Two novel α7 nicotinic acetylcholine receptor ligands: In vitro properties and their efficacy in collagen-induced arthritis in mice

PLoS ONE

Volumn 10, Issue 1, 2015, Pages

  Van Maanen, Marjolein A ^a   Papke, Roger L ^b   Koopman, Frieda A ^a   Koepke, Jessica ^a,c   Bevaart, Lisette ^a,c   Clark, Roger ^d   Lamppu, Diana ^d   Elbaum, Daniel ^e   LaRosa, Gregory J ^d   Tak, Paul P ^a   Vervoordeldonk, Margriet J ^a,c  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c Arthrogen BV   (Netherlands)

^d Cornerstone Therapeutics Inc ^*  (United States)

^e DEC Associ LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 CHLORO 2,4 DIMETHOXYPHENYL) 3 (5 METHYL 3 ISOXAZOLYL)UREA; 2 [2 ((PYRIDIN 3 YLOXY)METHYL)PIPERAZIN 1 YL]OXAZOLO[4,5 B]PYRIDINE; ANTIINFLAMMATORY AGENT; ANTIRHEUMATIC AGENT; BUNGAROTOXIN RECEPTOR; N (4 METHOXYPHENYL) 2 ((PYRIDIN 3 YLOXY)METHYL)PIPERAZINE 1 CARBOXAMIDE; UNCLASSIFIED DRUG; ACETYLCHOLINE; ANILIDE; LIGAND; OXAZOLE DERIVATIVE; PIPERAZINE DERIVATIVE; PMP-072; PMP-311; PYRIDINE DERIVATIVE;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; AREA UNDER THE CURVE; ARTICLE; COLLAGEN-INDUCED ARTHRITIS; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENTIATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; JOINT DESTRUCTION; JOINT RADIOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; RAT; RECEPTOR AFFINITY; RECEPTOR DOWN REGULATION; SCORING SYSTEM; SYNOVITIS; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; ARTHRITIS, EXPERIMENTAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; INBRED MOUSE STRAIN; INFLAMMATION; KNEE; METABOLISM; PATHOLOGY; PC12 CELL LINE; SIGNAL TRANSDUCTION; XENOPUS;

MUS;

ACETYLCHOLINE; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANILIDES; ANIMALS; ARTHRITIS, EXPERIMENTAL; CELL LINE; INFLAMMATION; KNEE JOINT; LIGANDS; MICE; MICE, INBRED STRAINS; OXAZOLES; PC12 CELLS; PIPERAZINES; PYRIDINES; RATS; SIGNAL TRANSDUCTION; XENOPUS;

EID: 84921916845     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0116227     Document Type: Article

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