메뉴 건너뛰기




Volumn 17, Issue 20, 2003, Pages 2514-2519

The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis

Author keywords

Apoptosis; DMST; MST1; Sav; Tumor suppressor; Wts

Indexed keywords

CYCLIN E; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE;

EID: 0142123293     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1134003     Document Type: Article
Times cited : (340)

References (30)
  • 1
    • 0033231936 scopus 로고    scopus 로고
    • An emerging blueprint for apoptosis in Drosophila
    • Abrams, J.M. 1999. An emerging blueprint for apoptosis in Drosophila. Trends Cell. Biol. 9: 435-440.
    • (1999) Trends Cell. Biol. , vol.9 , pp. 435-440
    • Abrams, J.M.1
  • 2
    • 0035694931 scopus 로고    scopus 로고
    • Distinct roles of central missing and dispatched in sending the Hedgehog signal
    • Amanai, K. and Jiang, J. 2001. Distinct roles of central missing and dispatched in sending the Hedgehog signal. Development 128: 5119-5127.
    • (2001) Development , vol.128 , pp. 5119-5127
    • Amanai, K.1    Jiang, J.2
  • 3
    • 0028329349 scopus 로고
    • Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein
    • Basler, K. and Struhl, G. 1994. Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein, Nature 368: 208-214.
    • (1994) Nature , vol.368 , pp. 208-214
    • Basler, K.1    Struhl, G.2
  • 5
    • 0029101740 scopus 로고
    • Cloning and characterization of a human protein kinase with homology to Ste20
    • Creasy, C.L. and Chernoff, J. 1995a. Cloning and characterization of a human protein kinase with homology to Ste20. J. Biol. Chem. 270: 21695-21700.
    • (1995) J. Biol. Chem. , vol.270 , pp. 21695-21700
    • Creasy, C.L.1    Chernoff, J.2
  • 6
    • 0029558439 scopus 로고
    • Cloning and characterization of a member of the MST subfamily of Ste20-like kinases
    • -. 1995b. Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene 167: 303-306.
    • (1995) Gene , vol.167 , pp. 303-306
  • 7
    • 0029788972 scopus 로고    scopus 로고
    • The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain
    • Creasy, C.L., Ambrose, D.M., and Chernoff, J. 1996. The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain. J. Biol. Chem. 271: 21049-21053.
    • (1996) J. Biol. Chem. , vol.271 , pp. 21049-21053
    • Creasy, C.L.1    Ambrose, D.M.2    Chernoff, J.3
  • 8
    • 0035341895 scopus 로고    scopus 로고
    • The Ste20 group kinases as regulators of MAP kinase cascades
    • Dan, I., Watanabe, N.M., and Kusumi, A. 2001. The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell. Biol. 11: 220-230.
    • (2001) Trends Cell. Biol. , vol.11 , pp. 220-230
    • Dan, I.1    Watanabe, N.M.2    Kusumi, A.3
  • 9
    • 0030584086 scopus 로고    scopus 로고
    • Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
    • Freeman, M. 1996. Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87: 651-660.
    • (1996) Cell , vol.87 , pp. 651-660
    • Freeman, M.1
  • 10
    • 0037044808 scopus 로고    scopus 로고
    • Mapping of MST1 kinase sites of phosphorylation: Activation and autophosphorylation
    • Glantschnig, H., Rodan, G.A., and Reszka, A.A. 2002. Mapping of MST1 kinase sites of phosphorylation: Activation and autophosphorylation. J. Biol. Chem. 277: 42987-42996.
    • (2002) J. Biol. Chem. , vol.277 , pp. 42987-42996
    • Glantschnig, H.1    Rodan, G.A.2    Reszka, A.A.3
  • 12
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D. and Weinberg, R.A. 2000. The hallmarks of cancer. Cell 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 13
    • 0030918591 scopus 로고    scopus 로고
    • MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase
    • Hirai, S., Katoh, M., Terada, M., Kyriakis, J.M., Zon, L.I., Rana, A., Avruch, J., and Ohno, S. 1997. MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase. J. Biol. Chem. 272: 15167-15173.
    • (1997) J. Biol. Chem. , vol.272 , pp. 15167-15173
    • Hirai, S.1    Katoh, M.2    Terada, M.3    Kyriakis, J.M.4    Zon, L.I.5    Rana, A.6    Avruch, J.7    Ohno, S.8
  • 14
    • 0028918468 scopus 로고
    • Protein kinase A and Hedgehog signalling in Drosophila limb development
    • Jiang, J. and Struhl, G. 1995. Protein kinase A and Hedgehog signalling in Drosophila limb development. Cell 80: 563-572.
    • (1995) Cell , vol.80 , pp. 563-572
    • Jiang, J.1    Struhl, G.2
  • 15
    • 0032576777 scopus 로고    scopus 로고
    • Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
    • -. 1998. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 391: 493-496.
    • (1998) Nature , vol.391 , pp. 493-496
  • 16
    • 0028902594 scopus 로고
    • The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation
    • Justice, R.W., Zilian, O., Woods, D.F., Noll, M., and Bryant, P.J. 1995. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes & Dev. 9: 534-546.
    • (1995) Genes & Dev. , vol.9 , pp. 534-546
    • Justice, R.W.1    Zilian, O.2    Woods, D.F.3    Noll, M.4    Bryant, P.J.5
  • 17
    • 0037023722 scopus 로고    scopus 로고
    • Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)
