Calcitriol reduces thrombospondin-1 and increases vascular endothelial growth factor in breast cancer cells: Implications for tumor angiogenesis

Journal of Steroid Biochemistry and Molecular Biology

Volumn 144, Issue PART A, 2014, Pages 215-222

  García Quiroz, Janice ^a   Rivas Suárez, Mariana ^a   García Becerra, Rocío ^a   Barrera, David ^a   Martínez Reza, Isela ^a   Ordaz Rosado, David ^a   Santos Martinez, Nancy ^a   Villanueva, Octavio ^a   Santos Cuevas, Clara L ^b   Avila, Euclides ^a   Gamboa Domínguez, Armando ^a   Halhali, Ali ^a   Larrea, Fernando ^a   Díaz, Lorenza ^a  

^a INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^b INSTITUTO NACIONAL DE INVESTIGACIONES NUCLEARES   (Mexico)

Author keywords

Angiogenesis; Necrosis; Serum VEGF; Vitamin D

Indexed keywords

CALCITRIOL; CD31 ANTIGEN; THROMBOSPONDIN 1; VASCULOTROPIN; VITAMIN D; MESSENGER RNA;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BIOLOGICAL ACTIVITY; BREAST CANCER; BREAST CANCER CELL LINE; CANCER INHIBITION; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENCE ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MAMMARY GLAND; NONHUMAN; PHENOTYPE; PRIMARY CELL CULTURE; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; REVIEW; TUMOR BIOPSY; TUMOR VASCULARIZATION; TUMOR VOLUME; ARTICLE; BODY WEIGHT; CANCER CELL; HYPERCALCEMIA; IMMUNOCYTOCHEMISTRY; MOUSE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION;

ANIMALIA; MUS;

ANGIOGENESIS; NECROSIS; SERUM VEGF; VITAMIN D;

ANGIOGENESIS INHIBITORS; ANIMALS; BLOTTING, WESTERN; BONE DENSITY CONSERVATION AGENTS; BREAST NEOPLASMS; CALCITRIOL; CARCINOMA, DUCTAL, BREAST; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THROMBOSPONDIN 1; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84906790509     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2013.09.019     Document Type: Article

References (39)

