TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis

Carcinogenesis

Volumn 33, Issue 1, 2012, Pages 59-67

  Zhao, Dong ^a,b   Zhi, Xu ^a,b   Zhou, Zhongmei ^a   Chen, Ceshi ^a  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR ALPHA; FIBROBLAST GROWTH FACTOR; KRUPPEL LIKE FACTOR 5; PDZ PROTEIN; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE E3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; BREAST CELL; CARCINOGENESIS; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE TARGETING; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; TRANSCRIPTION INITIATION; UBIQUITINATION; UPREGULATION; XENOGRAFT;

EID: 84855404337     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr242     Document Type: Article

References (36)

1. Tong,D. et al. (2006) Expression of KLF5 is a prognostic factor for diseasefree survival and overall survival in patients with breast cancer. Clin. Cancer Res., 12, 2442-2448.
2. Zhao,D. et al. (2010) The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation. Cancer Res., 70, 4728-4738.
3. Ben-Porath,I. et al. (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet., 40, 499-507.
4. Zheng,H.Q. et al. (2009) Kruppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1. Oncogene, 28, 3702-3713.
5. Chen,C. et al. (2005) Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells. J. Biol. Chem., 280, 41553-41561.
6. Wang,K. et al. (2009) YAP, TAZ, and Yorkie: a conserved family of signalresponsive transcriptional coregulators in animal development and human disease. Biochem. Cell Biol., 87, 77-91.
7. Chan,S.W. et al. (2008) A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. Cancer Res., 68, 2592-2598.
8. Lei,Q.Y. et al. (2008) TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol. Cell. Biol., 28, 2426-2436.
9. Chan,S.W. et al. (2009) TEADs mediate nuclear retention of TAZ to promote oncogenic transformation. J. Biol. Chem., 284, 14347-14358.
10. Varelas,X. et al. (2008) TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat. Cell Biol., 10, 837-848.
11. Murakami,M. et al. (2006) Transcriptional activity of Pax3 is co-activated by TAZ. Biochem. Biophys. Res. Commun., 339, 533-539.
12. Di Palma,T. et al. (2009) TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. Exp. Cell Res., 315, 162-175.
13. Murakami,M. et al. (2005) AWW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc. Natl Acad. Sci. USA., 102, 18034-18039.
14. Park,K.S. et al. (2004) TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J. Biol. Chem., 279, 17384-17390.
15. Hong,J.H. et al. (2005) TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science, 309, 1074-1078.
16. Jeong,H. et al. (2010) TAZ as a novel enhancer of MyoD-mediated myogenic differentiation. FASEB J., 24, 3310-3320.
17. Chan,S.W. et al. (2010) WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ. Oncogene, 30, 600-610.
18. Li,Y. et al. (2008) WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis. Cell Death Differ., 15, 1941-1951.
19. Chen,C. et al. (2006) KLF5 promotes cell proliferation and tumorigenesis through gene regulationin the TSU-Pr1 human bladder cancer cell line. Int. J. Cancer, 118, 1346-1355.
20. Chen,C. et al. (2007) The amplified WWP1 gene is a potential molecular target in breast cancer. Int. J. Cancer, 121, 2834-2841.
21. Takahashi,Y. et al. (2005) Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. Clin. Cancer Res., 11, 1380-1385.
22. McConnell,B.B. et al. (2009) Haploinsufficiency of Kruppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine. Cancer Res., 69, 4125-4133.
23. Liu,C.Y. et al. (2010) The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J. Biol. Chem., 285, 37159-37169.
24. Usui,S. et al. (2004) Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. J. Biol. Chem., 279, 12300-12311.
25. Guo,P. et al. (2009) Acetylation of KLF5 alters the assembly of p15 transcription factors in transforming growth factor-beta-mediated induction in epithelial cells. J. Biol. Chem., 284, 18184-18193.
26. Liu,R. et al. (2009) KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization. J. Biol. Chem., 284, 16791-16798.
27. Jiang,J. et al. (2008) A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat. Cell Biol., 10, 353-360.
28. Mitani,A. et al. (2009) Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice. Am. J. Respir. Crit. Care Med., 180, 326-338.
29. Aizawa,K. et al. (2004) Regulation of platelet-derived growth factor-A chain by Kruppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB. J. Biol. Chem., 279, 70-76.
30. Parisi,S. et al. (2008) Klf5 is involved in self-renewal of mouse embryonic stem cells. J. Cell Sci., 121, 2629-2634.
31. Liu,R. et al. (2011) The induction of KLF5 transcription factor by progesterone contributes to progesterone-induced breast cancer cell proliferation and dedifferentiation. Mol. Endocrinol., 25, 1137-1144.
32. Chan,S.W. et al. (2010) The hippo pathway in biological control and cancer development. J. Cell. Physiol., 226, 928-939.
33. Ding,L. et al. (2010) Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature, 464, 999-1005.
34. Shindo,T. et al. (2002) Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat. Med., 8, 856-863.
35. Czubayko,F. et al. (1997) A secreted FGF-binding protein can serve as the angiogenic switch in human cancer. Nat. Med., 3, 1137-1140.
36. Wan,H. et al. (2008) Kruppel-like factor 5 is required for perinatal lung morphogenesis and function. Development, 135, 2563-2572.