메뉴 건너뛰기




Volumn 4 S, Issue 1, 2012, Pages 74-89

Intranasal treatment of neurodegenerative diseases and stroke

Author keywords

Alzheimer's disease; Dementia; Diabetes; Intranasal; Neurodegenerative; Review; Stroke

Indexed keywords

CLONAZEPAM; DONEPEZIL; GALANTAMINE; INSULIN; NIMODIPINE; OXYTOCIN; PLACEBO; QUILOSTIGMINE; RIFAMPICIN; RISPERIDONE; RIVASTIGMINE; SUMATRIPTAN; DRUG;

EID: 84862286848     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: 10.2741/252     Document Type: Article
Times cited : (43)

References (170)
  • 2
    • 58149192688 scopus 로고    scopus 로고
    • Delivery of peptides to the brain: Emphasis on therapeutic development
    • WA Banks: Delivery of peptides to the brain: emphasis on therapeutic development. Biopolymers 90, 589-594 (2008)
    • (2008) Biopolymers , vol.90 , pp. 589-594
    • Banks, W.A.1
  • 4
    • 0014005338 scopus 로고
    • Clinical experience with intranasal oxytocin spray
    • C Jones: Clinical experience with intranasal oxytocin spray. Med J Aust 2, 1099-1101 (1966)
    • (1966) Med J Aust , vol.2 , pp. 1099-1101
    • Jones, C.1
  • 5
    • 0015226292 scopus 로고
    • Intranasal oxytocin in eighteen hundred patients. A study on its safety as used in a community hospital
    • RT Hoover: Intranasal oxytocin in eighteen hundred patients. A study on its safety as used in a community hospital. Am J Obstet Gynecol 110, 788-794 (1971)
    • (1971) Am J Obstet Gynecol , vol.110 , pp. 788-794
    • Hoover, R.T.1
  • 6
    • 0014629086 scopus 로고
    • Induction of labour. A comparison of intranasal and transbuccal administration of oxytocin
    • S Sjostedt: Induction of labour. A comparison of intranasal and transbuccal administration of oxytocin. Acta Obstet Gynecol Scand Suppl 7, Suppl 7:1-17 (1969)
    • (1969) Acta Obstet Gynecol Scand Suppl , vol.7 , Issue.SUPPL. 7 , pp. 1-17
    • Sjostedt, S.1
  • 7
    • 0014921742 scopus 로고
    • Experience of the use of intranasal, buccal and intravenous oxytocin as methods of inducing labour
    • J Laine: Experience of the use of intranasal, buccal and intravenous oxytocin as methods of inducing labour. Acta Obstet Gynecol Scand 49, 149-159 (1970)
    • (1970) Acta Obstet Gynecol Scand , vol.49 , pp. 149-159
    • Laine, J.1
  • 10
    • 77949833508 scopus 로고    scopus 로고
    • Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
    • S. Dhuria, L. Hanson, W. Frey, 2nd: Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci 99, 1654-1673 (2010)
    • (2010) J Pharm Sci , vol.99 , pp. 1654-1673
    • Dhuria, S.1    Hanson, L.2    Frey II, W.3
  • 11
    • 0037802511 scopus 로고    scopus 로고
    • Bypassing the blood-brain barrier to deliver therapeutic agents to the brain and spinal cord
    • WHn Frey: Bypassing the blood-brain barrier to deliver therapeutic agents to the brain and spinal cord. Drug Del Tech 2, 46-49 (2002)
    • (2002) Drug Del Tech , vol.2 , pp. 46-49
    • Frey, W.H.N.1
  • 12
    • 3242740239 scopus 로고    scopus 로고
    • Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
    • DOI 10.1016/j.neuroscience.2004.05.029, PII S0306452204004002
    • R. Thorne, G. Pronk, V Padmanabhan, WHn Frey: Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 127, 481-496 (2004) (Pubitemid 38950662)
    • (2004) Neuroscience , vol.127 , Issue.2 , pp. 481-496
    • Thorne, R.G.1    Pronk, G.J.2    Padmanabhan, V.3    Frey II, W.H.4
  • 13
    • 33846808559 scopus 로고    scopus 로고
    • Approaches for drug deposition in the human olfactory epithelium
    • D. Dhanda, WH. Frey, D Leopold, UB Kompella: Approaches for drug deposition in the human olfactory epithelium. Drug Del Tech 5, 64-72 (2005)
    • (2005) Drug Del Tech , vol.5 , pp. 64-72
    • Dhanda, D.1    Frey, W.H.2    Leopold, D.3    Kompella, U.B.4
  • 14
    • 0037660915 scopus 로고    scopus 로고
    • The chemical senses
    • Kandel ER, Schwartz JH, Jessell TM, eds, McGraw-Hill Companies, New York
    • LB Buck. The chemical senses. In: Principles of neural science. Eds: Kandel ER, Schwartz JH, Jessell TM, eds. pp. 625-652 McGraw-Hill Companies, New York: (2000)
    • (2000) Principles of Neural Science , pp. 625-652
    • Buck, L.B.1
  • 15
    • 28744446712 scopus 로고    scopus 로고
    • The Grueneberg ganglion of the mouse projects axons to glomeruli in the olfactory bulb
    • DOI 10.1111/j.1460-9568.2005.04468.x
    • S. Fuss, M Omura, P Mombaerts: The Grueneberg ganglion of the mouse projects axons to glomeruli in the olfactory bulb. Eur J Neurosci 22, 2649-2654 (2005) (Pubitemid 41759007)
    • (2005) European Journal of Neuroscience , vol.22 , Issue.10 , pp. 2649-2654
    • Fuss, S.H.1    Omura, M.2    Mombaerts, P.3
  • 16
    • 27844472122 scopus 로고    scopus 로고
    • The Grueneberg ganglion projects to the olfactory bulb
    • DOI 10.1097/01.wnr.0000186597.72081.10
    • D. Koos, SE Fraser: The Grueneberg ganglion projects to the olfactory bulb. Neuroreport 16, 1929-1932 (2005) (Pubitemid 41653516)
    • (2005) NeuroReport , vol.16 , Issue.17 , pp. 1929-1932
    • Koos, D.S.1    Fraser, S.E.2
  • 17
    • 0022552302 scopus 로고
    • Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey
    • B. Balin, R. Broadwell, M Salcman, M el-Kalliny: Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey. J Comp Neurol 251, 260-280 (1986) (Pubitemid 16027854)
    • (1986) Journal of Comparative Neurology , vol.251 , Issue.2 , pp. 260-280
    • Balin, B.J.1    Broadwell, R.D.2    Salcman, M.3    El-Kalliny, M.4
  • 18
    • 0035994292 scopus 로고    scopus 로고
    • Visualization of in vivo olfactory uptake and transfer using fluorescein dextran
    • B Jansson, E Bjork: Visualization of in vivo olfactory uptake and transfer using fluorescein dextran. J Drug Target. 10, 379-386 (2002)
    • (2002) J Drug Target. , vol.10 , pp. 379-386
    • Jansson, B.1    Bjork, E.2
  • 19
    • 40949134628 scopus 로고    scopus 로고
    • Delivery of interferon-beta to the monkey nervous system following intranasal administration
    • R. Thorne, L. Hanson, T. Ross, D Tung. WH Frey, 2nd: Delivery of interferon-beta to the monkey nervous system following intranasal administration. Neuroscience 152, 785-797 (2008)
    • (2008) Neuroscience , vol.152 , pp. 785-797
    • Thorne, R.1    Hanson, L.2    Ross, T.3    Tung, D.4    Frey II, W.H.5
  • 20
    • 44649136051 scopus 로고    scopus 로고
    • Intranasal administration delivers peptoids to the rat central nervous system
    • T. Ross, R. Zuckermann, C Reinhard. WH Frey, 2nd: Intranasal administration delivers peptoids to the rat central nervous system. Neurosci Lett 439, 30-33 (2008)
    • (2008) Neurosci Lett , vol.439 , pp. 30-33
    • Ross, T.1    Zuckermann, R.2    Reinhard, C.3    Frey II, W.H.4
  • 22
    • 9644296596 scopus 로고    scopus 로고
    • Neurogenesis in the adult olfactory neuroepithelium
    • Doty RL, ed. 93-113. Marcel Dekker, Inc., New York
    • A Mackay-Sim. Neurogenesis in the adult olfactory neuroepithelium. In: Handbook of olfaction and gustation. Eds: Doty RL, ed. 93-113. Marcel Dekker, Inc., New York: (2003)
