The impact of vitamin D on pregnancy: A systematic review

Acta Obstetricia et Gynecologica Scandinavica

Volumn 91, Issue 12, 2012, Pages 1357-1367

  Christesen, Henrik T ^a,b   Falkenberg, Tine ^a   Lamont, Ronald F ^a,c   Jørgensen, Jan S ^a,b  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Obstetric morbidity; pregnancy; vitamin D

Indexed keywords

1,25 DIHYDROXYERGOCALCIFEROL; 25 HYDROXYVITAMIN D; CALCIUM; VITAMIN D;

BREAST CANCER; CALCIUM INTAKE; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG MEGADOSE; FEMALE FERTILITY; GESTATIONAL AGE; HUMAN; MATERNAL HYPERTENSION; OUTCOME ASSESSMENT; PATHOGENESIS; PREECLAMPSIA; PREGNANCY; PREGNANCY DIABETES MELLITUS; PREGNANCY OUTCOME; PRIORITY JOURNAL; PUERPERAL DEPRESSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYMPTOM; SYSTEMATIC REVIEW; VAGINITIS; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; WEIGHT GAIN;

BLOOD GLUCOSE; CESAREAN SECTION; DEPRESSION, POSTPARTUM; DIABETES, GESTATIONAL; FEMALE; FERTILITY; HUMANS; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; VAGINOSIS, BACTERIAL; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84870873616     PISSN: 00016349     EISSN: 16000412     Source Type: Journal    
DOI: 10.1111/aogs.12000     Document Type: Review

References (73)

