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Volumn 61, Issue 1, 2015, Pages 98-107

Treatment response in the PIVENS trial is associated with decreased hedgehog pathway activity

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ALPHA TOCOPHEROL; ASPARTATE AMINOTRANSFERASE; CYTOKERATIN 18; CYTOKERATIN 8; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR SOX9; ALANINE AMINOTRANSFERASE; VITAMIN;

EID: 84920984254     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27235     Document Type: Article
Times cited : (62)

References (50)
  • 2
    • 34247643846 scopus 로고    scopus 로고
    • Pediatric nonalcoholic fatty liver disease (NAFLD): a "growing" problem?
    • Roberts EA. Pediatric nonalcoholic fatty liver disease (NAFLD): a "growing" problem? J Hepatol 2007;46:1133-1142.
    • (2007) J Hepatol , vol.46 , pp. 1133-1142
    • Roberts, E.A.1
  • 5
    • 70049089646 scopus 로고    scopus 로고
    • Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal
    • Alkhouri N, Dixon LJ, Feldstein AE. Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal. Expert Rev Gastroenterol Hepatol 2009;3:445-451.
    • (2009) Expert Rev Gastroenterol Hepatol , vol.3 , pp. 445-451
    • Alkhouri, N.1    Dixon, L.J.2    Feldstein, A.E.3
  • 6
    • 84881317164 scopus 로고    scopus 로고
    • Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity
    • Herms A, Bosch M, Ariotti N, Reddy BJ, Fajardo A, Fernández-Vidal A, et al. Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity. Curr Biol 2013;23:1489-1496.
    • (2013) Curr Biol , vol.23 , pp. 1489-1496
    • Herms, A.1    Bosch, M.2    Ariotti, N.3    Reddy, B.J.4    Fajardo, A.5    Fernández-Vidal, A.6
  • 9
    • 79952231349 scopus 로고    scopus 로고
    • for the NASH CRN. Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings
    • Brunt EM, Kleiner DE, Wilson LA, Belt P, Neuschwnader-Tetri BA; for the NASH CRN. Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings. Hepatology 2011;53:810-820.
    • (2011) Hepatology , vol.53 , pp. 810-820
    • Brunt, E.M.1    Kleiner, D.E.2    Wilson, L.A.3    Belt, P.4    Neuschwnader-Tetri, B.A.5
  • 10
    • 40949123364 scopus 로고    scopus 로고
    • Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis
    • Lackner C, Gogg-Kamerer M, Zatloukal K, Stumptner C, Brunt EM, Denk H. Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis. J Hepatol 2008;48:821-888.
    • (2008) J Hepatol , vol.48 , pp. 821-888
    • Lackner, C.1    Gogg-Kamerer, M.2    Zatloukal, K.3    Stumptner, C.4    Brunt, E.M.5    Denk, H.6
  • 11
    • 84880419922 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: pathogenesis and novel therapeutic approaches
    • Schuppan D, Schattenberg JM. Non-alcoholic steatohepatitis: pathogenesis and novel therapeutic approaches. J Gastroenterol Hepatol 2013;28(Suppl 1):68-76.
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 68-76
    • Schuppan, D.1    Schattenberg, J.M.2
  • 13
    • 77951722845 scopus 로고    scopus 로고
    • Signals from dying hepatocytes trigger growth of liver progenitors
    • Jung Y, Witek RP, Syn WK, Choi SS, Omenetti A, Premont R, et al. Signals from dying hepatocytes trigger growth of liver progenitors. Gut 2010;59:655-65.
    • (2010) Gut , vol.59 , pp. 655-665
    • Jung, Y.1    Witek, R.P.2    Syn, W.K.3    Choi, S.S.4    Omenetti, A.5    Premont, R.6
  • 15
    • 84861573996 scopus 로고    scopus 로고
    • NASH CRN. Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease
    • Guy CD, Suzuki A, Zdanowicz M, Abdelmalek MF, Burchette J, Unalp A, et al., NASH CRN. Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease. Hepatology 2012;55:1711-1721.
    • (2012) Hepatology , vol.55 , pp. 1711-1721
    • Guy, C.D.1    Suzuki, A.2    Zdanowicz, M.3    Abdelmalek, M.F.4    Burchette, J.5    Unalp, A.6
  • 17
    • 69549105422 scopus 로고    scopus 로고
    • Apoptosis in Drosophila: compensatory proliferation and undead cells
    • Martín FA, Peréz-Garijo A, Morata G. Apoptosis in Drosophila: compensatory proliferation and undead cells. Int J Dev Biol 2010;53:1341-1347.