    • (2003) Handbook of Olfaction and Gustation
    • Mackay-Sim, A.1
  • 23
    • 0742305132 scopus 로고    scopus 로고
    • Response of Olfactory Ensheathing Cells to the Degeneration and Regeneration of the Peripheral Olfactory System and the Involvement of the Neuregulins
    • DOI 10.1002/cne.11045
    • S. Williams, R. Franklin, SC Barnett: Response of olfactory ensheathing cells to the degeneration and regeneration of the peripheral olfactory system and the involvement of the neuregulins. J Comp Neurol 470, 50-62 (2004) (Pubitemid 38160697)
    • (2004) Journal of Comparative Neurology , vol.470 , Issue.1 , pp. 50-62
    • Williams, S.K.1    Franklin, R.J.M.2    Barnett, S.C.3
  • 24
    • 3242740239 scopus 로고    scopus 로고
    • Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
    • DOI 10.1016/j.neuroscience.2004.05.029, PII S0306452204004002
    • R. Thorne, G. Pronk, V Padmanabhan, WH Frey: Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 127, 481-496 (2004) (Pubitemid 38950662)
    • (2004) Neuroscience , vol.127 , Issue.2 , pp. 481-496
    • Thorne, R.G.1    Pronk, G.J.2    Padmanabhan, V.3    Frey II, W.H.4
  • 25
    • 0035693963 scopus 로고    scopus 로고
    • Delivery of neurotrophic factors to the central nervous system: Pharmacokinetic considerations
    • R. Thorne, W. Frey, 2nd: Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerations. Clin Pharmacokinet 40, 907-946 (2001) (Pubitemid 34066688)
    • (2001) Clinical Pharmacokinetics , vol.40 , Issue.12 , pp. 907-946
    • Thorne, R.G.1    Frey, W.H.2
  • 26
    • 0022477568 scopus 로고
    • Transneuronal transport of peroxidase-conjugated wheat germ agglutinin (WGA-HRP) from the olfactory epithelium to the brain of the adult rat
    • H Baker, RF Spencer: Transneuronal transport of peroxidase-conjugated wheat germ agglutinin (WGA-HRP) from the olfactory epithelium to the brain of the adult rat. Exp Brain Res 63, 461-473 (1986) (Pubitemid 16036221)
    • (1986) Experimental Brain Research , vol.63 , Issue.3 , pp. 461-473
    • Baker, H.1    Spencer, R.F.2
  • 27
    • 0022384030 scopus 로고
    • Endocytic and exocytic pathways of the neuronal secretory process and trans-synaptic transfer of wheat germ agglutinin-horseradish peroxidase in vivo
    • DOI 10.1002/cne.902420410
    • R. Broadwell, BJ Balin: Endocytic and exocytic pathways of the neuronal secretory process and transsynaptic transfer of wheat germ agglutinin- horseradish peroxidase in vivo. J Comp Neurol 242, 632-650 (1985) (Pubitemid 16176081)
    • (1985) Journal of Comparative Neurology , vol.242 , Issue.4 , pp. 632-650
    • Broadwell, R.D.1    Balin, B.J.2
  • 28
    • 0015166062 scopus 로고
    • Uptake of exogenous proteins in mouse olfactory cells
    • K Kristensson, Y Olsson: Uptake of exogenous proteins in mouse olfactory cells. Acta Neuropathol 19, 145-154 (1971)
    • (1971) Acta Neuropathol , vol.19 , pp. 145-154
    • Kristensson, K.1    Olsson, Y.2
  • 29
    • 0032229326 scopus 로고    scopus 로고
    • Delivery of nerve growth factor to the brain via the olfactory pathway
    • X. Chen, J. Fawcett, Y. Rahman, T. Ala, WH Frey Ii: Delivery of Nerve Growth Factor to the Brain via the Olfactory Pathway. J. Alzheimers. Dis. 1, 35-44 (1998)
    • (1998) J. Alzheimers. Dis. , vol.1 , pp. 35-44
    • Chen, X.1    Fawcett, J.2    Rahman, Y.3    Ala, T.4    Frey II, W.H.5
  • 30
    • 12344302551 scopus 로고    scopus 로고
    • Intranasal delivery of nerve growth factor to protect the central nervous system against acute cerebral infarction
    • H. Zhao, X. Liu, X. Mao, CF Chen: Intranasal delivery of nerve growth factor to protect the central nervous system against acute cerebral infarction. Chin Med Sci J 19, 257-261 (2004) (Pubitemid 40128007)
    • (2004) Chinese Medical Sciences Journal , vol.19 , Issue.4 , pp. 257-261
    • Zhao, H.-M.1    Liu, X.-F.2    Mao, X.-W.3    Chen, C.-F.4
  • 31
    • 2442446226 scopus 로고    scopus 로고
    • Anatomy of the human nasal passages
    • Doty RL, ed, Marcel Dekker, Inc., New York
    • D. Clerico, W. To, DC Lanza. Anatomy of the human nasal passages. In: Handbook of olfaction and gustation. Eds: Doty RL, ed. 1-16. Marcel Dekker, Inc., New York (2003)
    • (2003) Handbook of Olfaction and Gustation , pp. 1-16
    • Clerico, D.1    To, W.2    Lanza, D.C.3
  • 32
    • 84883694425 scopus 로고
    • 15th revised Classic Collectors edition ed. New York: Bounty Books
    • H Gray. Gray's anatomy., 15th revised (Classic Collectors edition) ed. New York: Bounty Books, 1978
    • (1978) Gray's anatomy.
    • Gray, H.1
  • 33
    • 0037066058 scopus 로고    scopus 로고
    • Trigeminal collaterals in the nasal epithelium and olfactory bulb: A potential route for direct modulation of olfactory information by trigeminal stimuli
    • DOI 10.1002/cne.10143
    • M. Schaefer, B Bottger. WL Silver, TE Finger: Trigeminal collaterals in the nasal epithelium and olfactory bulb: a potential route for direct modulation of olfactory information by trigeminal stimuli. J Comp Neurol 444, 221-226 (2002) (Pubitemid 34117087)
    • (2002) Journal of Comparative Neurology , vol.444 , Issue.3 , pp. 221-226
    • Schaefer, M.L.1    Bottger, B.2    Silver, W.L.3    Finger, T.E.4
  • 34
    • 2442528684 scopus 로고    scopus 로고
    • Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: A non-invasive treatment strategy for multiple sclerosis
    • DOI 10.1016/j.jneuroim.2004.02.011, PII S0165572804000773
    • T. Ross, P. Martinez, J. Renner, R. Thorne, L. Hanson, WH Frey: Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis. Journal of Neuroimmunology 151, 66-77 (2004) (Pubitemid 38624401)
    • (2004) Journal of Neuroimmunology , vol.151 , Issue.1-2 , pp. 66-77
    • Ross, T.M.1    Martinez, P.M.2    Renner, J.C.3    Thorne, R.G.4    Hanson, L.R.5    Frey II, W.H.6
  • 35
    • 59149092853 scopus 로고    scopus 로고
    • Novel vasoconstrictor formulation to enhance intranasal targeting of neuropeptide therapeutics to the central nervous system
    • S. Dhuria, L. Hanson, W. Frey, 2nd: Novel vasoconstrictor formulation to enhance intranasal targeting of neuropeptide therapeutics to the central nervous system. J Pharmacol Exp Ther 328, 312-320 (2009)
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 312-320
    • Dhuria, S.1    Hanson, L.2    Frey II, W.3
  • 36
    • 20444400364 scopus 로고    scopus 로고
    • Intranasal administration of hypocretin 1 (orexin A) bypasses the blood-brain barrier & targets the brain: A new strategy for the treatment of narcolepsy
    • L. Hanson, P. Martinez, S Taheri. L Kamsheh, E Mignot, WHI Frey: Intranasal administration of hypocretin 1 (orexin A) bypasses the blood-brain barrier & targets the brain: A new strategy for the treatment of narcolepsy. Drug Del Tech 4, 66-70 (2004)
    • (2004) Drug Del Tech , vol.4 , pp. 66-70
    • Hanson, L.1    Martinez, P.2    Taheri, S.3    Kamsheh, L.4    Mignot, E.5    Frey, W.H.I.6
  • 37
    • 0002781622 scopus 로고
    • Blood and nerve supply of the nasal lining
