Influence of physical state of β-carotene (crystallized versus solubilized) on bioaccessibility

Journal of Agricultural and Food Chemistry

Volumn 63, Issue 3, 2015, Pages 990-997

  Xia, Ziyuan ^a,b   McClements, David Julian ^a,c   Xiao, Hang ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b SICHUAN UNIVERSITY   (China)

^c KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Bioaccessibility; Crystallization; Delivery systems; Digestion; Nanoemulsions; Solubilization; carotene

Indexed keywords

BIOCHEMISTRY; CRYSTALLIZATION; SLUDGE DIGESTION; SOLUBILITY;

BIOACCESSIBILITY; BIOACTIVE COMPONENTS; BIOLOGICAL EFFECTS; DELIVERY SYSTEMS; GASTROINTESTINAL TRACT; NANO-EMULSIONS; ORAL BIOAVAILABILITIES; SOLUBILIZATION;

OILS AND FATS;

BETA CAROTENE; EMULSION;

BIOAVAILABILITY; BIOLOGICAL MODEL; CHEMISTRY; CRYSTALLIZATION; DIGESTION; DRUG DELIVERY SYSTEM; EMULSION; GASTROINTESTINAL TRACT; HUMAN; METABOLISM; SOLUBILITY;

BETA CAROTENE; BIOLOGICAL AVAILABILITY; CRYSTALLIZATION; DIGESTION; DRUG DELIVERY SYSTEMS; EMULSIONS; GASTROINTESTINAL TRACT; HUMANS; MODELS, BIOLOGICAL; SOLUBILITY;

EID: 84921860336     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf504673v     Document Type: Article

References (33)

