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Brannon PM, Picciano MF. Vitamin D in pregnancy and lactation in humans. Annu Rev Nutr 2011; 31:89-115.
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Brannon, P.M.1
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e1-8.. National Health and Nutrition Examination Survey2001-2006 survey of Vitamin D deficiency among US women in a nationally representative sample. Well controlled study that compares levels between pregnant and nonpregnant women. Does not control for dietary quality or sun exposure
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Ginde AA, Sullivan AF, Mansbach JM, Camargo CA Jr. Vitamin D insufficiency in pregnant and nonpregnant women of childbearing age in the United States. Am J Obstet Gynecol 2010; 202:436; e1-8.. National Health and Nutrition Examination Survey 2001-2006 survey of Vitamin D deficiency among US women in a nationally representative sample. Well controlled study that compares levels between pregnant and nonpregnant women. Does not control for dietary quality or sun exposure.
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Ginde, A.A.1
Sullivan, A.F.2
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Camargo Jr., C.A.4
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8
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80052191413
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Expression profiling of vitamin D receptor in placenta, decidua and ovary of pregnant mice
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Mouse study that shows evidence of varying vitamin D levels in reproductive tissues during gestation giving evidence of a role for vitamin D in the physiology of reproduction
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Shahbazi M, Jeddi-Tehrani M, Zareie M, et al. Expression profiling of vitamin D receptor in placenta, decidua and ovary of pregnant mice. Placenta 2011; 32:657-664. Mouse study that shows evidence of varying vitamin D levels in reproductive tissues during gestation giving evidence of a role for vitamin D in the physiology of reproduction.
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Shahbazi, M.1
Jeddi-Tehrani, M.2
Zareie, M.3
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9
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79959954401
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Global maternal early pregnancy peripheral blood mRNA and miRNA expression profiles according to plasma 25-hydroxyvitamin D concentrations
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Genetic evidence of hundreds of genes induced differentially in pregnant women depending on vitamin D levels
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Enquobahrie DA, Williams MA, Qiu C, et al. Global maternal early pregnancy peripheral blood mRNA and miRNA expression profiles according to plasma 25-hydroxyvitamin D concentrations. J Matern Fetal Neonatal Med 2011; 24:1002-1012. Genetic evidence of hundreds of genes induced differentially in pregnant women depending on vitamin D levels.
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Enquobahrie, D.A.1
Williams, M.A.2
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10
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Vitamin D induces innate antibacterial responses in human trophoblasts via an intracrine pathway
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Liu N, Kaplan AT, Low J, et al. Vitamin D induces innate antibacterial responses in human trophoblasts via an intracrine pathway. Biol Reprod 2009; 80:398-406.
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3 on cytokine production by human decidual cells
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Evans KN, Nguyen L, Chan J, et al. Effects of 25-hydroxyvitamin D3 and 1 25-dihydroxyvitamin D3 on cytokine production by human decidual cells. Biol Reprod 2006; 75:816-822. (Pubitemid 44845586)
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Kilby, M.D.6
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Vitamin D and the regulation of placental inflammation
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Liu NQ, Kaplan AT, Lagishetty V, et al. Vitamin D and the regulation of placental inflammation. J Immunol 2011; 186:5968-5974.
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Liu, N.Q.1
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Lagishetty, V.3
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Halhali A, Figueras AG, Diaz L, et al. Effects of calcitriol on calbindins gene expression and lipid peroxidation in human placenta. J Steroid Biochem Mol Biol 2010; 121 (1-2):448-451.
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Halhali, A.1
Figueras, A.G.2
Diaz, L.3
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14
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77957238649
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This high quality case-control study involved excellent control for potential confounding factors, a power calculation and an appropriate control group In addition, the measurement of vitamin D levels was sophisticated lending a better understanding of the complex vitamin D steroid system. Powe et al. found no evidence that vitamin D levels in the first trimester were associated with subsequent preeclampsia
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Powe CE, Seely EW, Rana S, et al. First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia. Hypertension 2010; 56:758-763. This high quality case-control study involved excellent control for potential confounding factors, a power calculation and an appropriate control group. In addition, the measurement of vitamin D levels was sophisticated lending a better understanding of the complex vitamin D steroid system. Powe et al. found no evidence that vitamin D levels in the first trimester were associated with subsequent preeclampsia.
