Activation of PPAR-α induces cell cycle arrest and inhibits transforming growth factor-β1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells

Cellular Signalling

Volumn 25, Issue 5, 2013, Pages 1252-1263

  Lien, Sheng Chieh ^a,b   Wei, Shu Yi ^a   Chang, Shun Fu ^c   Chang, Margaret Dah Tsyr ^b   Chang, Jang Yang ^a   Chiu, Jeng Jiann ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Cell cycle; Mesenchymal cell; PPAR ; Smad; Smooth muscle differentiation

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CELL MARKER; CYCLIN A; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN E; MYOSIN HEAVY CHAIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; S6 KINASE; SERUM RESPONSE FACTOR; SMAD2 PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; TRANSGELIN;

ANIMAL CELL; ARTICLE; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; G1 PHASE CELL CYCLE CHECKPOINT; GENETIC TRANSFECTION; INTRACELLULAR SIGNALING; MESENCHYME CELL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SMOOTH MUSCLE FIBER;

ANIMALS; CELL DIFFERENTIATION; CLOFIBRATE; CYCLIN D; CYCLIN-DEPENDENT KINASE 4; G1 PHASE CELL CYCLE CHECKPOINTS; MESENCHYMAL STROMAL CELLS; MICE; MYOCYTES, SMOOTH MUSCLE; PHENOTYPE; PHOSPHORYLATION; PPAR ALPHA; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA INTERFERENCE; RNA, SMALL INTERFERING; SERUM RESPONSE FACTOR; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84875090022     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.01.021     Document Type: Article

References (37)

1. Raines E.W., Ross R. British Heart Journal 1993, 69:S30-S37.
2. Owens G.K., Kumar M.S., Wamhoff B.R. Physiological Reviews 2004, 84:767-801.
3. Owens G.K. Physiological Reviews 1995, 75:487-517.
4. Kumar M.S., Owens G.K. Arteriosclerosis, Thrombosis, and Vascular Biology 2003, 23:737-747.
5. Wilcox J.N., Nelken N.A., Coughlin S.R., Gordon D., Schall T.J. Journal of Atherosclerosis and Thrombosis 1994, 1(Suppl. 1):S10-S13.
6. Hirschi K.K., Rohovsky S.A., D'Amore P.A. The Journal of Cell Biology 1998, 141:805-814.
7. Derynck R., Feng X.H. Biochimica et Biophysica Acta 1997, 1333:F105-F150.
8. Lien S.C., Usami S., Chien S., Chiu J.J. Cellular Signalling 2006, 18:1270-1278.
9. Sato M., Kawai-Kowase K., Sato H., Oyama Y., Kanai H., Ohyama Y., Suga T., Maeno T., Aoki Y., Tamura J., Sakamoto H., Nagai R., Kurabayashi M. Arteriosclerosis, Thrombosis, and Vascular Biology 2005, 25:341-347.
10. Tsai S., Hollenbeck S.T., Ryer E.J., Edlin R., Yamanouchi D., Kundi R., Wang C., Liu B., Kent K.C. American Journal of Physiology. Heart and Circulatory Physiology 2009, 297:H540-H549.
11. Seay U., Sedding D., Krick S., Hecker M., Seeger W., Eickelberg O. The Journal of Pharmacology and Experimental Therapeutics 2005, 315:1005-1012.
12. Moraes L.A., Piqueras L., Bishop-Bailey D. Pharmacology & Therapeutics 2006, 110:371-385.
13. Gizard F., Amant C., Barbier O., Bellosta S., Robillard R., Percevault F., Sevestre H., Krimpenfort P., Corsini A., Rochette J., Glineur C., Fruchart J.C., Torpier G., Staels B. The Journal of Clinical Investigation 2005, 115:3228-3238.
14. Lim H.J., Lee S., Park J.H., Lee K.S., Choi H.E., Chung K.S., Lee H.H., Park H.Y. Atherosclerosis 2009, 202:446-454.
15. Ward J.E., Gould H., Harris T., Bonacci J.V., Stewart A.G. British Journal of Pharmacology 2004, 141:517-525.
16. Wullschleger S., Loewith R., Hall M.N. Cell 2006, 124:471-484.
17. Martin K.A., Rzucidlo E.M., Merenick B.L., Fingar D.C., Brown D.J., Wagner R.J., Powell R.J. American Journal of Physiology. Cell Physiology 2004, 286:C507-C517.
18. Liu Y., Fanburg B.L. American Journal of Respiratory Cell and Molecular Biology 2006, 34:182-191.
19. Solway J., Seltzer J., Samaha F.F., Kim S., Alger L.E., Niu Q., Morrisey E.E., Ip H.S., Parmacek M.S. The Journal of Biological Chemistry 1995, 270:13460-13469.
20. Kota B.P., Huang T.H., Roufogalis B.D. Pharmacological Research 2005, 51:85-94.
21. Tsai M.C., Chen L., Zhou J., Tang Z., Hsu T.F., Wang Y., Shih Y.T., Peng H.H., Wang N., Guan Y., Chien S., Chiu J.J. Circulation Research 2009, 105:471-480.
22. Pearce L.R., Komander D., Alessi D.R. Nature Reviews. Molecular Cell Biology 2010, 11:9-22.
23. Manning B.D., Cantley L.C. Cell 2007, 129:1261-1274.
24. Huston E., Lynch M.J., Mohamed A., Collins D.M., Hill E.V., MacLeod R., Krause E., Baillie G.S., Houslay M.D. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:12791-12796.
25. Persad S., Attwell S., Gray V., Mawji N., Deng J.T., Leung D., Yan J., Sanghera J., Walsh M.P., Dedhar S. The Journal of Biological Chemistry 2001, 276:27462-27469.
26. Kawakami Y., Nishimoto H., Kitaura J., Maeda-Yamamoto M., Kato R.M., Littman D.R., Leitges M., Rawlings D.J., Kawakami T. The Journal of Biological Chemistry 2004, 279:47720-47725.
27. Lamouille S., Connolly E., Smyth J.W., Akhurst R.J., Derynck R. Journal of Cell Science 2012, 125:1259-1273.
28. Vi L., de Lasa C., DiGuglielmo G.M., Dagnino L. The Journal of Investigative Dermatology 2011, 131:586-593.
29. Huang J., Manning B.D. Biochemical Society Transactions 2009, 37:217-222.
30. Whitman M. Genes & Development 1998, 12:2445-2462.
31. Remy I., Montmarquette A., Michnick S.W. Nature Cell Biology 2004, 6:358-365.
32. Grabacka M., Plonka P.M., Urbanska K., Reiss K. Clinical Cancer Research 2006, 12:3028-3036.
33. Schniewind B., Groth S., Sebens Muerkoster S., Sipos B., Schafer H., Kalthoff H., Fandrich F., Ungefroren H. Oncogene 2007, 26:4850-4862.
34. Rudini N., Felici A., Giampietro C., Lampugnani M., Corada M., Swirsding K., Garre M., Liebner S., Letarte M., ten Dijke P., Dejana E. The EMBO Journal 2008, 27:993-1004.
35. Khan R., Agrotis A., Bobik A. Cardiovascular Research 2007, 74:223-234.
36. Schulick A.H., Taylor A.J., Zuo W., Qiu C.B., Dong G., Woodward R.N., Agah R., Roberts A.B., Virmani R., Dichek D.A. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:6983-6988.
37. Margariti A., Zeng L., Xu Q. Histology and Histopathology 2006, 21:979-985.