Cyclic tertiary sulfamates: Selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives

European Journal of Medicinal Chemistry

Volumn 84, Issue , 2014, Pages 240-246

  De Monte, Celeste ^a   Carradori, Simone ^a   Secci, Daniela ^a   D'Ascenzio, Melissa ^a   Vullo, Daniela ^b   Ceruso, Mariangela ^b   Supuran, Claudiu T ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Acesulfame derivatives; Anticancer agents; N alkylation; O alkylation; Selective hCA IX hCAXII inhibitors; Sulfamate

Indexed keywords

1 [(6 METHYL 2,2 DIOXIDO 1,2,3 OXATHIAZIN 4 YL)OXY]PROPAN 2 ONE; 2 [(6 METHYL 2,2 DIOXIDO 1,2,3 OXATHIAZIN 4YL)OXY] 1 PHENYLETHANONE; 3 (2 FLUOROBENZYL) 6 METHYL 1,2,3 OXATHIAZIN 4(3H)ONE 2,2 DIOXIDE; 3 (2,6 DIFLUOROBENZYL) 6 METHYL 1,2,3 OXATHIAZIN 4(3H)ONE 2,2 DIOXIDE; 3 (3 BROMOBENZYL) 6 METHYL 1,2,3 OXATHIAZIN 4(3H)ONE 2,2 DIOXIDE; 3 (3 FLUOROBENZYL) 6 METHYL 1,2,3 OXATHIAZIN 4(3H)ONE 2,2 DIOXIDE; 4 [(2 BROMOBENZYL)OXY] 6 METHYL 1,2,3 OXATHIAZINE 2,2 DIOXIDE; 4 [(3 FLUOROBENZYL)OXY] 6 METHYL 1,2,3 OXATHIAZINE 2,2 DIOXIDE; 4 [(6 METHYL 2,2 DIOXIDO 4 OXO 1,2,3 OXATHIAZIN 3(4H) YL)METHYL]BENZONITRILE; 6 METHYL 3 (2 NITROBENZYL) 1,2,3 OXATHIAZIN 4(3H)ONE 2,2 DIOXIDE; 6 METHYL 3 (2 OXO 2 PHENYLETHYL) 1,2,3 OXATHIAZIN 4(3H)ONE 2,2 DIOXIDE; 6 METHYL 3 (2 OXOPROPYL) 1,2,3 OXATHIAZIN 4(3H)ONE 2,2 DIOXIDE; 6 METHYL 3 (3 NITROBENZYL) 1,2,3 OXATHIAZIN 4(3H)ONE 2,2 DIOXIDE; 6 METHYL 3 (PROP 2 EN 1 YL) 1,2,3 OXATHIAZIN 4(3H)ONE 2,2 DIOXIDE; 6 METHYL 4 (PROP 2 EN 1 YLOXY) 1,2,3 OXATHIAZINE 2,2 DIOXIDE; 6 METHYL 4 (PROP 2 YN 1 YLOXY) 1,2,3 OXATHIAZINE 2,2 DIOXIDE; 6 METHYL 4 [(2 NITROBENZYL)OXY] 1,2,3 OXATHIAZINE 2,2 DIOXIDE; 6 METHYL 4 [(3 NITROBENZYL)OXY] 1,2,3 OXATHIAZINE 2,2 DIOXIDE; ACESULFAME; ACESULFAME DERIVATIVE; ANTINEOPLASTIC AGENT; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; E6 METHYL 3 [2 (3 NITROPHENYL) 2 OXOETHYL] 1,2,3 OXATHIAZIN 4 (3H)ONE; ETHYL (6 METHYL 2,2 DIOXIDO 4 OXO 1,2,3 OXATHIAZIN 3(4H)YL)ACETATE; ETHYL [(6 METHYL 2,2 DIOXIDO 1,2,3 OXATHIAZIN 4YL)OXY]ACETATE; UNCLASSIFIED DRUG; [(6 METHYL 2,2 DIOXIDO 1,2,3 OXATHIAZIN 4 YL)OXY]ACETONITRILE; ACETOSULFAME; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; ISOPROTEIN; SULFAMIC ACID; SULFONIC ACID DERIVATIVE; THIAZINE DERIVATIVE;

ARTICLE; CANCER CELL LINE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOLECULAR MODEL; PHARMACOPHORE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; PROTEIN ISOFORMS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS; THIAZINES;

EID: 84904288691     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.07.014     Document Type: Article

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