The power issue: Determination of KB or Ki from IC50 - A closer look at the Cheng-Prusoff equation, the Schild plot and related power equations

Journal of Pharmacological and Toxicological Methods

Volumn 46, Issue 2, 2001, Pages 61-71

  Cheng, Hsien C ^a  

^a SANOFI   (France)

Author keywords

Asymptote; Concentration ratio; KB; Methods; Proportionality constant; Schild plot

Indexed keywords

ACCURACY; AGONIST; ANALYTIC METHOD; ARTICLE; ASSAY; CONCENTRATION RESPONSE; DISSOCIATION CONSTANT; ERROR; IC 50; SIMULATION; BINDING COMPETITION; CHEMICAL MODEL; DOSE RESPONSE;

BINDING, COMPETITIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL;

EID: 0035527674     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(02)00166-1     Document Type: Article

References (17)

1. Some quantitative uses of drug antagonists
2. i from IC50
3. Analysis of dose response curves using proportionality equations
4. 50) of an enzymatic reaction
5. Analysis of combined drug effects: A new look at a very old problem
6. The Cheng-Prusoff relationship: Something lost in the translation
7. Theories of drug antagonism
8. The Schild regression in the process of receptor classification
9. b from inhibition curves in functional experiments: Alternatives to the Cheng-Prusoff equation
10. Further concerns over Cheng-Prusoff analysis
11. Quantification of drug action
12. x and competitive drug antagonism
13. Molecular basis of pharmacologic selectivity
14. Cumulative dose-response curves: II. Techniques for the making of dose-response curves in isolated organs and the evaluation of drug parameters