    • Proctor DF, Andersen I, eds, Elsevier Biomedical Press, Amsterdam
    • N Cauna. Blood and nerve supply of the nasal lining. In: The nose: Upper airway physiology and the atmospheric environment. Eds: Proctor DF, Andersen I, eds. 45-69 Elsevier Biomedical Press, Amsterdam (1982)
    • (1982) The Nose: Upper Airway Physiology and the Atmospheric Environment , pp. 45-69
    • Cauna, N.1
  • 38
    • 0023179807 scopus 로고
    • Fenestrated endothelia in vessels of the nasal mucosa. An electron-microscopic study in the rabbit
    • DOI 10.1007/BF00453492
    • G Grevers, U Herrmann: Fenestrated endothelia in vessels of the nasal mucosa. An electron-microscopic study in the rabbit. Arch Otorhinolaryngol 244, 55-60 (1987) (Pubitemid 17083392)
    • (1987) Archives of Oto-Rhino-Laryngology , vol.244 , Issue.1 , pp. 55-60
    • Grevers, G.1    Herrmann, U.2
  • 39
    • 0018375096 scopus 로고
    • An ultrastructural study of the endonasal microcirculation in the Wistar rat during fetal and early postnatal life
    • P Va. Diest, MW Kanan: An ultrastructural study of the endonasal microcirculation in the Wistar rat during fetal and early postnatal life. J Anat 128, 293-300 (1979) (Pubitemid 9118352)
    • (1979) Journal of Anatomy , vol.128 , Issue.2 , pp. 293-300
    • Van Diest, P.1    Kanan, M.W.2
  • 40
    • 0019556901 scopus 로고
    • Efflux of radiolabeled polyethylene glycols and albumin from rat brain
    • H. Cserr, D. Cooper, P. Suri, CS Patlak: Efflux of radiolabeled polyethylene glycols and albumin from rat brain. Am J Physiol 240, F319-328 (1981)
    • (1981) Am J Physiol , vol.240
    • Cserr, H.1    Cooper, D.2    Suri, P.3    Patlak, C.S.4
  • 42
    • 33745275175 scopus 로고    scopus 로고
    • The "Perivascular Pump" Driven by Arterial Pulsation Is a Powerful Mechanism for the Distribution of Therapeutic Molecules within the Brain
    • DOI 10.1016/j.ymthe.2006.02.018, PII S1525001606001134
    • P Hadaczek. Y Yamashita, H Mirek. L Tamas, M. Bohn, C Noble. JW Park, K Bankiewicz: The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain. Mol Ther 14, 69-78 (2006) (Pubitemid 43922142)
    • (2006) Molecular Therapy , vol.14 , Issue.1 , pp. 69-78
    • Hadaczek, P.1    Yamashita, Y.2    Mirek, H.3    Tamas, L.4    Bohn, M.C.5    Noble, C.6    Park, J.W.7    Bankiewicz, K.8
  • 43
    • 0025103546 scopus 로고
    • Rapid solute transport throughout the brain via paravascular fluid pathways
    • M. Rennels, O. Blaumanis, PA Grady: Rapid solute transport throughout the brain via paravascular fluid pathways. Adv Neurol 52, 431-439 (1990)
    • (1990) Adv Neurol , vol.52 , pp. 431-439
    • Rennels, M.1    Blaumanis, O.2    Grady, P.A.3
  • 44
    • 0021959647 scopus 로고
    • Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space
    • DOI 10.1016/0006-8993(85)91383-6
    • M. Rennels, T. Gregory, O. Blaumanis, K Fujimoto, PA Grady: Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space. Brain Res 326, 47-63 (1985) (Pubitemid 15160009)
    • (1985) Brain Research , vol.326 , Issue.1 , pp. 47-63
    • Rennels, M.L.1    Gregory, T.F.2    Blaumanis, O.R.3
  • 45
    • 0020646195 scopus 로고
    • Factors influencing exit of substances from cerebrospinal fluid into deep cervical lymph of the rabbit
    • M. Bradbury, RJ Westrop: Factors influencing exit of substances from cerebrospinal fluid into deep cervical lymph of the rabbit. J Physiol 339, 519-534 (1983) (Pubitemid 13104105)
    • (1983) Journal of Physiology , vol.VOL. 339 , pp. 519-534
    • Bradbury, M.W.B.1    Westrop, R.J.2
  • 46
    • 30444445129 scopus 로고    scopus 로고
    • How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes
    • DOI 10.1182/blood-2005-01-0154
    • E Hatterer. N Davoust, M Didier-Bazes. C Vuaillat, C Malcus. MF Belin, S Nataf: How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes. Blood 107, 806-812 (2006) (Pubitemid 43076409)
    • (2006) Blood , vol.107 , Issue.2 , pp. 806-812
    • Hatterer, E.1    Davoust, N.2    Didier-Bazes, M.3    Vuaillat, C.4    Malcus, C.5    Belin, M.-F.6    Nataf, S.7
  • 47
    • 33749414503 scopus 로고    scopus 로고
    • Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species
    • M Johnston. A Zakharov, C Papaiconomou. G Salmasi, D Armstrong: Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species. Cerebrospinal Fluid Res 1, 2 (2004)
    • (2004) Cerebrospinal Fluid Res , vol.1 , pp. 2
    • Johnston, M.1    Zakharov, A.2    Papaiconomou, C.3    Salmasi, G.4    Armstrong, D.5
  • 48
    • 0027740941 scopus 로고
    • CSF drains directly from the subarachnoid space into nasal lymphatics in the rat. Anatomy, histology and immunological significance
    • S Kida. A Pantazis, RO Weller: CSF drains directly from the subarachnoid space into nasal lymphatics in the rat. Anatomy, histology and immunological significance. Neuropathol Appl Neurobiol 19, 480-488 (1993) (Pubitemid 24010674)
    • (1993) Neuropathology and Applied Neurobiology , vol.19 , Issue.6 , pp. 480-488
    • Kida, S.1    Pantazis, A.2    Weller, R.O.3
  • 49
    • 33645820117 scopus 로고    scopus 로고
    • The olfactory route for cerebrospinal fluid drainage into the peripheral lymphatic system
    • DOI 10.1111/j.1365-2990.2006.00737.x
    • B. Walter, V. Valera, S Takahashi, T Ushiki: The olfactory route for cerebrospinal fluid drainage into the peripheral lymphatic system. Neuropathol Appl Neurobiol 32, 388-396 (2006) (Pubitemid 44015580)
    • (2006) Neuropathology and Applied Neurobiology , vol.32 , Issue.4 , pp. 388-396
    • Walter, B.A.1    Valera, V.A.2    Takahashi, S.3    Ushiki, T.4
  • 50
    • 85047698627 scopus 로고    scopus 로고
    • Sniffing neuropeptides: A transnasal approach to the human brain
    • DOI 10.1038/nn849
    • J Born. T Lange, W Kern. GP McGregor, U Bickel, HL Fehm: Sniffing neuropeptides: a transnasal approach to the human brain. Nature Neuroscience 5, 514-516 (2002) (Pubitemid 34568991)
    • (2002) Nature Neuroscience , vol.5 , Issue.6 , pp. 514-516
    • Born, J.1    Lange, T.2    Kern, W.3    McGregor, G.P.4    Bickel, U.5    Fehm, H.L.6
  • 51
    • 56549112905 scopus 로고    scopus 로고
    • Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy
    • G. Francis, J. Martinez, W. Liu, K Xu. A Ayer, J Fine. UI Tuor, G Glazner. LR Hanson, W. Frey, 2nd, C Toth: Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy. Brain 131, 3311-3334 (2008)
    • (2008) Brain , vol.131 , pp. 3311-3334
    • Francis, G.1    Martinez, J.2    Liu, W.3    Xu, K.4    Ayer, A.5    Fine, J.6    Tuor, U.I.7    Glazner, G.8    Hanson, L.R.9    Frey II, W.10    Toth, C.11
  • 53
    • 67650172577 scopus 로고    scopus 로고
    • Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system
    • S. Dhuria, L. Hanson, W. Frey, 2nd: Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system. J Pharm Sci 98, 2501-2515 (2009)
    • (2009) J Pharm Sci , vol.98 , pp. 2501-2515
    • Dhuria, S.1    Hanson, L.2    Frey II, W.3
  • 54
    • 1042269557 scopus 로고    scopus 로고
    • Is nose-to-brain transport of drugs in man a reality?