    • (2010) Int J Dev Biol , vol.53 , pp. 1341-1347
    • Martín, F.A.1    Peréz-Garijo, A.2    Morata, G.3
  • 18
    • 5044248528 scopus 로고    scopus 로고
    • Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways
    • Ryoo HD, Gorenc T, Steller H. Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways. Dev Cell 2004;7:491-501.
    • (2004) Dev Cell , vol.7 , pp. 491-501
    • Ryoo, H.D.1    Gorenc, T.2    Steller, H.3
  • 19
    • 42049095950 scopus 로고    scopus 로고
    • Distinct mechanisms of apoptosis-induced compensatory proliferation in proliferating and differentiating tissues in the Drosophila eye
    • Fan Y, Bergmann A. Distinct mechanisms of apoptosis-induced compensatory proliferation in proliferating and differentiating tissues in the Drosophila eye. Dev Cell 2008;14:399-410.
    • (2008) Dev Cell , vol.14 , pp. 399-410
    • Fan, Y.1    Bergmann, A.2
  • 20
    • 79951833653 scopus 로고    scopus 로고
    • Mitogenic signaling from apoptotic cells in Drosophila
    • Morata G, Shlevkov E, Pérez-Garijo A. Mitogenic signaling from apoptotic cells in Drosophila. Dev Growth Differ 2011;53:168-176.
    • (2011) Dev Growth Differ , vol.53 , pp. 168-176
    • Morata, G.1    Shlevkov, E.2    Pérez-Garijo, A.3
  • 21
    • 34548857335 scopus 로고    scopus 로고
    • Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox
    • Rubartelli A, Lotze MT. Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox. Trends Immunol 2007;28:429-436.
    • (2007) Trends Immunol , vol.28 , pp. 429-436
    • Rubartelli, A.1    Lotze, M.T.2
  • 22
    • 84879414522 scopus 로고    scopus 로고
    • The mechanisms of Hedgehog signaling and its roles in development and disease
    • Briscoe J, Thérond PP. The mechanisms of Hedgehog signaling and its roles in development and disease. Nat Rev Mol Cell Biol 2013;14:416-429.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 416-429
    • Briscoe, J.1    Thérond, P.P.2
  • 23
    • 84893092076 scopus 로고    scopus 로고
    • Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease (severe NAFLD gene signature)
    • Moylan CA, Pang H, Dellinger A, Suzuki A, Garrett M, Ashley-Koch AE, et al. Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease (severe NAFLD gene signature). Hepatology 2014;59:471-482.
    • (2014) Hepatology , vol.59 , pp. 471-482
    • Moylan, C.A.1    Pang, H.2    Dellinger, A.3    Suzuki, A.4    Garrett, M.5    Ashley-Koch, A.E.6
  • 25
    • 84880651918 scopus 로고    scopus 로고
    • Vismodegib suppresses TRAIL-mediated liver injury in a mouse model of nonalcoholic steatohepatitis
    • Hirsova P, Ibrahim SH, Bronk SF, Yagita H, Gores GJ. Vismodegib suppresses TRAIL-mediated liver injury in a mouse model of nonalcoholic steatohepatitis. PLoS One 2013;8:e70599doi.
    • (2013) PLoS One , vol.8 , pp. e70599
    • Hirsova, P.1    Ibrahim, S.H.2    Bronk, S.F.3    Yagita, H.4    Gores, G.J.5
  • 26
    • 20044374023 scopus 로고    scopus 로고
    • Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al., Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 27
    • 0042033294 scopus 로고    scopus 로고
    • Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease
    • Roskams T, Yang SQ, Koteish A, Durnez A, DeVos R, Huang X, et al. Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease. Am J Pathol 2003;163:1301-1311.
    • (2003) Am J Pathol , vol.163 , pp. 1301-1311
    • Roskams, T.1    Yang, S.Q.2    Koteish, A.3    Durnez, A.4    DeVos, R.5    Huang, X.6
  • 30
    • 41549118422 scopus 로고    scopus 로고
    • The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer
    • Omenetti A, Diehl AM. The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer. Am J Physiol Gastrointest Liver Physiol 2008;294:G595-598.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294 , pp. G595-G598
    • Omenetti, A.1    Diehl, A.M.2
  • 31
    • 84871191893 scopus 로고    scopus 로고
    • Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma
    • Chan IS, Guy CD, Chen Y, Lu J, Swiderska-Syn M, Michelotti GA, et al. Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma. Cancer Res 2012;72:6344-6350.
