The expression of intercellular adhesion molecule-1 induced by cd40-cd40l ligand signaling in orbital fibroblasts in patients with graves' ophthalmopathy

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 9, 2010, Pages 4652-4660

  Zhao, Li Quan ^a   Wei, Rui Li ^a   Cheng, Jin Wei ^a   Cai, Ji Ping ^a   Li, You ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; I KAPPA B; MITOGEN ACTIVATED PROTEIN KINASE; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOLYSIS; ENDOCRINE OPHTHALMOPATHY; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RNA SYNTHESIS; SIGNAL TRANSDUCTION; BIOPSY; CELL CULTURE; CYTOLOGY; GENETICS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

ANTIGENS, CD40; BIOPSY; CD40 LIGAND; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; GRAVES OPHTHALMOPATHY; HUMANS; I-KAPPA B PROTEINS; INTERCELLULAR ADHESION MOLECULE-1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RNA, MESSENGER;

EID: 77957335301     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-3789     Document Type: Article

References (40)

1. Bahn RS, Heufelder AE. Pathogenesis of Graves' ophthalmopathy. N Engl J Med. 1993;329(20):1468-1475
2. Heufelder AE. Pathogenesis of ophthalmopathy in autoimmune thyroid disease. Rev Endocr Metab Disord. 2000;1(1-2):87-95.
3. Smith RS, Smith TJ, Blieden TM, Phipps RP. Fibroblasts as sentinel cells: synthesis of chemokines and regulation of inflammation. Am J Pathol. 1997;151(2):317-322.
4. Cao HJ, Wang HS, Zhang Y, Lin HY, Phipps RP, Smith TJ. Activation of human orbital fibroblasts through CD40 engagement results in a dramatic induction of hyaluronan synthesis and prostaglandin endoperoxide H synthase-2 expression: insights into potential pathogenic mechanisms of thyroid-associated ophthalmopathy. J Biol Chem. 1998;273(45):29615-29625
5. Smith TJ. Novel aspects of orbital fibroblast pathology. J Endocrinol Invest. 2004;27(3):246-253.
6. Smith TJ. Orbital fibroblasts exhibit a novel pattern of responses to proinflammatory cytokines: potential basis for the pathogenesis of thyroid-associated ophthalmopathy. Thyroid. 2002;12(3):197-203.
7. Heufelder AE, Bahn RS. Elevated expression in situ of selectin and immunoglobulin superfamily type adhesion molecules in retroocular connective tissues from patients with Graves' ophthalmopathy. Clin Exp Immunol. 1993;91(3):381-389.
8. Kahaly G, Hansen C, Felke B, Dienes HP. Immunohistochemical staining of retrobulbar adipose tissue in Graves' ophthalmopathy. Clin Immunol Immunopathol. 1994;73(1):53-62
9. Roebuck KA, Finnegan A. Regulation of intercellular adhesion molecule-1 (CD54) gene expression. J Leukoc Biol. 1999;66(6):876-888.
10. Heufelder AE, Bahn RS. Graves' immunoglobulins and cytokines stimulate the expression of intercellular adhesion molecule-1 (ICAM-1) in cultured Graves' orbital fibroblasts. Eur J Clin Invest. 1992;22(8):529-537.
11. Li Y, Chen L, Teng W, Shan Z, Li Z. Effect of immunoglobulin G from patients with Graves' ophthalmopathy and interferon gamma in intercellular adhesion molecule-1 and human leucocyte antigen-DR expression in human retroocular fibroblasts. Chin Med J (Engl). 2000;113(8):752-755.
12. Yang D, Hiromatsu Y, Hoshino T, Inoue Y, Itoh K, Nonaka K. Dominant infiltration of T(H)1-type CD4+ T cells at the retrobulbar space of patients with thyroid-associated ophthalmopathy. Thyroid. 1999;9(3):305-310.
13. Eckstein AK, Quadbeck B, Tews S, et al. Thyroid associated ophthalmopathy: evidence for CD4(+) yΔ T cells; de novo differentiation of RFD7(+) macrophages, but not of RFD1(+) dendritic cells; and loss of yΔ and αβ T cell receptor expression. Br J Ophthalmol. 2004;88(6):803-808.
14. Sempowski GD, Rozenblit J, Smith TJ, Phipps RP. Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production. Am J Physiol. 1998;274(3 pt 1):C707-C714.
15. Feldon SE, Park DJ, O'Loughlin CW, et al. Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves' ophthalmopathy. Invest Ophthalmol Vis Sci. 2005;46(11):3913-3921.
16. Salmaso C, Olive D, Pesce G, Bagnasco M. Costimulatory molecules and autoimmune thyroid diseases. Autoimmunity. 2002; 35(3):159-167.
17. Ajjan RA, Weetman AP. New understanding of the role of cytokines in the pathogenesis of Graves' ophthalmopathy. J Endocrinol Invest. 2004;27(3):237-245.
18. van Kooten C, Banchereau J. CD40-CD40 ligand. J Leukoc Biol. 2000;67(1):2-17.
