Cooperative binding and synergistic activation by RelA and C/EBPβ on the intercellular adhesion molecule-1 promoter

Cell Growth and Differentiation

Volumn 9, Issue 11, 1998, Pages 949-959

  Catron, Katrina M ^a   Brickwood, Janice R ^a   Shang, Catherine ^b   Li, Ying ^a   Shannon, M Frances ^b,c   Parks, Thomas P ^a,d  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

^c Australian National University   (Australia)

^d Adamis Pharmaceuticals Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; RECOMBINANT PROTEIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BINDING SITE; CELL LINE; CONTROLLED STUDY; DNA PROTEIN COMPLEX; ENHANCER REGION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION;

BINDING SITES; BIOLOGICAL TRANSPORT; CCAAT-ENHANCER-BINDING PROTEINS; CELL NUCLEUS; DNA-BINDING PROTEINS; DRUG SYNERGISM; HELA CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-REL; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR RELA; TUMOR CELLS, CULTURED;

STAPHYLOCOCCUS PHAGE 187;

EID: 0031793464     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Kishimoto, T. K., and Rothlein, R. Integrins, ICAMs, and selectins. Role and regulation of adhesion molecules in neutrophil recruitment to inflammatory sites. Adv. Pharmacol., 25: 117-169, 1994.
2. Springer, T. A. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell, 76: 301-314, 1994.
3. Simmons, D., Makgoba, M. W., and Seed, B. ICAM, an adhesion ligand of LFA-1, is homologous to the neural adhesion molecule NCAM. Nature (Lond.), 331: 624-627, 1998.
4. Staunton, D. E., Marlin, S. D., Stratowa, C., Dustin, M. L., and Springer, T. A. Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell, 52: 925-933, 1988.
5. Reilly, P. L., Woska, J. R. J., Jeanfavre, D. D., McNally, E., Rothlein, R., and Bormann, B. J. The native structure of intercellular adhesion molecule 1 (ICAM-1) is a dimer. Correlation with binding to LFA-1. J. Immunol., 155: 529-532, 1995.
6. Pober, J. S., Lapierre, L. A., Stolpen, A. H., Brock, T. A., Springer, T. A., Fiers, W., Bevilacqua, M. P., Mendrick, D. L., and Gimbrone, M. A. J. Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species. J. Immunol., 138: 3319-3324, 1987.
7. Pober, J. S., Gimbrone, M. A. J., Lapierre, L. A., Mendrick, D. L., Fiers, W., Rothlein, R., and Springer, T. A. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J. Immunol., 137: 1893-1896, 1986.
8. Dustin, M. L., Rothlein, R., Bhan, A. K., Dinarello, C. A., and Springer, T. A. Induction by IL-1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol., 137: 245-254, 1986.
9. Myers, C. L., Desai, S. N., Schembri-King, J., Letts, G. L., and Wallace, R. W. Discriminatory effects of protein kinase inhibitors and calcium ionophore on endothelial ICAM-1 induction. Am. J. Physiol., 262: C365-C373, 1992.
10. Lane, T. A., Lamkin, G. E., and Wancewicz, E. Modulation of endothelial cell expression of intercellular adhesion molecule 1 by protein kinase C activation. Biochem. Biophys. Res. Commun., 161: 945-952, 1989.
11. Gundel, R. H., Wegner, C. D., Torcellini, C. A., Clarke, C. C., Haynes, N., Rothlein, R., Smith, C. W., and Letts, L. G. Endothelial leukocyte adhesion molecule-1 mediates antigen-induced acute airway inflammation and late-phase airway obstruction in monkeys. J. Clin. Invest., 88: 1407-1411, 1991.
12. Mentzer, S. J., Rothlein, R., Springer, T. A., and Faller, D. V. Intercellular adhesion molecule-1 (ICAM-1) is involved in the cytolytic T lymphocyte interaction with a human synovial cell line. J. Cell. Physiol., 37: 173-178, 1988.
13. Roos, E., and Roossien, F. F. Involvement of leukocyte function-associated antigen-1 (LFA-1) in the invasion of hepatocyte cultures by lymphoma and T-cell hybridoma cells. J. Cell Biol., 105: 553-559, 1987.
14. Entman, M. L., Youker, K., Shoji, T., Kukielka, G., Shappell, S. B., Taylor, A. A., and Smith, C. W. Neutrophil induced oxidative injury of cardiac myocytes. A compartmented system requiring CD11b/CD18-ICAM-1 adherence. J. Clin. Invest., 90: 1335-1345, 1992.