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Hypertension
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Powe, C.E.1
Seely, E.W.2
Rana, S.3
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15
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80055061896
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Vitamin D status in pregnant Indian women across trimesters and different seasons and its correlation with neonatal serum 25-hydroxyvitamin D levels
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Marwaha RK, Tandon N, Chopra S, et al. Vitamin D status in pregnant Indian women across trimesters and different seasons and its correlation with neonatal serum 25-hydroxyvitamin D levels. Br J Nutr 2011; 106:1383-1389.
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Marwaha, R.K.1
Tandon, N.2
Chopra, S.3
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16
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79952240621
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Profound vitamin D deficiency in a diverse group of women during pregnancy living in a sun-rich environment at latitude 32 degrees N
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Hamilton SA, McNeil R, Hollis BW, et al. Profound vitamin D deficiency in a diverse group of women during pregnancy living in a sun-rich environment at latitude 32 degrees N. Int J Endocrinol 2010; 2010:917428.
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Hamilton, S.A.1
McNeil, R.2
Hollis, B.W.3
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17
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Vitamin D insufficiency is prevalent and vitamin D is inversely associated with PTH and calcitriol in pregnant adolescents
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Young BE, Mcnanley TJ, Cooper EM, et al. Vitamin D insufficiency is prevalent and vitamin D is inversely associated with PTH and calcitriol in pregnant adolescents. J Bone Miner Res 2011; 27:177-186.
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J Bone Miner Res
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Young, B.E.1
Mcnanley, T.J.2
Cooper, E.M.3
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18
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Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness
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This fair-quality randomized controlled trial in South Carolina showed higher than expected baseline vitamin D levels, increased levels of 25(OH)D in response to supplementation and no change in pregnancy outcomes measured. The study was flawed in that it did not have an intention to treat analysis. The analysis excluded up to 30% of the participants who were not compliant
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Hollis BW, Johnson D, Hulsey TC, et al. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 2011; 26:2341-2357. This fair-quality randomized controlled trial in South Carolina showed higher than expected baseline vitamin D levels, increased levels of 25(OH)D in response to supplementation and no change in pregnancy outcomes measured. The study was flawed in that it did not have an intention to treat analysis. The analysis excluded up to 30% of the participants who were not compliant.
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(2011)
J Bone Miner Res
, vol.26
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Hollis, B.W.1
Johnson, D.2
Hulsey, T.C.3
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The relationship between PTH and 25-hydroxy vitamin D early in pregnancy
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Haddow JE, Neveux LM, Palomaki GE, et al. The relationship between PTH and 25-hydroxy vitamin D early in pregnancy. Clin Endocrinol (Oxf) 2011; 75:309-314.
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Haddow, J.E.1
Neveux, L.M.2
Palomaki, G.E.3
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20
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84859771888
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Institute of Medicine Dietary reference intakes for calcium and vitamin D Washington, DC: The National Academies Press IOM guidelines for vitamin D supplementation with a special section devoted to pregnancy. Found no evidence that vitamin D deficiency is related to any outcome besides bone health. Recommends vitamin D deficiency be defined as less than 12 ng/l. Recommends routine supplementation of 600 IU 25(OH)D daily in pregnancy to promote bone health only
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Institute of Medicine. Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press; 2011. IOM guidelines for vitamin D supplementation with a special section devoted to pregnancy. Found no evidence that vitamin D deficiency is related to any outcome besides bone health. Recommends vitamin D deficiency be defined as less than 12 ng/l. Recommends routine supplementation of 600 IU 25(OH)D daily in pregnancy to promote bone health only.
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(2011)
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21
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79959681567
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Vitamin D screening and supplementation during pregnancy
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ACOG Committee ACOG guidelines for vitamin D supplementation in pregnancy. Does not recommend routine screening. Recommends 600 IU daily in pregnancy. Physicians may consider screening women thought to be at high risk for deficiency. Physicians may recommend treating pregnant women with deficiency (<20 ng/l) with 1000-2000 IU 25(OH)D daily
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ACOG Committee. Vitamin D: Screening and supplementation during pregnancy. Obstet Gynecol 2011; 118:197-198. ACOG guidelines for vitamin D supplementation in pregnancy. Does not recommend routine screening. Recommends 600 IU daily in pregnancy. Physicians may consider screening women thought to be at high risk for deficiency. Physicians may recommend treating pregnant women with deficiency (
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(2011)
Obstet Gynecol
, vol.118
, pp. 197-198
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22
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80051907553
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Vitamin D status and its predictive factors in pregnancy in 2 Australian populations
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Shows the inaccuracy of directly comparing 25(OH)D levels measured by different assays
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Perampalam S, Ganda K, Chow KA, et al. Vitamin D status and its predictive factors in pregnancy in 2 Australian populations. Aust N Z J Obstet Gynaecol 2011; 51:353-359. Shows the inaccuracy of directly comparing 25(OH)D levels measured by different assays.