    • DOI 10.1211/0022357022539
    • L Illum: Is nose-to-brain transport of drugs in man a reality? J Pharm Pharmacol 56, 3-17 (2004) (Pubitemid 38195323)
    • (2004) Journal of Pharmacy and Pharmacology , vol.56 , Issue.1 , pp. 3-17
    • Illum, L.1
  • 55
    • 23744505489 scopus 로고    scopus 로고
    • Localization and differential activity of P-glycoprotein in the bovine olfactory and nasal respiratory mucosae
    • DOI 10.1007/s11095-005-5420-3
    • K. Kandimalla, MD Donovan: Localization and differential activity of P-glycoprotein in the bovine olfactory and nasal respiratory mucosae. Pharm Res 22, 1121-1128 (2005) (Pubitemid 41127070)
    • (2005) Pharmaceutical Research , vol.22 , Issue.7 , pp. 1121-1128
    • Kandimalla, K.K.1    Donovan, M.D.2
  • 56
    • 17644413537 scopus 로고    scopus 로고
    • Functional evidence for P-glycoprotein at the nose-brain barrier
    • DOI 10.1007/s11095-004-9013-3
    • C. Graff, GM Pollack: Functional evidence for Pglycoprotein at the nose-brain barrier. Pharm Res 22, 86-93 (2005) (Pubitemid 40558150)
    • (2005) Pharmaceutical Research , vol.22 , Issue.1 , pp. 86-93
    • Graff, C.L.1    Pollack, G.M.2
  • 58
    • 16444385695 scopus 로고    scopus 로고
    • Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: Implications on nose-to-brain transport
    • DOI 10.1002/jps.20284
    • K. Kandimalla, MD Donovan: Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: implications on nose-to-brain transport. J Pharm Sci 94, 613-624 (2005) (Pubitemid 40476525)
    • (2005) Journal of Pharmaceutical Sciences , vol.94 , Issue.3 , pp. 613-624
    • Kandimalla, K.K.1    Donovan, M.D.2
  • 59
    • 0042626540 scopus 로고    scopus 로고
    • P-glycoprotein attenuates brain uptake of substrates after nasal instillation
    • DOI 10.1023/A:1025053115583
    • C. Graff, GM Pollack: P-Glycoprotein attenuates brain uptake of substrates after nasal instillation. Pharm Res 20, 1225-1230 (2003) (Pubitemid 36951847)
    • (2003) Pharmaceutical Research , vol.20 , Issue.8 , pp. 1225-1230
    • Graff, C.L.1    Pollack, G.M.2
  • 61
    • 0026586445 scopus 로고
    • Drug metabolism in the nasal mucosa
    • MA Sarkar: Drug metabolism in the nasal mucosa. Pharm Res 9, 1-9 (1992)
    • (1992) Pharm Res , vol.9 , pp. 1-9
    • Sarkar, M.A.1
  • 62
    • 0028205292 scopus 로고
    • Expression of the tight junction protein ZO-1 in the olfactory system: Presence of ZO-1 on olfactory sensory neurons and glial cells
    • F Miragall. D Krause, U d. Vries, R Dermietzel: Expression of the tight junction protein ZO-1 in the olfactory system: presence of ZO-1 on olfactory sensory neurons and glial cells. J Comp Neurol 341, 433-448 (1994) (Pubitemid 24072838)
    • (1994) Journal of Comparative Neurology , vol.341 , Issue.4 , pp. 433-448
    • Miragall, F.1    Krause, D.2    De Vries, U.3    Dermietzel, R.4
  • 63
    • 33645345962 scopus 로고    scopus 로고
    • Intranasal mucoadhesive microemulsions of clonazepam: Preliminary studies on brain targeting
    • T. Vyas, A. Babbar, R. Sharma, S Singh, A Misra: Intranasal mucoadhesive microemulsions of clonazepam: preliminary studies on brain targeting. J Pharm Sci 95, 570-580 (2006)
    • (2006) J Pharm Sci , vol.95 , pp. 570-580
    • Vyas, T.1    Babbar, A.2    Sharma, R.3    Singh, S.4    Misra, A.5
  • 64
    • 33645731771 scopus 로고    scopus 로고
    • Preliminary brain-targeting studies on intranasal mucoadhesive microemulsions of sumatriptan
    • T. Vyas, A. Babbar, R. Sharma, S Singh, A Misra: Preliminary brain-targeting studies on intranasal mucoadhesive microemulsions of sumatriptan. AAPS Pharm Sci Tech 7, E8 (2006)
    • (2006) AAPS Pharm Sci Tech , vol.7
    • Vyas, T.1    Babbar, A.2    Sharma, R.3    Singh, S.4    Misra, A.5
  • 65
    • 44449106460 scopus 로고    scopus 로고
    • Intranasal nanoemulsion based brain targeting drug delivery system of risperidone
    • M Kumar. A Misra, A. Babbar, A. Mishra, P Mishra, K Pathak: Intranasal nanoemulsion based brain targeting drug delivery system of risperidone. Int J Pharm 358, 285-291 (2008)
    • (2008) Int J Pharm , vol.358 , pp. 285-291
    • Kumar, M.1    Misra, A.2    Babbar, A.3    Mishra, A.4    Mishra, P.5    Pathak, K.6
  • 66
    • 1842789813 scopus 로고    scopus 로고
    • Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain
    • DOI 10.1016/j.ijpharm.2004.01.039, PII S0378517304000870
    • Q Zhang. X Jiang, W Jiang. W Lu, L Su, Z Shi: Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain. Int J Pharm 275, 85-96 (2004) (Pubitemid 38481522)
    • (2004) International Journal of Pharmaceutics , vol.275 , Issue.1-2 , pp. 85-96
    • Zhang, Q.1    Jiang, X.2    Jiang, W.3    Lu, W.4    Su, L.5    Shi, Z.6
  • 68
    • 54949153043 scopus 로고    scopus 로고
    • Preparation of estradiol chitosan nanoparticles for improving nasal absorption and brain targeting
    • X Wang. N Chi, X Tang: Preparation of estradiol chitosan nanoparticles for improving nasal absorption and brain targeting. Eur J Pharm Biopharm 70, 735-740 (2008)
    • (2008) Eur J Pharm Biopharm , vol.70 , pp. 735-740
    • Wang, X.1    Chi, N.2    Tang, X.3
  • 69
    • 33744967949 scopus 로고    scopus 로고
    • Evaluation of brain-targeting for the nasal delivery of estradiol by the microdialysis method
    • DOI 10.1016/j.ijpharm.2006.02.055, PII S0378517306001943
    • X Wang. H He, W Leng, X Tang: Evaluation of brain-targeting for the nasal delivery of estradiol by the microdialysis method. Int J Pharm 317, 40-46 (2006) (Pubitemid 43866343)
    • (2006) International Journal of Pharmaceutics , vol.317 , Issue.1 , pp. 40-46
    • Wang, X.1    He, H.2    Leng, W.3    Tang, X.4
  • 71
    • 0242288486 scopus 로고    scopus 로고
    • Absorption Enhancers for Nasal Drug Delivery
    • DOI 10.2165/00003088-200342130-00003
    • S. Davis, L Illum: Absorption enhancers for nasal drug delivery. Clin Pharmacokinet 42, 1107-1128 (2003) (Pubitemid 37357648)
    • (2003) Clinical Pharmacokinetics , vol.42 , Issue.13 , pp. 1107-1128
    • Davis, S.S.1    Illum, L.2
  • 73
    • 0028323017 scopus 로고
    • Direct drug transport from the rat nasal cavity to the cerebrospinal fluid: The relation to the dissociation of the drug
    • T Sakane. M Akizuki, S Yamashita. H Sezaki, T Nadai: Direct drug transport from the rat nasal cavity to the cerebrospinal fluid: the relation to the dissociation of the drug. J Pharm Pharmacol 46, 378-379 (1994) (Pubitemid 24140941)
    • (1994) Journal of Pharmacy and Pharmacology , vol.46 , Issue.5 , pp. 378-379
    • Sakane, T.1    Akizuki, M.2    Yamashita, S.3    Sezaki, H.4    Nadai, T.5
  • 74
    • 44749094651 scopus 로고    scopus 로고
    • Evaluation of direct transport pathways of glycine receptor antagonists and an angiotensin antagonist from the nasal cavity to the central nervous system in the rat model
    • S. Charlton, J Whetstone. ST Fayinka, K. Read, L Illum, SS Davis: Evaluation of direct transport pathways of glycine receptor antagonists and an angiotensin antagonist from the nasal cavity to the central nervous system in the rat model. Pharm Res 25, 1531-1543 (2008)
    • (2008) Pharm Res , vol.25 , pp. 1531-1543
    • Charlton, S.1    Whetstone, J.2    Fayinka, S.T.3    Read, K.4    Illum, L.5    Davis, S.S.6
  • 76
    • 34249984138 scopus 로고    scopus 로고
    • Evaluation of effect of ephedrine on the transport of drugs from the nasal cavity to the systemic circulation and the central nervous system
    • DOI 10.1080/10611860701393370, PII 779249156
