DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway

Cell Death and Disease

Volumn 3, Issue 1, 2012, Pages

  Kang, M A ^a,b   So, E Y ^b   Simons, A L ^c   Spitz, D R ^c   Ouchi, T ^a,b,d  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

DNA damage; H2AX; Nox1; Rac1; ROS

Indexed keywords

ACETYLCYSTEINE; DNA; GUANOSINE TRIPHOSPHATASE; HISTONE H2AX; PROTEIN; PROTEIN NOXA; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; ZINOSTATIN; ANTIOXIDANT; CYTOTOXIN; H2AFX PROTEIN, HUMAN; HISTONE; NOX1 PROTEIN, HUMAN; NOXA1 PROTEIN, HUMAN; PROTEIN 14 3 3; RAC1 PROTEIN, HUMAN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; CELL DEATH; DRUG ANTAGONISM; DRUG EFFECT; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSFECTION; GENETICS; METABOLISM; PHOSPHORYLATION; PLASMID; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

14-3-3 PROTEINS; ACETYLCYSTEINE; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANTIOXIDANTS; CELL DEATH; CELL LINE, TUMOR; CYTOTOXINS; DNA DAMAGE; FLOW CYTOMETRY; GENE EXPRESSION; HISTONES; HUMANS; NADPH OXIDASE; PHOSPHORYLATION; PLASMIDS; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSFECTION; ZINOSTATIN;

EID: 84856866918     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2011.134     Document Type: Article

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