Akt isoforms differentially protect against stroke-induced neuronal injury by regulating mTOR activities

Journal of Cerebral Blood Flow and Metabolism

Volumn 33, Issue 12, 2013, Pages 1875-1885

  Xie, Rong ^a,b   Cheng, Michelle ^a,c   Li, Mei ^a,d   Xiong, Xiaoxing ^a,c   Daadi, Marcel ^a,c   Sapolsky, Robert M ^a,c   Zhao, Heng ^a,c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FUDAN UNIVERSITY   (China)

^c STANFORD UNIVERSITY   (United States)

^d XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Akt1; Akt3; Cerebral ischemia; mTOR; Stroke

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; ISOPROTEIN; LENTIVIRUS VECTOR; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN AKT1; PROTEIN AKT3; PROTEIN KINASE B; RAPAMYCIN; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; CELL DEATH; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENE TRANSFER; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; WESTERN BLOTTING;

ANIMALS; BRAIN; BRAIN ISCHEMIA; CELL DEATH; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; LENTIVIRUS; MALE; NEURONS; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84889093552     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2013.132     Document Type: Article

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