    • S. Charlton, S. Davis, L Illum: Evaluation of effect of ephedrine on the transport of drugs from the nasal cavity to the systemic circulation and the central nervous system. J Drug Target 15, 370-377 (2007) (Pubitemid 46887868)
    • (2007) Journal of Drug Targeting , vol.15 , Issue.5 , pp. 370-377
    • Charlton, S.T.1    Davis, S.S.2    Illum, L.3
  • 77
    • 29944434476 scopus 로고    scopus 로고
    • Carbamazepine uptake into rat brain following intra-olfactory transport
    • DOI 10.1211/jpp.58.1.0008
    • N. Barakat, S. Omar, AA Ahmed: Carbamazepine uptake into rat brain following intra-olfactory transport. J Pharm Pharmacol 58, 63-72 (2006) (Pubitemid 43041997)
    • (2006) Journal of Pharmacy and Pharmacology , vol.58 , Issue.1 , pp. 63-72
    • Barakat, N.S.1    Omar, S.A.2    Ahmed, A.A.E.3
  • 79
    • 33846549026 scopus 로고    scopus 로고
    • Drug brain distribution following intranasal administration of Huperzine A in situ gel in rats
    • DOI 10.1111/j.1745-7254.2007.00486.x
    • Y Zhao. P Yue, T Tao, QH Chen: Drug brain distribution following intranasal administration of Huperzine A in situ gel in rats. Acta Pharmacol Sin 28, 273-278 (2007) (Pubitemid 46155546)
    • (2007) Acta Pharmacologica Sinica , vol.28 , Issue.2 , pp. 273-278
    • Zhao, Y.1    Yue, P.2    Tao, T.3    Chen, Q.-H.4
  • 80
    • 34547655840 scopus 로고    scopus 로고
    • Brain delivery of vasoactive intestinal peptide enhanced with the nanoparticles conjugated with wheat germ agglutinin following intranasal administration
    • DOI 10.1016/j.jconrel.2007.05.026, PII S0168365907002702
    • X Gao. B Wu, Q Zhang. J Chen, J Zhu. W Zhang, Z Rong. H Chen, X Jiang: Brain delivery of vasoactive intestinal peptide enhanced with the nanoparticles conjugated with wheat germ agglutinin following intranasal administration. J Control Release 121, 156-167 (2007) (Pubitemid 47212537)
    • (2007) Journal of Controlled Release , vol.121 , Issue.3 , pp. 156-167
    • Gao, X.1    Wu, B.2    Zhang, Q.3    Chen, J.4    Zhu, J.5    Zhang, W.6    Rong, Z.7    Chen, H.8    Jiang, X.9
  • 82
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • J Hardy, DJ Selkoe: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356 (2002) (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 83
    • 0031459646 scopus 로고    scopus 로고
    • Relationship between apolipoprotein E and the amyloid deposits and dystrophic neurites of Alzheimer's disease
    • T. Dickson, H. Saunders, JC Vickers: Relationship between apolipoprotein E and the amyloid deposits and dystrophic neurites of Alzheimer's disease. Neuropathol Appl Neurobiol 23, 483-491 (1997) (Pubitemid 28019850)
    • (1997) Neuropathology and Applied Neurobiology , vol.23 , Issue.6 , pp. 483-491
    • Dickson, T.C.1    Saunders, H.L.2    Vickers, J.C.3
  • 84
    • 0042508791 scopus 로고    scopus 로고
    • Neuropathologic changes in Alzheimer's disease
    • GL Wenk: Neuropathologic changes in Alzheimer's disease. J Clin Psychiatry 64 Suppl 9, 7-10 (2003) (Pubitemid 37040372)
    • (2003) Journal of Clinical Psychiatry , vol.64 , Issue.SUPPL. 9 , pp. 7-10
    • Wenk, G.L.1
  • 85
    • 34249697099 scopus 로고    scopus 로고
    • Forecasting the global burden of Alzheimer's disease
    • DOI 10.1016/j.jalz.2007.04.381, PII S155252600700475X
    • R Brookmeyer. E Johnson, K Ziegler-Graham, HM Arrighi: Forecasting the global burden of Alzheimer's disease. Alzheimers Dement 3, 186-191 (2007) (Pubitemid 46825511)
    • (2007) Alzheimer's and Dementia , vol.3 , Issue.3 , pp. 186-191
    • Brookmeyer, R.1    Johnson, E.2    Ziegler-Graham, K.3    Arrighi, H.M.4
  • 86
    • 0028914970 scopus 로고
    • Prevalence of Alzheimer's disease and vascular dementia: Association with education. The Rotterdam study
    • A Ott. MM Breteler, F va. Harskamp, J. Claus, T. van der Cammen, D. Grobbee, A Hofman: Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study. BMJ 310, 970-973 (1995)
    • (1995) BMJ , vol.310 , pp. 970-973
    • Ott, A.1    Breteler, M.M.2    Van Harskamp, F.3    Claus, J.4    Van Der Cammen, T.5    Grobbee, D.6    Hofman, A.7
  • 88
    • 77957313578 scopus 로고    scopus 로고
    • Effects of donepezil on activities of daily living: Integrated analysis of patient data from studies in mild, moderate and severe Alzheimer's disease
    • S Gauthier. OL Lopez, G Waldemar. RW Jones, J Cummings. R Zhang, R Schindler, E Schwam: Effects of donepezil on activities of daily living: integrated analysis of patient data from studies in mild, moderate and severe Alzheimer's disease. Int Psychogeriatr 22, 973-983 (2010)
    • (2010) Int Psychogeriatr , vol.22 , pp. 973-983
    • Gauthier, S.1    Lopez, O.L.2    Waldemar, G.3    Jones, R.W.4    Cummings, J.5    Zhang, R.6    Schindler, R.7    Schwam, E.8
  • 89
    • 77954717034 scopus 로고    scopus 로고
    • Predictors of adherence among Alzheimer's disease patients receiving oral therapy
    • B Borah. P Sacco, V Zarotsky: Predictors of adherence among Alzheimer's disease patients receiving oral therapy. Curr Med Res Opin 26, 1957-1965
    • Curr Med Res Opin , vol.26 , pp. 1957-1965
    • Borah, B.1    Sacco, P.2    Zarotsky, V.3
  • 90
    • 77649242351 scopus 로고    scopus 로고
    • Factors associated with serious adverse reactions to cholinesterase inhibitors: A study of spontaneous reporting
    • A Pariente. DJ Sanctussy, G Miremont-Salame. N Moore, F Haramburu, A Fourrier-Reglat: Factors associated with serious adverse reactions to cholinesterase inhibitors: a study of spontaneous reporting. CNS Drugs 24, 55-63 (2010)
    • (2010) CNS Drugs , vol.24 , pp. 55-63
    • Pariente, A.1    Sanctussy, D.J.2    Miremont-Salame, G.3    Moore, N.4    Haramburu, F.5    Fourrier-Reglat, A.6
  • 91
    • 42649133143 scopus 로고    scopus 로고
    • DNA vaccine therapy for Alzheimer's disease: Present status and future direction
    • DOI 10.1089/rej.2007.0638
    • Y Okura, Y Matsumoto: DNA vaccine therapy for Alzheimer's disease: present status and future direction. Rejuvenation Res 11, 301-308 (2008) (Pubitemid 351601163)
    • (2008) Rejuvenation Research , vol.11 , Issue.2 , pp. 301-308
    • Okura, Y.1    Matsumoto, Y.2
  • 92
    • 33947385878 scopus 로고    scopus 로고
    • Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of A1-6 upregulates IL-10 expression and reduces amyloid load in a Mo/ Hu APPswe PS1dE9 mouse model of Alzheimer's disease
    • DOI 10.1002/jgm.993
    • H. Kim, K Tahara. JA Maxwell, R Lalonde. T Fukuiwa, K Fujihashi. KR Van Kampen, F. Kong, D. Tang, K Fukuchi: Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of Abeta1-6 upregulates IL-10 expression and reduces amyloid load in a Mo/Hu APPswe PS1dE9 mouse model of Alzheimer's disease. J Gene Med 9, 88-98 (2007) (Pubitemid 46444486)
    • (2007) Journal of Gene Medicine , vol.9 , Issue.2 , pp. 88-98
    • Kim, H.-D.1    Tahara, K.2    Maxwell, J.A.3    Lalonde, R.4    Fukuiwa, T.5    Fujihashi, K.6    Van Kampen, K.R.7    Kong, F.-K.8    Tang, D.-C.C.9    Fukuchi, K.-I.10
  • 93
    • 34548203883 scopus 로고    scopus 로고
    • Enhancing Th2 immune responses against amyloid protein by a DNA prime-adenovirus boost regimen for Alzheimer's disease
    • DOI 10.1016/j.imlet.2007.06.006, PII S0165247807001423
    • H. Kim, J. Jin, J. Maxwell, K Fukuchi: Enhancing Th2 immune responses against amyloid protein by a DNA primeadenovirus boost regimen for Alzheimer's disease. Immunol Lett 112, 30-38 (2007) (Pubitemid 47331686)
    • (2007) Immunology Letters , vol.112 , Issue.1 , pp. 30-38
    • Kim, H.-D.1    Jin, J.-J.2    Maxwell, J.A.3    Fukuchi, K.-i.4
  • 94
    • 33646938005 scopus 로고    scopus 로고
