Regulation of calcitriol biosynthesis and activity: Focus on gestational vitamin D deficiency and adverse pregnancy outcomes

Nutrients

Volumn 7, Issue 1, 2015, Pages 443-480

  Olmos Ortiz, Andrea ^a   Avila, Euclides ^a   Durand Carbajal, Marta ^a   Díaz, Lorenza ^a  

^a INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

Author keywords

Gestational pathologies; Maternal diet; Micronutrient; Placenta

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; 25 HYDROXYVITAMIN D; 3 (OR 17) BETA HYDROXYSTEROID DEHYDROGENASE; AROMATASE; BETA DEFENSIN; CALCITONIN; CALCITRIOL; CHORIONIC GONADOTROPIN; COLECALCIFEROL 24 HYDROXYLASE; COLECALCIFEROL 27 HYDROXYLASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME; CYTOKINE; FIBROBLAST GROWTH FACTOR 23; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOPONTIN; PARATHYROID HORMONE; PHOSPHATE; PROLACTIN; PROTEIN KINASE C; RETINOID X RECEPTOR; SECALCIFEROL; SOMATOMEDIN C; TRANSCRIPTION FACTOR HOXA10; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG; CALCIUM; FIBROBLAST GROWTH FACTOR;

CALCIUM ABSORPTION; CALCIUM TRANSPORT; CEREBRAL PALSY; CHEMILUMINESCENCE IMMUNOASSAY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEEDBACK SYSTEM; FEMALE; GENE EXPRESSION; HEMODYNAMICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERBILIRUBINEMIA; HYPERCALCEMIA; HYPOGLYCEMIA; INNATE IMMUNITY; LOW BIRTH WEIGHT; MASS FRAGMENTOGRAPHY; META ANALYSIS (TOPIC); MULTICENTER STUDY (TOPIC); OSTEOPOROSIS; PLACENTAL CALCIUM TRANSPORT; POLYCYTHEMIA; PREECLAMPSIA; PREGNANCY COMPLICATION; PREGNANCY DIABETES MELLITUS; PREGNANCY OUTCOME; PREMATURE FETUS MEMBRANE RUPTURE; PREMATURE LABOR; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; TANDEM MASS SPECTROMETRY; VAGINITIS; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN D METABOLISM; VITAMIN D RESPONSIVE ELEMENT; VITAMIN SUPPLEMENTATION; BIOSYNTHESIS; BLOOD; DRUG EFFECTS; MATERNAL NUTRITION; METABOLISM; OBSERVATIONAL STUDY; PLACENTA; PREGNANCY;

CALCITRIOL; CALCIUM; CYTOKINES; FEMALE; FIBROBLAST GROWTH FACTORS; HUMANS; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; META-ANALYSIS AS TOPIC; OBSERVATIONAL STUDIES AS TOPIC; PARATHYROID HORMONE; PHOSPHATES; PLACENTA; PREGNANCY; PREGNANCY OUTCOME; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VITAMIN D DEFICIENCY;

EID: 84920949757     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu7010443     Document Type: Review

References (252)

1. Bikle, D. Highlights from the 16th vitamin D workshop, San Francisco, CA, June 11–14, 2013. J. Steroid Biochem. Mol. Biol. 2014, 144, 1–4.
2. Wacker, M.; Holick, M.F. Sunlight and vitamin D: A global perspective for health. Derm. Endocrinol. 2013, 5, 51–108.
3. Nykjaer, A.; Dragun, D.; Walther, D.; Vorum, H.; Jacobsen, C.; Herz, J.; Melsen, F.; Christensen, E.I.; Willnow, T.E. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell 1999, 96, 507–515.
4. Nykjaer, A.; Fyfe, J.C.; Kozyraki, R.; Leheste, J.R.; Jacobsen, C.; Nielsen, M.S.; Verroust, P.J.; Aminoff, M.; de la Chapelle, A.; Moestrup, S.K.; et al. Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3). Proc. Natl. Acad. Sci. USA 2001, 98, 13895–13900.
5. Morris, S.M.; Tallquist, M.D.; Rock, C.O.; Cooper, J.A. Dual roles for the dab2 adaptor protein in embryonic development and kidney transport. EMBO J. 2002, 21, 1555–1564.
6. Dusso, A.S.; Brown, A.J.; Slatopolsky, E. Vitamin D. Am. J. Physiol. Ren. Physiol. 2005, 289, 8–28.
7. Costa, J.L.; Eijk, P.P.; van de Wiel, M.A.; ten Berge, D.; Schmitt, F.; Narvaez, C.J.; Welsh, J.; Ylstra, B. Anti-proliferative action of vitamin D in MCF7 is still active after siRNA-VDR knock-down. BMC Genomics 2009, 10, 499.
8. Haussler, M.R.; Jurutka, P.W.; Mizwicki, M.; Norman, A.W. Vitamin D receptor (VDR)-mediated actions of 1alpha,25(OH)(2)vitamin D(3): Genomic and non-genomic mechanisms. Best Pract. Res. Clin. Endocrinol. Metab. 2011, 25, 543–559
9. Sylvia, V.L.; Schwartz, Z.; Ellis, E.B.; Helm, S.H.; Gomez, R.; Dean, D.D.; Boyan, B.D. Nongenomic regulation of protein kinase C isoforms by the vitamin D metabolites 1 alpha,25-(OH)2D3 and 24R,25-(OH)2D3. J. Cell. Physiol. 1996, 167, 380–393.
10. Beno, D.W.; Brady, L.M.; Bissonnette, M.; Davis, B.H. Protein kinase C and mitogen-activated protein kinase are required for 1,25-dihydroxyvitamin D3-stimulated EGR induction. J. Biol. Chem. 1995, 270, 3642–3647.
11. Berg, J.P.; Haug, E. Vitamin D: A hormonal regulator of the cAMP signaling pathway. Crit. Rev. Biochem. Mol. Biol. 1999, 34, 315–323.
12. Avila, E.; Diaz, L.; Barrera, D.; Halhali, A.; Mendez, I.; Gonzalez, L.; Zuegel, U.; Steinmeyer, A.; Larrea, F. Regulation of vitamin D hydroxylases gene expression by 1,25-dihydroxyvitamin D3 and cyclic AMP in cultured human syncytiotrophoblasts. J. Steroid Biochem. Mol. Biol. 2007, 103, 90–96.
13. Morelli, S.; de Boland, A.R.; Boland, R.L. Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblasts treated with 1,25-dihydroxyvitamin D3. Biochem. J. 1993, 289, 675–679.
14. Zanello, L.P.; Norman, A.W. 1 alpha,25(OH)2 vitamin D3-mediated stimulation of outward anionic currents in osteoblast-like ROS 17/2.8 cells. Biochem. Biophys. Res. Commun. 1996, 225, 551–556.
15. Nemere, I.; Dormanen, M.C.; Hammond, M.W.; Okamura, W.H.; Norman, A.W. Identification of a specific binding protein for 1 alpha,25-dihydroxyvitamin D3 in basal-lateral membranes of chick intestinal epithelium and relationship to transcaltachia. J. Biol. Chem. 1994, 269, 23750–23756.
16. Quesada, J.M.; Martin-Malo, A.; Santiago, J.; Hervas, F.; Martinez, M.E.; Castillo, D.; Barrio, V.; Aljama, P. Effect of calcitriol on insulin secretion in uraemia. Nephrol. Dial. Transplant. 1990, 5, 1013–1017.
17. Sergeev, I.N.; Rhoten, W.B. 1,25-dihydroxyvitamin D3 evokes oscillations of intracellular calcium in a pancreatic beta-cell line. Endocrinology 1995, 136, 2852–2861.
18. Noda, M.; Vogel, R.L.; Craig, A.M.; Prahl, J.; DeLuca, H.F.; Denhardt, D.T. Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (spp-1 or osteopontin) gene expression. Proc. Natl. Acad. Sci. USA 1990, 87, 9995–9999.
19. Liu, M.; Lee, M.H.; Cohen, M.; Bommakanti, M.; Freedman, L.P. Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev. 1996, 10, 142–153.
20. Kriebitzsch, C.; Verlinden, L.; Eelen, G.; van Schoor, N.M.; Swart, K.; Lips, P.; Meyer, M.B.; Pike, J.W.; Boonen, S.; Carlberg, C.; et al. 1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine beta-synthase. J. Bone Miner. Res. 2011, 26, 2991–3000.
21. Yuan, W.; Pan, W.; Kong, J.; Zheng, W.; Szeto, F.L.; Wong, K.E.; Cohen, R.; Klopot, A.; Zhang, Z.; Li, Y.C. 1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter. J. Biol. Chem. 2007, 282, 29821–29830.
22. Garcia-Quiroz, J.; Rivas-Suarez, M.; Garcia-Becerra, R.; Barrera, D.; Martinez-Reza, I.; Ordaz-Rosado, D.; Santos, N.; Villanueva, O.; Santos-Cuevas, C.L.; Avila, E.; et al.Calcitriol reduces thrombospondin-1 and increases vascular endothelial growth factor in breast cancer cells: Implications for tumor angiogenesis. J. Steroid Biochem. Mol. Biol. 2014, 144, 215–222.
