25(OH)D2half-life is shorter than 25(OH)D3half-life and is influenced by DBP concentration and genotype

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 9, 2014, Pages 3373-3381

  Jones, K S ^a,b   Assar, S ^a   Harnpanich, D ^a   Bouillon, R ^c   Lambrechts, D ^c,d   Prentice, A ^a,b   Schoenmakers, I ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b Medical Research Council Keneba   (Gambia)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYERGOCALCIFEROL; CALCIFEDIOL; VITAMIN D BINDING PROTEIN; CALCIUM INTAKE; COLECALCIFEROL 24 HYDROXYLASE; CYP24A1 PROTEIN, HUMAN; CYP27C1 PROTEIN, HUMAN; CYTOCHROME P450; DEUTERIUM; PARATHYROID HORMONE; SECALCIFEROL; VITAMIN;

ADULT; ARTICLE; CALCIUM INTAKE; CONTROLLED STUDY; DBP GENE; DRUG HALF LIFE; ETHNIC DIFFERENCE; GAMBIA; GENE; GENOTYPE; GENOTYPING TECHNIQUE; HOMOZYGOTE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PROTEIN BLOOD LEVEL; UNITED KINGDOM; VITAMIN BLOOD LEVEL; VITAMIN D HALF LIFE; VITAMIN D HYDROXYLASE GENE; VITAMIN D METABOLISM; YOUNG ADULT; BIOLOGICAL MODEL; BLOOD; CLINICAL TRIAL; DIAGNOSTIC USE; GENETICS; METABOLISM; MULTICENTER STUDY; STATISTICAL MODEL;

24,25-DIHYDROXYVITAMIN D 3; 25-HYDROXYVITAMIN D 2; ADULT; CALCIFEDIOL; CALCIUM, DIETARY; CYTOCHROME P-450 ENZYME SYSTEM; DEUTERIUM; GAMBIA; GENOTYPE; GREAT BRITAIN; HUMANS; LINEAR MODELS; MALE; MODELS, BIOLOGICAL; PARATHYROID HORMONE; VITAMIN D-BINDING PROTEIN; VITAMIN D3 24-HYDROXYLASE; VITAMINS; YOUNG ADULT;

EID: 84907190829     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-1714     Document Type: Article

References (40)