    • Short amyloid- (A) immunogens reduce cerebral A load and learning deficits in an Alzheimer's disease mouse model in the absence of an A-specific cellular immune response
    • DOI 10.1523/JNEUROSCI.0381-06.2006
    • M Maier. TJ Seabrook, N. Lazo, L Jiang. P Das, C Janus, CA Lemere: Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response. J Neurosci 26, 4717-4728 (2006) (Pubitemid 44315311)
    • (2006) Journal of Neuroscience , vol.26 , Issue.18 , pp. 4717-4728
    • Maier, M.1    Seabrook, T.J.2    Lazo, N.D.3    Jiang, L.4    Das, P.5    Janus, C.6    Lemere, C.A.7
  • 97
    • 0037125974 scopus 로고    scopus 로고
    • Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice
    • S Capsoni. S Giannotta, A Cattaneo: Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc Natl Acad Sci U S A 99, 12432-12437 (2002)
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 12432-12437
    • Capsoni, S.1    Giannotta, S.2    Cattaneo, A.3
  • 100
    • 0035689690 scopus 로고    scopus 로고
    • Nasal vaccination with -amyloid peptide for the treatment of Alzheimer's disease
    • DOI 10.1089/10445490152717569
    • C. Lemere, R Maron. DJ Selkoe, HL Weiner: Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease. DNA Cell Biol 20, 705-711 (2001) (Pubitemid 34072837)
    • (2001) DNA and Cell Biology , vol.20 , Issue.11 , pp. 705-711
    • Lemere, C.A.1    Maron, R.2    Selkoe, D.J.3    Weiner, H.L.4
  • 102
    • 24644435506 scopus 로고    scopus 로고
    • Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears -amyloid in a mouse model of Alzheimer disease
    • DOI 10.1172/JCI23241
    • D Frenkel. R Maron, D. Burt, HL Weiner: Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease. J Clin Invest 115, 2423-2433 (2005) (Pubitemid 41266204)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.9 , pp. 2423-2433
    • Frenkel, D.1    Maron, R.2    Burt, D.S.3    Weiner, H.L.4
  • 103
    • 34248354279 scopus 로고    scopus 로고
    • Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage
    • DOI 10.1007/s12031-007-0016-5, PII JMN312165
    • Y Matsuoka. AJ Gray, C Hirata-Fukae. SS Minami, E. Waterhouse, M. Mattson, F. La Ferla, I Gozes, PS Aisen: Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage. J Mol Neurosci 31, 165-170 (2007) (Pubitemid 46742300)
    • (2007) Journal of Molecular Neuroscience , vol.31 , Issue.2 , pp. 165-170
    • Matsuoka, Y.1    Gray, A.J.2    Hirata-Fukae, C.3    Minami, S.S.4    Waterhouse, E.G.5    Mattson, M.P.6    LaFerla, F.M.7    Gozes, I.8    Aisen, P.S.9
  • 104
    • 37049015188 scopus 로고    scopus 로고
    • NAP, a neuroprotective drug candidate in clinical trials, stimulates microtubule assembly in the living cell
    • DOI 10.2174/156720507783018208
    • I Gozes, I Divinski: NAP, a neuroprotective drug candidate in clinical trials, stimulates microtubule assembly in the living cell. Curr Alzheimer Res 4, 507-509 (2007) (Pubitemid 350248382)
    • (2007) Current Alzheimer Research , vol.4 , Issue.5 , pp. 507-509
    • Gozes, I.1    Divinski, I.2
  • 106
    • 45149115313 scopus 로고    scopus 로고
    • Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease
    • DOI 10.1038/sj.npp.1301591, PII 1301591
    • M Yamada. T Chiba, J Sasabe. K Terashita, S Aiso, M Matsuoka: Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease. Neuropsychopharmacology 33, 2020-2032 (2008) (Pubitemid 351832605)
    • (2008) Neuropsychopharmacology , vol.33 , Issue.8 , pp. 2020-2032
    • Yamada, M.1    Chiba, T.2    Sasabe, J.3    Terashita, K.4    Aiso, S.5    Matsuoka, M.6
  • 108
    • 0035895267 scopus 로고    scopus 로고
    • Nasal administration of a physostigmine analogue (NXX-066) for Alzheimer's disease to rats
    • DOI 10.1016/S0378-5173(00)00612-8, PII S0378517300006128
    • M Dahlin, E Bjork: Nasal administration of a physostigmine analogue (NXX-066) for Alzheimer's disease to rats. Int J Pharm 212, 267-274 (2001) (Pubitemid 32119452)
    • (2001) International Journal of Pharmaceutics , vol.212 , Issue.2 , pp. 267-274
    • Dahlin, M.1    Bjork, E.2
  • 109
    • 0033605046 scopus 로고    scopus 로고
    • NXX-066 in patients with Alzheimer's disease: A bridging study
    • DOI 10.1016/S0024-3205(99)00053-3, PII S0024320599000533
    • J. Sramek, J Hourani. SS Jhee, NR Cutler: NXX-066 in patients with Alzheimer's disease: a bridging study. Life Sci 64, 1215-1221 (1999) (Pubitemid 29156869)
    • (1999) Life Sciences , vol.64 , Issue.14 , pp. 1215-1221
    • Sramek, J.J.1    Hourani, J.2    Jhee, S.S.3    Cutler, N.R.4
  • 110
    • 1542498664 scopus 로고    scopus 로고
    • Alternative routes of insulin delivery
    • DOI 10.1046/j.1464-5491.2003.01076.x
    • D. Owens, B Zinman, G Bolli: Alternative routes of insulin delivery. Diabetic Medicine 20, 886-898 (2003) (Pubitemid 41701487)
    • (2003) Diabetic Medicine , vol.20 , Issue.11 , pp. 886-898
    • Owens, D.R.1    Zinman, B.2    Bolli, G.3
  • 113
    • 1242316296 scopus 로고    scopus 로고
    • Insulin and neurodegenerative disease: Shared and specific mechanisms
    • DOI 10.1016/S1474-4422(04)00681-7
    • S Craft, GS Watson: Insulin and neurodegenerative disease: shared and specific mechanisms. Lancet Neurol 3, 169-178 (2004) (Pubitemid 38229951)
    • (2004) Lancet Neurology , vol.3 , Issue.3 , pp. 169-178
    • Craft, S.1    Watson, G.S.2
  • 114
    • 0033378682 scopus 로고    scopus 로고
    • A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease
    • L Frolich. D Blum-Degen, P Riederer, S Hoyer: A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease. Annals of the New York Academy of Sciences 893, 290-293 (1999) (Pubitemid 30038089)
    • (1999) Annals of the New York Academy of Sciences , vol.893 , pp. 290-293
    • Frolich, L.1    Blum-Degen, D.2    Riederer, P.3    Hoyer, S.4
  • 115
    • 57049125529 scopus 로고    scopus 로고
    • Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin
    • C. Jolivalt, C. Lee, K. Beiswenger, J. Smith, M Orlov. MA Torrance, E Masliah: Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin. J Neurosci Res 86, 3265-3274 (2008)
    • (2008) J Neurosci Res , vol.86 , pp. 3265-3274
    • Jolivalt, C.1    Lee, C.2    Beiswenger, K.3    Smith, J.4    Orlov, M.5    Torrance, M.A.6    Masliah, E.7
  • 116
    • 33845462866 scopus 로고    scopus 로고
    • Brain aging in very old men with type 2 diabetes: The Honolulu-Asia Aging Study
    • DOI 10.2337/dc06-0243
    • E. Korf, L. White, P Scheltens, LJ Launer: Brain aging in very old men with type 2 diabetes: the Honolulu-Asia Aging Study. Diabetes Care 29, 2268-2274 (2006) (Pubitemid 44899864)
    • (2006) Diabetes Care , vol.29 , Issue.10 , pp. 2268-2274
    • Korf, E.S.C.1    White, L.R.2    Scheltens, P.H.3    Launer, L.J.4
  • 117
    • 5344256250 scopus 로고    scopus 로고
    • Hyperinsulinemia and risk of Alzheimer disease
    • J. Luchsinger, M. Tang, S Shea, R Mayeux: Hyperinsulinemia and risk of Alzheimer disease. Neurology 63, 1187-1192 (2004) (Pubitemid 39350015)
    • (2004) Neurology , vol.63 , Issue.7 , pp. 1187-1192
    • Luchsinger, J.A.1    Tang, M.-X.2    Shea, S.3    Mayeux, R.4
  • 118
    • 42249116015 scopus 로고    scopus 로고
    • Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair
    • T. Nelson, M. Sun, J Hongpaisan, DL Alkon: Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair. Eur J Pharmacol 585, 76-87 (2008)
    • (2008) Eur J Pharmacol , vol.585 , pp. 76-87
    • Nelson, T.1    Sun, M.2    Hongpaisan, J.3    Alkon, D.L.4
  • 119
    • 33646358276 scopus 로고    scopus 로고
    • Alzheimer's disease could be "type 3 diabetes"