23. Liu, P.T.; Stenger, S.; Tang, D.H.; Modlin, R.L. Cutting edge: Vitamin D-mediated human antimicrobial activity against mycobacterium tuberculosis is dependent on the induction of cathelicidin. J. Immunol. 2007, 179, 2060–2063.
24. Wang, T.T.; Nestel, F.P.; Bourdeau, V.; Nagai, Y.; Wang, Q.; Liao, J.; Tavera-Mendoza, L.; Lin, R.; Hanrahan, J.W.; Mader, S.; et al. Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J. Immunol. 2004, 173, 2909–2912.
25. Thompson, P.D.; Jurutka, P.W.; Whitfield, G.K.; Myskowski, S.M.; Eichhorst, K.R.; Dominguez, C.E.; Haussler, C.A.; Haussler, M.R. Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements. Biochem. Biophys. Res. Commun. 2002, 299, 730–738.
26. Henry, H.L. Regulation of vitamin D metabolism. Best Pract. Res. Clin. Endocrinol. Metab. 2011, 25, 531–541.
27. Rost, C.R.; Bikle, D.D.; Kaplan, R.A. In vitro stimulation of 25-hydroxycholecalciferol 1 alpha-hydroxylation by parathyroid hormone in chick kidney slices: Evidence for a role for adenosine 3′,5′-monophosphate. Endocrinology 1981, 108, 1002–1006.
28. Zierold, C.; Mings, J.A.; DeLuca, H.F. Parathyroid hormone regulates 25-hydroxyvitamin D(3)-24-hydroxylase mRNA by altering its stability. Proc. Natl. Acad. Sci. USA 2001, 98, 13572–13576.
29. Shimada, T.; Kakitani, M.; Yamazaki, Y.; Hasegawa, H.; Takeuchi, Y.; Fujita, T.; Fukumoto, S.; Tomizuka, K.; Yamashita, T. Targeted ablation of FGF23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J. Clin. Invest. 2004, 113, 561–568.
30. Shimada, T.; Hasegawa, H.; Yamazaki, Y.; Muto, T.; Hino, R.; Takeuchi, Y.; Fujita, T.; Nakahara, K.; Fukumoto, S.; Yamashita, T. FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J. Bone Miner. Res. 2004, 19, 429–435.
31. Bikle, D.D. Vitamin D metabolism, mechanism of action, and clinical applications. Chem. Biol. 2014, 21, 319–329.
32. Nesbitt, T.; Drezner, M.K. Insulin-like growth factor-I regulation of renal 25-hydroxyvitamin D-1-hydroxylase activity. Endocrinology 1993, 132, 133–138.
33. Menaa, C.; Vrtovsnik, F.; Friedlander, G.; Corvol, M.; Garabedian, M. Insulin-like growth factor I, a unique calcium-dependent stimulator of 1,25-dihydroxyvitamin D3 production. Studies in cultured mouse kidney cells. J. Biol. Chem. 1995, 270, 25461–25467.
34. Kawashima, H.; Torikai, S.; Kurokawa, K. Calcitonin selectively stimulates 25-hydroxyvitamin D3-1 alpha-hydroxylase in proximal straight tubule of rat kidney. Nature 1981, 291, 327–329.
35. Overbergh, L.; Stoffels, K.; Valckx, D.; Giulietti, A.; Bouillon, R.; Mathieu, C. Regulation of 25-hydroxyvitamin D-1alpha-hydroxylase by IFNgamma in human monocytic THP1 cells. J. Steroid Biochem. Mol. Biol. 2004, 89–90, 453–455.
36. Gyetko, M.R.; Hsu, C.H.; Wilkinson, C.C.; Patel, S.; Young, E. Monocyte 1 alpha-hydroxylase regulation: Induction by inflammatory cytokines and suppression by dexamethasone and uremia toxin. J. Leukoc. Biol. 1993, 54, 17–22.
37. Pryke, A.M.; Duggan, C.; White, C.P.; Posen, S.; Mason, R.S. Tumor necrosis factor-alpha induces vitamin D-1-hydroxylase activity in normal human alveolar macrophages. J. Cell. Physiol. 1990, 142, 652–656.
38. Adams, J.S.; Gacad, M.A. Characterization of 1 alpha-hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis. J. Exp. Med. 1985, 161, 755–765.
39. Xie, Z.; Munson, S.J.; Huang, N.; Portale, A.A.; Miller, W.L.; Bikle, D.D. The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytes. J. Biol. Chem. 2002, 277, 36987–36990.
40. Bikle, D.D.; Pillai, S.; Gee, E.; Hincenbergs, M. Tumor necrosis factor-alpha regulation of 1,25-dihydroxyvitamin D production by human keratinocytes. Endocrinology 1991, 129, 33–38.
41. Bikle, D.D.; Pillai, S.; Gee, E.; Hincenbergs, M. Regulation of 1,25-dihydroxyvitamin D production in human keratinocytes by interferon-gamma. Endocrinology 1989, 124, 655–660.
42. Ren, S.; Nguyen, L.; Wu, S.; Encinas, C.; Adams, J.S.; Hewison, M. Alternative splicing of vitamin D-24-hydroxylase: A novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis. J. Biol. Chem. 2005, 280, 20604–20611.
43. Novakovic, B.; Sibson, M.; Ng, H.K.; Manuelpillai, U.; Rakyan, V.; Down, T.; Beck, S.; Fournier, T.; Evain-Brion, D.; Dimitriadis, E.; et al. Placenta-specific methylation of the vitamin D 24-hydroxylase gene: Implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface. J. Biol. Chem. 2009, 284, 14838–14848.
44. Chung, I.; Karpf, A.R.; Muindi, J.R.; Conroy, J.M.; Nowak, N.J.; Johnson, C.S.; Trump, D.L. Epigenetic silencing of CYP24 in tumor-derived endothelial cells contributes to selective growth inhibition by calcitriol. J. Biol. Chem. 2007, 282, 8704–8714.
45. Matilainen, J.M.; Malinen, M.; Turunen, M.M.; Carlberg, C.; Vaisanen, S. The number of vitamin D receptor binding sites defines the different vitamin D responsiveness of the CYP24 gene in malignant and normal mammary cells. J. Biol. Chem. 2010, 285, 24174–24183.
46. Noyola-Martinez, N.; Diaz, L.; Zaga-Clavellina, V.; Avila, E.; Halhali, A.; Larrea, F.; Barrera, D. Regulation of CYP27B1 and CYP24A1 gene expression by recombinant pro-inflammatory cytokines in cultured human trophoblasts. J. Steroid Biochem. Mol. Biol. 2014, 144, 106–109.
47. Rosen, C.J.; Adams, J.S.; Bikle, D.D.; Black, D.M.; Demay, M.B.; Manson, J.E.; Murad, M.H.; Kovacs, C.S. The nonskeletal effects of vitamin D: An endocrine society scientific statement. Endocr. Rev. 2012, 33, 456–492.
48. Rubin, L.P.; Yeung, B.; Vouros, P.; Vilner, L.M.; Reddy, G.S. Evidence for human placental synthesis of 24,25-dihydroxyvitamin D3 and 23,25-dihydroxyvitamin D3. Pediatr. Res. 1993, 34, 98–104.
49. Higashi, T.; Mitamura, K.; Ohmi, H.; Yamada, N.; Shimada, K.; Tanaka, K.; Honjo, H. Levels of 24,25-dihydroxyvitamin D3, 25-hydroxyvitamin D3 and 25-hydroxyvitamin D3 3-sulphate in human plasma. Ann. Clin. Biochem. 1999, 36, 43–47.
50. Lester, G.E.; Gray, T.K.; Lorenc, R.S. Evidence for maternal and fetal differences in vitamin D metabolism. Proc. Soc. Exp. Biol. Med. 1978, 159, 303–307.
51. Halhali, A.; Diaz, L.; Sanchez, I.; Garabedian, M.; Bourges, H.; Larrea, F. Effects of IGF-I on 1,25-dihydroxyvitamin D(3) synthesis by human placenta in culture. Mol. Hum. Reprod. 1999, 5, 771–776.
52. Brannon, P.M.; Picciano, M.F. Vitamin D in pregnancy and lactation in humans. Ann. Rev. Nutr. 2011, 31, 89–115.
53. Kumar, R.; Cohen, W.R.; Silva, P.; Epstein, F.H. Elevated 1,25-dihydroxyvitamin D plasma levels in normal human pregnancy and lactation. J. Clin. Invest. 1979, 63, 342–344.
54. Seki, K.; Makimura, N.; Mitsui, C.; Hirata, J.; Nagata, I. Calcium-regulating hormones and osteocalcin levels during pregnancy: A longitudinal study. Am. J. Obstet. Gynecol. 1991, 164, 1248–1252.