    • (2012) Cancer Res , vol.72 , pp. 6344-6350
    • Chan, I.S.1    Guy, C.D.2    Chen, Y.3    Lu, J.4    Swiderska-Syn, M.5    Michelotti, G.A.6
  • 33
    • 0023900132 scopus 로고
    • Alpha-tocopherol and inhibition of cytolysis in glutathione-depleted hepatocytes in primary culture
    • Hishinuma I, Nakamura T. Alpha-tocopherol and inhibition of cytolysis in glutathione-depleted hepatocytes in primary culture. J Nutr Sci Vitaminol (Tokyo) 1988;34:11-23.
    • (1988) J Nutr Sci Vitaminol (Tokyo) , vol.34 , pp. 11-23
    • Hishinuma, I.1    Nakamura, T.2
  • 34
    • 0026275823 scopus 로고
    • Effects of antioxidants on survival of adult rat hepatocytes under various oxygen tensions in serum-free primary culture
    • Miyazaki M, Bai L, Tsuboi S, Seshimo K, Namba M. Effects of antioxidants on survival of adult rat hepatocytes under various oxygen tensions in serum-free primary culture. Acta Med Okayama 1991;45:441-444.
    • (1991) Acta Med Okayama , vol.45 , pp. 441-444
    • Miyazaki, M.1    Bai, L.2    Tsuboi, S.3    Seshimo, K.4    Namba, M.5
  • 35
    • 0026562502 scopus 로고
    • The acrolein cytotoxicity and cytoprotective action of alpha-tocopherol in primary cultured rat hepatocytes
    • Watanabe M, Sugimoto M, Ito K. The acrolein cytotoxicity and cytoprotective action of alpha-tocopherol in primary cultured rat hepatocytes. Gastroenterol Jpn 1992;27:199-205.
    • (1992) Gastroenterol Jpn , vol.27 , pp. 199-205
    • Watanabe, M.1    Sugimoto, M.2    Ito, K.3
  • 37
    • 79960739850 scopus 로고    scopus 로고
    • Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish
    • Thakur PC, Stuckenholz C, Rivera MR, Davison JM, Yao JK, Amsterdam A, et al. Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish. Hepatology 2011;54:452-462.
    • (2011) Hepatology , vol.54 , pp. 452-462
    • Thakur, P.C.1    Stuckenholz, C.2    Rivera, M.R.3    Davison, J.M.4    Yao, J.K.5    Amsterdam, A.6
  • 38
    • 59849085125 scopus 로고    scopus 로고
    • Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells
    • Witek RP, Yang L, Liu R, Jung Y, Omenetti A, Syn WK, et al. Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells. Gastroenterology 2009;136:320-330.
    • (2009) Gastroenterology , vol.136 , pp. 320-330
    • Witek, R.P.1    Yang, L.2    Liu, R.3    Jung, Y.4    Omenetti, A.5    Syn, W.K.6
  • 39
    • 78751479915 scopus 로고    scopus 로고
    • Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis
    • Syn WK, Choi SS, Liaskou E, Karaca GF, Agboola KM, Oo YH, et al. Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. Hepatology 2011;53:106-115.
    • (2011) Hepatology , vol.53 , pp. 106-115
    • Syn, W.K.1    Choi, S.S.2    Liaskou, E.3    Karaca, G.F.4    Agboola, K.M.5    Oo, Y.H.6
  • 40
    • 84896495748 scopus 로고    scopus 로고
    • Osteopontin binding to lipopolysaccharide lowers tumor necrosis factor-α and prevents early alcohol-induced liver injury in mice
    • Ge X, Leung TM, Arriazu E, Lu Y, Urtasun R, Christensen B, et al. Osteopontin binding to lipopolysaccharide lowers tumor necrosis factor-α and prevents early alcohol-induced liver injury in mice. Hepatology 2014;59:1600-1616.
    • (2014) Hepatology , vol.59 , pp. 1600-1616
    • Ge, X.1    Leung, T.M.2    Arriazu, E.3    Lu, Y.4    Urtasun, R.5    Christensen, B.6
  • 41
    • 84896722464 scopus 로고    scopus 로고
    • Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH
    • Sutti S, Jindal A, Locatelli I, Vacchiano M, Gigliotti L, Bozzola C, et al. Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH. Hepatology 2014;59:886-897.
