Synthesis and evaluation of a conditionally-silent agonist for the α7 nicotinic acetylcholine receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 14, 2013, Pages 4145-4149

  Chojnacka, Kinga ^a   Papke, Roger L ^b   Horenstein, Nicole A ^a  

^a University of Florida   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Allosteric modulator; Ion channel; Nicotinic receptor; Silent agonist

Indexed keywords

BUNGAROTOXIN RECEPTOR; ION CHANNEL; NICOTINIC AGENT; POTASSIUM CARBONATE; SODIUM HYDROXIDE;

ANIMAL CELL; ARTICLE; ARYLATION; BINDING SITE; CHEMICAL BOND; CLAISEN CONDENSATION; CONTROLLED STUDY; CRYSTALLIZATION; DECARBOXYLATION; DRUG SCREENING; DRUG SYNTHESIS; HYDROGEN BOND; HYDROLYSIS; NONHUMAN; PHARMACOPHORE; RING OPENING; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; XENOPUS LAEVIS;

ALLOSTERIC REGULATION; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; CATALYSIS; ISOXAZOLES; OOCYTES; PALLADIUM; PHENYLUREA COMPOUNDS; PIPERIDINES; PYRIDINES; XENOPUS;

EID: 84879415652     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.039     Document Type: Article

References (23)

1. D.K. Williams, C. Peng, M.R. Kimbrell, and R.L. Papke Mol. Pharmacol. 82 2012 746
2. A. Taly, P. Corringer, D. Guedin, P. Lestage, and J. Changeux Nat. Rev. Drug Disc. 8 2009 733
3. W.J. de Jonge, and L. Ulloa Br. J. Pharmacol. 151 2007 915
4. A. Mazurov, T. Hauser, and C. Miller Curr. Med. Chem. 13 2006 1567
5. N.A. Horenstein, F.M. Leonik, and R.L. Papke Mol. Pharmacol. 74 2008 1496
6. D.K. Williams, J. Wang, and R.L. Papke Biochem. Pharmacol. 82 2011 915
7. J.H. Gronlien, M. Hakerud, H. Ween, K. Thorin-Hagene, C.A. Briggs, M. Gopalakrishnan, and J. Malysz Mol. Pharmacol. 72 2007 715
8. R. Hurst, M. Hajos, M. Raggenbass, T. Wall, N. Higdon, J. Lawson, K. Rutherford-Root, M. Berkenpas, W. Hoffmann, D. Piotrowski, V. Groppi, G. Allaman, R. Ogier, S. Bertrand, D. Bertrand, and S. Arneric J. Neurosci. 25 2005 4396
9. D.K. Williams, J. Wang, and R.L. Papke Mol. Pharmacol. 80 2011 1013
10. K.J. Tracey J. Clin. Invest. 117 2007 289
11. H.R. Arias, V.E. Richards, D. Nga, M.E. Ghafoori, V. Le, and S.A. Mousa Int. J. Biochem. Cell Biol. 41 2009 1441
12. M.V. Skok J. Leukocyte Biol. 86 2009 1
13. M.S. Thomsen, and J.D. Mikkelsen J. Neuroimmunol. 251 2012 65
14. P. VanderGraaf, E. VanSchaick, R. Mathot, A. Ijzerman, and M. Danhof J. Pharmacol. Exp. Ther. 283 1997 809
15. C.A. Briggs, J.H. Gronlien, P. Curzon, D.B. Timmermann, H. Ween, K. Thorin-Hagene, P. Kerr, D.J. Anderson, J. Malysz, T. Dyhring, G.M. Olsen, D. Peters, W.H. Bunnelle, and M. Gopalakrishnan Br. J. Pharmacol. 158 2009 1486
16. J. Wang, R.L. Papke, and N.A. Horenstein Bioorg. Med. Chem. Lett. 19 2009 474
17. J. Zoltewicz, and M. Cruskie Org. Prep. Proced. Int. 27 1995 510
18. C. Liu, and W. Yang Chem. Commun. 2009 6267
19. A. Giovannini, D. Savoia, and A. Umanironchi J. Org. Chem. 54 1989 228
20. Peters, P.; Olsen, G. N.; Nielsen, S. F.; Nielsen, E. O.; U.S. Patent 72,823, 2004.
21. F. Trecourt, G. Breton, V. Bonnet, F. Mongin, F. Marsais, and G. Queguiner Tetrahedron 56 2000 1349
22. R.L. Papke, and C. Stokes Methods 51 2010 121
23. J.H. Grønlien, M. Håkerud, H. Ween, K. Thorin-Hagene, C.A. Briggs, M. Gopalakrishnan, and J. Malysz Mol. Pharmacol. 72 2007 715