55. Dahlman, T.; Sjoberg, H.E.; Bucht, E. Calcium homeostasis in normal pregnancy and puerperium. A longitudinal study. Acta Obstet. Gynecol. Scand. 1994, 73, 393–398.
56. Cross, N.A.; Hillman, L.S.; Allen, S.H.; Krause, G.F.; Vieira, N.E. Calcium homeostasis and bone metabolism during pregnancy, lactation, and postweaning: A longitudinal study. Am. J. Clin. Nutr. 1995, 61, 514–523.
57. Kovacs, C.S. Calcium and bone metabolism disorders during pregnancy and lactation. Endocrinol. Metab. Clin. North Am. 2011, 40, 795–826.
58. Moller, U.K.; Streym, S.; Mosekilde, L.; Heickendorff, L.; Flyvbjerg, A.; Frystyk, J.; Jensen, L.T.; Rejnmark, L. Changes in calcitropic hormones, bone markers and insulin-like growth factor I (IGF-I) during pregnancy and postpartum: A controlled cohort study. Osteoporos. Int. 2013, 24, 1307–1320.
59. Ritchie, L.D.; Fung, E.B.; Halloran, B.P.; Turnlund, J.R.; Van Loan, M.D.; Cann, C.E.; King, J.C. A longitudinal study of calcium homeostasis during human pregnancy and lactation and after resumption of menses. Am. J. Clin. Nutr. 1998, 67, 693–701.
60. Tuan, R.S.; Moore, C.J.; Brittingham, J.W.; Kirwin, J.J.; Akins, R.E.; Wong, M. In vitro study of placental trophoblast calcium uptake using JEG-3 human choriocarcinoma cells. J. Cell Sci. 1991, 98, 333–342.
61. Halhali, A.; Figueras, A.G.; Diaz, L.; Avila, E.; Barrera, D.; Hernandez, G.; Larrea, F. Effects of calcitriol on calbindins gene expression and lipid peroxidation in human placenta. J. Steroid Biochem. Mol. Biol. 2010, 121, 448–451.
62. Belkacemi, L.; Zuegel, U.; Steinmeyer, A.; Dion, J.P.; Lafond, J. Calbindin-D28k (CaBP28k) identification and regulation by 1,25-dihydroxyvitamin D3 in human choriocarcinoma cell line JEG-3. Mol. Cell. Endocrinol. 2005, 236, 31–41.
63. Young, B.E.; Cooper, E.M.; McIntyre, A.W.; Kent, T.; Witter, F.; Harris, Z.L.; O’Brien, K.O. Placental vitamin D receptor (VDR) expression is related to neonatal vitamin D status, placental calcium transfer, and fetal bone length in pregnant adolescents. FASEB J. 2014, 28, 2029–2037.
64. Ardawi, M.S.; Nasrat, H.A.; HS, B.A.A. Calcium-regulating hormones and parathyroid hormone-related peptide in normal human pregnancy and postpartum: A longitudinal study. Eur. J. Endocrinol. 1997, 137, 402–409.
65. Ron, M.; Menczel, J.; Schwartz, L.; Palti, Z.; Kidroni, G. Vitamin D3 metabolites in amniotic fluid in relation with maternal and fetal sera in term pregnancies. J. Perinat. Med. 1987, 15, 282–290.
66. Gupta, M.M.; Kuppuswamy, G.; Subramanian, A.R. Transplacental transfer of 25-hydroxycholecalciferol. Postgrad. Med. J. 1982, 58, 408–410.
67. Wilson, S.G.; Retallack, R.W.; Kent, J.C.; Worth, G.K.; Gutteridge, D.H. Serum free 1,25-dihydroxyvitamin D and the free 1,25-dihydroxyvitamin D index during a longitudinal study of human pregnancy and lactation. Clin. Endocrinol. (Oxf.) 1990, 32, 613–622.
68. Paulson, S.K.; Ford, K.K.; Langman, C.B. Pregnancy does not alter the metabolic clearance of 1,25-dihydroxyvitamin D in rats. Am. J. Physiol. 1990, 258, E158–E162.
69. Weisman, Y.; Harell, A.; Edelstein, S.; David, M.; Spirer, Z.; Golander, A. 1 alpha, 25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 in vitro synthesis by human decidua and placenta. Nature 1979, 281, 317–319.
70. Diaz, L.; Sanchez, I.; Avila, E.; Halhali, A.; Vilchis, F.; Larrea, F. Identification of a 25-hydroxyvitamin D3 1alpha-hydroxylase gene transcription product in cultures of human syncytiotrophoblast cells. J. Clin. Endocrinol. Metab. 2000, 85, 2543–2549.
71. Whitsett, J.A.; Ho, M.; Tsang, R.C.; Norman, E.J.; Adams, K.G. Synthesis of 1,25-dihydroxyvitamin D3 by human placenta in vitro. J. Clin. Endocrinol. Metab. 1981, 53, 484–488.
72. Kirby, B.J.; Ma, Y.; Martin, H.M.; Buckle Favaro, K.L.; Karaplis, A.C.; Kovacs, C.S. Upregulation of calcitriol during pregnancy and skeletal recovery after lactation do not require parathyroid hormone. J. Bone Miner. Res. 2013, 28, 1987–2000.
73. Sanz-Salvador, L.; Garcia-Perez, M.A.; Tarin, J.J.; Cano, A. Endocrinology in pregnancy: Bone metabolic changes during pregnancy: A period of vulnerability to osteoporosis and fracture. Eur. J. Endocrinol. 2015, 172, 53–65.
74. Simmonds, C.S.; Kovacs, C.S. Role of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in regulating mineral homeostasis during fetal development. Crit. Rev. Eukaryot. Gene Expr. 2010, 20, 235–273.
75. Weisman, Y.; Vargas, A.; Duckett, G.; Reiter, E.; Root, A.W. Synthesis of 1,25-dihydroxyvitamin D in the nephrectomized pregnant rat. Endocrinology 1978, 103, 1992–1996.
76. Blum, M.; Weisman, Y.; Turgeman, S.; Cabili, S.; Wollman, Y.; Peer, G.; Stern, N.; Silverberg, D.; Schwartz, D.; Iaina, A. Pregnancy decreases immunoreactive parathyroid hormone level in rats with chronic renal failure. Clin. Sci. (Lond.) 1999, 96, 427–430.
77. Zehnder, D.; Bland, R.; Williams, M.C.; McNinch, R.W.; Howie, A.J.; Stewart, P.M.; Hewison, M. Extrarenal expression of 25-hydroxyvitamin D(3)-1 alpha-hydroxylase. J. Clin. Endocrinol. Metab. 2001, 86, 888–894.
78. Zehnder, D.; Evans, K.N.; Kilby, M.D.; Bulmer, J.N.; Innes, B.A.; Stewart, P.M.; Hewison, M. The ontogeny of 25-hydroxyvitamin D(3) 1alpha-hydroxylase expression in human placenta and decidua. Am. J. Pathol. 2002, 161, 105–114.
79. Evans, K.N.; Bulmer, J.N.; Kilby, M.D.; Hewison, M. Vitamin D and placental-decidual function. J. Soc. Gynecol. Investig. 2004, 11, 263–271.
80. Bikle, D.D.; Gee, E.; Halloran, B.; Haddad, J.G. Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. J. Clin. Invest. 1984, 74, 1966–1971.
81. Chun, R.F.; Peercy, B.E.; Orwoll, E.S.; Nielson, C.M.; Adams, J.S.; Hewison, M. Vitamin D and DBP: The free hormone hypothesis revisited. J. Steroid Biochem. Mol. Biol. 2014, 144, 132–137.
82. Burke, K.A.; Jauniaux, E.; Burton, G.J.; Cindrova-Davies, T. Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation. Placenta 2013, 34, 1105–1109.
83. Akour, A.A.; Gerk, P.; Kennedy, M.J. Megalin expression in human term and preterm placental villous tissues: Effect of gestational age and sample processing and storage time. J. Pharmacol. Toxicol. Methods 2014, doi:10.1016/j.vascn.2014.10.001.
84. Christensen, E.I.; Birn, H. Megalin and cubilin: Multifunctional endocytic receptors. Nat. Rev. Mol. Cell Biol. 2002, 3, 256–266.
85. Safadi, F.F.; Thornton, P.; Magiera, H.; Hollis, B.W.; Gentile, M.; Haddad, J.G.; Liebhaber, S.A.; Cooke, N.E. Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. J. Clin. Invest. 1999, 103, 239–251.
86. Johnson, J.A.; Grande, J.P.; Roche, P.C.; Kumar, R. Immunohistochemical detection and distribution of the 1,25-dihydroxyvitamin D3 receptor in rat reproductive tissues. Histochem. Cell Biol. 1996, 105, 7–15.
87. Shahbazi, M.; Jeddi-Tehrani, M.; Zareie, M.; Salek-Moghaddam, A.; Akhondi, M.M.; Bahmanpoor, M.; Sadeghi, M.R.; Zarnani, A.H. Expression profiling of vitamin D receptor in placenta, decidua and ovary of pregnant mice. Placenta 2011, 32, 657–664.