1. Institute of Medicine. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: The National Acadamies Press; 2011.
2. HolickMF,BiancuzzoRM,ChenTC,et al. VitaminD2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab. 2008;93: 677-681.
3. Heaney RP, Recker RR, Grote J, Horst RL, Armas LA. Vitamin D3 is more potent than vitaminD2 in humans. J Clin Endocrinol Metab. 2011;96: E447-E452.
4. Binkley N, Gemar D, Engelke J, et al. Evaluation of ergocalciferol or cholecalciferol dosing, 1,600 IU daily or 50 000 IU monthly in older adults. J Clin Endocrinol Metab. 2011;96: 981-988.
5. Demetriou ET, Travison TG, Holick MF. Effect of treatment with 50 000 IU vitamin D2 every other week on serum 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, and total 25-hydroxyvitamin D in a clinical setting. Endocr Pract. 2012;18: 399-402.
6. Pietras SM, Obayan BK, CaiMH,HolickMF.VitaminD2 treatment for vitamin D deficiency and insufficiency for up to 6 years. Arch Intern Med. 2009;169: 1806-1808.
7. Armas LA, Hollis BW, Heaney RP. VitaminD2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004;89: 5387-5391.
8. Romagnoli E, Mascia ML, Cipriani C, et al. Short and long-Term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitaminD2) or cholecalciferol (vitaminD3) in the elderly. J Clin Endocrinol Metab. 2008;93: 3015-3020.
9. Glendenning P,ChewGT,SeymourHM,et al. Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after supplementation with ergocalciferol and cholecalciferol. Bone. 2009;45: 870-875.
10. Biancuzzo RM, Young A, Bibuld D, et al. Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults. Am J Clin Nutr. 2010;91: 1621-1626.
11. Thacher TD, Obadofin MO, O'Brien KO, Abrams SA. The effect of vitamin D2 and vitamin D3 on intestinal calcium absorption in Nigerian children with rickets. J Clin Endocrinol Metab. 2009;94: 3314-3321.
12. Hollis BW. Comparison of equilibrium and disequilibrium assay conditions for ergocalciferol, cholecalciferol and their major metabolites. J Steroid Biochem. 1984;21: 81-86.
13. Bouillon R. The vitamin D binding protein, DBP. In: Feldman D, Pike JW, Adams JS, eds. Vitamin D. London: Elsevier; 2011, 57-72.
14. Schoenmakers I, Ginty F, Jarjou LM, et al. Interrelation of parathyroid hormone and vitaminDmetabolites in adolescents from theUK and The Gambia. J Steroid Biochem Mol Biol. 2010;121: 217-220.
15. Kambou MI, Ferrell RE. Ethnic variation in vitamin D-binding protein (GC): a review of isoelectric focusing studies in human populations. Hum Genet. 1986;72: 281-293.
16. Prentice A. Vitamin D deficiency: a global perspective. Nutr Rev. 2008;66: S153-S164.
17. Jones KS, Schoenmakers I, Bluck LJ, Ding S, Prentice A. Plasma appearance and disappearance of an oral dose of 25-hydroxyvitamin D2 in healthy adults. Br J Nutr. 2012;107: 1128-1137.
18. Bouillon R, Baelen HV, Moor PD. The measurement of the vitamin D-binding protein in human serum. J Clin Endocrinol Metab. 1977; 45: 225-231.
19. Casetta B, Jans I, Billen J, Vanderschueren D, Bouillon R. Development of a method for the quantification of 1-,25(OH)2-vitamin D3 in serum by liquid chromatography tandem mass spectrometry without derivatization. Eur J Mass Spectrom. 2010;16: 81-89.
20. Ding S, Schoenmakers I, Jones K, Koulman A, Prentice A, Volmer DA. Quantitative determination of vitaminDmetabolites in plasma using UHPLC-MS/MS. Anal Bioanal Chem. 2010;398: 779-789.
21. Hatse S, Lambrechts D, Verstuyf A, et al. Vitamin D status at breast cancer diagnosis: correlation with tumor characteristics, disease outcome, and genetic determinants of vitamin D insufficiency. Carcinogenesis. 2012;33: 1319-1326.
22. Powe CE, Ricciardi C, Berg AH, et al. Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res. 2011;26: 1609-1616.
23. Chun RF, Peercy BE, Adams JS, Hewison M. Vitamin D binding protein and monocyte response to 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D: analysis by mathematical modeling. PLoS One. 2012;7: e30773.
24. Bouillon R, Van Assche FA, Van Baelen H, Heyns W, De Moor P. Influence of the vitamin D-binding protein on the serum concentration of 1,25-dihydroxyvitamin D3: Significance of the free 1,25-dihydroxyvitamin D3 concentration. J Clin Invest. 1981;67: 589-596.
25. Trang HM, Cole DE, Rubin LA, Pierratos A, Siu S, Vieth R. Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2. Am J Clin Nutr. 1998;68: 854-858.
26. Fisk CM, Theobald HE, Sanders TA. Fortified malted milk drinks containing low-dose ergocalciferol and cholecalciferol do not differ in their capacity to raise serum 25-hydroxyvitaminDconcentrations in healthy men and women not exposed to UV-B. J Nutr. 2012;142: 1286-1290.
27. Lauridsen AL, Vestergaard P, Hermann AP, et al. Plasma concentrations of 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binding protein): a cross-sectional study on 595 early postmenopausal women. Calcif Tissue Int. 2005;77: 15-22.
28. Bouillon R, van Baelen H, de Moor P. Comparative study of the affinity of the serum vitamin D-binding protein. J Steroid Biochem. 1980;13: 1029-1034.
29. Porter TR, Stephensen CB, Mulligan K, et al. Team AMNfHAIs. Genetic associations with 25-hydroxyvitamin D deficiency in HIV-1-infected youth: fine-mapping for the GC/DBP gene that encodes the vitamin D-binding protein. Front Genet. 2013;4: 234.
30. Sinotte M, Diorio C, Berube S, Pollak M, Brisson J. Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women. Am J Clin Nutr. 2009;89: 634-640.
31. Chun RF, Peercy BE, Orwoll ES, Nielson CM, Adams JS, Hewison M. VitaminDand DBP: the free hormone hypothesis revisited [published online October 3, 2013]. J Steroid Biochem Mol Biol. 2014. doi: 10.1016/j/jsbmb.2013.09.12.
32. PoweCE, EvansMK,Wenger J, et al. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med. 2013;369: 1991-2000.
33. Anderson PH, Lee AM, Anderson SM, Sawyer RK, O'Loughlin PD, MorrisHA.The effect of dietary calcium on 1,25(OH)2D3 synthesis and sparing of serum 25(OH)D3 levels. J Steroid Biochem Mol Biol. 2010;121: 288-292.
34. Clements MR, Davies M, Hayes ME, et al. The role of 1,25-dihydroxyvitaminDin the mechanism of acquired vitaminDdeficiency. Clin Endocrinol (Oxf). 1992;37: 17-27.
35. Clements MR, Johnson L, Fraser DR. A new mechanism for induced vitaminDdeficiency in calcium deprivation. Nature. 1987; 325: 62-65.
36. Duplessis CA, Harris EB, Watenpaugh DE, Horn WG. Vitamin D supplementation in underway submariners. Aviat Space Environ Med. 2005;76: 569-575.
37. Wagner D, Hanwell HE, Schnabl K, et al. The ratio of serum 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 is predictive of 25-hydroxyvitamin D3 response to vitamin D3 supplementation. J Steroid Biochem Mol Biol. 2011;126: 72-77.
38. Abboud M, Puglisi DA, Davies BN, et al. Evidence for a specific uptake and retention mechanism for 25-hydroxyvitamin D (25OHD) in skeletal muscle cells. Endocrinology. 2013;154: 3022-3030.
39. Toutain PL, Bousquet-Melou A. Plasma terminal half-life. J Vet Pharmacol Ther. 2004;27: 427-439.
40. Lawson DE, Douglas J, Lean M, Sedrani S. Estimation of vitaminD3 and 25-hydroxyvitamin D3 in muscle and adipose tissue of rats and man. Clin Chim Acta. 1986;157: 175-181.