1. S. Kazerounian, K.O. Yee, and J. Lawler Thrombospondins in cancer Cell. Mol. Life Sci. 65 5 2008 700 712
2. K.O. Yee, C.M. Connolly, M. Duquette, S. Kazerounian, R. Washington, and J. Lawler The effect of thrombospondin-1 on breast cancer metastasis Breast Cancer Res. Treat. 114 1 2009 85 96
3. T.N. Wang, X. Qian, M.S. Granick, M.P. Solomon, V.L. Rothman, D.H. Berger, and G.P. Tuszynski Thrombospondin-1 (TSP-1) promotes the invasive properties of human breast cancer J. Surg. Res. 63 1 1996 39 43
4. K.K. Deeb, D.L. Trump, and C.S. Johnson Vitamin D signalling pathways in cancer: potential for anticancer therapeutics Nat. Rev. Cancer 7 9 2007 684 700
5. J.C. Fleet, M. DeSmet, R. Johnson, and Y. Li Vitamin D and cancer: A review of molecular mechanisms Biochem. J. 441 1 2012 61 76
6. D. Zehnder, R. Bland, R.S. Chana, D.C. Wheeler, A.J. Howie, M.C. Williams, P.M. Stewart, and M. Hewison Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: A novel autocrine determinant of vascular cell adhesion J. Am. Soc. Nephrol. 13 3 2002 621 629
7. D.J. Mantell, P.E. Owens, N.J. Bundred, E.B. Mawer, and A.E. Canfield 1Alpha, 25-dihydroxyvitamin D(3) inhibits angiogenesis in vitro and in vivo Circ. Res. 87 3 2000 214 220
8. M. Lansink, P. Koolwijk, V. van Hinsbergh, and T. Kooistra Effect of steroid hormones and retinoids on the formation of capillary-like tubular structures of human microvascular endothelial cells in fibrin matrices is related to urokinase expression Blood 92 3 1998 927 938
9. R. Lin, N. Amizuka, T. Sasaki, M.M. Aarts, H. Ozawa, D. Goltzman, J.E. Henderson, and J.H. White 1Alpha, 25-dihydroxyvitamin D3 promotes vascularization of the chondro-osseous junction by stimulating expression of vascular endothelial growth factor and matrix metalloproteinase 9 J. Bone Miner. Res. 17 9 2002 1604 1612
10. T. Yamamoto, O. Kozawa, K. Tanabe, S. Akamatsu, H. Matsuno, S. Dohi, H. Hirose, and T. Uematsu 1,25-Dihydroxyvitamin D3 stimulates vascular endothelial growth factor release in aortic smooth muscle cells: role of p38 mitogen-activated protein kinase Arch. Biochem. Biophys. 398 1 2002 1 6
11. M. Grundmann, M. Haidar, S. Placzko, R. Niendorf, N. Darashchonak, C.A. Hubel, and F. von Versen-Hoynck Vitamin D improves the angiogenic properties of endothelial progenitor cells Am. J. Physiol. Cell Physiol. 303 9 2012 C954 C962
12. N.I. Fernandez-Garcia, H.G. Palmer, M. Garcia, A. Gonzalez-Martin, M. del Rio, D. Barettino, O. Volpert, A. Munoz, and B. Jimenez 1Alpha,25- dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human colon carcinoma cells Oncogene 24 43 2005 6533 6544
13. M.J. Levine, and D. Teegarden 1Alpha,25-dihydroxycholecalciferol increases the expression of vascular endothelial growth factor in C3H10T1/2 mouse embryo fibroblasts J. Nutr. 134 9 2004 2244 2250
14. R. Pramanik, A. Ueno, H. Nishikawa, T. Nagata, and H. Inoue Osteotropic factor-stimulated synthesis of thrombospondin in rat dental pulp cells FEBS Lett. 393 2-3 1996 193 196
15. J.R. Wu-Wong, M. Nakane, and J. Ma Vitamin D analogs modulate the expression of plasminogen activator inhibitor-1, thrombospondin-1 and thrombomodulin in human aortic smooth muscle cells J. Vasc. Res. 44 1 2007 11 18
16. R. Garcia-Becerra, L. Diaz, J. Camacho, D. Barrera, D. Ordaz-Rosado, A. Morales, C.S. Ortiz, E. Avila, E. Bargallo, M. Arrecillas, A. Halhali, and F. Larrea Calcitriol inhibits Ether-A go-go potassium channel expression and cell proliferation in human breast cancer cells Exp. Cell Res. 316 3 2010 433 442
17. I. Chung, G. Han, M. Seshadri, B.M. Gillard, W.D. Yu, B.A. Foster, D.L. Trump, and C.S. Johnson Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor angiogenesis in vivo Cancer Res. 69 3 2009 967 975
18. R.J. Bernardi, C.S. Johnson, R.A. Modzelewski, and D.L. Trump Antiproliferative effects of 1alpha,25-dihydroxyvitamin D(3) and vitamin D analogs on tumor-derived endothelial cells Endocrinology 143 7 2002 2508 2514
19. P. Furigay, and N. Swamy Anti-endothelial properties of 1,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of calcitriol J. Steroid Biochem. Mol. Biol. 89-90 1-5 2004 427 431
20. M. Ben-Shoshan, S. Amir, D.T. Dang, L.H. Dang, Y. Weisman, and N.J. Mabjeesh 1Alpha,25-dihydroxyvitamin D3 (calcitriol) inhibits hypoxia-inducible factor-1/vascular endothelial growth factor pathway in human cancer cells Mol. Cancer Ther. 6 4 2007 1433 1439