88. Zarnani, A.H.; Shahbazi, M.; Salek-Moghaddam, A.; Zareie, M.; Tavakoli, M.; Ghasemi, J.; Rezania, S.; Moravej, A.; Torkabadi, E.; Rabbani, H.; et al. Vitamin D3 receptor is expressed in the endometrium of cycling mice throughout the estrous cycle. Fertil. Steril. 2010, 93, 2738–2743.
89. Evans, K.N.; Nguyen, L.; Chan, J.; Innes, B.A.; Bulmer, J.N.; Kilby, M.D.; Hewison, M. Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells. Biol. Reprod. 2006, 75, 816–822.
90. Liu, N.; Kaplan, A.T.; Low, J.; Nguyen, L.; Liu, G.Y.; Equils, O.; Hewison, M. Vitamin D induces innate antibacterial responses in human trophoblasts via an intracrine pathway. Biol. Reprod. 2009, 80, 398–406.
91. Diaz, L.; Noyola-Martinez, N.; Barrera, D.; Hernandez, G.; Avila, E.; Halhali, A.; Larrea, F. Calcitriol inhibits TNF-alpha-induced inflammatory cytokines in human trophoblasts. J. Reprod. Immunol. 2009, 81, 17–24.
92. Noyola-Martinez, N.; Diaz, L.; Avila, E.; Halhali, A.; Larrea, F.; Barrera, D. Calcitriol downregulates TNF-alpha and IL-6 expression in cultured placental cells from preeclamptic women. Cytokine 2013, 61, 245–250.
93. Olmos-Ortiz, A.; Noyola-Martinez, N.; Barrera, D.; Zaga-Clavellina, V.; Avila, E.; Halhali, A.; Biruete, B.; Larrea, F.; Diaz, L. IL-10 inhibits while calcitriol reestablishes placental antimicrobial peptides gene expression. J. Steroid Biochem. Mol. Biol. 2014, doi:10.1016/ j.jsbmb.2014.07.012.
94. Halhali, A.; Acker, G.M.; Garabedian, M. 1,25-dihydroxyvitamin D3 induces in vivo the decidualization of rat endometrial cells. J. Reprod. Fertil. 1991, 91, 59–64.
95. Barrera, D.; Avila, E.; Hernandez, G.; Halhali, A.; Biruete, B.; Larrea, F.; Diaz, L. Estradiol and progesterone synthesis in human placenta is stimulated by calcitriol. J. Steroid Biochem. Mol. Biol. 2007, 103, 529–532.
96. Barrera, D.; Avila, E.; Hernandez, G.; Mendez, I.; Gonzalez, L.; Halhali, A.; Larrea, F.; Morales, A.; Diaz, L. Calcitriol affects hCG gene transcription in cultured human syncytiotrophoblasts. Reprod. Biol. Endocrinol. 2008, 6, 3.
97. Stephanou, A.; Ross, R.; Handwerger, S. Regulation of human placental lactogen expression by 1,25-dihydroxyvitamin D3. Endocrinology 1994, 135, 2651–2656.
98. Binkley, N.; Ramamurthy, R.; Krueger, D. Low vitamin D status: Definition, prevalence, consequences, and correction. Endocrinol. Metab. Clin. North Am. 2010, 39, 287–301.
99. Levine, B.S.; Song, M. Pharmacokinetics and efficacy of pulse oral versus intravenous calcitriol in hemodialysis patients. J. Am. Soc. Nephrol. 1996, 7, 488–496.
100. Batchelor, A.J.; Watson, G.; Compston, J.E. Changes in plasma half-life and clearance of 3h-25-hydroxyvitamin D3 in patients with intestinal malabsorption. Gut 1982, 23, 1068–1071.
101. Dawson-Hughes, B.; Heaney, R.P.; Holick, M.F.; Lips, P.; Meunier, P.J.; Vieth, R. Estimates of optimal vitamin D status. Osteoporos. Int. 2005, 16, 713–716.
102. Pepe, J.; Romagnoli, E.; Nofroni, I.; Pacitti, M.T.; de Geronimo, S.; Letizia, C.; Tonnarini, G.; Scarpiello, A.; D’Erasmo, E.; Minisola, S. Vitamin D status as the major factor determining the circulating levels of parathyroid hormone: A study in normal subjects. Osteoporos. Int. 2005, 16, 805–812.
103. Heaney, R.P. Functional indices of vitamin D status and ramifications of vitamin D deficiency. Am. J. Clin. Nutr. 2004, 80, 1706–1709.
104. Vigano, P.; Lattuada, D.; Mangioni, S.; Ermellino, L.; Vignali, M.; Caporizzo, E.; Panina-Bordignon, P.; Besozzi, M.; di Blasio, A.M. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J. Mol. Endocrinol. 2006, 36, 415–424.
105. Barrera, D.; Noyola-Martinez, N.; Avila, E.; Halhali, A.; Larrea, F.; Diaz, L. Calcitriol inhibits interleukin-10 expression in cultured human trophoblasts under normal and inflammatory conditions. Cytokine 2012, 57, 316–321.
106. Avila, E.; Garcia-Becerra, R.; Rodriguez-Rasgado, J.A.; Diaz, L.; Ordaz-Rosado, D.; Zugel, U.; Steinmeyer, A.; Barrera, D.; Halhali, A.; Larrea, F.; et al. Calcitriol down-regulates human ether a go-go 1 potassium channel expression in cervical cancer cells. Anticancer Res. 2010, 30, 2667–2672.
107. Delvin, E.E.; Gagnon, L.; Arabian, A.; Gibb, W. Influence of calcitriol on prolactin and prostaglandin production by human decidua. Mol. Cell Endocrinol. 1990, 71, 177–183.
108. Narahara, H.; Miyakawa, I.; Johnston, J.M. The inhibitory effect of 1,25-dihydroxyvitamin D3 on the secretion of platelet-activating factor acetylhydrolase by human decidual macrophages. J. Clin. Endocrinol. Metab. 1995, 80, 3121–3126.
109. Daftary, G.S.; Taylor, H.S. Endocrine regulation of HOX genes. Endocr. Rev. 2006, 27, 331–355.
110. Holick, M.F.; Binkley, N.C.; Bischoff-Ferrari, H.A.; Gordon, C.M.; Hanley, D.A.; Heaney, R.P.; Murad, M.H.; Weaver, C.M. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 2011, 96, 1911–1930.
111. Ross, A.C.; Manson, J.E.; Abrams, S.A.; Aloia, J.F.; Brannon, P.M.; Clinton, S.K.; Durazo-Arvizu, R.A.; Gallagher, J.C.; Gallo, R.L.; Jones, G.; et al. The 2011 Report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: What clinicians need to know. J. Clin. Endocrinol. Metab. 2011, 96, 53–58.
112. Aghajafari, F.; Nagulesapillai, T.; Ronksley, P.E.; Tough, S.C.; O’Beirne, M.; Rabi, D.M. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: Systematic review and meta-analysis of observational studies. BMJ 2013, 346, 1169.
113. Barrett, H.; McElduff, A. Vitamin D and pregnancy: An old problem revisited. Best Pract. Res. Clin. Endocrinol. Metab. 2010, 24, 527–529.
114. Bodnar, L.M.; Simhan, H.N. Vitamin D may be a link to black-white disparities in adverse birth outcomes. Obstet. Gynecol. Surv. 2010, 65, 273–284.
115. Christesen, H.T.; Falkenberg, T.; Lamont, R.F.; Jorgensen, J.S. The impact of vitamin D on pregnancy: A systematic review. Acta Obstet. Gynecol. Scandinav. 2012, 91, 1357–1367.
116. Nassar, N.; Halligan, G.H.; Roberts, C.L.; Morris, J.M.; Ashton, A.W. Systematic review of first-trimester vitamin D normative levels and outcomes of pregnancy. Am. J. Obstet. Gynecol. 2011, 205, 208.e201–208.e207.
117. Thorne-Lyman, A.; Fawzia, W.W. Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: A systematic review and meta-analysis. Paediatr. Perinat. Epidemiol. 2012, 26, 75–90.
118. Urrutia, R.P.; Thorp, J.M. Vitamin D in pregnancy: Current concepts. Curr. Opin. Obstet. Gynecol. 2012, 24, 57–64.
119. Wei, S.Q.; Qi, H.P.; Luo, Z.C.; Fraser, W.D. Maternal vitamin D status and adverse pregnancy outcomes: A systematic review and meta-analysis. J Matern. Fetal Neonatal Med. 2013, 26, 889–899.
120. Report of the National high blood pressure Education Program Working Group on high blood pressure in pregnancy. Am. J. Obstet. Gynecol. 2000, 183, 1–22.
121. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, january 2002. American College of Obstetricians and Gynecologists. Int. J. Gynaecol. Obstet. 2002, 77, 67–75.
122. Baumwell, S.; Karumanchi, S.A. Pre-eclampsia: Clinical manifestations and molecular mechanisms. Nephron Clin. Pract. 2007, 106, c72–c81.