    • (2014) Hepatology , vol.59 , pp. 886-897
    • Sutti, S.1    Jindal, A.2    Locatelli, I.3    Vacchiano, M.4    Gigliotti, L.5    Bozzola, C.6
  • 42
    • 84886879974 scopus 로고    scopus 로고
    • Targeting hedgehog signaling in cancer: research and clinical developments
    • Xie J, Bartels CM, Barton SW, Gu D. Targeting hedgehog signaling in cancer: research and clinical developments. Oncol Targets Ther 2013;6:1425-1435.
    • (2013) Oncol Targets Ther , vol.6 , pp. 1425-1435
    • Xie, J.1    Bartels, C.M.2    Barton, S.W.3    Gu, D.4
  • 43
    • 84872417679 scopus 로고    scopus 로고
    • Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists
    • Kim J, Aftab BT, Tang JY, Kim D, Lee AH, Rezaee M, et al. Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell 2013;23:23-34.
    • (2013) Cancer Cell , vol.23 , pp. 23-34
    • Kim, J.1    Aftab, B.T.2    Tang, J.Y.3    Kim, D.4    Lee, A.H.5    Rezaee, M.6
  • 44
    • 84867848829 scopus 로고    scopus 로고
    • Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling
    • Wang J, Mook RA Jr, Lu J, Gooden DM, Ribeiro A, Guo A, et al. Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling. Bioorg Med Chem 2012;20:6751-6757.
    • (2012) Bioorg Med Chem , vol.20 , pp. 6751-6757
    • Wang, J.1    Mook, R.A.2    Lu, J.3    Gooden, D.M.4    Ribeiro, A.5    Guo, A.6
  • 45
    • 84888873502 scopus 로고    scopus 로고
    • The improvement of cognitive functions is associated with a decrease of plasma osteopontin levels in natalizumab treated relapsing multiple sclerosis
    • Iaffaldano P, Ruggieri M, Viterbo RG, Mastrapasqua M, Trojano M. The improvement of cognitive functions is associated with a decrease of plasma osteopontin levels in natalizumab treated relapsing multiple sclerosis. Brain Behav Immun 2014;35:96-101.
    • (2014) Brain Behav Immun , vol.35 , pp. 96-101
    • Iaffaldano, P.1    Ruggieri, M.2    Viterbo, R.G.3    Mastrapasqua, M.4    Trojano, M.5
  • 46
    • 26944482355 scopus 로고    scopus 로고
    • Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development
    • McGlinn E, van Bueren KL, Fiorenza S, Mo R, Poh AM, Forrest A, et al. Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development. Mech Dev 2005;122:1218-1233.
    • (2005) Mech Dev , vol.122 , pp. 1218-1233
    • McGlinn, E.1    van Bueren, K.L.2    Fiorenza, S.3    Mo, R.4    Poh, A.M.5    Forrest, A.6
  • 48
    • 84882245596 scopus 로고    scopus 로고
    • Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability
    • Pajvani UB, Qiang L, Kangsamaksin T, Kitajewski J, Ginsberg HN, Accili D. Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability. Nat Med 2013;19:1054-1060.
    • (2013) Nat Med , vol.19 , pp. 1054-1060
    • Pajvani, U.B.1    Qiang, L.2    Kangsamaksin, T.3    Kitajewski, J.4    Ginsberg, H.N.5    Accili, D.6
  • 49
    • 73349130440 scopus 로고    scopus 로고
    • Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate
    • Pospisilik JA, Schramek D, Schnidar H, Cronin SJ, Nehme NT, Zhang X, et al. Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell 2010;140:148-160.
    • (2010) Cell , vol.140 , pp. 148-160
    • Pospisilik, J.A.1    Schramek, D.2    Schnidar, H.3    Cronin, S.J.4    Nehme, N.T.5    Zhang, X.6
  • 50
    • 84867536639 scopus 로고    scopus 로고
    • Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat
    • Teperino R, Amann S, Bayer M, McGee SL, Loipetzberger A, Connor T, et al. Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell 2012;151:414-426.
    • (2012) Cell , vol.151 , pp. 414-426
    • Teperino, R.1    Amann, S.2    Bayer, M.3    McGee, S.L.4    Loipetzberger, A.5    Connor, T.6


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