15. Farina, A. R., Cappabianca, L., Mackay, A. R., Tiberio, A., Tacconelli, A., Tessitore, A., Frati, L., Martinotti, S., and Gulino, A. Transcriptional regulation of intercellular adhesion molecule 1 by phorbol ester in human neuroblastoma cell line SK-N-SH involves jun- and fos-containing activator protein 1 site binding complex(es). Cell Growth Differ., 8: 789-800, 1997.
16. Bouillon, M., and Audette, M. Retinoic acid-stimulated intercellular adhesion molecule-1 expression on SK-N-SH cells: calcium/calmodulin-dependent pathway. Cancer Res., 54: 4144-4149, 1994.
17. Tessier, P., Audette, M., Cattaruzzi, P., and McColl, S. R. Up-regulation by tumor necrosis factor α of intercellular adhesion molecule 1 expression and function in synovial fibroblasts and its inhibition by glucocorticoids. Arthritis Rheumatism, 36: 1528-1539, 1993.
18. Wertheimer, S. J., Myers, C. L., Wallace, R. W., and Parks, T. P. Intercellular adhesion molecule-1 gene expression in human endothelial cells: differential regulation by tumor necrosis factor-α and phorbol myristate acetate. J. Biol. Chem., 267: 12030-12035, 1992.
19. van de Stolpe, A., Caldenhoven, E., Stade, B. G., Koenderman, L., Raaijmakers, J. A., Johnson, J. P., and van der Saag, P. T. 12-O-Tetradecanoylphorbol-13-acetate- and tumor necrosis factor α-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecule-1 promoter. J. Biol. Chem., 269: 6185-6192, 1194.
20. Collins, T., Read, M. A., Neish, A. S., Whitley, M. Z., Thanos, D., and Maniatis, T. Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers. FASEB J., 9: 899-909, 1995.
21. Muller, S., Kammerbauer, C., Simons, U., Shibagaki, N., Li, L. J., Caughman, S. W., and Degitz, K. Transcriptional regulation of intercellular adhesion molecule-1: PMA-induction is mediated by NF-κB. J. Invest. Dermatol., 104: 970-975, 1995.
22. Stratowa, C., and Audette, M. Transcriptional regulation of the human intercellular adhesion molecule-1 gene: a short overview. Immunobiology, 193: 293-304, 1995.
23. Mukaida, N., Mahe, Y., and Matsushima, K. Cooperative interaction of nuclear factor-κB- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines. J. Biol. Chem., 265: 21128-21133, 1990.
24. Nishizawa, M., and Nagata, S. Regulatory elements responsible for inducible expression of the granulocyte colony-stimulating factor gene in macrophages. Mol. Cell. Biol., 10: 2002-2011, 1990.
25. Schreck, R., and Baeuerle, P. A. NF-κB as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene. Mol. Cell. Biol., 10: 1281-1286, 1990.
26. Ghosh, P., Tan, T. H., Rice, N. R., Sica, A., and Young, H. A. The interleukin 2 CD28-responsive complex contains at least three members of the NF-κB family: c-Rel, p50, and p65. Proc. Natl. Acad. Sci. USA, 90: 1696-1700, 1993.
27. Hou, J., Baichwal, V., and Cao, Z. Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1. Proc. Natl. Acad. Sci. USA, 91: 11641-11645, 1994.
28. Ledebur, H. C., and Parks, T. P. Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. Essential roles of a variant NF-κB site and p65 homodimers. J. Biol. Chem., 270: 933-943, 1995.
29. Baldwin, A. S. J. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol., 14: 649-683, 1996.
30. Beg, A. A., and Baldwin, A. S. J. The IκB proteins: multifunctional regulators of Rel/NF-κB transcription factors. Genes Dev., 7: 2064-2070, 1993.
31. Baeuerle, P. A., and Baltimore, D. NF-κB: ten years after. Cell, 87: 13-20, 1996.
32. Baeuerle, P. A., and Henkel, T. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol., 12: 141-179, 1994.
33. Wissink, S., van Heerde, E. C., Schmitz, M. L., Kalkhoven, E., van der Burg, B., Baeuerle, P. A., and van der Saag, P. T. Distinct domains of the RelA NF-κB subunit are required for negative cross-talk and direct interaction with the glucocorticoid receptor. J. Biol. Chem., 272; 22278-22284, 1997.
34. Palvimo, J. J., Reinikainen, P., Ikonen, T., Kallio, P. J., Moilanen, A., and Janne, O. A. Mutual transcriptional interference between RelA and androgen receptor. J. Biol. Chem., 271: 24151-24156, 1996.
35. Xu, X., Prorock, C., Ishikawa, H., Maldonado, E., Ito, Y., and Gelinas, C. Functional interaction of the v-Rel and C-Rel oncoproteins with the TATA-binding protein and association with transcription factor IIB. Mol. Cell. Biol., 13: 6733-6741, 1993.