123. Palei, A.C.; Spradley, F.T.; Warrington, J.P.; George, E.M.; Granger, J.P. Pathophysiology of hypertension in pre-eclampsia: A lesson in integrative physiology. Acta Physiol. 2013, 208, 224–233.
124. Gernand, A.D.; Bodnar, L.M.; Klebanoff, M.A.; Parks, W.T.; Simhan, H.N. Maternal serum 25-hydroxyvitamin D and placental vascular pathology in a multicenter US cohort. Am. J. Clin. Nutr. 2013, 98, 383–388.
125. Halhali, A.; Bourges, H.; Carrillo, A.; Garabedian, M. Lower circulating insulin-like growth factor I and 1,25-dihydroxyvitamin D levels in preeclampsia. Rev. Invest. Clin. 1995, 47, 259–266.
126. Halhali, A.; Diaz, L.; Avila, E.; Ariza, A.C.; Garabedian, M.; Larrea, F. Decreased fractional urinary calcium excretion and serum 1,25-dihydroxyvitamin D and IGF-I levels in preeclampsia. J. Steroid Biochem. Mol. Biol. 2007, 103, 803–806.
127. Halhali, A.; Tovar, A.R.; Torres, N.; Bourges, H.; Garabedian, M.; Larrea, F. Preeclampsia is associated with low circulating levels of insulin-like growth factor I and 1,25-dihydroxyvitamin D in maternal and umbilical cord compartments. J. Clin. Endocrinol. Metab. 2000, 85, 1828–1833.
128. Diaz, E.; Halhali, A.; Luna, C.; Diaz, L.; Avila, E.; Larrea, F. Newborn birth weight correlates with placental zinc, umbilical insulin-like growth factor I, and leptin levels in preeclampsia. Arch. Med. Res. 2002, 33, 40–47.
129. Robinson, C.J.; Alanis, M.C.; Wagner, C.L.; Hollis, B.W.; Johnson, D.D. Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia. Am. J. Obstet. Gynecol. 2010, 203, 366.e361–366.e366.
130. Xu, L.; Lee, M.; Jeyabalan, A.; Roberts, J.M. The relationship of hypovitaminosis D and IL-6 in preeclampsia. Am. J. Obstet. Gynecol. 2014, 210, 149.e141–149.e147.
131. Ullah, M.I.; Koch, C.A.; Tamanna, S.; Rouf, S.; Shamsuddin, L. Vitamin D deficiency and the risk of preeclampsia and eclampsia in Bangladesh. Horm. Metab. Res. 2013, 45, 682–687.
132. Wei, S.Q.; Audibert, F.; Luo, Z.C.; Nuyt, A.M.; Masse, B.; Julien, P.; Fraser, W.D. Maternal plasma 25-hydroxyvitamin D levels, angiogenic factors, and preeclampsia. Am. J. Obstet. Gynecol. 2013, 208, 390.e391–390.e396.
133. Baker, A.M.; Haeri, S.; Camargo, C.A., Jr.; Espinola, J.A.; Stuebe, A.M. A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia. J. Clin. Endocrinol. Metab. 2010, 95, 5105–5109.
134. Bodnar, L.M.; Catov, J.M.; Simhan, H.N.; Holick, M.F.; Powers, R.W.; Roberts, J.M. Maternal vitamin D deficiency increases the risk of preeclampsia. J. Clin. Endocrinol. Metab. 2007, 92, 3517–3522.
135. Abedi, P.; Mohaghegh, Z.; Afshary, P.; Latifi, M. The relationship of serum vitamin D with pre-eclampsia in the iranian women. Matern. Child. Nutr. 2014, 10, 206–212.
136. Diaz, L.; Arranz, C.; Avila, E.; Halhali, A.; Vilchis, F.; Larrea, F. Expression and activity of 25-hydroxyvitamin D-1 alpha-hydroxylase are restricted in cultures of human syncytiotrophoblast cells from preeclamptic pregnancies. J. Clin. Endocrinol. Metab. 2002, 87, 3876–3882.
137. Bodnar, L.M.; Simhan, H.N.; Catov, J.M.; Roberts, J.M.; Platt, R.W.; Diesel, J.C.; Klebanoff, M.A. Maternal vitamin D status and the risk of mild and severe preeclampsia. Epidemiology 2014, 25, 207–214.
138. Woodham, P.C.; Brittain, J.E.; Baker, A.M.; Leann Long, D.; Haeri, S.; Camargo, C.A.J.; Boggess, K.A.; Stuebe, A.M. Midgestation maternal serum 25-hydroxyvitamin D level and soluble fms-like tyrosine kinase 1/placental growth factor ratio as predictors of severe preeclampsia. Hypertension 2011, 58, 1120–1125.
139. Haugen, M.; Brantsæter, A.L.; Trogstad, L.; Alexander, J.; Roth, C.; Magnus, P.; Meltzera, H.M. Vitamin D supplementation and reduced risk of preeclampsia in nulliparous women. Epidemiology 2009, 20, 720–726.
140. Hyppönen, E.; Cavadino, A.; Williams, D.; Fraser, A.; Vereczkey, A.; Fraser, W.D.; Bánhidy, F.; Lawlor, D.; Czeizel, A.E. Vitamin D and pre-eclampsia: Original data, systematic review and meta-analysis. Ann. Nutr. Metab. 2013, 63, 331–340.
141. Tabesh, M.; Salehi-Abargouei, A.; Esmaillzadeh, A. Maternal vitamin D status and risk of pre-eclampsia: A systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 2013, 98, 3165–3173.
142. Shand, A.W.; Nassar, N.; von Dadelszen, P.; Innis, S.M.; Green, T.J. Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia. BJOG 2010, 117, 1593–1598.
143. Powe, C.E.; Seely, E.W.; Rana, S.; Bhan, I.; Ecker, J.; Karumanchi, S.A.; Thadhani, R. First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia. Hypertension 2010, 56, 758–763.
144. Mashburn, J. Vaginal infections update. J. Midwifery Womens Health 2012, 57, 629–634.
145. Denney, J.M.; Culhane, J.F. Bacterial vaginosis: A problematic infection from both a perinatal and neonatal perspective. Semin. Fetal Neonatal Med. 2009, 14, 200–203.
146. Allsworth, J.E.; Peipert, J.F. Prevalence of bacterial vaginosis: 2001–2004 National Health and Nutrition Examination Survey data. Obstet. Gynecol. 2007, 109, 114–120.
147. Prietl, B.; Treiber, G.; Pieber, T.R.; Amrein, K. Vitamin D and immune function. Nutrients 2013, 5, 2502–2521.
148. Hewison, M. Vitamin D and immune function: An overview. Proc. Nutr. Soc. 2012, 71, 50–61.
149. Bodnar, L.M.; Krohn, M.A.; Simhan, H.N. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J. Nutr. 2009, 139, 1157–1161.
150. Dunlop, A.L.; Taylor, R.N.; Tangpricha, V.; Fortunato, S.; Menon, R. Maternal vitamin D, folate, and polyunsaturated fatty acid status and bacterial vaginosis during pregnancy. Infect. Dis. Obstet. Gynecol. 2011, 2011, 216217.
151. Hensel, K.J.; Randis, T.M.; Gelber, S.E.; Ratner, A.J. Pregnancy-specific association of vitamin D deficiency and bacterial vaginosis. Am. J. Obstet. Gynecol. 2011, 204, 41–49.
152. Rustveld, L.O.; Kelsey, S.F.; Sharma, R. Association between maternal infections and preeclampsia: A systematic review of epidemiologic studies. Matern. Child. Health J. 2008, 12, 223–242.
153. Hertting, O.; Holm, A.; Luthje, P.; Brauner, H.; Dyrdak, R.; Jonasson, A.F.; Wiklund, P.; Chromek, M.; Brauner, A. Vitamin D induction of the human antimicrobial peptide cathelicidin in the urinary bladder. PLoS One 2010, 5, 15580.
154. Boggess, K.A.; Espinola, J.A.; Moss, K.; Beck, J.; Offenbacher, S.; Camargo, C.A. Vitamin D status and periodontal disease among pregnant women. J. Periodontol. 2011, 82, 195–200.
155. Lowry, M.B.; Guo, C.; Borregaard, N.; Gombart, A.F. Regulation of the human cathelicidin antimicrobial peptide gene by 1alpha,25-dihydroxyvitamin D in primary immune cells. J. Steroid Biochem. Mol. Biol. 2014, 143, 183–191.
156. Mendez-Samperio, P. The human cathelicidin hCAP18/LL-37: A multifunctional peptide involved in mycobacterial infections. Peptides 2010, 31, 1791–1798.
157. Campbell, G.R.; Spector, S.A. Autophagy induction by vitamin D inhibits both mycobacterium tuberculosis and human immunodeficiency virus type 1. Autophagy 2012, 8, 1523–1525.
158. Campbell, G.R.; Spector, S.A. Vitamin D inhibits human immunodeficiency virus type 1 and mycobacterium tuberculosis infection in macrophages through the induction of autophagy. PLoS Pathog. 2012, 8, 1002689.