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Aust N Z J Obstet Gynaecol
, vol.51
, pp. 353-359
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Perampalam, S.1
Ganda, K.2
Chow, K.A.3
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23
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44249122585
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Accuracy and clinical implications of seven 25-hydroxyvitamin D methods compared with liquid chromatography-tandem mass spectrometry as a reference
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Roth HJ, Schmidt-Gayk H, Weber H, Niederau C. Accuracy and clinical implications of seven 25-hydroxyvitamin D methods compared with liquid chromatography-tandem mass spectrometry as a reference. Ann Clin Biochem 2008; 45 (Pt 2):153-159. (Pubitemid 351724586)
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Roth, H.J.1
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Niederau, C.4
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24
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79959322763
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Isotope dilution ultra performance liquid chromatography-tandem mass spectrometry method for simultaneous measurement of 25-hydroxyvitamin D2 25-hydroxyvitamin D3 and 3-epi-25-hydroxyvitamin D3 in human serum
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Schleicher RL, Encisco SE, Chaudhary-Webb M, et al. Isotope dilution ultra performance liquid chromatography-tandem mass spectrometry method for simultaneous measurement of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3 and 3-epi-25-hydroxyvitamin D3 in human serum. Clin Chim Acta 2011; 412 (17-18):1594-1599.
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80052551596
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Vitamin D status: United States, 2001-2006
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Using national data and the IOM cut point for deficiency, this group found a low prevalence of vitamin D deficiency or insufficiency among pregnant women in the United States
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Looker AC, Johnson CL, Lacher DA, et al. Vitamin D status: United States, 2001-2006. NCHS Data Brief 2011; (59):1-8. Using national data and the IOM cut point for deficiency, this group found a low prevalence of vitamin D deficiency or insufficiency among pregnant women in the United States.
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NCHS Data Brief
, Issue.59
, pp. 1-8
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Looker, A.C.1
Johnson, C.L.2
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26
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78649981498
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Vitamin D deficiency in pregnant women and their newborns as seen at a tertiary-care center in Karachi, Pakistan
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Karim SA, Nusrat U, Aziz S. Vitamin D deficiency in pregnant women and their newborns as seen at a tertiary-care center in Karachi, Pakistan. Int J Gynaecol Obstet 2011; 112:59-62.
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Int J Gynaecol Obstet
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27
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Suboptimal vitamin D levels in pregnant women despite supplement use
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Li W, Green TJ, Innis SM, et al. Suboptimal vitamin D levels in pregnant women despite supplement use. Can J Public Health 2011; 102:308-312.
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Can J Public Health
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Li, W.1
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28
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78650314867
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Association of modifiable and nonmodifiable factors with vitamin D status in pregnant women and neonates in Oakland, CA
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This study attempted to control for dietary and sun exposure to vitamin D in order to understand risk factors associated with vitamin D deficiency in a diverse US population. They found that inner arm skin pigmentation was more associated with vitamin D deficiency than stated race/ethnicity and that vitamin D levels increased with supplementation. They found no association between vitamin D levels and low birthweight or cesarean section
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Dror DK, King JC, Durand DJ, Allen LH. Association of modifiable and nonmodifiable factors with vitamin D status in pregnant women and neonates in Oakland, CA. J Am Diet Assoc 2011; 111:111-116. This study attempted to control for dietary and sun exposure to vitamin D in order to understand risk factors associated with vitamin D deficiency in a diverse US population. They found that inner arm skin pigmentation was more associated with vitamin D deficiency than stated race/ethnicity and that vitamin D levels increased with supplementation. They found no association between vitamin D levels and low birthweight or cesarean section.
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J Am Diet Assoc
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King, J.C.2
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29
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Yu CK, Ertl R, Samaha R, et al. Normal range of maternal serum vitamin d at 11-13 weeks' gestation. Fetal Diagn Ther 2011; 30:94-99.
