Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function

Nature

Volumn 498, Issue 7452, 2013, Pages 123-126

  Kim, Jungwook ^a   Xiao, Hui ^a   Bonanno, Jeffrey B ^a   Kalyanaraman, Chakrapani ^b   Brown, Shoshana ^b   Tang, Xiangying ^a   Al Obaidi, Nawar F ^a   Patskovsky, Yury ^a   Babbitt, Patricia C ^b   Jacobson, Matthew P ^b   Lee, Young Sam ^c   Almo, Steven C ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; METHYLTRANSFERASE; PHENYLPYRUVIC ACID; PREPHENATE DEHYDRATASE; PROTEIN CMOA; PROTEIN CMOB; S ADENOSYLMETHIONINE; TRANSFER RNA; UNCLASSIFIED DRUG; URIDINE;

CATALYSIS; CRYSTALLIZATION; CRYSTALLOGRAPHY; ENZYME ACTIVITY; GENOME; LIGAND; METABOLITE; MICROBIAL COMMUNITY; PURIFICATION; RNA; X-RAY SPECTROSCOPY;

ARTICLE; BIOTRANSFORMATION; CATALYSIS; CHEMICAL REACTION; CODON; CYANOBACTERIUM; DECARBOXYLATION; GENOMICS; METHANOCALDOCOCCUS JANNASCHII; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTON TRANSPORT; PURIFICATION; RNA STRUCTURE; STRUCTURE ANALYSIS; VERRUCOMICROBIA; WILD TYPE;

BIOCATALYSIS; BIOSYNTHETIC PATHWAYS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANECARBOXYLIC ACIDS; CYCLOHEXENES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; LIGANDS; METHYLTRANSFERASES; MODELS, MOLECULAR; MOLECULAR WEIGHT; ONE-CARBON GROUP TRANSFERASES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; RNA, BACTERIAL; RNA, TRANSFER; S-ADENOSYLMETHIONINE; URIDINE;

NEGIBACTERIA;

EID: 84878685711     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12180     Document Type: Article

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