Development of a high-throughput calcium flux assay for identification of all ligand types including positive, negative, and silent allosteric modulators for G protein-coupled receptors

Assay and Drug Development Technologies

Volumn 10, Issue 5, 2012, Pages 457-467

  Noblin, Devin J ^a   Bertekap, Robert L ^b   Burford, Neil T ^b   Hendricson, Adam ^b   Zhang, Litao ^b   Knox, Ronald ^b   Banks, Martyn ^b   O'connell, Jonathan ^b   Alt, Andrew ^b  

^a YALE UNIVERSITY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ASSAY; CELL CULTURE; DESENSITIZATION; FLUORESCENCE IMAGING; HIGH THROUGHPUT SCREENING; NEGATIVE ALLOSTERIC MODULATOR; NONHUMAN; POSITIVE ALLOSTERIC MODULATOR; SILENT ALLOSTERIC MODULATOR; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANIMALS; CALCIUM SIGNALING; CHO CELLS; CRICETINAE; CRICETULUS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84867246771     PISSN: 1540658X     EISSN: 15578127     Source Type: Journal    
DOI: 10.1089/adt.2011.443     Document Type: Article

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