Erratum: Temporally distinct roles of ATM and ROS in genotoxic-stress-dependent induction and maintenance of cellular senescence (Journal of Cell Science (2015) 128 (342-353) DOI: 10.1242/jcs.159517);Temporally distinct roles of ATM and ROS in genotoxic-stressdependent induction and maintenance of cellular senescence

Journal of Cell Science

Volumn 128, Issue 2, 2015, Pages 342-353

  Nair, Raji R ^a   Bagheri, Meisam ^a   Saini, Deepak Kumar ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

ATM kinase; Cellular senescence; DNA damage response; Reactive oxygen species

Indexed keywords

ATM PROTEIN; DNA; PROTEIN P53; REACTIVE OXYGEN METABOLITE; ATM PROTEIN, HUMAN; BROXURIDINE; TP53 PROTEIN, HUMAN;

ARTICLE; CELL AGING; CELL DEATH; CELL FATE; CELL VIABILITY; CELLULAR PARAMETERS; CONTROLLED STUDY; DNA DAMAGE; DNA DAMAGE RESPONSE; GENE EXPRESSION PROFILING; GENOTOXICITY; PRIORITY JOURNAL; STRESS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; HUMAN; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ATAXIA TELANGIECTASIA MUTATED PROTEINS; BROMODEOXYURIDINE; CELL AGING; DNA DAMAGE; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84921368176     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.259033     Document Type: Erratum

References (79)

