Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 308, Issue 2, 2015, Pages L208-L220

  Tang, Haiyang ^a,b   Chen, Jiwang ^b   Fraidenburg, Dustin R ^b   Song, Shanshan ^a,b   Sysol, Justin R ^b   Drennan, Abigail R ^b   Offermanns, Stefan ^c   Ye, Richard D ^b   Bonini, Marcelo G ^b   Minshall, Richard D ^b   Garcia, Joe G N ^a   Machado, Roberto F ^b   Makino, Ayako ^a   Yuan, Jason X J ^a,b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

Akt mammalian target of rapamycin signaling; Hypoxia; Pulmonary vascular remodeling; Smooth muscle cell proliferation

Indexed keywords

AKT1 KINASE; MAMMALIAN TARGET OF RAPAMYCIN; OXYGEN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEIN KINASE B BETA; UNCLASSIFIED DRUG; AKT1 PROTEIN, MOUSE; AKT2 PROTEIN, MOUSE; MTOR PROTEIN, MOUSE; PROTEIN KINASE B; PTEN PROTEIN, MOUSE; SMALL INTERFERING RNA; TAMOXIFEN; TARGET OF RAPAMYCIN KINASE;

AKT1 KINASE DEFICIENCY; ANIMAL CELL; ARTERIAL PRESSURE; ARTICLE; CELL PROLIFERATION; CELL PROLIFERATION ASSAY; CONTROLLED STUDY; ENZYME DEFICIENCY; HEART RIGHT VENTRICLE HYPERTROPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; LONG TERM EXPOSURE; LUNG BLOOD VESSEL; LUNG VASCULAR RESISTANCE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN KINASE B BETA DEFICIENCY; PULMONARY HYPERTENSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; VASCULAR REMODELING; WESTERN BLOTTING; WILD TYPE; ANIMAL; ANOXIA; BIOSYNTHESIS; BLOOD PRESSURE; C57BL MOUSE; CELL MOTION; CYTOLOGY; GENETICS; KNOCKOUT MOUSE; LUNG; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PULMONARY ARTERY; RNA INTERFERENCE; VASCULAR RESISTANCE; VASCULAR SMOOTH MUSCLE; VASCULARIZATION;

ANIMALS; ANOXIA; BLOOD PRESSURE; CELL MOVEMENT; CELL PROLIFERATION; HUMANS; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; PULMONARY ARTERY; RNA INTERFERENCE; RNA, SMALL INTERFERING; TAMOXIFEN; TOR SERINE-THREONINE KINASES; VASCULAR REMODELING; VASCULAR RESISTANCE;

EID: 84921299135     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00242.2014     Document Type: Article

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