Meal triacylglycerol profile modulates postprandial absorption of carotenoids in humans

Molecular Nutrition and Food Research

Volumn 56, Issue 6, 2012, Pages 866-877

  Goltz, Shellen R ^a   Campbell, Wayne W ^b   Chitchumroonchokchai, Chureeporn ^c   Failla, Mark L ^c   Ferruzzi, Mario G ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Bioavailability; Carotenoids; Clinical trial; Dietary triacylglycerol; Postprandial absorption

Indexed keywords

ALPHA CAROTENE; ALPHA-CAROTENE; CANOLA OIL; CAROTENOID; MONOUNSATURATED FATTY ACID; SOYBEAN OIL; TRIACYLGLYCEROL; XANTHOPHYLL;

ADOLESCENT; ADULT; ARTICLE; BLOOD; BUTTER; CHEMISTRY; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; FEMALE; HUMAN; INTESTINE ABSORPTION; LIPID DIET; MALE; METABOLISM; MIDDLE AGED; NUTRITIONAL VALUE; POSTPRANDIAL STATE; RANDOMIZED CONTROLLED TRIAL; VEGETABLE;

ADOLESCENT; ADULT; BUTTER; CAROTENOIDS; CROSS-OVER STUDIES; DIET, HIGH-FAT; FATTY ACIDS, MONOUNSATURATED; FEMALE; HUMANS; INTESTINAL ABSORPTION; LUTEIN; MALE; MIDDLE AGED; NUTRITIVE VALUE; POSTPRANDIAL PERIOD; SOYBEAN OIL; TRIGLYCERIDES; VEGETABLES; YOUNG ADULT;

EID: 84862583155     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201100687     Document Type: Article

References (41)

