1,25-dihydroxyvitamin D 3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine β-synthase

Journal of Bone and Mineral Research

Volumn 26, Issue 12, 2011, Pages 2991-3000

  Kriebitzsch, Carsten ^a   Verlinden, Lieve ^a   Eelen, Guy ^a   Van Schoor, Natasja M ^b   Swart, Karin ^b   Lips, Paul ^b   Meyer, Mark B ^c   Pike, J Wesley ^c   Boonen, Steven ^a   Carlberg, Carsten ^d   Vitvitsky, Victor ^e   Bouillon, Roger ^a   Banerjee, Ruma ^e   Verstuyf, Annemieke ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

^e UNIVERSITY OF MICHIGAN   (United States)

Author keywords

1,25(OH) 2D 3; CYSTATHIONINE B SYNTHASE (CBS); HOMOCYSTEINE (HCY); OSTEOPOROSIS; VITAMIN D RECEPTOR (VDR)

Indexed keywords

CALCITRIOL; CREATININE; CYSTATHIONINE; CYSTATHIONINE BETA SYNTHASE; CYSTEINE; HOMOCYSTEINE; MESSENGER RNA; VITAMIN D RECEPTOR;

ADULT; AGED; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ANIMAL CELL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENZYME ACTIVITY; ENZYME REGULATION; EX VIVO STUDY; FEMALE; GENE CLUSTER; GENE INACTIVATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTRON; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OSTEOBLAST; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SULFATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION; VITAMIN BLOOD LEVEL; WESTERN BLOTTING;

AGED; AGED, 80 AND OVER; AMINO ACIDS; ANIMALS; BLOTTING, WESTERN; CELL LINE; CYSTATHIONINE BETA-SYNTHASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HOMOCYSTEINE; HUMANS; METABOLIC NETWORKS AND PATHWAYS; MICE; MICE, INBRED C57BL; MIDDLE AGED; OSTEOBLASTS; PROTEIN BINDING; RECEPTORS, CALCITRIOL; RESPONSE ELEMENTS; RNA, MESSENGER; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION; VITAMIN D;

EID: 81855184659     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.493     Document Type: Article

References (42)

1. Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, Lieben L, Mathieu C, Demay M,. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev. 2008 Oct; 29 (6): 726-76.
2. Schuster I,. Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan; 1814 (1): 186-99.
3. 3 and its structural analogs on gene expression in cancer cells-a microarray approach. Anticancer Res. 2009 Sep; 29 (9): 3471-83.
4. Bouillon R, Bischoff-Ferrari H, Willett W,. Vitamin D and health: perspectives from mice and man. J Bone Miner Res. 2008 Jul; 23 (7): 974-9. (Pubitemid 351915717)
5. Boonen S, Vanderschueren D, Haentjens P, Lips P,. Calcium and vitamin D in the prevention and treatment of osteoporosis-a clinical update. J Intern Med. 2006 Jun; 259 (6): 539-52.
6. Hofbauer LC, Hamann C, Ebeling PR,. Approach to the patient with secondary osteoporosis. Eur J Endocrinol. 2010 Jun; 162 (6): 1009-20.
7. McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, Hannan MT, Cupples LA, Kiel DP,. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med. 2004 May 13; 350 (20): 2042-9. (Pubitemid 38596555)
8. van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM, van der Klift M, de Jonge R, Lindemans J, de Groot LC, Hofman A, Witteman JC, van Leeuwen JP, Breteler MM, Lips P, Pols HA, Uitterlinden AG,. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med. 2004 May 13; 350 (20): 2033-41.
9. Lubec B, Fang-Kircher S, Lubec T, Blom HJ, Boers GH,. Evidence for McKusick's hypothesis of deficient collagen cross-linking in patients with homocystinuria. Biochim Biophys Acta. 1996 Apr 12; 1315 (3): 159-62. (Pubitemid 26128323)
10. Saito M, Marumo K,. Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporos Int. 2010 Feb; 21 (2): 195-214.
11. Koh JM, Lee YS, Kim YS, Kim DJ, Kim HH, Park JY, Lee KU, Kim GS,. Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation. J Bone Miner Res. 2006 Jul; 21 (7): 1003-11. (Pubitemid 43962829)
12. Stipanuk MH, Dominy JE Jr, Lee JI, Coloso RM,. Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism. J Nutr. 2006 Jun; 136 (6 Suppl): 1652S-9S. (Pubitemid 43765376)
13. 2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. J Biol Chem. 2009 Apr 24; 284 (17): 11601-12.
14. 2S biogenesis via alternative trans-sulfuration reactions. J Biol Chem. 2009 Aug 14; 284 (33): 22457-66.
15. Eberhardt RT, Forgione MA, Cap A, Leopold JA, Rudd MA, Trolliet M, Heydrick S, Stark R, Klings ES, Moldovan NI, Yaghoubi M, Goldschmidt-Clermont PJ, Farber HW, Cohen R, Loscalzo J,. Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J Clin Invest. 2000 Aug; 106 (4): 483-91. (Pubitemid 30666381)
16. Robert K, Maurin N, Vayssettes C, Siauve N, Janel N,. Cystathionine beta synthase deficiency affects mouse endochondral ossification. Anat Rec A Discov Mol Cell Evol Biol. 2005 Jan; 282 (1): 1-7. (Pubitemid 40076249)
17. Levasseur R,. Bone tissue and hyperhomocysteinemia. Joint Bone Spine. 2009 May; 76 (3): 234-40.
18. 3. J Biol Chem. 2005 Nov 11; 280 (45): 37319-30. (Pubitemid 41642337)
19. Daci E, Udagawa N, Martin TJ, Bouillon R, Carmeliet G,. The role of the plasminogen system in bone resorption in vitro. J Bone Miner Res. 1999 Jun; 14 (6): 946-52. (Pubitemid 29262889)
20. Vitvitsky V, Dayal S, Stabler S, Zhou Y, Wang H, Lentz SR, Banerjee R,. Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia. Am J Physiol Regul Integr Comp Physiol. 2004 Jul; 287 (1): R39-46. (Pubitemid 38856309)
21. Meyer MB, Goetsch PD, Pike JW,. Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone. J Steroid Biochem Mol Biol. 2010 Jul; 121 (1-2): 136-41.
22. 3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts. J Bone Miner Res. 2005 Feb; 20 (2): 305-17.
23. Kolhouse JF, Stabler SP, Allen RH,. Identification and perturbation of mutant human fibroblasts based on measurements of methylmalonic acid and total homocysteine in the culture media. Arch Biochem Biophys. 1993 Jun; 303 (2): 355-60. (Pubitemid 23199833)
24. Mosharov E, Cranford MR, Banerjee R,. The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes. Biochemistry. 2000 Oct 24; 39 (42): 13005-11.
25. Finkelstein JD,. Pathways and regulation of homocysteine metabolism in mammals. Semin Thromb Hemost. 2000; 26 (3): 219-25.
26. Bookout AL, Jeong Y, Downes M, Yu R, Evans RM, Mangelsdorf DJ,. Tissue-specific expression patterns of nuclear receptors [Internet]. Nuclear Receptor Signaling Atlas; 2005 Jun 1. Available at. Accessed September 18, 2011.
27. Prudova A, Bauman Z, Braun A, Vitvitsky V, Lu SC, Banerjee R,. S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Proc Natl Acad Sci U S A. 2006 Apr 25; 103 (17): 6489-94.
28. Taoka S, Widjaja L, Banerjee R,. Assignment of enzymatic functions to specific regions of the PLP-dependent heme protein cystathionine beta-synthase. Biochemistry. 1999 Oct 5; 38 (40): 13155-61.
29. Ge Y, Konrad MA, Matherly LH, Taub JW,. Transcriptional regulation of the human cystathionine beta-synthase -1b basal promoter: synergistic transactivation by transcription factors NF-Y and Sp1/Sp3. Biochem J. 2001 Jul 1; 357 (Pt 1): 97-105. (Pubitemid 32642907)
30. Wang L, Jhee KH, Hua X, DiBello PM, Jacobsen DW, Kruger WD,. Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice. Circ Res. 2004 May 28; 94 (10): 1318-24. (Pubitemid 38724477)
31. 3 regulates the synthesis of gamma-glutamyl transpeptidase and glutathione levels in rat primary astrocytes. J Neurochem. 1999 Aug; 73 (2): 859-66. (Pubitemid 29339862)
32. Herrmann M, Tami A, Wildemann B, Wolny M, Wagner A, Schorr H, Taban-Shomal O, Umanskaya N, Ross S, Garcia P, Hubner U, Herrmann W,. Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone. Bone. 2009 Mar; 44 (3): 467-75.
33. Rodan SB, Imai Y, Thiede MA, Wesolowski G, Thompson D, Bar-Shavit Z, Shull S, Mann K, Rodan GA,. Characterization of a human osteosarcoma cell line (Saos-2) with osteoblastic properties. Cancer Res. 1987 Sep 15; 47 (18): 4961-6. (Pubitemid 17143047)
34. Heaney RP,. The Vitamin D requirement in health and disease. J Steroid Biochem Mol Biol. 2005 Oct; 97 (1-2): 13-9. (Pubitemid 41546209)
35. Lips P, Bouillon R, van Schoor NM, Vanderschueren D, Verschueren S, Kuchuk N, Milisen K, Boonen S,. Reducing fracture risk with calcium and vitamin D. Clin Endocrinol (Oxf). 2010 Sep; 73 (3): 277-85. Review.
36. Rosen CJ, Clinical practice,. Vitamin D insufficiency. N Engl J Med. 2011 Jan 20; 364 (3): 248-54.
37. van Guldener C, Stehouwer CD,. Homocysteine and methionine metabolism in renal failure. Semin Vasc Med. 2005 May; 5 (2): 201-8. (Pubitemid 40944295)
38. Selhub J,. Public health significance of elevated homocysteine. Food Nutr Bull. 2008 Jun; 29 (2 Suppl): S116-25.
39. Raposo B, Rodriguez C, Martinez-Gonzalez J, Badimon L,. High levels of homocysteine inhibit lysyl oxidase (LOX) and downregulate LOX expression in vascular endothelial cells. Atherosclerosis. 2004 Nov; 177 (1): 1-8. (Pubitemid 39361132)
40. Liu G, Nellaiappan K, Kagan HM,. Irreversible inhibition of lysyl oxidase by homocysteine thiolactone and its selenium and oxygen analogues. Implications for homocystinuria. J Biol Chem. 1997 Dec 19; 272 (51): 32370-7. (Pubitemid 28011919)
41. Kang AH, Trelstad RL,. A collagen defect in homocystinuria. J Clin Invest. 1973 Oct; 52 (10): 2571-8.
42. Saposnik G, Ray JG, Sheridan P, McQueen M, Lonn E,. Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial. Stroke. 2009 Apr; 40 (4): 1365-72.