1. Sachan A, Gupta R, Das V, Agarwal A, Awasthi PK, Bhatia V,. High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India. Am J Clin Nutr. 2005; 81: 1060-4.
2. Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM,. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab. 2007; 92: 3517-22.
3. Bowyer L, Catling-Paull C, Diamond T, Homer C, Davis G, Craig ME,. Vitamin D, PTH and calcium levels in pregnant women and their neonates. Clin Endocrinol. 2009; 70: 372-7.
4. Scholl TO, Chen XH,. Vitamin D intake during pregnancy: Association with maternal characteristics and infant birth weight. Early Hum Dev. 2009; 85: 231-4.
5. Kazemi A, Sharifi F, Jafari N, Mousavinasab N,. High prevalence of vitamin D deficiency among pregnant women and their newborns in an Iranian population. J Womens Health. 2009; 18: 835-9.
6. Mulligan ML, Felton SK, Riek AE, Bernal-Mizrachi C,. Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol. 2010; 202: 429.
7. Brunvand L, Quigstad E, Urdal P, Haug E,. Vitamin D deficiency and fetal growth. Early Hum Dev. 1996; 45: 27-33.
8. Dijkstra SH, van Beek A, Janssen JW, de Vleeschouwer LHM, Huysman WA, van den Akker ELT,. High prevalence of vitamin D deficiency in newborn infants of high-risk mothers. Arch Dis Child. 2007; 92: 750-3.
9. Bodnar LM, Simhan HN, Powers RW, Frank MP, Cooperstein E, Roberts JM,. High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates. J Nutr. 2007; 137: 447-52.
10. Nicolaidou P, Hatzistamatiou Z, Papadopoulou A, Kaleyias J, Floropoulou E, Lagona E, et al,. Low vitamin D status in mother-newborn pairs in Greece. Calcified Tissue Int. 2006; 78: 337-42.
11. Javaid MK, Crozier SR, Harvey NC, Gale CR, Dennison EM, Boucher BJ, et al,. Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet. 2006; 367: 36-43.
12. Holmes VA, Barnes MS, Alexander HD, McFaul P, Wallace JM,. Vitamin D deficiency and insufficiency in pregnant women: a longitudinal study. Br J Nutr. 2009; 102: 876-81.
13. Madar AA, Stene LC, Meyer HE,. Vitamin D status among immigrant mothers from Pakistan, Turkey and Somalia and their infants attending child health clinics in Norway. Br J Nutr. 2009; 101: 1052-8.
14. Farrant HJ, Krishnaveni GV, Hill JC, et al,. Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variation in newborn size. Eur J Clin Nutr. 2009; 63: 646-52.
15. Ginde AA, Wolfe P, Camargo CA, Jr, Schwartz RS,. Defining vitamin D status by secondary hyperparathyroidism in the U.S. population. J Endocrinol Invest. 2012; 35: 42-8.
16. Marya RK, Rathee S, Lata V, Mudgil S,. Effects of vitamin D supplementation in pregnancy. Gynecol Obstet Invest. 1981; 12: 155-61.
17. Yu CK, Sykes L, Sethi M, Teoh TG, Robinson S,. Vitamin D deficiency and supplementation during pregnancy. Clin Endocrinol. 2009; 70: 685-90.
18. Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL,. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res. 2011; 26: 2341-57.
19. Brooke OG, Brown IR, Bone CD, et al,. Vitamin D supplements in pregnant Asian women: effects on calcium status and fetal growth. Br Med J. 1980; 280: 751-4.
20. Mallet E, Gugi B, Brunelle P, Henocq A, Basuyau JP, Lemeur H,. Vitamin D supplementation in pregnancy: a controlled trial of two methods. Obstet Gynecol. 1986; 68: 300-4.
21. Delvin EE, Salle BL, Glorieux FH, Adeleine P, David LS,. Vitamin D supplementation during pregnancy: effect on neonatal calcium homeostasis. J Pediatr. 1986; 109: 328-34.
22. Sahu M, Das V, Aggarwal A, Rawat V, Saxena P, Bhatia V,. Vitamin D replacement in pregnant women in rural north India: a pilot study. Eur J Clin Nutr. 2009; 63: 1157-9.
23. Marya RK, Rathee S, Dua V, Sangwan K,. Effect of vitamin D supplementation during pregnancy on foetal growth. Indian J Med Res. 1988; 88: 488-92.
24. Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickmon C, et al,. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril. 2010; 94: 1314-9.
25. Blomberg JM, Bjerrum PJ, Jessen TE, Nielsen JE, Joensen UN, Olesen IA, et al,. Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Hum Reprod. 2011; 26: 1307-17.
26. Haugen M, Brantsaeter AL, Trogstad L, Alexander J, Roth C, Magnus P, et al,. Vitamin D supplementation and reduced risk of preeclampsia in nulliparous women. Epidemiology. 2009; 20: 720-6.
27. Baker AM, Haeri S, Camargo CA, Jr, Espinola JA, Stuebe AM,. A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia. J Clin Endocrinol Metab. 2010; 95: 5105-9.
28. Robinson CJ, Alanis MC, Wagner CL, Hollis BW, Johnson DD,. Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia. Am J Obstet Gynecol. 2010; 203: 366.
29. Woodham PC, Brittain JE, Baker AM, Long DL, Haeri S, Camargo CA Jr, et al,. Midgestation maternal serum 25-hydroxyvitamin D level and soluble fms-like tyrosine kinase 1/placental growth factor ratio as predictors of severe preeclampsia. Hypertension. 2011; 58: 1120-5.
30. Powe CE, Seely EW, Rana S, Bhan I, Ecker J, Karumanchi SA, et al,. First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia. Hypertension. 2010; 56: 758-63.
31. Shand AW, Nassar N, Von DP, Innis SM, Green TJ,. Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia. Br J Obstet Gynaecol. 2010; 117: 1593-8.
32. Azar M, Basu A, Jenkins AJ, Nankervis AJ, Hanssen KF, Scholz H, et al,. Serum carotenoids and fat-soluble vitamins in women with type 1 diabetes and preeclampsia: a longitudinal study. Diabetes Care. 2011; 34: 1258-64.
