hepatocellular carcinoma. Eur. J. Cancer, 45, 2041-2049.
-
(2009)
Eur. J. Cancer
, vol.45
, pp. 2041-2049
-
-
Lin, Y.W.1
Yan, M.D.2
Shih, Y.L.3
Hsieh, C.B.4
-
20
-
-
28244502271
-
Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers
-
Luo, X., He, Q., Huang, Y. and Sheikh, M.S. (2005) Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers. Cancer Res., 65, 10725-10733.
-
(2005)
Cancer Res
, vol.65
, pp. 10725-10733
-
-
Luo, X.1
He, Q.2
Huang, Y.3
Sheikh, M.S.4
-
21
-
-
84856971590
-
The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis
-
Zalli, D., Bayliss, R. and Fry, A.M. (2012) The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis. Hum. Mol. Genet., 21, 1155-1171.
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 1155-1171
-
-
Zalli, D.1
Bayliss, R.2
Fry, A.M.3
-
22
-
-
17744380191
-
TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins
-
Kanai, F., Marignani, P.A., Sarbassova, D., Yagi, R., Hall, R.A., Donowitz, M., Hisaminato, A., Fujiwara, T., Ito, Y., Cantley, L.C. et al. (2000) TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J., 19, 6778-6791.
-
(2000)
EMBO J
, vol.19
, pp. 6778-6791
-
-
Kanai, F.1
Marignani, P.A.2
Sarbassova, D.3
Yagi, R.4
Hall, R.A.5
Donowitz, M.6
Hisaminato, A.7
Fujiwara, T.8
Ito, Y.9
Cantley, L.C.10
-
23
-
-
77955418239
-
Cystic kidney disease: the role of Wnt signaling
-
Lancaster, M.A. and Gleeson, J.G. (2010) Cystic kidney disease: the role of Wnt signaling. Trends Mol. Med., 16, 349-360.
-
(2010)
Trends Mol. Med.
, vol.16
, pp. 349-360
-
-
Lancaster, M.A.1
Gleeson, J.G.2
-
24
-
-
77951101203
-
The primary cilium: a signalling centre during vertebrate development
-
Goetz, S.C. and Anderson, K.V. (2010) The primary cilium: a signalling centre during vertebrate development. Nat. Rev. Genet., 11, 331-344.
-
(2010)
Nat. Rev. Genet.
, vol.11
, pp. 331-344
-
-
Goetz, S.C.1
Anderson, K.V.2
-
25
-
-
33645769011
-
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease
-
Shillingford, J.M., Murcia, N.S., Larson, C.H., Low, S.H., Hedgepeth, R., Brown, N., Flask, C.A., Novick, A.C., Goldfarb, D.A., Kramer-Zucker, A. et al. (2006) The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc. Natl Acad. Sci. USA, 103, 5466-5471.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 5466-5471
-
-
Shillingford, J.M.1
Murcia, N.S.2
Larson, C.H.3
Low, S.H.4
Hedgepeth, R.5
Brown, N.6
Flask, C.A.7
Novick, A.C.8
Goldfarb, D.A.9
Kramer-Zucker, A.10
-
26
-
-
79953787286
-
Altered Hippo signalling in polycystic kidney disease
-
Happe, H., van der Wal, A.M., Leonhard, W.N., Kunnen, S.J., Breuning, M.H., de Heer, E. and Peters, D.J. (2011) Altered Hippo signalling in polycystic kidney disease. J. Pathol., 224, 133-142.
-
(2011)