    • H Pilcher: Alzheimer's disease could be "type 3 diabetes". Lancet Neurol 5, 388-389 (2006)
    • (2006) Lancet Neurol , vol.5 , pp. 388-389
    • Pilcher, H.1
  • 120
    • 10944228564 scopus 로고    scopus 로고
    • Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: Implications for Alzheimer's disease intervention
    • DOI 10.1523/JNEUROSCI.2860-04.2004
    • L Zhao. B Teter, T Morihara. GP Lim, S. Ambegaokar, O. Ubeda, S. Frautschy, GM Cole: Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. Journal of Neuroscience 24, 11120-11126 (2004) (Pubitemid 40012971)
    • (2004) Journal of Neuroscience , vol.24 , Issue.49 , pp. 11120-11126
    • Zhao, L.1    Teter, B.2    Morihara, T.3    Lim, G.P.4    Ambegaokar, S.S.5    Ubeda, O.J.6    Frautschy, S.A.7    Cole, G.M.8
  • 125
    • 73649112749 scopus 로고    scopus 로고
    • Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease
    • Y Deng. B Li, Y Liu. K Iqbal, I Grundke-Iqbal, CX Gong: Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease. Am J Pathol 175, 2089-2098 (2009)
    • (2009) Am J Pathol , vol.175 , pp. 2089-2098
    • Deng, Y.1    Li, B.2    Liu, Y.3    Iqbal, K.4    Grundke-Iqbal, I.5    Gong, C.X.6
  • 126
    • 43449101830 scopus 로고    scopus 로고
    • Oxytocin Shapes the Neural Circuitry of Trust and Trust Adaptation in Humans
    • DOI 10.1016/j.neuron.2008.04.009, PII S0896627308003279
    • T Baumgartner. M Heinrichs, A Vonlanthen. U Fischbacher, E Fehr: Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron 58, 639-650 (2008) (Pubitemid 351672358)
    • (2008) Neuron , vol.58 , Issue.4 , pp. 639-650
    • Baumgartner, T.1    Heinrichs, M.2    Vonlanthen, A.3    Fischbacher, U.4    Fehr, E.5
  • 127
    • 20444497343 scopus 로고    scopus 로고
    • Oxytocin increases trust in humans
    • DOI 10.1038/nature03701
    • M Kosfeld. M Heinrichs, P. Zak, U Fischbacher, E Fehr: Oxytocin increases trust in humans. Nature 435, 673-676 (2005) (Pubitemid 40825511)
    • (2005) Nature , vol.435 , Issue.7042 , pp. 673-676
    • Kosfeld, M.1    Heinrichs, M.2    Zak, P.J.3    Fischbacher, U.4    Fehr, E.5
  • 129
    • 22144447448 scopus 로고    scopus 로고
    • Intranasal oxytocin administration attenuates the ACTH stress response in monkeys
    • DOI 10.1016/j.psyneuen.2005.04.002, PII S030645300500082X
    • K. Parker, C. Buckmaster, A. Schatzberg, DM Lyons: Intranasal oxytocin administration attenuates the ACTH stress response in monkeys. Psychoneuroendocrinology 30, 924-929 (2005) (Pubitemid 40977915)
    • (2005) Psychoneuroendocrinology , vol.30 , Issue.9 , pp. 924-929
    • Parker, K.J.1    Buckmaster, C.L.2    Schatzberg, A.F.3    Lyons, D.M.4
  • 132
    • 77955657213 scopus 로고    scopus 로고
    • Antigen-specific therapy of EAE via intranasal delivery of filamentous phage displaying a myelin immunodominant epitope
    • I. Rakover, N Zabavnik. R Kopel, M Paz-Rozner, B Solomon: Antigen-specific therapy of EAE via intranasal delivery of filamentous phage displaying a myelin immunodominant epitope. J Neuroimmunol 225, 68-76 (2010)
    • (2010) J Neuroimmunol , vol.225 , pp. 68-76
    • Rakover, I.1    Zabavnik, N.2    Kopel, R.3    Paz-Rozner, M.4    Solomon, B.5
  • 134
    • 77958450795 scopus 로고    scopus 로고
    • Nasal administration of stem cells: A promising novel route to treat neonatal ischemic brain damage
    • C. van Velthoven, A Kavelaars. F van Bel, CJ Heijnen: Nasal administration of stem cells: a promising novel route to treat neonatal ischemic brain damage. Pediatr Res 68, 419-422 (2010)
    • (2010) Pediatr Res , vol.68 , pp. 419-422
    • Van Velthoven, C.1    Kavelaars, A.2    Van Bel, F.3    Heijnen, C.J.4
  • 135
    • 0141446220 scopus 로고    scopus 로고
    • Obesity, insulin resistance, -cell autoimmunity, and the changing clinical epidemiology of childhood diabetes
    • DOI 10.2337/diacare.26.10.2954
    • AL Rosenbloom: Obesity, Insulin Resistance, beta-Cell Autoimmunity, and the Changing Clinical Epidemiology of Childhood Diabetes. Diabetes Care 26, 2954-2956 (2003) (Pubitemid 37205576)
    • (2003) Diabetes Care , vol.26 , Issue.10 , pp. 2954-2956
    • Rosenbloom, A.L.1
  • 136
    • 2342466734 scopus 로고    scopus 로고
    • Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030
    • DOI 10.2337/diacare.27.5.1047
    • S Wild. G Roglic, A Green. R Sicree, H King: Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27, 1047-1053 (2004) (Pubitemid 38579764)
    • (2004) Diabetes Care , vol.27 , Issue.5 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 137
    • 33847303686 scopus 로고    scopus 로고
    • Trends in diabetes prevalence, incidence, and mortality in Ontario, Canada 1995-2005: A population-based study
    • DOI 10.1016/S0140-6736(07)60361-4, PII S0140673607603614
    • L. Lipscombe, JE Hux: Trends in diabetes prevalence, incidence, and mortality in Ontario, Canada 1995-2005: a population-based study. Lancet. 369, 750-756 (2007) (Pubitemid 46321630)
    • (2007) Lancet , vol.369 , Issue.9563 , pp. 750-756
    • Lipscombe, L.L.1    Hux, J.E.2
  • 141
    • 33645093717 scopus 로고    scopus 로고
    • Hippocampal volume and cognitive performance in long-standing Type 1 diabetic patients without macrovascular complications
    • B. Lobnig, O Kromeke. C Optenhostert-Porst, OT Wolf: Hippocampal volume and cognitive performance in long-standing Type 1 diabetic patients without macrovascular complications. Diabet Med 23, 32-39 (2006)
    • (2006) Diabet Med , vol.23 , pp. 32-39
    • Lobnig, B.1    Kromeke, O.2    Optenhostert-Porst, C.3    Wolf, O.T.4
  • 142
    • 33745317068 scopus 로고    scopus 로고
    • Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes
    • DOI 10.2337/diabetes.55.04.06.db05-1323
    • S. Manschot, A. Brands, G. van der, R. Kessels, A Algra. LJ Kappelle, GJ Biessels: Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes. Diabetes 55, 1106-1113 (2006) (Pubitemid 44100188)
    • (2006) Diabetes , vol.55 , Issue.4 , pp. 1106-1113
    • Manschot, S.M.1    Brands, A.M.A.2    Van Der Grond, J.3    Kessels, R.P.C.4    Algra, A.5    Kappelle, L.J.6    Biessels, G.J.7
  • 144
    • 38149065205 scopus 로고    scopus 로고
    • Cognition and diabetes: A lifespan perspective
    • G. Biessels, I. Deary, CM Ryan: Cognition and diabetes: a lifespan perspective. Lancet Neurol 7, 184-190 (2008)
    • (2008) Lancet Neurol , vol.7 , pp. 184-190
    • Biessels, G.1    Deary, I.2    Ryan, C.M.3
  • 146
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
    • Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 333, 1581-1587 (1995)
    • (1995) N Engl J Med , vol.333 , pp. 1581-1587
  • 147
    • 15244341974 scopus 로고    scopus 로고
    • Recombinant tissue plasminogen activator (rtPA) for stroke: The perspective at 8 years
    • DOI 10.1097/01.nrl.0000156205.66116.84
    • JL Frey: Recombinant tissue plasminogen activator (rtPA) for stroke. The perspective at 8 years. Neurologist 11, 123-133 (2005) (Pubitemid 40388435)
    • (2005) Neurologist , vol.11 , Issue.2 , pp. 123-133
    • Frey, J.L.1
  • 148
    • 0026640989 scopus 로고
    • Therapeutic use of insulin-like growth factor I: Lessons from in vivo animal studies
    • P. Gluckman, GR Ambler: Therapeutic use of insulin-like growth factor I: lessons from in vivo animal studies. Acta Paediatr Suppl 383, 134-136 (1992)
    • (1992) Acta Paediatr Suppl , vol.383 , pp. 134-136
    • Gluckman, P.1    Ambler, G.R.2
  • 150
    • 0035875455 scopus 로고    scopus 로고
    • Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage
    • DOI 10.1016/S0022-510X(01)00532-9, PII S0022510X01005329