1. Aliouat-Denis, C. M., Dendouga, N., Van den Wyngaert, I., Goehlmann, H., Steller, U., van de Weyer, I., Van Slycken, N., Andries, L., Kass, S., Luyten, W. et al. (2005). p53-independent regulation of p21Waf1/Cip1 expression and senescence by Chk2. Mol. Cancer Res. 3, 627-634.
2. Aruoma, O. I., Halliwell, B., Hoey, B. M. and Butler, J. (1989). The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic. Biol. Med. 6, 593-597.
3. Barascu, A., Le Chalony, C., Pennarun, G., Genet, D., Imam, N., Lopez, B. and Bertrand, P. (2012). Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation. EMBO J. 31, 1080-1094.
4. Ben-Porath, I. and Weinberg, R. A. (2005). The signals and pathways activating cellular senescence. Int. J. Biochem. Cell Biol. 37, 961-976.
5. Blasina, A., Price, B. D., Turenne, G. A. and McGowan, C. H. (1999). Caffeine inhibits the checkpoint kinase ATM. Curr. Biol. 9, 1135-1138.
6. Chen, Q. and Ames, B. N. (1994). Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc. Natl. Acad. Sci. USA 91, 4130-4134.
7. Chen, Q. M., Tu, V. C. and Liu, J. (2000). Measurements of hydrogen peroxide induced premature senescence: senescence-associated beta-galactosidase and DNA synthesis index in human diploid fibroblasts with down-regulated p53 or Rb. Biogerontology 1, 335-339.
8. Chen, J. H., Hales, C. N. and Ozanne, S. E. (2007). DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res. 35, 7417-7428.
9. Cho, J. H., Saini, D. K., Karunarathne, W. K., Kalyanaraman, V. and Gautam, N. (2011). Alteration of Golgi structure in senescent cells and its regulation by a G protein c subunit. Cell. Signal. 23, 785-793.
10. Colavitti, R. and Finkel, T. (2005). Reactive oxygen species as mediators of cellular senescence. IUBMB Life 57, 277-281.
11. Cooke, M. S., Evans, M. D., Dizdaroglu, M. and Lunec, J. (2003). Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J. 17, 1195-1214.
12. Coppé, J. P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P. Y. and Campisi, J. (2008). Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 6, e301.
13. Coppé, J. P., Desprez, P. Y., Krtolica, A. and Campisi, J. (2010). The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. 5, 99-118.
14. d'Adda di Fagagna, F. (2008). Living on a break: cellular senescence as a DNA-damage response. Nat. Rev. Cancer 8, 512-522.
15. Davidson, B. L. and Harper, S. Q. (2005). Viral delivery of recombinant short hairpin RNAs. Methods Enzymol. 392, 145-173.
16. Del Nagro, C. J., Choi, J., Xiao, Y., Rangell, L., Mohan, S., Pandita, A., Zha, J., Jackson, P. K. and O'Brien, T. (2014). Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death. Cell Cycle 13, 303-314.
17. Di Micco, R., Fumagalli, M., Cicalese, A., Piccinin, S., Gasparini, P., Luise, C., Schurra, C., Garre', M., Nuciforo, P. G., Bensimon, A. et al. (2006). Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444, 638-642.
18. Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., Pereira-Smith, O. et al. (1995). A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 92, 9363-9367.
19. Ditch, S. and Paull, T. T. (2012). The ATM protein kinase and cellular redox signaling: beyond the DNA damage response. Trends Biochem. Sci. 37, 15-22.
20. Duan, J., Duan, J., Zhang, Z. and Tong, T. (2005). Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening. Int. J. Biochem. Cell Biol. 37, 1407-1420.
21. Dumont, P., Burton, M., Chen, Q. M., Gonos, E. S., Frippiat, C., Mazarati, J. B., Eliaers, F., Remacle, J. and Toussaint, O. (2000). Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast. Free Radic. Biol. Med. 28, 361-373.
22. Eriko, M., Nakabayashi, K., Suzuki, T., Kaul, S. C., Ogino, H., Fujii, M., Mitsui, Y. and Ayusawa, D. (1999). 5-Bromodeoxyuridine induces senescence-like phenomena in mammalian cells regardless of cell type or species. J. Biochem. 126, 1052-1059.
23. Erol, A. (2011). Genotoxic stress-mediated cell cycle activities for the decision of cellular fate. Cell Cycle 10, 3239-3248.
24. Freund, A., Orjalo, A. V., Desprez, P. Y. and Campisi, J. (2010). Inflammatory networks during cellular senescence: causes and consequences. Trends Mol. Med. 16, 238-246.
25. Furumoto, K., Inoue, E., Nagao, N., Hiyama, E. and Miwa, N. (1998). Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci. 63, 935-948.
26. Gewirtz, D. A. (1999). A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem. Pharmacol. 57, 727-741.