J. Pathol.
, vol.224
, pp. 133-142
-
-
Happe, H.1
van der Wal, A.M.2
Leonhard, W.N.3
Kunnen, S.J.4
Breuning, M.H.5
de Heer, E.6
Peters, D.J.7
-
27
-
-
84864076896
-
The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate beta-catenin signaling
-
Borgal, L., Habbig, S., Hatzold, J., Liebau, M.C., Dafinger, C., Sacarea, I., Hammerschmidt, M., Benzing, T. and Schermer, B. (2012) The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate beta-catenin signaling. J. Biol. Chem., 287, 25370-25380.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 25370-25380
-
-
Borgal, L.1
Habbig, S.2
Hatzold, J.3
Liebau, M.C.4
Dafinger, C.5
Sacarea, I.6
Hammerschmidt, M.7
Benzing, T.8
Schermer, B.9
-
28
-
-
79954616437
-
Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia
-
Liebau, M.C., Hopker, K., Muller, R.U., Schmedding, I., Zank, S., Schairer, B., Fabretti, F., Hohne, M., Bartram, M.P., Dafinger, C. et al. (2011) Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia. J. Biol. Chem., 286, 14237-14245.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 14237-14245
-
-
Liebau, M.C.1
Hopker, K.2
Muller, R.U.3
Schmedding, I.4
Zank, S.5
Schairer, B.6
Fabretti, F.7
Hohne, M.8
Bartram, M.P.9
Dafinger, C.10
-
29
-
-
77951895173
-
Inv acts as a molecular anchor for Nphp3 and Nek8 in the proximal segment of primary cilia
-
Shiba, D., Manning, D.K., Koga, H., Beier, D.R. and Yokoyama, T. (2010) Inv acts as a molecular anchor for Nphp3 and Nek8 in the proximal segment of primary cilia. Cytoskeleton (Hoboken), 67, 112-119.
-
(2010)
Cytoskeleton (Hoboken)
, vol.67
, pp. 112-119
-
-
Shiba, D.1
Manning, D.K.2
Koga, H.3
Beier, D.R.4
Yokoyama, T.5
-
30
-
-
84864290600
-
The ciliary protein Nek8/Nphp9 acts downstream of Inv/Nphp2 during pronephros morphogenesis and left-right establishment in zebrafish
-
Fukui, H., Shiba, D., Asakawa, K., Kawakami, K. and Yokoyama, T. (2012) The ciliary protein Nek8/Nphp9 acts downstream of Inv/Nphp2 during pronephros morphogenesis and left-right establishment in zebrafish. FEBS Lett, 586, 2273-2279.
-
(2012)
FEBS Lett
, vol.586
, pp. 2273-2279
-
-
Fukui, H.1
Shiba, D.2
Asakawa, K.3
Kawakami, K.4
Yokoyama, T.5
-
31
-
-
70349154193
-
The NIMA-related kinase NEK1 cycles through the nucleus
-
Hilton, L.K., White, M.C. and Quarmby, L.M. (2009) The NIMA-related kinase NEK1 cycles through the nucleus. Biochem. Biophys. Res. Commun., 389, 52-56.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.389
, pp. 52-56
-
-
Hilton, L.K.1
White, M.C.2
Quarmby, L.M.3
-
32
-
-
0242266916
-
Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner
-
Debnath, J., Walker, S.J. and Brugge, J.S. (2003) Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. J. Cell Biol., 163, 315-326.
-
(2003)
J. Cell Biol.
, vol.163
, pp. 315-326
-
-
Debnath, J.1
Walker, S.J.2
Brugge, J.S.3
-
33
-
-
79960019930
-
Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics
-
Dafinger, C., Liebau, M.C., Elsayed, S.M., Hellenbroich, Y., Boltshauser, E., Korenke, G.C., Fabretti, F., Janecke, A.R., Ebermann, I., Nurnberg, G. et al. (2011) Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics. J. Clin. Invest., 121, 2662-2667.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 2662-2667
-
-
Dafinger, C.1
Liebau, M.C.2
Elsayed, S.M.3
Hellenbroich, Y.4
Boltshauser, E.5
Korenke, G.C.6
Fabretti, F.7
Janecke, A.R.8
Ebermann, I.9
Nurnberg, G.10
-
34
-
-
29244472858
-
Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia
-
Schermer, B., Hopker, K., Omran, H., Ghenoiu, C., Fliegauf, M., Fekete, A., Horvath, J., Kottgen, M., Hackl, M., Zschiedrich, S. et al. (2005) Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia. EMBO J., 24, 4415-4424.
-
(2005)
EMBO J
, vol.24
, pp. 4415-4424
-
-
Schermer, B.1
Hopker, K.2
Omran, H.3
Ghenoiu, C.4
Fliegauf, M.5
Fekete, A.6
Horvath, J.7
Kottgen, M.8
Hackl, M.9
Zschiedrich, S.10
-
35
-
-
0016756272
-
Continuous cultures of fused cells secreting antibody of predefined specificity
-
Kohler, G. and Milstein, C. (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature, 256, 495-497.
-
(1975)
Nature
, vol.256
, pp. 495-497
-
-
Kohler, G.1
Milstein, C.2
|