    • Lee, K.K. and Yonehara, S. 2002. Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). J. Biol. Chem. 277: 12351-12358.
    • (2002) J. Biol. Chem. , vol.277 , pp. 12351-12358
    • Lee, K.K.1    Yonehara, S.2
  • 18
    • 0032507878 scopus 로고    scopus 로고
    • Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis
    • Lee, K.K., Murakawa, M., Nishida, E., Tsubuki, S., Kawashima, S., Sakamaki, K., and Yonehara, S. 1998. Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis. Oncogene 16: 3029-3037.
    • (1998) Oncogene , vol.16 , pp. 3029-3037
    • Lee, K.K.1    Murakawa, M.2    Nishida, E.3    Tsubuki, S.4    Kawashima, S.5    Sakamaki, K.6    Yonehara, S.7
  • 19
    • 0035379556 scopus 로고    scopus 로고
    • MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
    • Lee, K.K., Ohyama, T., Yajima, N., Tsubuki, S., and Yonehara, S. 2001. MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. J. Biol. Chem. 276: 19276-19285.
    • (2001) J. Biol. Chem. , vol.276 , pp. 19276-19285
    • Lee, K.K.1    Ohyama, T.2    Yajima, N.3    Tsubuki, S.4    Yonehara, S.5
  • 20
    • 0034053414 scopus 로고    scopus 로고
    • Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics
    • Newsome, T.P., Asling, B., and Dickson, B.J. 2000. Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Development 127: 851-860.
    • (2000) Development , vol.127 , pp. 851-860
    • Newsome, T.P.1    Asling, B.2    Dickson, B.J.3
  • 21
    • 0028844991 scopus 로고
    • Ectopic cyclin E expression induces premature entry into S phase and disrupts pattern formation in the Drosophila eye imaginal disc
    • Richardson, H., O'Keefe, L.V., Marty, T., and Saint, R. 1995. Ectopic cyclin E expression induces premature entry into S phase and disrupts pattern formation in the Drosophila eye imaginal disc. Development 121: 3371-3379.
    • (1995) Development , vol.121 , pp. 3371-3379
    • Richardson, H.1    O'Keefe, L.V.2    Marty, T.3    Saint, R.4
  • 22
    • 0030838880 scopus 로고    scopus 로고
    • Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2
    • Robbins, D.J., Nybakken, K.E., Kobayashi, R., Sisson, J.C., Bishop, J.M., and Therond, P.P. 1997. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Cell 90: 225-234.
    • (1997) Cell , vol.90 , pp. 225-234
    • Robbins, D.J.1    Nybakken, K.E.2    Kobayashi, R.3    Sisson, J.C.4    Bishop, J.M.5    Therond, P.P.6
  • 23
    • 0036300083 scopus 로고    scopus 로고
    • Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1
    • Ryoo, H.D., Bergmann, A., Gonen, H., Ciechanover, A., and Steller, H. 2002. Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat. Cell. Biol. 4: 432-438.
    • (2002) Nat. Cell. Biol. , vol.4 , pp. 432-438
    • Ryoo, H.D.1    Bergmann, A.2    Gonen, H.3    Ciechanover, A.4    Steller, H.5
  • 25
    • 0345192349 scopus 로고    scopus 로고
    • A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype
    • Stowers, R.S. and Schwarz, T.L. 1999. A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype. Genetics 152: 1631-1639.
    • (1999) Genetics , vol.152 , pp. 1631-1639
    • Stowers, R.S.1    Schwarz, T.L.2
  • 26
    • 0037162714 scopus 로고    scopus 로고
    • Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
    • Tapon, N., Harvey, K.F., Bell, D.W., Wahrer, D.C., Schiripo, T.A., Haber, D.A., and Hariharan, I.K. 2002. salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 110: 467-478.
    • (2002) Cell , vol.110 , pp. 467-478
    • Tapon, N.1    Harvey, K.F.2    Bell, D.W.3    Wahrer, D.C.4    Schiripo, T.A.5    Haber, D.A.6    Hariharan, I.K.7
  • 27
    • 0002576958 scopus 로고    scopus 로고
    • Histological techniques for the Drosophila eye
    • (eds. W. Sullivan, et al.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Wolff, T. 2000. Histological techniques for the Drosophila eye. In Drosophila protocols (eds. W. Sullivan, et al.), pp. 201-272. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (2000) Drosophila Protocols , pp. 201-272
    • Wolff, T.1
  • 28
    • 0000258255 scopus 로고
    • Pattern formation in the Drosophila retina
    • (eds. B. Bate and A. Martines Arias). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Wolff, T. and Ready, D.F. 1993. Pattern formation in the Drosophila retina. In The development of Drosophila melanogaster (eds. B. Bate and A. Martines Arias), pp. 1277-1325. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (1993) The Development of Drosophila Melanogaster , pp. 1277-1325
    • Wolff, T.1    Ready, D.F.2
  • 29
    • 0028929414 scopus 로고
    • Identifying tumor suppressors in genetic mosaics: The Drosophila lats gene encodes a putative protein kinase
    • Xu, T., Wang, W., Zhang, S., Stewart, R.A., and Yu, W. 1995. Identifying tumor suppressors in genetic mosaics: The Drosophila lats gene encodes a putative protein kinase. Development 121: 1053-1063.
    • (1995) Development , vol.121 , pp. 1053-1063
    • Xu, T.1    Wang, W.2    Zhang, S.3    Stewart, R.A.4    Yu, W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.