21. A. Cardus, S. Panizo, M. Encinas, X. Dolcet, C. Gallego, M. Aldea, E. Fernandez, and J.M. Valdivielso 1,25-Dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter Atherosclerosis 204 1 2009 85 89
22. E. Riboldi, T. Musso, E. Moroni, C. Urbinati, S. Bernasconi, M. Rusnati, L. Adorini, M. Presta, and S. Sozzani Cutting edge: proangiogenic properties of alternatively activated dendritic cells J. Immunol. 175 5 2005 2788 2792
23. A. Cardus, E. Parisi, C. Gallego, M. Aldea, E. Fernandez, and J.M. Valdivielso 1,25-Dihydroxyvitamin D3 stimulates vascular smooth muscle cell proliferation through a VEGF-mediated pathway Kidney Int. 69 8 2006 1377 1384
24. M.I. Koukourakis, V. Limberis, I. Tentes, E. Kontomanolis, A. Kortsaris, E. Sivridis, and A. Giatromanolaki Serum VEGF levels and tissue activation of VEGFR2/KDR receptors in patients with breast and gynecologic cancer Cytokine 53 3 2011 370 375
25. K.W. Colston, and C.M. Hansen Mechanisms implicated in the growth regulatory effects of vitamin D in breast cancer Endocr. Relat. Cancer 9 1 2002 45 59
26. E. Avila, R. Garcia-Becerra, J.A. Rodriguez-Rasgado, L. Diaz, D. Ordaz-Rosado, U. Zugel, A. Steinmeyer, D. Barrera, A. Halhali, F. Larrea, and J. Camacho Calcitriol down-regulates human ether a go-go 1 potassium channel expression in cervical cancer cells Anticancer Res. 30 7 2010 2667 2672
27. J. Garcia-Quiroz, R. Garcia-Becerra, D. Barrera, N. Santos, E. Avila, D. Ordaz-Rosado, M. Rivas-Suarez, A. Halhali, P. Rodriguez, A. Gamboa-Dominguez, H. Medina-Franco, J. Camacho, F. Larrea, and L. Diaz Astemizole synergizes calcitriol antiproliferative activity by inhibiting CYP24A1 and upregulating VDR: A novel approach for breast cancer therapy PLoS One 7 9 2012 e45063
28. M. Simboli-Campbell, C.J. Narvaez, M. Tenniswood, and J. Welsh 1,25-Dihydroxyvitamin D3 induces morphological and biochemical markers of apoptosis in MCF-7 breast cancer cells J. Steroid Biochem. Mol. Biol. 58 4 1996 367 376
29. T. Ylikomi, I. Laaksi, Y.R. Lou, P. Martikainen, S. Miettinen, P. Pennanen, S. Purmonen, H. Syvala, A. Vienonen, and P. Tuohimaa Antiproliferative action of vitamin D Vitam. Horm. 64 2002 357 406
30. F. Jiang, J. Bao, P. Li, S.V. Nicosia, and W. Bai Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase J. Biol. Chem. 279 51 2004 53213 53221
31. J. Adams, P.J. Carder, S. Downey, M.A. Forbes, K. MacLennan, V. Allgar, S. Kaufman, S. Hallam, R. Bicknell, J.J. Walker, F. Cairnduff, P.J. Selby, T.J. Perren, M. Lansdown, and R.E. Banks Vascular endothelial growth factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of tamoxifen Cancer Res. 60 11 2000 2898 2905
32. G.P. Tuszynski, T.B. Gasic, V.L. Rothman, K.A. Knudsen, and G.J. Gasic Thrombospondin, a potentiator of tumor cell metastasis Cancer Res. 47 15 1987 4130 4133
33. S.M. Hyder, Y. Liang, and J. Wu Estrogen regulation of thrombospondin-1 in human breast cancer cells Int. J. Cancer 125 5 2009 1045 1053
34. S.M. Hyder, Y. Liang, J. Wu, and V. Welbern Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells Endocr. Relat. Cancer 16 3 2009 809 817
35. T.N. Wang, X.H. Qian, M.S. Granick, M.P. Solomon, V.L. Rothman, D.H. Berger, and G.P. Tuszynski Inhibition of breast cancer progression by an antibody to a thrombospondin-1 receptor Surgery 120 2 1996 449 454
36. Y.W. Zhang, Y. Su, O.V. Volpert, and G.F. Vande Woude Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation Proc. Natl. Acad. Sci. USA 100 22 2003 12718 12723
37. A. Rosso, M. Pansera, A. Zamoner, L. Zanatta, H. Bouraima-Lelong, S. Carreau, and F.R. Silva 1Alpha,25(OH)2-vitamin D3 stimulates rapid plasma membrane calcium influx via MAPK activation in immature rat Sertoli cells Biochimie 94 1 2012 146 154
38. M.G. Fakih, D.L. Trump, J.R. Muindi, J.D. Black, R.J. Bernardi, P.J. Creaven, J. Schwartz, M.G. Brattain, A. Hutson, R. French, and C.S. Johnson A phase I pharmacokinetic and pharmacodynamic study of intravenous calcitriol in combination with oral gefitinib in patients with advanced solid tumors Clin. Cancer Res. 13 4 2007 1216 1223
39. T.M. Beer Development of weekly high-dose calcitriol based therapy for prostate cancer Urol. Oncol. 21 5 2003 399 405