159. Wan, M.; van der Does, A.M.; Tang, X.; Lindbom, L.; Agerberth, B.; Haeggstrom, J.Z. Antimicrobial peptide LL-37 promotes bacterial phagocytosis by human macrophages. J. Leukoc. Biol. 2014, 95, 971–981.
160. Frew, L.; Stock, S.J. Antimicrobial peptides and pregnancy. Reproduction 2011, 141, 725–735.
161. Thota, C.; Farmer, T.; Garfield, R.E.; Menon, R.; Al-Hendy, A. Vitamin D elicits anti-inflammatory response, inhibits contractile-associated proteins, and modulates Toll-like receptors in human myometrial cells. Reprod. Sci. 2013, 20, 463–475.
162. Bodnar, L.M.; Rouse, D.J.; Momirova, V.; Peaceman, A.M.; Sciscione, A.; Spong, C.Y.; Varner, M.W.; Malone, F.D.; Iams, J.D.; Mercer, B.M.; et al. Maternal 25-hydroxyvitamin D and preterm birth in twin gestations. Obstet. Gynecol. 2013, 122, 91–98.
163. Thorp, J.M.; Camargo, C.A.; McGee, P.L.; Harper, M.; Klebanoff, M.A.; Sorokin, Y.; Varner, M.W.; Wapner, R.J.; Caritis, S.N.; Iams, J.D.; et al. Vitamin D status and recurrent preterm birth: A nested case-control study in high-risk women. BJOG 2012, 119, 1617–1623.
164. American Diabetes Association. Gestational diabetes mellitus. Diabetes Care 2003, 26 (Suppl. 1), 103–105.
165. American Diabetes Association. Standards of medical care in diabetes--2012. Diabetes Care 2012, 35 (Suppl. 1), 11–63.
166. Wang, Z.; Kanguru, L.; Hussein, J.; Fitzmaurice, A.; Ritchie, K. Incidence of adverse outcomes associated with gestational diabetes mellitus in low- and middle-income countries. Int. J. Gynaecol. Obstet. 2013, 121, 14–19.
167. Wendland, E.M.; Torloni, M.R.; Falavigna, M.; Trujillo, J.; Dode, M.A.; Campos, M.A.; Duncan, B.B.; Schmidt, M.I. Gestational diabetes and pregnancy outcomes—A systematic review of the world health organization (WHO) and the International Association of Diabetes in Pregnancy Study Groups (IADPSG) diagnostic criteria. BMC Pregnancy Childbirth 2012, 12, 23.
168. Norman, A.W.; Frankel, J.B.; Heldt, A.M.; Grodsky, G.M. Vitamin D deficiency inhibits pancreatic secretion of insulin. Science 1980, 209, 823–825.
169. Cho, G.J.; Hong, S.C.; Oh, M.J.; Kim, H.J. Vitamin D deficiency in gestational diabetes mellitus and the role of the placenta. Am. J. Obstet. Gynecol. 2013, 209, 560 e561–560 e568.
170. Clifton-Bligh, R.J.; McElduff, P.; McElduff, A. Maternal vitamin D deficiency, ethnicity and gestational diabetes. Diabetes Med. 2008, 25, 678–684.
171. Parlea, L.; Bromberg, I.L.; Feig, D.S.; Vieth, R.; Merman, E.; Lipscombe, L.L. Association between serum 25-hydroxyvitamin D in early pregnancy and risk of gestational diabetes mellitus. Diabetes Med. 2012, 29, 25–32.
172. Soheilykhah, S.; Mojibian, M.; Rashidi, M.; Rahimi-Saghand, S.; Jafari, F. Maternal vitamin D status in gestational diabetes mellitus. Nutr. Clin. Pract. 2010, 25, 524–527.
173. Zhang, C.; Qiu, C.; Hu, F.B.; David, R.M.; van Dam, R.M.; Bralley, A.; Williams, M.A. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One 2008, 3, 3753.
174. Zuhur, S.S.; Erol, R.S.; Kuzu, I.; Altuntas, Y. The relationship between low maternal serum 25-hydroxyvitamin D levels and gestational diabetes mellitus according to the severity of 25-hydroxyvitamin D deficiency. Clinics (Sao Paulo) 2013, 68, 658–664.
175. Maghbooli, Z.; Hossein-Nezhad, A.; Karimi, F.; Shafaei, A.R.; Larijani, B. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metab. Res. Rev. 2008, 24, 27–32.
176. Napartivaumnuay, N.; Niramitmahapanya, S.; Deerochanawong, C.; Suthornthepavarakul, T.; Sarinnapakorn, V.; Jaruyawongs, P. Maternal 25 hydroxyvitamin D level and its correlation in thai gestational diabetes patients. J. Med. Assoc. Thail. 2013, 96 (Suppl. 3), 69–76.
177. Burris, H.H.; Rifas-Shiman, S.L.; Kleinman, K.; Litonjua, A.A.; Huh, S.Y.; Rich-Edwards, J.W.; Camargo, C.A., Jr.; Gillman, M.W. Vitamin D deficiency in pregnancy and gestational diabetes mellitus. Am. J. Obstet. Gynecol. 2012, 207, 182.e181–182.e188.
178. Wang, O.; Nie, M.; Hu, Y.Y.; Zhang, K.; Li, W.; Ping, F.; Liu, J.T.; Chen, L.M.; Xing, X.P. Association between vitamin D insufficiency and the risk for gestational diabetes mellitus in pregnant chinese women. Biomed. Environ. Sci. 2012, 25, 399–406.
179. Poel, Y.H.; Hummel, P.; Lips, P.; Stam, F.; van der Ploeg, T.; Simsek, S. Vitamin D and gestational diabetes: A systematic review and meta-analysis. Eur. J. Intern. Med. 2012, 23, 465–469.
180. Senti, J.; Thiele, D.K.; Anderson, C.M. Maternal vitamin D status as a critical determinant in gestational diabetes. J. Obstet. Gynecol. Neonatal. Nurs. 2012, 41, 328–338.
181. Lau, S.L.; Gunton, J.E.; Athayde, N.P.; Byth, K.; Cheung, N.W. Serum 25-hydroxyvitamin D and glycated haemoglobin levels in women with gestational diabetes mellitus. Med. J. Aust. 2011, 194, 334–337.
182. Makgoba, M.; Nelson, S.M.; Savvidou, M.; Messow, C.M.; Nicolaides, K.; Sattar, N. First-trimester circulating 25-hydroxyvitamin D levels and development of gestational diabetes mellitus. Diabetes Care 2011, 34, 1091–1093.
183. McLeod, D.S.; Warner, J.V.; Henman, M.; Cowley, D.; Gibbons, K.; McIntyre, H.D. Associations of serum vitamin D concentrations with obstetric glucose metabolism in a subset of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort. Diabetes Med. 2012, 29, 199–204.
184. Walsh, J.M.; McGowan, C.A.; Kilbane, M.; McKenna, M.J.; McAuliffe, F.M. The relationship between maternal and fetal vitamin D, insulin resistance, and fetal growth. Reprod. Sci. 2013, 20, 536–541.
185. Jelsma, J.G.; van Poppel, M.N.; Galjaard, S.; Desoye, G.; Corcoy, R.; Devlieger, R.; van Assche, A.; Timmerman, D.; Jans, G.; Harreiter, J.; et al. Dali: Vitamin D and lifestyle intervention for gestational diabetes mellitus (GDM) prevention: An european multicentre, randomised trial-study protocol. BMC Pregnancy Childbirth 2013, 13, 142.
186. Asemi, Z.; Hashemi, T.; Karamali, M.; Samimi, M.; Esmaillzadeh, A. Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: A double-blind randomized controlled clinical trial. Am. J. Clin. Nutr. 2013, 98, 1425–1432.
187. Mozaffari-Khosravi, H.; Hosseinzadeh-Shamsi-Anar, M.; Salami, M.A.; Hadinedoushan, H.; Mozayan, M.R. Effects of a single post-partum injection of a high dose of vitamin D on glucose tolerance and insulin resistance in mothers with first-time gestational diabetes mellitus. Diabetes Med. 2012, 29, 36–42.
188. Baker, A.M.; Haeri, S.; Camargo, C.A., Jr.; Stuebe, A.M.; Boggess, K.A. First-trimester maternal vitamin D status and risk for gestational diabetes (GDM) a nested case-control study. Diabetes Metab. Res. Rev. 2012, 28, 164–168.
189. Savvidou, M.D.; Akolekar, R.; Samaha, R.B.; Masconi, A.P.; Nicolaides, K.H. Maternal serum 25-hydroxyvitamin D levels at 11(+0) -13(+6) weeks in pregnant women with diabetes mellitus and in those with macrosomic neonates. BJOG 2011, 118, 951–955.
190. Farrant, H.J.; Krishnaveni, G.V.; Hill, J.C.; Boucher, B.J.; Fisher, D.J.; Noonan, K.; Osmond, C.; Veena, S.R.; Fall, C.H. Vitamin D insufficiency is common in indian mothers but is not associated with gestational diabetes or variation in newborn size. Eur. J. Clin. Nutr. 2009, 63, 646–652.
