Sazetidine-A, a novel ligand that desensitizes α4β2 nicotinic acetylcholine receptors without activating them

Molecular Pharmacology

Volumn 70, Issue 4, 2006, Pages 1454-1460

  Xiao, Yingxian ^a   Fan, Hong ^b   Musachio, John L ^b,d   Wei, Zhi Liang ^c,e   Chellappan, Sheela K ^c   Kozikowski, Alan P ^c   Kellar, Kenneth J ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^e EVOTEC AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AZETIDINE DERIVATIVE; LIGAND; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4BETA2; RECEPTOR SUBUNIT; SAZETIDINE A; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; EMBRYO; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION;

AZETIDINES; BINDING SITES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; NICOTINIC AGONISTS; PYRIDINES; RADIOLIGAND ASSAY; RECEPTORS, NICOTINIC; UP-REGULATION;

EID: 33748927988     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.027318     Document Type: Article

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