36. Kerr, L. D., Ransone, L. J., Wamsley, P., Schmitt, M. J., Boyer, T. G., Zhou, Q., Berk, A. J., and Verma, I. M. Association between protooncoprotein Rel and TATA-binding protein mediates transcriptional activation of NF-κB. Nature (Lond.), 365: 412-419, 1993.
37. Himes, S. R., Coles, L. S., Reeves, R., and Shannon, M. F. High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters. Immunity, 5: 479-489, 1996.
38. Akira, S., Isshiki, H., Sugita, T., Tanabe, O., Kinoshita, S., Nishio, Y., Nakajima, T., Hirano, T., and Kishimoto, T. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J., 9: 1897-1906, 1990.
39. Cao, Z., Umek, R. M., and McKnight, S. L. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev., 5: 1538-1552, 1991.
40. Descombes, P., Chojkier, M., Lichtsteiner, S., Falvey, E., and Schibler, U. LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev., 4: 1541-1551, 1990.
41. Akira, S., and Kishimoto, T. IL-6 and NF-LI6 in acute-phase response and viral infection. Immunol. Rev., 127: 25-50, 1992.
42. MacDougald, O. A., and Lane, M. D. Transcriptional regulation of gene expression during adipocyte differentiation. Annu. Rev. Biochem., 64: 345-373, 1995.
43. Wedel, A., and Ziegler-Heitbrock, H. W. The C/EBP family of transcription factors. Immunobiology, 193: 171-185, 1995.
44. Kingston, R. E. Transcriptional control and differentiation: the HLH family, c-myc, and C/EBP. Curr. Opin. Cell Biol., 1: 1081-1087, 1989.
45. Johnson, P. F., and McKnight, S. L. Eukaryotic transcriptional regulatory proteins. Annu. Rev. Biochem., 58: 799-839, 1989.
46. Stein, B., Cogswell, P. C., and Baldwin, A. S. J. Functional and physical associations between NF-κB and C/EBP family members: a Rel domain-bZIP interaction. Mol. Cell. Biol., 13: 3964-3974, 1993.
47. LeClair, K. P., Blanar, M. A., and Sharp, P. A. The p50 subunit of NF-κB associates with the NF-IL6 transcription factor. Proc. Natl. Acad. Sci. USA, 89: 8145-8149, 1992.
48. Voraberger, G., Schafer, R., and Stratowa, C. Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5′-regulatory region. Induction by cytokines and phorbol ester. J. Immunol., 147: 2777-2786, 1991.
49. Dunn, S. M., Coles, L. S., Lang, R. K., Gerondakis, S., Vadas, M. A., and Shannon, M. F. Requirement for nuclear factor (NF)-κB p65 and NF-interleukin-6 binding elements in the tumor necrosis factor response region of the granulocyte colony-stimulating factor promoter. Blood, 83: 2469-2479, 1994.
50. Kunsch, C., Lang, R. K., Rosen, C. A., and Shannon, M. F. Synergistic transcriptional activation of the IL-8 gene by NF-κB p65 (RelA) and NF-IL-6. J. Immunol., 153: 153-164, 1994.
51. Stein, B., and Baldwin, A. S. J. Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-κB. Mol. Cell. Biol., 13: 7191-7198, 1993.
52. Yin, M., Yang, S. Q., Lin, H. Z., Lane, M. D., Chatterjee, S., and Diehl, A. M. Tumor necrosis factor-α promotes nuclear localization of cytokine-inducible CCAAT/enhancer binding protein isoforms in hepatocytes. J. Biol. Chem., 271: 17974-17978, 1996.
53. Trautwein, C., Caelles, C., van der Geer, P., Hunter, T., Karin, M., and Chojkier, M. Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature (Lond.), 364: 544-547, 1993.
54. Zhong, H., SuYang, H., Erdjument-Bromage, H., Tempst, P., and Ghosh, S. The transcriptional activity of NF-κB is regulated by the IκB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell, 89: 413-424, 1997.
55. Wegner, M., Cao, Z., and Rosenfeld, M. G. Calcium-regulated phosphorylation within the leucine zipper of C/EBPβ. Science (Washington DC), 256: 370-373, 1992.
56. Tanaka, Y., Hayashi, M., Takagi, S., and Yoshie, O. Differential transactivation of the intercellular adhesion molecule 1 gene promoter by Tax1 and Tax2 of human T-cell leukemia viruses. J. Virol., 70: 8508-8517, 1996.
57. Kunsch, C., Ruben, S. M., and Rosen, C. A. Selection of optimal κB/Rel DNA-binding motifs: interaction of both subunits of NF-κB with DNA is required for transcriptional activation. Mol. Cell. Biol., 12: 4412-4421, 1992.
58. Greenberg, M. E., and Bender, T. P. Isolation of nuclei by dounce homogenization. In: F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (eds.), Current Protocols in Molecular Biology, pp. 4.10.4-4.10.5. New York: John Wiley and Sons, Inc., 1994.