191. Tomedi, L.E.; Simhan, H.N.; Bodnar, L.M. Early-pregnancy maternal vitamin D status and maternal hyperglycaemia. Diabetes Med. 2013, 30, 1033–1039.
192. Mirzaei, K.; Hossein-Nezhad, A.; Keshavarz, S.A.; Eshaghi, S.M.; Koohdani, F.; Saboor-Yaraghi, A.A.; Hosseini, S.; Tootee, A.; Djalali, M. Insulin resistance via modification of PGC1alpha function identifying a possible preventive role of vitamin D analogues in chronic inflammatory state of obesity. A double blind clinical trial study. Minerva Med. 2014, 105, 63–78.
193. Alkharfy, K.M.; Al-Daghri, N.M.; Yakout, S.M.; Hussain, T.; Mohammed, A.K.; Krishnaswamy, S. Influence of vitamin D treatment on transcriptional regulation of insulin-sensitive genes. Metab. Syndr. Relat. Disord. 2013, 11, 283–288.
194. Manna, P.; Jain, S.K. Vitamin D up-regulates glucose transporter 4 (GLUT4) translocation and glucose utilization mediated by cystathionine-gamma-lyase (CSE) activation and H2Ss formation in 3T3L1 adipocytes. J. Biol. Chem. 2012, 287, 42324–42332.
195. Meerza, D.; Naseem, I.; Ahmed, J. Effect of 1, 25(OH)(2) vitamin D(3) on glucose homeostasis and DNA damage in type 2 diabetic mice. J. Diabetes Complicat. 2012, 26, 363–368.
196. Zhang, J.; Merialdi, M.; Platt, L.D.; Kramer, M.S. Defining normal and abnormal fetal growth: Promises and challenges. Am. J. Obstet. Gynecol. 2010, 202, 522–528.
197. Mayer, C.; Joseph, K.S. Fetal growth: A review of terms, concepts and issues relevant to obstetrics. Ultrasound Obstet. Gynecol. 2013, 41, 136–145.
198. Burris, H.H.; Mitchell, A.A.; Werler, M.M. Periconceptional multivitamin use and infant birth weight disparities. Ann. Epidemiol. 2010, 20, 233–240.
199. Kovacs, C.S. Maternal vitamin D deficiency: Fetal and neonatal implications. Semin. Fetal Neonatal Med. 2013, 18, 129–135.
200. Brunvand, L.; Quigstad, E.; Urdal, P.; Haug, E. Vitamin D deficiency and fetal growth. Early Hum. Dev. 1996, 45, 27–33.
201. Gale, C.R.; Robinson, S.M.; Harvey, N.C.; Javaid, M.K.; Jiang, B.; Martyn, C.N.; Godfrey, K.M.; Cooper, C. Maternal vitamin D status during pregnancy and child outcomes. Eur. J. Clin. Nutr. 2008, 62, 68–77.
202. Agarwal, R.; Virmani, D.; Jaipal, M.L.; Gupta, S.; Gupta, N.; Sankar, M.J.; Bhatia, S.; Agarwal, A.; Devgan, V.; Deorari, A.; et al. Vitamin D status of low birth weight infants in Delhi: A comparative study. J. Trop. Pediatr. 2012, 58, 446–450.
203. Gernand, A.D.; Simhan, H.N.; Klebanoff, M.A.; Bodnar, L.M. Maternal serum 25-hydroxyvitamin D and measures of newborn and placental weight in a U.S. multicenter cohort study. J. Clin. Endocrinol. Metab. 2013, 98, 398–404.
204. Ertl, R.; Yu, C.K.; Samaha, R.; Akolekar, R.; Nicolaides, K.H. Maternal serum vitamin D at 11–13 weeks in pregnancies delivering small for gestational age neonates. Fetal Diagn. Ther. 2012, 31, 103–108.
205. Namgung, R.; Tsang, R.C.; Specker, B.L.; Sierra, R.I.; Ho, M.L. Reduced serum osteocalcin and 1,25-dihydroxyvitamin D concentrations and low bone mineral content in small for gestational age infants: Evidence of decreased bone formation rates. J. Pediatr. 1993, 122, 269–275.
206. Van den Berg, G.; van Eijsden, M.; Vrijkotte, T.G.; Gemke, R.J. Suboptimal maternal vitamin D status and low education level as determinants of small-for-gestational-age birth weight. Eur. J. Nutr. 2013, 52, 273–279.
207. Scholl, T.O.; Chen, X. Vitamin D intake during pregnancy: Association with maternal characteristics and infant birth weight. Early Hum. Dev. 2009, 85, 231–234.
208. Mannion, C.A.; Gray-Donald, K.; Koski, K.G. Association of low intake of milk and vitamin D during pregnancy with decreased birth weight. CMAJ 2006, 174, 1273–1277.
209. Bodnar, L.M.; Catov, J.M.; Zmuda, J.M.; Cooper, M.E.; Parrott, M.S.; Roberts, J.M.; Marazita, M.L.; Simhan, H.N. Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women. J. Nutr. 2010, 140, 999–1006.
210. Kalra, P.; Das, V.; Agarwal, A.; Kumar, M.; Ramesh, V.; Bhatia, E.; Gupta, S.; Singh, S.; Saxena, P.; Bhatia, V. Effect of vitamin D supplementation during pregnancy on neonatal mineral homeostasis and anthropometry of the newborn and infant. Br. J. Nutr. 2012, 108, 1052–1058.
211. Young, B.E.; McNanley, T.J.; Cooper, E.M.; McIntyre, A.W.; Witter, F.; Harris, Z.L.; O’Brien, K.O. Maternal vitamin D status and calcium intake interact to affect fetal skeletal growth in utero in pregnant adolescents. Am. J. Clin. Nutr. 2012, 95, 1103–1112.
212. Diogenes, M.E.; Bezerra, F.F.; Rezende, E.P.; Taveira, M.F.; Pinhal, I.; Donangelo, C.M. Effect of calcium plus vitamin D supplementation during pregnancy in brazilian adolescent mothers: A randomized, placebo-controlled trial. Am. J. Clin. Nutr. 2013, 98, 82–91.
213. Morley, R.; Carlin, J.B.; Pasco, J.A.; Wark, J.D.; Ponsonby, A.L. Maternal 25-hydroxyvitamin D concentration and offspring birth size: Effect modification by infant VDR genotype. Eur. J. Clin. Nutr. 2009, 63, 802–804.
214. Jones, K.S.; Assar, S.; Harnpanich, D.; Bouillon, R.; Lambrechts, D.; Prentice, A.; Schoenmakers, I. 25(OH)D2 half-life is shorter than 25(OH)D3 half-life and is influenced by DBP concentration and genotype. J. Clin. Endocrinol. Metab. 2014, 99, 3373–3381.
215. McGrath, J.J.; Saha, S.; Burne, T.H.; Eyles, D.W. A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations. J. Steroid Biochem. Mol. Biol. 2010, 121, 471–477.
216. Wang, T.J.; Zhang, F.; Richards, J.B.; Kestenbaum, B.; van Meurs, J.B.; Berry, D.; Kiel, D.P.; Streeten, E.A.; Ohlsson, C.; Koller, D.L.; et al. Common genetic determinants of vitamin D insufficiency: A genome-wide association study. Lancet 2010, 376, 180–188.
217. Barry, E.L.; Rees, J.R.; Peacock, J.L.; Mott, L.A.; Amos, C.I.; Bostick, R.M.; Figueiredo, J.C.; Ahnen, D.J.; Bresalier, R.S.; Burke, C.A.; et al. Genetic variants in CYP2R1, CYP24A1, and VDR modify the efficacy of vitamin D3 supplementation for increasing serum 25-hydroxyvitamin D levels in a randomized controlled trial. J. Clin. Endocrinol. Metab. 2014, 99, 2133–2137.
218. Jones, K.S.; Assar, S.; Vanderschueren, D.; Bouillon, R.; Prentice, A.; Schoenmakers, I. Predictors of 25(OH)D half-life and plasma 25(OH)D concentration in the Gambia and the UK. Osteoporos. Int. 2014, doi: 10.1007/s00198-014-2905-0.
219. Karras, S.N.; Anagnostis, P.; Annweiler, C.; Naughton, D.P.; Petroczi, A.; Bili, E.; Harizopoulou, V.; Tarlatzis, B.C.; Persinaki, A.; Papadopoulou, F.; et al. Maternal vitamin D status during pregnancy: The mediterranean reality. Eur. J. Clin. Nutr. 2014, 68, 864–869.
220. Wuertz, C.; Gilbert, P.; Baier, W.; Kunz, C. Cross-sectional study of factors that influence the 25-hydroxyvitamin D status in pregnant women and in cord blood in Germany. Br. J. Nutr. 2013, 110, 1895–1902.