27. Guo, Z., Kozlov, S., Lavin, M. F., Person, M. D. and Paull, T. T. (2010). ATM activation by oxidative stress. Science 330, 517-521.
28. Hayflick, L. (1965). The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37, 614-636.
29. Hickson, I., Zhao, Y., Richardson, C. J., Green, S. J., Martin, N. M., Orr, A. I., Reaper, P. M., Jackson, S. P., Curtin, N. J. and Smith, G. C. (2004). Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 64, 9152-9159.
30. Itahana, K., Campisi, J. and Dimri, G. P. (2007). Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay. Methods Mol. Biol. 371, 21-31.
31. Ivanov, V. N., Zhou, H., Partridge, M. A. and Hei, T. K. (2009). Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells. Cancer Res. 69, 3510-3519.
32. Jeyapalan, J. C. and Sedivy, J. M. (2008). Cellular senescence and organismal aging. Mech. Ageing Dev. 129, 467-474.
33. Kanaar, R., Hoeijmakers, J. H. and van Gent, D. C. (1998). Molecular mechanisms of DNA double strand break repair. Trends Cell Biol. 8, 483-489.
34. Kang, M. A., So, E. Y., Simons, A. L., Spitz, D. R. and Ouchi, T. (2012). DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway. Cell Death Dis. 3, e249.
35. Krtolica, A., Parrinello, S., Lockett, S., Desprez, P. Y. and Campisi, J. (2001). Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl. Acad. Sci. USA 98, 12072-12077.
36. Kuilman, T., Michaloglou, C., Mooi, W. J. and Peeper, D. S. (2010). The essence of senescence. Genes Dev. 24, 2463-2479.
37. Kumazaki, T., Robetorye, R. S., Robetorye, S. C. and Smith, J. R. (1991). Fibronectin expression increases during in vitro cellular senescence: correlation with increased cell area. Exp. Cell Res. 195, 13-19.
38. Lawless, C., Wang, C., Jurk, D., Merz, A., Zglinicki, T. and Passos, J. F. (2010). Quantitative assessment of markers for cell senescence. Exp. Gerontol. 45, 772-778.
39. Lee, J. H. and Paull, T. T. (2004). Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 304, 93-96.
40. Lee, J. H. and Paull, T. T. (2005). ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308, 551-554.
41. Lee, A. C., Fenster, B. E., Ito, H., Takeda, K., Bae, N. S., Hirai, T., Yu, Z. X., Ferrans, V. J., Howard, B. H. and Finkel, T. (1999). Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J. Biol. Chem. 274, 7936-7940.
42. Leontieva, O. V. and Blagosklonny, M. V. (2010). DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence. Aging (Albany, NY) 2, 924-935.
43. Li, Y. and Yang, D. Q. (2010). The ATM inhibitor KU-55933 suppresses cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt. Mol. Cancer Ther. 9, 113-125.
44. Liu, B., Chen, Y. and St Clair, D. K. (2008). ROS and p53: a versatile partnership. Free Radic. Biol. Med. 44, 1529-1535.
45. Lu, T. and Finkel, T. (2008). Free radicals and senescence. Exp. Cell Res. 314, 1918-1922.
46. Macip, S., Igarashi, M., Fang, L., Chen, A., Pan, Z. Q., Lee, S. W. and Aaronson, S. A. (2002). Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. EMBO J. 21, 2180-2188.
47. Maicher, A., Kastner, L., Dees, M. and Luke, B. (2012). Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence. Nucleic Acids Res. 40, 6649-6659.
48. Mao, Z., Ke, Z., Gorbunova, V. and Seluanov, A. (2012). Replicatively senescent cells are arrested in G1 and G2 phases. Aging (Albany, NY) 4, 431-435.
49. Masterson, J. C. and O'Dea, S. (2007). 5-Bromo-2-deoxyuridine activates DNA damage signalling responses and induces a senescence-like phenotype in p16-null lung cancer cells. Anticancer Drugs 18, 1053-1068.
50. Matlashewski, G., Banks, L., Pim, D. and Crawford, L. (1986). Analysis of human p53 proteins and mRNA levels in normal and transformed cells. Eur. J. Biochem. 154, 665-672.
51. Mirzayans, R., Andrais, B., Scott, A., Wang, Y. W. and Murray, D. (2013). Ionizing radiation-induced responses in human cells with differing TP53 status. Int. J. Mol. Sci. 14, 22409-22435.
52. Mishra, K. P. (2004). Cell membrane oxidative damage induced by gamma-radiation and apoptotic sensitivity. J. Environ. Pathol. Toxicol. Oncol. 23, 61-66.
53. Mizutani, H., Tada-Oikawa, S., Hiraku, Y., Kojima, M. and Kawanishi, S. (2005). Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide. Life Sci. 76, 1439-1453.