19. Chen CC, Chen JJ, Chou CY. Protein kinase cα but not p44/42 mitogen-activated protein kinase, p38, or c-Jun NH(2)-terminal kinase is required for intercellular adhesion molecule-1 expression mediated by interleukin-1β: involvement of sequential activation of tyrosine kinase, nuclear factor-kB-inducing kinase, and IkB kinase 2. Mol Pharmacol. 2000;58(6):1479-1489.
20. Dussault AA, Pouliot M. Rapid and simple comparison of messenger RNA levels using real-time PCR. Biol Proced Online. 2006;8: 1-10.
21. Witkowska AM, Borawska MH. Soluble intercellular adhesion molecule-1 (sICAM-1): an overview. Eur Cytokine Netw. 2004;15(2): 91-98.
22. Anderson ME, Siahaan TJ. Targeting ICAM-1/LFA-1 interaction for controlling autoimmune diseases: designing peptide and small molecule inhibitors. Peptides. 2003;24(3):487-501.
23. Yusuf-Makagiansar H, Anderson ME, Yakovleva TV, Murray JS, Siahaan TJ. Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases. Med Res Rev. 2002;22(2):146-167.
24. De Bellis A, Bizzarro A, Gattoni A, et al. Behavior of soluble intercellular adhesion molecule-1 and endothelial-leukocyte adhesion molecule-1 concentrations in patients with Graves' disease with or without ophthalmopathy and in patients with toxic adenoma. J Clin Endocrinol Metab. 1995;80(7):2118-2121.
25. Ozata M, Bolu E, Sengül A, et al. Soluble intercellular adhesion molecule-1 concentrations in patients with subacute thyroiditis and in patients with Graves' disease with or without ophthalmopathy. Endocr J. 1996;43(5):517-525.
26. Nowak M, Wielkoszyn ́ski T, Kos-Kudła B, et al. The blood concentration of intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) in patients with active thyroid- associated orbitopathy before and after methylprednisolone treatment. Endokrynol Pol. 2007;58(6):487-491.
27. Liu GQ, Wu ZY, Yang HS, Zheng JL, Lin Z. The inhibition effect of interleukin-1 receptor antagonist on interleukin-1 alpha-induced intercellular adhesion molecule-1 expression on orbital fibroblasts and adhesion of peripheral blood mononuclear cells. Zhonghua Yan Ke Za Zhi. 2003;39(9):528-532.
28. Smith TJ, Sempowski GD, Berenson CS, Cao HJ, Wang HS, Phipps RP. Human thyroid fibroblasts exhibit a distinctive phenotype in culture: characteristic ganglioside profile and functional CD40 expression. Endocrinology. 1997;138(12):5576-5588.
29. Saito M, Ota Y, Ohashi H, et al. CD40-CD40 ligand signal induces the intercellular adhesion molecule-1 expression through nuclear factor-B p50 in cultured salivary gland epithelial cells from patients with Sjögren's syndrome. Mod Rheumatol. 2007;17(1):45-53.
30. Dimitriou ID, Kapsogeorgou EK, Moutsopoulos HM, Manoussakis MN. CD40 on salivary gland epithelial cells: high constitutive expression by cultured cells from Sjögren's syndrome patients indicating their intrinsic activation. Clin Exp Immunol. 2002;127(2):386-392.
31. Mysliwiec J, Oklota M, Nikolajuk A, Waligorski D, Gorska M. Serum CD40/CD40L system in Graves' disease and Hashimoto's thyroiditis related to soluble Fas, FasL and humoral markers of autoimmune response. Immunol Invest. 2007;36(3):247-257.
32. Koumas L, Smith TJ, Phipps RP. Fibroblast subsets in the human orbit: Thy-1+ and Thy-1- subpopulations exhibit distinct phenotypes. Eur J Immunol. 2002;32(2):477-485.
33. Li Q, Verma IM. NF-B regulation in the immune system. Nat Rev Immunol. 2002;2(10):725-734.
34. Seger R, Krebs EG. The MαβαβAPK signaling cascade. FASEB J. 1995; 9(9):726-735.
35. Chen B, Tsui S, Smith TJ. IL-1 beta induces IL-6 expression in human orbital fibroblasts: identification of an anatomic-site specific phenotypic attribute relevant to thyroid-associated ophthalmopathy. J Immunol. 2005;175(2):1310-1319.
36. Li H, Nord EP. CD40/CD154 ligation induces mononuclear cell adhesion to human renal proximal tubule cells via increased ICAM-1 expression. Am J Physiol Renal Physiol. 2005;289(1): F145-F153.
37. Craxton A, Shu G, Graves JD, Saklatvala J, Krebs EG, Clark EA. p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes. J Immunol. 1998;161(7):3225-3236.
38. Kawai M, Masuda A, Kuwana M. A CD40-CD154 interaction in tissue fibrosis. Arthritis Rheum. 2008;58(11):3562-3573.
39. Jahnke A, Johnson JP. Intercellular adhesion molecule 1 (ICAM-1) is synergistically activated by TNF-α and IFN-Υ{hooked} responsive sites. Immunobiology. 1995;193(2-4):305-314.
40. Ballestas ME, Benveniste EN. Interleukin 1-β- and tumor necrosis factor-α-mediated regulation of ICAM-1 gene expression in astrocytes requires protein kinase C activity. Glia. 1995;14(4): 267-278.