    • X. Liu, J. Fawcett, R. Thorne, T. De For, W. Frey, 2nd: Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage. J Neurol Sci 187, 91-97 (2001) (Pubitemid 32618661)
    • (2001) Journal of the Neurological Sciences , vol.187 , Issue.1-2 , pp. 91-97
    • Liu, X.-F.1    Fawcett, J.R.2    Thorne, R.G.3    DeFor, T.A.4    Frey II, W.H.5
  • 151
    • 0035800541 scopus 로고    scopus 로고
    • Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion
    • DOI 10.1016/S0304-3940(01)01982-6, PII S0304394001019826
    • X. Liu, J. Fawcett, R. Thorne, WH Frey: Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion. Neuroscience Letters 308, 91-94 (2001) (Pubitemid 32703675)
    • (2001) Neuroscience Letters , vol.308 , Issue.2 , pp. 91-94
    • Liu, X.-F.1    Fawcett, J.R.2    Thorne, R.G.3    Frey Ii, W.H.4
  • 152
    • 1842584318 scopus 로고    scopus 로고
    • The Window of Opportunity for Treatment of Focal Cerebral Ischemic Damage with Noninvasive Intranasal Insulin-like Growth Factor-I in Rats
    • DOI 10.1016/j.jstrokecerebrovasdis.2004.01.005
    • X. Liu, J. Fawcett, L. Hanson, WH Frey: The window of opportunity for treatment of focal cerebral ischemic damage with noninvasive intranasal
    • (2004) Journal of Stroke and Cerebrovascular Diseases , vol.13 , Issue.1 , pp. 16-23
    • Liu, X.-F.1    Fawcett, J.R.2    Hanson, L.R.3    Frey II, W.H.4
  • 153
    • 67349099863 scopus 로고    scopus 로고
    • Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats
    • S Lin. LW Fan, P. Rhodes, Z Cai: Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats. Exp Neurol 217, 361-370 (2009)
    • (2009) Exp Neurol , vol.217 , pp. 361-370
    • Lin, S.1    Fan, L.W.2    Rhodes, P.3    Cai, Z.4
  • 154
    • 23744459392 scopus 로고    scopus 로고
    • Intranasal recombinant human erythropoietin protects rats against focal cerebral ischemia
    • DOI 10.1016/j.neulet.2005.07.008, PII S0304394005007913
    • Y. Yu, Q. Xu, Q Zhang. WP Zhang, L. Zhang, EQ Wei: Intranasal recombinant human erythropoietin protects rats against focal cerebral ischemia. Neurosci Lett 387, 5-10 (2005) (Pubitemid 41138199)
    • (2005) Neuroscience Letters , vol.387 , Issue.1 , pp. 5-10
    • Yu, Y.-P.1    Xu, Q.-Q.2    Zhang, Q.3    Zhang, W.-P.4    Zhang, L.-H.5    Wei, E.-Q.6
  • 156
    • 67650848390 scopus 로고    scopus 로고
    • Intranasal delivery of erythropoietin plus insulin-like growth factor-I for acute neuroprotection in stroke. Laboratory investigation
    • L Fletcher. S Kohli, S. Sprague, R. Scranton, S. Lipton, A Parra. DF Jimenez, M Digicaylioglu: Intranasal delivery of erythropoietin plus insulin-like growth factor-I for acute neuroprotection in stroke. Laboratory investigation. J Neurosurg 111, 164-170 (2009)
    • (2009) J Neurosurg , vol.111 , pp. 164-170
    • Fletcher, L.1    Kohli, S.2    Sprague, S.3    Scranton, R.4    Lipton, S.5    Parra, A.6    Jimenez, D.F.7    Digicaylioglu, M.8
  • 159
    • 67649992291 scopus 로고    scopus 로고
    • The dose-effectiveness of intranasal VEGF in treatment of experimental stroke
    • J. Yang, H. Liu, Z. Wang, S. Cheng, X Cheng. GL Xu, XF Liu: The dose-effectiveness of intranasal VEGF in treatment of experimental stroke. Neurosci Lett 461, 212-216 (2009)
    • (2009) Neurosci Lett , vol.461 , pp. 212-216
    • Yang, J.1    Liu, H.2    Wang, Z.3    Cheng, S.4    Cheng, X.5    Xu, G.L.6    Liu, X.F.7
  • 160
    • 0029819763 scopus 로고    scopus 로고
    • TGF-beta 1 protects hippocampal neurons against degeneration caused by transient global ischemia. Dose-response relationship and potential neuroprotective mechanisms
    • discussion 1615
    • P Henrich-Noack. JH Prehn, J Krieglstein: TGF-beta 1 protects hippocampal neurons against degeneration caused by transient global ischemia. Dose-response relationship and potential neuroprotective mechanisms. Stroke 27, 1609-1614; discussion 1615 (1996)
    • (1996) Stroke , vol.27 , pp. 1609-1614
    • Henrich-Noack, P.1    Prehn, J.H.2    Krieglstein, J.3
  • 161
    • 60649091914 scopus 로고    scopus 로고
    • Intranasal delivery of transforming growth factor-beta1 in mice after stroke reduces infarct volume and increases neurogenesis in the subventricular zone
    • M Ma. Y Ma, X Yi. R Guo, W Zhu. X Fan, G Xu. WH Frey, 2nd, X Liu: Intranasal delivery of transforming growth factor-beta1 in mice after stroke reduces infarct volume and increases neurogenesis in the subventricular zone. BMC Neurosci 9, 117 (2008)
    • (2008) BMC Neurosci , vol.9 , pp. 117
    • Ma, M.1    Ma, Y.2    Yi, X.3    Guo, R.4    Zhu, W.5    Fan, X.6    Xu, G.7    Frey II, W.H.8    Liu, X.9
  • 162
    • 55049099223 scopus 로고    scopus 로고
    • Intranasally delivered bFGF enhances neurogenesis in adult rats following cerebral ischemia
    • Z. Wang, S. Cheng, M. Ma, Y. Ma, J. Yang, G. Xu, XF Liu: Intranasally delivered bFGF enhances neurogenesis in adult rats following cerebral ischemia. Neurosci Lett 446, 30-35 (2008)
    • (2008) Neurosci Lett , vol.446 , pp. 30-35
    • Wang, Z.1    Cheng, S.2    Ma, M.3    Ma, Y.4    Yang, J.5    Xu, G.6    Liu, X.F.7
  • 163
    • 0037373179 scopus 로고    scopus 로고
    • Cerebral neurogenesis is induced by intranasal administration of growth factors
    • DOI 10.1002/ana.10506
    • K Jin. L Xie, J Childs. Y Sun, X. Mao, A Logvinova, DA Greenberg: Cerebral Neurogenesis Is Induced by Intranasal Administration of Growth Factors. Ann Neurol 53, 405-409 (2003) (Pubitemid 36258647)
    • (2003) Annals of Neurology , vol.53 , Issue.3 , pp. 405-409
    • Jin, K.1    Xie, L.2    Childs, J.3    Sun, Y.4    Mao, X.O.5    Logvinova, A.6    Greenberg, D.A.7
  • 165
    • 72649087478 scopus 로고    scopus 로고
    • Intranasal administration of PEGylated transforming growth factor-alpha improves behavioral deficits in a chronic stroke model
    • M Guerra-Crespo. A Sistos, D Gleason, JH Fallon: Intranasal administration of PEGylated transforming growth factor-alpha improves behavioral deficits in a chronic stroke model. J Stroke Cerebrovasc Dis 19, 3-9
    • J Stroke Cerebrovasc Dis , vol.19 , pp. 3-9
    • Guerra-Crespo, M.1    Sistos, A.2    Gleason, D.3    Fallon, J.H.4
  • 166
    • 68849086910 scopus 로고    scopus 로고
    • Combination therapy with intranasal NGF and electroacupuncture enhanced cell proliferation and survival in rats after stroke
    • S Cheng. M Ma, Y Ma. Z Wang, G Xu, X Liu: Combination therapy with intranasal NGF and electroacupuncture enhanced cell proliferation and survival in rats after stroke. Neurol Res 31, 753-758 (2009)
    • (2009) Neurol Res , vol.31 , pp. 753-758
    • Cheng, S.1    Ma, M.2    Ma, Y.3    Wang, Z.4    Xu, G.5    Liu, X.6
  • 167
    • 44449097256 scopus 로고    scopus 로고
    • MRI detection of secondary damage after stroke: Chronic iron accumulation in the thalamus of the rat brain
    • C Justicia. P Ramos-Cabrer, M Hoehn: MRI detection of secondary damage after stroke: chronic iron accumulation in the thalamus of the rat brain. Stroke 39, 1541-1547 (2008)
    • (2008) Stroke , vol.39 , pp. 1541-1547
    • Justicia, C.1    Ramos-Cabrer, P.2    Hoehn, M.3
  • 168
    • 44349181985 scopus 로고    scopus 로고
    • Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1 and erythropoietin
    • DOI 10.1007/s12264-008-0089-3
    • Y. Li, S. Ding, L Xiao. W Guo, Q Zhan: Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1 alpha and erythropoietin. Neurosci Bull 24, 89-95 (2008) (Pubitemid 351738284)
    • (2008) Neuroscience Bulletin , vol.24 , Issue.2 , pp. 89-95
    • Li, Y.-X.1    Ding, S.-J.2    Xiao, L.3    Guo, W.4    Zhan, Q.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.