Experimental strategies for functional annotation and metabolism discovery: Targeted screening of solute binding proteins and unbiased panning of metabolomes

Biochemistry

Volumn 54, Issue 3, 2015, Pages 909-931

  Vetting, Matthew W ^a   Al Obaidi, Nawar ^a   Zhao, Suwen ^b   San Francisco, Brian ^c   Kim, Jungwook ^a   Wichelecki, Daniel J ^c,d   Bouvier, Jason T ^c,d   Solbiati, Jose O ^c   Vu, Hoan ^e   Zhang, Xinshuai ^c   Rodionov, Dmitry A ^f,g   Love, James D ^a   Hillerich, Brandan S ^a   Seidel, Ronald D ^a   Quinn, Ronald J ^e   Osterman, Andrei L ^f   Cronan, John E ^d   Jacobson, Matthew P ^b   Gerlt, John A ^c,d   Almo, Steven C ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^e GRIFFITH UNIVERSITY   (Australia)

^f BURNHAM INSTITUTE   (United States)

^g INSTITUTE FOR INFORMATION TRANSMISSION PROBLEMS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; KNOWLEDGE BASED SYSTEMS; METABOLISM; PHYSIOLOGY; THROUGHPUT;

COMPONENT LIBRARIES; DIFFERENTIAL SCANNING FLUORIMETRY; EXPERIMENTAL STRATEGY; FUNCTIONAL ANNOTATION; GENOME SEQUENCE DATA; INHERENT LIMITATIONS; PATHWAY RECONSTRUCTION; TARGETED SCREENINGS;

PROTEINS;

ALANINE; BINDING PROTEIN; ETHANOLAMINE; CARBOHYDRATE; CARRIER PROTEIN; LIGAND;

ARTICLE; CRYSTALLOGRAPHY; FLUOROMETRY; GENE DISRUPTION; MASS SPECTROMETRY; METABOLOME; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; BACILLUS; CHEMISTRY; KINETICS; METABOLISM; METABOLOMICS; MOLECULAR CLONING; MOLECULAR GENETICS; PROCEDURES; REPRODUCIBILITY; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

BACILLUS; CARBOHYDRATES; CARRIER PROTEINS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; FLUOROMETRY; KINETICS; LIGANDS; METABOLIC NETWORKS AND PATHWAYS; METABOLOME; METABOLOMICS; MOLECULAR SEQUENCE ANNOTATION; REPRODUCIBILITY OF RESULTS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84921865985     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi501388y     Document Type: Article

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