Randomized controlled trial (RCT) of vitamin D supplementation in pregnancy in a population with endemic vitamin D deficiency

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 6, 2013, Pages 2337-2346

  Dawodu, Adekunle ^a   Saadi, Hussein F ^b   Bekdache, Gharid ^c   Javed, Yasin ^b   Altaye, Mekibib ^a   Hollis, Bruce W ^d  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^c TAWAM HOSPITAL   (United Arab Emirates)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; CALCIUM; COLECALCIFEROL;

ARTICLE; BLOOD SAMPLING; CALCIUM BLOOD LEVEL; CALCIUM URINE LEVEL; CONTROLLED STUDY; CREATININE URINE LEVEL; DOSE RESPONSE; DRUG DOSE COMPARISON; ENDEMIC DISEASE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MATERNAL CARE; MATERNAL NUTRITION; NUTRITIONAL STATUS; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; PATIENT SAFETY; PERINATAL CARE; PREGNANCY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION;

ADULT; CALCIUM; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; OUTCOME ASSESSMENT (HEALTH CARE); PARATHYROID HORMONE; PREGNANCY; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84878518652     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-1154     Document Type: Article

References (43)

1. Leffelaar ER, Vrijkotte TG, Van Eijsden M. Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth: results of the multi-ethnic Amsterdam Born Children and Their Development cohort. Br J Nutr. 2010;104:108-117.
2. Burris HH, Rifas-Shiman SL, Camargo CA Jr, et al. Plasma 25-hydroxyvitamin D during pregnancy and small-for-gestational age in black and white infants. Ann Epidemiol. 2012;22:581-586.
3. Ioannou C, Javaid MK, Mahon P, et al. The effect of maternal vitamin d concentration on fetal bone. J Clin Endocrinol Metab. 2012;97:E2070-E2077.
4. Mahon P, Harvey N, Crozier S, et al. Low maternal vitamin D status and fetal bone development: a cohort study. J Bone Miner Res. 2010;25:14-19.
5. Anatoliotaki M, Tsilimigaki A, Tsekoura T, Schinaki A, Stefanaki S, Nicolaidou P. Congenital rickets due to maternal vitamin D deficiency in a sunny island of Greece. Acta Paediatr. 2003;92:389-391. (Pubitemid 36408096)
6. Teaema FH, Al Ansari K. Nineteen cases of symptomatic neonatal hypocalcemia secondary to vitamin D deficiency: a 2-year study. J Trop Pediatr. 2010;56:108-110.
7. Belderbos ME, Houben ML, Wilbrink B, et al. Cord blood vitamin d deficiency is associated with respiratory syncytial virus bronchiolitis. Pediatrics. 2011;127:e1513-e1520.
8. Jones AP, Palmer D, Zhang G, Prescott SL. Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy. Pediatrics. 2012;130:e1128-e1135.
9. Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab. 2007;92:3517-3522. (Pubitemid 47435329)
10. Poel YH, Hummel P, Lips P, Stam F, Van Der Ploeg T, Simsek S. Vitamin D and gestational diabetes: a systematic review and meta-analysis. Eur J Intern Med. 2012;23:465-469.
11. Bodnar LM, Krohn MA, Simhan HN. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J Nutr. 2009;139:1157-1161.
12. Ullah MI, Uwaifo GI, Nicholas WC, Koch CA. Does vitamin D deficiency cause hypertension? Current evidence from clinical studies and potential mechanisms. Int J Endocrinol. 2010;2010:579640.
13. Institute of Medicine. Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press; 2011.
14. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911-1930.
15. Dawodu A, Wagner CL. Prevention of vitamin D deficiency in mothers and infants worldwide - a paradigm shift. Paediatr Int Child Health. 2012;32:3-13.
16. Sahu M, Bhatia V, Aggarwal A, et al. Vitamin D deficiency in rural girls and pregnant women despite abundant sunshine in northern India. Clin Endocrinol (Oxf). 2009;70:680-684.
17. Molla AM, Al Badawi M, Hammoud MS, et al. Vitamin D status of mothers and their neonates in Kuwait. Pediatr Int. 2005;47:649-652. (Pubitemid 43951546)
18. Dawodu A, Saadi HF, Bakdache G, Altaye M, Hollis BW. Extraordinarily high prevalence and lack of season variation of vitamin D deficiency in pregnant Arab women. Paper presented at: Annual Meeting of the Pediatric Academic Societies; May 1-4, 2010; Vancouver, British Columbia, Canada. Abstract E-PAS 2010; 1451.
19. Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr. 2005;135:317-322. (Pubitemid 40194499)
20. Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003;77:204-210. (Pubitemid 36015393)
21. Vieth R, Chan PC, Macfarlane GD. Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr. 2001;73:288-294. (Pubitemid 32109858)
22. Saadi HF, Dawodu A, Afandi BO, Zayed R, Benedict S, Nagelkerke N. Efficacy of daily and monthly high-dose calciferol in vitamin D-deficient nulliparous and lactating women. Am J Clin Nutr. 2007;85:1565-1571. (Pubitemid 46890425)
23. Institute of Medicine. 1997 Dietary reference intakes: calcium, phosphorus, magnesium, vitamin D and flouride. Washington, DC: National Academy Press.
24. Hollis BW, Kamerud JQ, Selvaag SR, Lorenz JD, Napoli JL. Determination of vitamin D status by radioimmunoassay with an 125I-labeled tracer. Clin Chem. 1993;39:529-533. (Pubitemid 23099026)
25. Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res. 2011;26:2341-2357.
26. Dawodu A, Agarwal A, Patel M, Ezimokhai M. Serum 25-hydroxyvitamin D and calcium homeostasis in the United Arab Emirates mothers and neonates: a preliminary report. Middle E Paediatr. 1997;2:9-12.
27. Heaney RP, Armas LA, Shary JR, Bell NH, Binkley N, Hollis BW. 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions. Am J Clin Nutr. 2008;87:1738-1742. (Pubitemid 351872637)
28. Appelgren KE, Nietert PJ, Hulsey TC, Hollis BW, Wagner CL. Analyzing adherence to prenatal supplement: does pill count measure up? Int J Endocrinol. 2010;2010:631971.
29. Sahu M, Das V, Aggarwal A, Rawat V, Saxena P, Bhatia V. Vitamin Dreplacement in pregnantwomenin rural north India: a pilot study. Eur J Clin Nutr. 2009;63:1157-1159.
30. Kalra P, Das V, Agarwal A, et al. Effect of vitamin D supplementation during pregnancy on neonatal mineral homeostasis and anthropometry of the newborn and infant. Br J Nutr. 2012;108:1052-1058.
31. Heaney RP. Vitamin D-baseline status and effective dose. N Engl J Med. 2012;367:77-78.
32. Baker AM, Haeri S, Camargo CA Jr, Espinola JA, Stuebe AM. A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia. J Clin Endocrinol Metab. 2010;95:5105-5109.
33. Zhang C, Qiu C, Hu FB, et al. Maternal plasma 25-Hydroxyvitamin Dconcentrations and the risk for gestational diabetes mellitus. PLoS One. 2008;3:e3753.
34. Walker VP, Zhang X, Rastegar I, et al. Cord blood vitamin D status impacts innate immune responses. J Clin Endocrinol Metab. 2011;96:1835-1843.
35. Okonofua F, Menon RK, Houlder S, Thomas M, Robinson D, O'Brien S, Dandona P. Calcium, vitamin D and parathyroid hormone relationships in pregnant Caucasian and Asian women and their neonates. Ann Clin Biochem. 1987;24(Pt 1):22-28. (Pubitemid 17021691)
36. Hamilton SA, McNeil R, Hollis BW, et al. Profound vitamin D deficiency in a diverse group of women during pregnancy living in a sun-rich environment at latitude 32 degrees N. Int J Endocrinol. 2010;2010:917428.
37. Morley R, Carlin JB, Pasco JA, Wark JD. Maternal 25-hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size. J Clin Endocrinol Metab. 2006;91:906-912. (Pubitemid 43357757)
38. Al-Daghri NM, Al-Attas OS, Al-Okail MS, et al. Severe hypovitaminosis D is widespread and more common in non-diabetics than diabetics in Saudi adults. Saudi Med J. 2010;31:775-780.
39. Vieth R, Ladak Y, Walfish PG. Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. J Clin Endocrinol Metab. 2003;88:185-191. (Pubitemid 36115163)
40. Thorne-Lyman A, Fawzi WW. Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis. Paediatr Perinat Epidemiol. 2012;26(suppl 1):75-90.
41. Bowyer L, Catling-Paull C, Diamond T, Homer C, Davis G, Craig ME. Vitamin D, PTH and calcium levels in pregnant women and their neonates. Clin Endocrinol (Oxf). 2009;70:372-377.
42. Bodnar LM, Catov JM, Zmuda JM, et al. Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women. J Nutr. 2010;140:999-1006.
43. Hollis BW, Wagner CL. Vitamin D and pregnancy: skeletal effects, nonskeletal effects, and birth outcomes. Calcif Tiss Int. 2013;92:128-139.