221. Wortsman, J.; Matsuoka, L.Y.; Chen, T.C.; Lu, Z.; Holick, M.F. Decreased bioavailability of vitamin D in obesity. Am. J. Clin. Nutr. 2000, 72, 690–693.
222. Abboud, M.; Puglisi, D.A.; Davies, B.N.; Rybchyn, M.; Whitehead, N.P.; Brock, K.E.; Cole, L.; Gordon-Thomson, C.; Fraser, D.R.; Mason, R.S. Evidence for a specific uptake and retention mechanism for 25-hydroxyvitamin D (25OHD) in skeletal muscle cells. Endocrinology 2013, 154, 3022–3030.
223. Abboud, M.; Gordon-Thomson, C.; Hoy, A.J.; Balaban, S.; Rybchyn, M.S.; Cole, L.; Su, Y.; Brennan-Speranza, T.C.; Fraser, D.R.; Mason, R.S. Uptake of 25-hydroxyvitamin D by muscle and fat cells. J. Steroid Biochem. Mol. Biol. 2014, 144, 232–236.
224. Josefson, J.L.; Feinglass, J.; Rademaker, A.W.; Metzger, B.E.; Zeiss, D.M.; Price, H.E.; Langman, C.B. Maternal obesity and vitamin D sufficiency are associated with cord blood vitamin D insufficiency. J. Clin. Endocrinol. Metab. 2013, 98, 114–119.
225. Bodnar, L.M.; Catov, J.M.; Roberts, J.M.; Simhan, H.N. Prepregnancy obesity predicts poor vitamin D status in mothers and their neonates. J. Nutr. 2007, 137, 2437–2442.
226. Crozier, S.R.; Harvey, N.C.; Inskip, H.M.; Godfrey, K.M.; Cooper, C.; Robinson, S.M. Maternal vitamin D status in pregnancy is associated with adiposity in the offspring: Findings from the Southampton Women’s Survey. Am. J. Clin. Nutr. 2012, 96, 57–63.
227. Morales, E.; Romieu, I.; Guerra, S.; Ballester, F.; Rebagliato, M.; Vioque, J.; Tardon, A.; Rodriguez Delhi, C.; Arranz, L.; Torrent, M.; et al. Maternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring. Epidemiology 2012, 23, 64–71.
228. Hossain, N.; Kanani, F.H.; Ramzan, S.; Kausar, R.; Ayaz, S.; Khanani, R.; Pal, L. Obstetric and neonatal outcomes of maternal vitamin D supplementation: Results of an open-label, randomized controlled trial of antenatal vitamin D supplementation in pakistani women. J. Clin. Endocrinol. Metab. 2014, 99, 2448–2455.
229. Wagner, C.L.; McNeil, R.; Hamilton, S.A.; Winkler, J.; Rodriguez Cook, C.; Warner, G.; Bivens, B.; Davis, D.J.; Smith, P.G.; Murphy, M.; et al. A randomized trial of vitamin D supplementation in 2 community health center networks in South Carolina. Am. J. Obstet. Gynecol. 2013, 208, 137.e1–137.e13.
230. Sahu, M.; Das, V.; Aggarwal, A.; Rawat, V.; Saxena, P.; Bhatia, V. Vitamin D replacement in pregnant women in rural north india: A pilot study. Eur. J. Clin. Nutr. 2009, 63, 1157–1159.
231. Yu, C.K.; Sykes, L.; Sethi, M.; Teoh, T.G.; Robinson, S. Vitamin D deficiency and supplementation during pregnancy. Clin. Endocrinol. (Oxf.) 2009, 70, 685–690.
232. Grant, C.C.; Stewart, A.W.; Scragg, R.; Milne, T.; Rowden, J.; Ekeroma, A.; Wall, C.; Mitchell, E.A.; Crengle, S.; Trenholme, A.; et al. Vitamin D during pregnancy and infancy and infant serum 25-hydroxyvitamin D concentration. Pediatrics 2014, 133, 143–153.
233. Dawodu, A.; Saadi, H.F.; Bekdache, G.; Javed, Y.; Altaye, M.; Hollis, B.W. Randomized controlled trial (RCT) of vitamin D supplementation in pregnancy in a population with endemic vitamin D deficiency. J. Clin. Endocrinol. Metab. 2013, 98, 2337–2346.
234. Hollis, B.W.; Johnson, D.; Hulsey, T.C.; Ebeling, M.; Wagner, C.L. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J. Bone Min. Res. 2011, 26, 2341–2357.
235. Hashemipour, S.; Lalooha, F.; Zahir Mirdamadi, S.; Ziaee, A.; Dabaghi Ghaleh, T. Effect of vitamin D administration in vitamin D-deficient pregnant women on maternal and neonatal serum calcium and vitamin d concentrations: A randomised clinical trial. Br. J. Nutr. 2013, 110, 1611–1616.
236. Roth, D.E.; al Mahmud, A.; Raqib, R.; Akhtar, E.; Black, R.E.; Baqui, A.H. Pharmacokinetics of high-dose weekly oral vitamin D3 supplementation during the third trimester of pregnancy in Dhaka, Bangladesh. Nutrients 2013, 5, 788–810.
237. Shakiba, M.; Iranmanesh, M.R. Vitamin D requirement in pregnancy to prevent deficiency in neonates: A randomised trial. Singap. Med. J. 2013, 54, 285–288.
238. Hollis, B.W. Assessment and interpretation of circulating 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in the clinical environment. Endocrinol. Metab. Clin. North Am. 2010, 39, 271–286.
239. Volmer, D.A.; Mendes, L.R.; Stokes, C.S. Analysis of vitamin D metabolic markers by mass spectrometry: Current techniques, limitations of the “gold standard” method, and anticipated future directions. Mass Spectrom. Rev. 2015, 34, 2–23.
240. Zhang, S.W.; Jian, W.; Sullivan, S.; Sankaran, B.; Edom, R.W.; Weng, N.; Sharkey, D. Development and validation of an LC-MS/MS based method for quantification of 25 hydroxyvitamin D2 and 25 hydroxyvitamin D3 in human serum and plasma. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2014, 961, 62–70.
241. Adaway, J.E.; Keevil, B.G.; Owen, L.J. Liquid chromatography tandem mass spectrometry in the clinical laboratory. Ann. Clin. Biochem. 2015, 52, 18–38.
242. Baecher, S.; Leinenbach, A.; Wright, J.A.; Pongratz, S.; Kobold, U.; Thiele, R. Simultaneous quantification of four vitamin D metabolites in human serum using high performance liquid chromatography tandem mass spectrometry for vitamin D profiling. Clin. Biochem. 2012, 45, 1491–1496
243. Shah, I.; Petroczi, A.; Naughton, D.P. Method for simultaneous analysis of eight analogues of vitamin D using liquid chromatography tandem mass spectrometry. Chem. Cent. J. 2012, 6, 112.
244. Higashi, T.; Goto, A.; Morohashi, M.; Ogawa, S.; Komatsu, K.; Sugiura, T.; Fukuoka, T.; Mitamura, K. Development and validation of a method for determination of plasma 25-hydroxyvitamin D3 3-sulfate using liquid chromatography/tandem mass spectrometry. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2014, 969, 230–234.
245. Van den Ouweland, J.M.; Beijers, A.M.; van Daal, H. Overestimation of 25-hydroxyvitamin D3 by increased ionisation efficiency of 3-epi-25-hydroxyvitamin D3 in LC-MS/MS methods not separating both metabolites as determined by an LC-MS/MS method for separate quantification of 25-hydroxyvitamin D3, 3-epi-25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 in human serum. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2014, 967, 195–202.
246. Lee, S.; Oncescu, V.; Mancuso, M.; Mehta, S.; Erickson, D. A smartphone platform for the quantification of vitamin D levels. Lab Chip 2014, 14, 1437–1442.
247. Powe, C.E.; Evans, M.K.; Wenger, J.; Zonderman, A.B.; Berg, A.H.; Nalls, M.; Tamez, H.; Zhang, D.; Bhan, I.; Karumanchi, S.A.; et al. Vitamin D-binding protein and vitamin D status of black americans and white americans. N. Engl. J. Med. 2013, 369, 1991–2000.
248. Powe, C.E.; Karumanchi, S.A.; Thadhani, R. Vitamin D-binding protein and vitamin D in blacks and whites. N. Engl. J. Med. 2014, 370, 880–881.
249. Autier, P.; Boniol, M.; Pizot, C.; Mullie, P. Vitamin D status and ill health: A systematic review. Lancet Diabet. Endocrinol. 2014, 2, 76–89.
250. Bolland, M.J.; Grey, A.; Gamble, G.D.; Reid, I.R. The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: A trial sequential meta-analysis. Lancet Diabetes Endocrinol. 2014, 2, 307–320.
251. Vitamin D: Chasing a myth? Lancet Diabetes Endocrinol. 2014, 2, 1; doi:10.1016/S2213-8587(13)70164-5.
252. Gillie, O. Controlled trials of vitamin D, causality and type 2 statistical error. Public Health Nutr. 2014, doi:10.1017/S1368980014002304.