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Fetal Diagn Ther
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Yu, C.K.1
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Vitamin D deficiency is common among pregnant women in rural Victoria
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Teale GR, Cunningham CE. Vitamin D deficiency is common among pregnant women in rural Victoria. Aust N Z J Obstet Gynaecol 2010; 50:259-261.
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Vitamin D deficiency and insufficiency is common during pregnancy
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Johnson DD, Wagner CL, Hulsey TC, et al. Vitamin D deficiency and insufficiency is common during pregnancy. Am J Perinatol 2011; 28:7-12.
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Am J Perinatol
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Johnson, D.D.1
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33
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79952744153
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Severe vitamin D deficiency in pregnant women of Somali origin living in Sweden
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Saaf M, Fernell E, Kristiansson F, et al. Severe vitamin D deficiency in pregnant women of Somali origin living in Sweden. Acta Paediatr 2011; 100:612-614.
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Acta Paediatr
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Saaf, M.1
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34
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79957944584
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Vitamin D status in pregnant omanis: A disturbingly high proportion of patients with low vitamin D stores
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Al KalbaniM, Elshafie O, Rawahi M, et al. Vitamin D status in pregnant omanis: A disturbingly high proportion of patients with low vitamin D stores. Sultan Qaboos Univ Med J 2011; 11:52-55.
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Al, Kalbani.M.1
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Rawahi, M.3
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35
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79955945548
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Vitamin D levels in pregnant women and newborns at a private tertiary care hospital in Delhi, India
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A large, well controlled study from India that showed that vitamin D deficiency increased in the second and third trimesters, whereas parathyroid hormone levels increased
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Agarwal N, Arya SC. Vitamin D levels in pregnant women and newborns at a private tertiary care hospital in Delhi, India. Int J Gynaecol Obstet 2011; 113:240-241. A large, well controlled study from India that showed that vitamin D deficiency increased in the second and third trimesters, whereas parathyroid hormone levels increased.
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Int J Gynaecol Obstet
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Agarwal, N.1
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A nested case-control study of firsttrimester maternal vitamin d status and risk for spontaneous preterm birth
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Baker AM, Haeri S, Camargo C, et al. A nested case-control study of firsttrimester maternal vitamin d status and risk for spontaneous preterm birth. Am J Perinatol 2011; 28:667-672.
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High prevalence of hypovitaminosis D in pregnant Japanese women with threatened premature delivery
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Shibata M, Suzuki A, Sekiya T, et al. High prevalence of hypovitaminosis D in pregnant Japanese women with threatened premature delivery. J Bone Miner Metab 2011; 29:615-620.
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Roth DE. Vitamin D supplementation during pregnancy: Safety considerations in the design and interpretation of clinical trials. J Perinatol 2011; 31:449-459.
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77954362186
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An interesting ecologic study that shows vitamin D deficiency to be lower than expected in some countries with low sun exposure. This suggests a role for dietary quality in improving vitamin D levels
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Lips P. Worldwide status of vitamin D nutrition. J Steroid Biochem Mol Biol 2010; 121 (1-2):297-300. An interesting ecologic study that shows vitamin D deficiency to be lower than expected in some countries with low sun exposure. This suggests a role for dietary quality in improving vitamin D levels.
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J Steroid Biochem Mol Biol
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Lips, P.1
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A systematic review of first-trimester vitamin D levels and their impact on the diagnosis of gestational diabetes and preeclampsia. This review found inconclusive evidence to support an assocation
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Nassar N, Halligan GH, Roberts CL. Systematic review of first-trimester vitamin D normative levels and outcomes of pregnancy. Am J Obstet Gynecol 2011; 205:208. A systematic review of first-trimester vitamin D levels and their impact on the diagnosis of gestational diabetes and preeclampsia. This review found inconclusive evidence to support an assocation.
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Am J Obstet Gynecol
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TePoel MR, Saftlas AF, Wallis AB. Association of seasonality with hypertension in pregnancy: A systematic review. J Reprod Immunol 2011; 89:140-152.
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Hossain N, Khanani R, Hussain-Kanani F, et al. High prevalence of vitamin D deficiency in Pakistani mothers and their newborns. Int J Gynaecol Obstet 2011; 112:229-233.
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Int J Gynaecol Obstet
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