54. Mukhopadhyay, P., Rajesh, M., Bátkai, S., Kashiwaya, Y., Haskó, G., Liaudet, L., Szabó, C. and Pacher, P. (2009). Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro. Am. J. Physiol. 296, H1466-H1483.
55. Passos, J. F. and Von Zglinicki, T. (2006). Oxygen free radicals in cell senescence: are they signal transducers? Free Radic. Res. 40, 1277-1283.
56. Passos, J. F., Simillion, C., Hallinan, J., Wipat, A. and von Zglinicki, T. (2009). Cellular senescence: unravelling complexity. Age (Dordr.) 31, 353-363.
57. Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W. and Vogelstein, B. (1997). A model for p53-induced apoptosis. Nature 389, 300-305.
58. Pospelova, T. V., Demidenko, Z. N., Bukreeva, E. I., Pospelov, V. A., Gudkov, A. V. and Blagosklonny, M. V. (2009). Pseudo-DNA damage response in senescent cells. Cell Cycle 8, 4112-4118.
59. Purvis, J. E., Karhohs, K. W., Mock, C., Batchelor, E., Loewer, A. and Lahav, G. (2012). p53 dynamics control cell fate. Science 336, 1440-1444.
60. Qu, K., Lin, T., Wang, Z., Liu, S., Chang, H., Xu, X., Meng, F., Zhou, L., Wei, J., Tai, M. et al. (2014). Reactive oxygen species generation is essential for cisplatininduced accelerated senescence in hepatocellular carcinoma. Front Med. 8, 227-235.
61. Radha, V., Sudhakar, C. and Swarup, G. (1999). Induction of p53 dependent apoptosis upon overexpression of a nuclear protein tyrosine phosphatase. FEBS Lett. 453, 308-312.
62. Rodier, F., Coppé, J. P., Patil, C. K., Hoeijmakers, W. A., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R. and Campisi, J. (2009). Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat. Cell Biol. 11, 973-979.
63. Roninson, I. B. (2002). Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts. Cancer Lett. 179, 1-14.
64. Rufini, A., Tucci, P., Celardo, I. and Melino, G. (2013). Senescence and aging: the critical roles of p53. Oncogene 32, 5129-5143.
65. Sablina, A. A., Budanov, A. V., Ilyinskaya, G. V., Agapova, L. S., Kravchenko, J. E. and Chumakov, P. M. (2005). The antioxidant function of the p53 tumor suppressor. Nat. Med. 11, 1306-1313.
66. Schneider, E. L. and Mitsui, Y. (1976). The relationship between in vitro cellular aging and in vivo human age. Proc. Natl. Acad. Sci. USA 73, 3584-3588.
67. Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. and Lowe, S. W. (1997). Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602.
68. Shiloh, Y. and Ziv, Y. (2013). The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat. Rev. Mol. Cell Biol. 14, 197-210.
69. Sliwinska, M. A., Mosieniak, G., Wolanin, K., Babik, A., Piwocka, K., Magalska, A., Szczepanowska, J., Fronk, J. and Sikora, E. (2009). Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells. Mech. Ageing Dev. 130, 24-32.
70. Surova, O. and Zhivotovsky, B. (2013). Various modes of cell death induced by DNA damage. Oncogene 32, 3789-3797.
71. Suzuki, T., Minagawa, S., Eriko, M., Ogino, H., Fujii, M., Mitsui, Y. and Ayusawa, D. (2001). Induction of senescence-associated genes by 5-bromodeoxyuridine in HeLa cells. Exp. Gerontol. 36, 465-474.
72. Tewey, K. M., Rowe, T. C., Yang, L., Halligan, B. D. and Liu, L. F. (1984). Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science 226, 466-468.
73. Thorn, C. F., Oshiro, C., Marsh, S., Hernandez-Boussard, T., McLeod, H., Klein, T. E. and Altman, R. B. (2011). Doxorubicin pathways: pharmacodynamics and adverse effects. Pharmacogenet. Genomics 21, 440-446.
74. van Maanen, J. M., Retèl, J., de Vries, J. and Pinedo, H. M. (1988). Mechanism of action of antitumor drug etoposide: a review. J. Natl. Cancer Inst. 80, 1526-1533.
75. von Zglinicki, T., Saretzki, G., Ladhoff, J., d'Adda di Fagagna, F. and Jackson, S. P. (2005). Human cell senescence as a DNA damage response. Mech. Ageing Dev. 126, 111-117.
76. Wrede, D., Tidy, J. A., Crook, T., Lane, D. and Vousden, K. H. (1991). Expression of RB and p53 proteins in HPV-positive and HPV-negative cervical carcinoma cell lines. Mol. Carcinog. 4, 171-175.
77. Yokochi, T. and Robertson, K. D. (2004). Doxorubicin inhibits DNMT1, resulting in conditional apoptosis. Mol. Pharmacol. 66, 1415-1420.
78. Zafarullah, M., Li, W. Q., Sylvester, J. and Ahmad, M. (2003). Molecular mechanisms of N-acetylcysteine actions. Cell. Mol. Life Sci. 60, 6-20.
79. Zgheib, O., Pataky, K., Brugger, J. and Halazonetis, T. D. (2009). An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks. Mol. Cell. Biol. 29, 1050-1058.