1. Rao, A.; Rao, L. G. Carotenoids and human health. Pharmacol. Res. 2007, 55, 207-216.
2. Agarwal, S.; Rao, A. Carotenoids and chronic diseases. Drug Metab. Drug Interact. 2000, 17, 189-210.
3. Elliott, R. Mechanisms of genomic and non-genomic actions of carotenoids. Biochim. Biophys. Acta (BBA) - Mol. Basis Dis. 2005, 1740, 147-154.
4. Johnson, E. J. The role of carotenoids in human health. Nutr. Clin. Care 2002, 5, 56-65.
5. Castenmiller, J. J.; West, C. E. Bioavailability and bioconversion of carotenoids. Annu. Rev. Nutr. 1998, 18, 19-38.
6. Thakkar, S. K.; Maziya-Dixon, B.; Dixon, A. G.; Failla, M. L. β-Carotene micellarization during in vitro digestion and uptake by Caco-2 cells is directly proportional to β-carotene content in different genotypes of cassava. J. Nutr. 2007, 137, 2229-2233.
7. van het Hof, K. H.; West, C. E.; Weststrate, J. A.; Hautvast, J. G. Dietary factors that affect the bioavailability of carotenoids. J. Nutr. 2000, 130, 503-506.
8. Yonekura, L.; Nagao, A. Intestinal absorption of dietary carotenoids. Mol. Nutr. Food Res. 2007, 51, 107-115.
9. Hörter, D.; Dressman, J. Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract. Adv. Drug Delivery Rev. 2001, 46, 75-87.
10. Qian, C.; Decker, E. A.; Xiao, H.; McClements, D. J. Nanoemulsion delivery systems: Influence of carrier oil on β-carotene bioaccessibility. Food Chem. 2012, 135, 1440-1447.
11. Rao, J.; Decker, E. A.; Xiao, H.; McClements, D. J. Nutraceutical nanoemulsions: influence of carrier oil composition (digestible versus indigestible oil) on β-carotene bioavailability. J. Sci. Food Agric. 2013, 93, 3175-3183.
12. Cornacchia, L.; Roos, Y. H. State of dispersed lipid carrier and interface composition as determinants of β-carotene stability in oil-inwater emulsions. J. Food Sci. 2011, 76, C1211-C1218.
13. Liu, Y.; Hou, Z.; Lei, F.; Chang, Y.; Gao, Y. Investigation into the bioaccessibility and microstructure changes of β-carotene emulsions during in vitro digestion. Innovative Food Sci. Emerging Technol. 2012, 15, 86-95.
14. Silva, H. D.; Cerqueira, M. A.; Souza, B. W.; Ribeiro, C.; Avides, M. C.; Quintas, M. A.; Coimbra, J. S.; Carneiro-da-Cunha, M. G.; Vicente, A. A. Nanoemulsions of β-carotene using a high-energy emulsification - evaporation technique. J. Food Eng. 2011, 102, 130-135.
15. Yuan, Y.; Gao, Y.; Zhao, J.; Mao, L. Characterization and stability evaluation of β-carotene nanoemulsions prepared by high pressure homogenization under various emulsifying conditions. Food Res. Int. 2008, 41, 61-68.
16. Goltz, S. R.; Campbell, W. W.; Chitchumroonchokchai, C.; Failla, M. L.; Ferruzzi, M. G. Meal triacylglycerol profile modulates postprandial absorption of carotenoids in humans. Mol. Nutr. Food Res. 2012, 56, 866-877.
17. Mao, Y.; McClements, D. J. Influence of electrostatic heteroaggregation of lipid droplets on their stability and digestibility under simulated gastrointestinal conditions. Food Funct. 2012, 3, 1025-1034.
18. Sarkar, A.; Goh, K. K. T.; Singh, H. Colloidal stability and interactions of milk-protein-stabilized emulsions in an artificial saliva. Food Hydrocolloids 2009, 23, 1270-1278.
19. Sarkar, A.; Goh, K. K.; Singh, R. P.; Singh, H. Behaviour of an oil-in-water emulsion stabilized by β-lactoglobulin in an in vitro gastric model. Food Hydrocolloids 2009, 23, 1563-1569.
20. Li, Y.; McClements, D. J. New mathematical model for interpreting pH-stat digestion profiles: impact of lipid droplet characteristics on in vitro digestibility. J. Agric. Food Chem. 2010, 58, 8085-8092.
21. Silletti, E.; Vingerhoeds, M. H.; Norde, W.; Van Aken, G. A. The role of electrostatics in saliva-induced emulsion flocculation. Food Hydrocolloids 2007, 21, 596-606.
22. Vingerhoeds, M. H.; Blijdenstein, T. B. J.; Zoet, F. D.; van Aken, G. A. Emulsion flocculation induced by saliva and mucin. Food Hydrocolloids 2005, 19, 915-922.
23. Golding, M.; Wooster, T. J.; Day, L.; Xu, M.; Lundin, L.; Keogh, J.; Clifton, P. Impact of gastric structuring on the lipolysis of emulsified lipids. Soft Matter 2011, 7, 3513-3523.
24. Nik, A. M.; Langmaid, S.; Wright, A. J. Digestibility and β-carotene release from lipid nanodispersions depend on dispersed phase crystallinity and interfacial properties. Food Funct. 2012, 3, 234-245.
25. McClements, D. J.; Xiao, H. Potential biological fate of ingested nanoemulsions: influence of particle characteristics. Food Funct. 2012, 3, 202-220.
26. Bellesi, F. A.; Ruiz-Henestrosa, V. M. P.; Pilosof, A. M. R. Behavior of protein interfacial films upon bile salts addition. Food Hydrocolloids 2014, 36, 115-122.
27. Nik, A. M.; Wright, A. J.; Corredig, M. Impact of interfacial composition on emulsion digestion and rate of lipid hydrolysis using different in vitro digestion models. Colloids Surf. B - Biointerfaces 2011, 83, 321-330.
28. Torcello-Gomez, A.; Maldonado-Valderrama, J.; Jodar-Reyes, A. B.; Foster, T. J. Interactions between pluronics (F127 and F68) and bile salts (NaTDC) in the aqueous phase and the interface of oil-in-water emulsions. Langmuir 2013, 29, 2520-2529.
29. Yao, M. F.; Xiao, H.; McClements, D. J. Delivery of lipophilic bioactives: assembly, disassembly, and reassembly of lipid nanoparticles. Annu. Rev. Food Sci. Technol. 2014, 5, 53-81.
30. McClements, D. J.; Li, Y. Review of in vitro digestion models for rapid screening of emulsion-based systems. Food Funct. 2010, 1, 32-59.
31. Li, Y.; McClements, D. J. Inhibition of lipase-catalyzed hydrolysis of emulsified triglyceride oils by low-molecular weight surfactants under simulated gastrointestinal conditions. Eur. J. Pharm. Biopharm. 2011, 79, 423-431.
32. Li, Y.; Hu, M.; McClements, D. J. Factors affecting lipase digestibility of emulsified lipids using an in vitro digestion model: proposal for a standardised pH-stat method. Food Chem. 2011, 126, 498-505.
33. Ensign, L. M.; Cone, R.; Hanes, J. Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers. Adv. Drug Delivery Rev. 2012, 64, 557-570.