Disruption of the active site solvent network in carbonic anhydrase II decreases the efficiency of proton transfer

Biochemistry

Volumn 35, Issue 51, 1996, Pages 16421-16428

  Jackman, Jane E ^a   Merz Jr , Kenneth M ^b   Fierke, Carol A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONATE DEHYDRATASE II;

AMINO ACID SUBSTITUTION; ARTICLE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME INDUCTION; ENZYME PURIFICATION; HUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; TRANSPORT KINETICS;

BINDING SITES; BUFFERS; CARBON DIOXIDE; CARBONIC ANHYDRASES; HUMANS; HYDROGEN-ION CONCENTRATION; IMIDAZOLES; KINETICS; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PROTONS; RECOMBINANT PROTEINS; SOLVENTS; WATER; ZINC;

FELIS CATUS;

EID: 0030476749     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961786+     Document Type: Article

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