1. Nkondjock, A., Ghadirian, P., Dietary carotenoids and risk of colon cancer: case-control study. Int. J. Cancer 2004, 110, 110-116.
2. Wu, K., Erdman, J. W., Jr., Schwartz, S. J., Platz, E. A. et al., Plasma and dietary carotenoids, and the risk of prostate cancer: a nested case-control study. Cancer Epidemiol. Biomarkers Prev. 2004, 13, 260-269.
3. Zheng, W., Blot, W. J., Diamond, E. L., Norkus, E. P. et al., Serum micronutrients and the subsequent risk of oral and pharyngeal cancer. Cancer Res. 1993, 53, 795-798.
4. Riboli, E., Norat, T., Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am. J. Clin. Nutr. 2003, 78, 559S-569S.
5. Millen, A. E., Tucker, M. A., Hartge, P., Halpern, A. et al., Diet and melanoma in a case-control study. Cancer Epidemiol. Biomarkers Prev. 2004, 13, 1042-1051.
6. Dwyer, J. H., Paul-Labrador, M. J., Fan, J., Shircore, A. M. et al., Progression of carotid intima-media thickness and plasma antioxidants: the Los Angeles atherosclerosis study. Arterioscler. Thromb. Vasc. Biol. 2004, 24, 313-319.
7. Joshipura, K. J., Hu, F. B., Manson, J. E., Stampfer, M. J., et al., The effect of fruit and vegetable intake on risk for coronary heart disease. Ann. Intern. Med. 2001, 134, 1106-1114.
8. Rissanen, T., Voutilainen, S., Nyyssonen, K., Salonen, J. T., Lycopene, atherosclerosis, and coronary heart disease. Exp. Biol. Med. (Maywood) 2002, 227, 900-907.
9. Rissanen, T., Voutilainen, S., Nyyssonen, K., Salonen, R., Salonen, J. T., Low plasma lycopene concentration is associated with increased intima-media thickness of the carotid artery wall. Arterioscler. Thromb. Vasc. Biol. 2000, 20, 2677-2681.
10. Beatty, S., Murray, I. J., Henson, D. B., Carden, D. et al., Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Invest. Ophthalmol. Vis. Sci. 2001, 42, 439-446.
11. Mares-Perlman, J. A., Fisher, A. I., Klein, R., Palta, M. et al., Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. Am. J. Epidemiol. 2001, 153, 424-432.
12. Moeller, S. M., Jacques, P. F., Blumberg, J. B., The potential role of dietary xanthophylls in cataract and age-related macular degeneration. J. Am. Coll. Nutr. 2000, 19, 522S-527S.
13. United States Department of Health and Human Services, U.S.D.o.A., and United States Dietary Guidelines Committee, Report of the Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans, 2010. 2010.
14. Yonekura, L., Nagao, A., Intestinal absorption of dietary carotenoids. Mol. Nutr. Food Res. 2007, 51, 107-115.
15. Yeum, K. J., Russell, R. M., Carotenoid bioavailability and bioconversion. Annu. Rev. Nutr. 2002, 22, 483-504.
16. Stahl, W., van den Berg, H., Arthur, J., Bast, A. et al., Bioavailability and metabolism. Mol. Aspects Med. 2002, 23, 39-100.
17. Tyssandier, V., Reboul, E., Dumas, J. F., Bouteloup-Demange, C. et al., Processing of vegetable-borne carotenoids in the human stomach and duodenum. Am. J. Physiol. Gastrointest. Liver Physiol. 2003, 284, G913-G923.
18. Parker, R. S., Swanson, J. E., You, C. S., Edwards, A. J., Huang, T., Bioavailability of carotenoids in human subjects. Proc. Nutr. Soc. 1999, 58, 155-162.
19. Roodenburg, A. J., Leenen, R., van het Hof, K. H., Weststrate, J. A., Tijburg, L. B., Amount of fat in the diet affects bioavailability of lutein esters but not of alpha-carotene, beta-carotene, and vitamin E in humans. Am. J. Clin. Nutr. 2000, 71, 1187-1193.
20. Brown, M. J., Ferruzzi, M. G., Nguyen, M. L., Cooper, D. A., et al., Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection. Am. J. Clin. Nutr. 2004, 80, 396-403.
21. Hu, X., Jandacek, R. J., White, W. S., Intestinal absorption of beta-carotene ingested with a meal rich in sunflower oil or beef tallow: postprandial appearance in triacylglycerol-rich lipoproteins in women. Am. J. Clin. Nutr. 2000, 71, 1170-1180.
22. Mekki, N., Charbonnier, M., Borel, P., Leonardi, J. et al., Butter differs from olive oil and sunflower oil in its effects on postprandial lipemia and triacylglycerol-rich lipoproteins after single mixed meals in healthy young men. J. Nutr. 2002, 132, 3642-3649.
23. van Vliet, T., Schreurs, W. H., and van den Berg, H., Intestinal beta-carotene absorption and cleavage in men: response of beta-carotene and retinyl esters in the triglyceride-rich lipoprotein fraction after a single oral dose of beta-carotene. Am. J. Clin. Nutr. 1995, 62, 110-116.
24. Service, U.S.D.o.A.E.R., USDA Food Consumption Per Capita Data System. 2004.
25. Forman, M. R., Beecher, G. R., Muesing, R., Lanza, E. et al., The fluctuation of plasma carotenoid concentrations by phase of the menstrual cycle: a controlled diet study. Am. J. Clin. Nutr. 1996, 64, 559-565.
26. Forman, M. R., Johnson, E. J., Lanza, E., Graubard, B. I. et al., Effect of menstrual cycle phase on the concentration of individual carotenoids in lipoproteins of premenopausal women: a controlled dietary study. Am. J. Clin. Nutr. 1998, 67, 81-87.
27. Weintraub, M. S., Eisenberg, S., Breslow, J. L., Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil. J. Clin. Invest. 1987, 79, 1110-1119.
28. Gianturco, S. H., Bradley, W. A., The role of apolipoprotein processing in receptor recognition of VLDL. Methods Enzymol. 1986, 129, 319-344.
29. Kean, E. G., Hamaker, B. R., Ferruzzi, M. G., Carotenoid bioaccessibility from whole grain and degermed maize meal products. J. Agric. Food Chem. 2008, 56, 9918-9926.
30. Usansky, J., Desai, A., Tang-Liu, D., 2011 PK functions for Microsoft Excel. Available from
31. Unlu, N. Z., Bohn, T., Clinton, S. K., Schwartz, S. J., Carotenoid absorption from salad and salsa by humans is enhanced by the addition of avocado or avocado oil. J. Nutr. 2005, 135, 431-436.
32. Prince, M. R., Frisoli, J. K., Beta-carotene accumulation in serum and skin. Am. J. Clin. Nutr. 1993, 57, 175-181.
33. Jayarajan, P., Reddy, V., Mohanram, M., Effect of dietary fat on absorption of beta carotene from green leafy vegetables in children. Indian J. Med. Res. 1980, 71, 53-56.
34. Hollander, D., Ruble, P. E., Jr., Beta-carotene intestinal absorption: bile, fatty acid, pH, and flow rate effects on transport. Am. J. Physiol. 1978, 235, E686-E691.
35. Lakshminarayana, R., Raju, M., Krishnakantha, T. P., Baskaran, V., Lutein and zeaxanthin in leafy greens and their bioavailability: olive oil influences the absorption of dietary lutein and its accumulation in adult rats. J. Agric. Food Chem. 2007, 55, 6395-6400.
36. Lee, A., Thurnham, D. I., Chopra, M., Consumption of tomato products with olive oil but not sunflower oil increases the antioxidant activity of plasma. Free Radic. Biol. Med. 2000, 29, 1051-1055.
37. Clark, R. M., Yao, L., She, L., Furr, H. C., A comparison of lycopene and astaxanthin absorption from corn oil and olive oil emulsions. Lipids 2000, 35, 803-806.
38. Ockner, R. K., Manning, J. A., Fatty acid-binding protein in small intestine. Identification, isolation, and evidence for its role in cellular fatty acid transport. J. Clin. Invest. 1974, 54, 326-338.
39. Council, N. R. (Eds.), Fat Content and Composition of Animal Products: Proceedings of a Symposium 1976, National Academy of Science, Washington, DC. 1976
40. Borel, P., Tyssandier, V., Mekki, N., Grolier, P. et al., Chylomicron beta-carotene and retinyl palmitate responses are dramatically diminished when men ingest beta-carotene with medium-chain rather than long-chain triglycerides. J. Nutr. 1998, 128, 1361-1367.
41. van Greevenbroek, M. M., van Meer, G., Erkelens, D. W., de Bruin, T. W., Effects of saturated, mono-, and polyunsaturated fatty acids on the secretion of apo B containing lipoproteins by Caco-2 cells. Atherosclerosis 1996, 121, 139-150.