33. Hofmeyr GJ, Duley L, Atallah A,. Dietary calcium supplementation for prevention of pre-eclampsia and related problems: a systematic review and commentary. Br J Obstet Gynaecol. 2007; 114: 933-43.
34. Marya RK, Rathee S, Manrow M,. Effect of calcium and vitamin D supplementation on toxaemia of pregnancy. Gynecol Obstet Invest. 1987; 24: 38-42.
35. Halhali A, Tovar AR, Torres N, Bourges H, Garabedian M, Larrea F,. Preeclampsia is associated with low circulating levels of insulin-like growth factor I and 1,25-dihydroxyvitamin D in maternal and umbilical cord compartments. J Clin Endocrinol Metab. 2000; 85: 1828-33.
36. Halhali A, Diaz L, Avila E, Ariza AC, Garabedian M, Larrea F,. Decreased fractional urinary calcium excretion and serum 1,25-dihydroxyvitamin D and IGF-I levels in preeclampsia. J Steroid Biochem Mol Biol. 2007; 103: 803-6.
37. Hypponen E, Hartikainen AL, Sovio U, Jarvelin MR, Pouta A,. Does vitamin D supplementation in infancy reduce the risk of pre-eclampsia?. Eur J Clin Nutr. 2007; 61: 1136-9.
38. Maghbooli Z, Hossein-Nezhad A, Karimi F, Shafaei AR, Larijani B,. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metab Res Rev. 2008; 24: 27-32.
39. Zhang C, Qiu C, Hu FB, David RM, van Dam RM, Bralley A, et al,. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One. 2008; 3: e3753.
40. Parlea L, Bromberg IL, Feig DS, Vieth R, Merman E, Lipscombe LL,. Association between serum 25-hydroxyvitamin D in early pregnancy and risk of gestational diabetes mellitus. Diabet Med. 2011. DOI: 10.1111/j.1464-5491.2011. 03550.x. [Epub ahead of print].
41. Clifton-Bligh RJ, McElduff P, McElduff A,. Maternal vitamin D deficiency, ethnicity and gestational diabetes. Diabetic Med. 2008; 25: 678-84.
42. Baker AM, Haeri S, Camargo CA Jr, Stuebe AM, Boggess KA,. First trimester maternal vitamin D status and risk for gestational diabetes mellitus (GDM): a nested case-control study. Diabetes Metab Res Rev. 2012; 28: 164-8.
43. Makgoba M, Nelson SM, Savvidou M, Messow CM, Nicolaides K, Sattar N,. First-trimester circulating 25-hydroxyvitamin D levels and development of gestational diabetes mellitus. Diabetes Care. 2011; 34: 1091-3.
44. Bodnar LM, Krohn MA, Simhan HN,. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J Nutr. 2009; 139: 1157-61.
45. Davis LM, Chang SC, Mancini J, Nathanson MS, Witter FR, O'Brien KO,. Vitamin D insufficiency is prevalent among pregnant African American adolescents. J Pediatr Adolesc Gynecol. 2010; 23: 45-52.
46. Hensel KJ, Randis TM, Gelber SE, Ratner AJ,. Pregnancy-specific association of vitamin D deficiency and bacterial vaginosis. Am J Obstet Gynecol. 2011; 204: 41-9.
47. Dunlop AL, Taylor RN, Tangpricha V, Fortunato S, Menon R,. Maternal vitamin D, folate, and polyunsaturated fatty acid status and bacterial vaginosis during pregnancy. Infect Dis Obstet Gynecol. 2011; 2011: 216217.
48. Merewood A, Mehta SD, Chen TC, Bauchner H, Holick MF,. Association between vitamin D deficiency and primary cesarean section. J Clin Endocrinol Metab. 2009; 94: 940-5.
49. Camargo CA, Rifas-Shiman SL, Litonjua AA, Rich-Edwards JW, Weiss ST, Gold DR, et al,. Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr. 2007; 85: 788-95.
50. Leffelaar ER, Vrijkotte TG, van EM,. Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth: results of the multi-ethnic Amsterdam born children and their development cohort. Br J Nutr. 2010; 104: 108-17.
51. Morley R, Carlin JB, Pasco JA, Wark JD,. Maternal 25-hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size. J Clin Endocrinol Metab. 2006; 91: 906-12.
52. Svare JA, Schmidt H, Hansen BB, Lose G,. Bacterial vaginosis in a cohort of Danish pregnant women: prevalence and relationship with preterm delivery, low birthweight and perinatal infections. Br J Obstet Gynaecol. 2006; 113: 1419-25.
53. Baker AM, Haeri S, Camargo CA, Stuebe AM, Boggess KA,. A nested case-control study of first-trimester maternal vitamin D status and risk for spontaneous preterm birth. Am J Perinatol. 2011; 28: 667-72.
54. Mehta S, Hunter DJ, Mugusi FM, Spiegelman D, Manji KP, Giovannucci EL, et al,. Perinatal outcomes, including mother-to-child transmission of HIV, and child mortality and their association with maternal vitamin D status in Tanzania. J Infect Dis. 2009; 200: 1022-30.
55. Shibata M, Suzuki A, Sekiya T, Sekiguchi S, Asano S, Udagawa Y, et al,. High prevalence of hypovitaminosis D in pregnant Japanese women with threatened premature delivery. J Bone Miner Metab. 2011; 29: 615-20.
56. Murphy PK, Mueller M, Hulsey TC, Ebeling MD, Wagner CL,. An exploratory study of postpartum depression and vitamin d. J Am Psychiatr Nurses Assoc. 2010; 16: 170-7.
57. Agborsangaya CB, Surcel HM, Toriola AT, Pukkala E, Parkkila S, Tuohimaa P, et al,. Serum 25-hydroxyvitamin D at pregnancy and risk of breast cancer in a prospective study. Eur J Cancer. 2010; 46: 467-70.
58. Lucas RM, Ponsonby AL, Pasco JA, Morley R,. Future health implications of prenatal and early-life vitamin D status. Nutr Rev. 2008; 66: 710-20.
59. Halloran BP, Deluca HF,. Effect of vitamin D deficiency on fertility and reproductive capacity in the female rat. J Nutr. 1980; 110: 1573-80.
60. Byrdwell WC, DeVries J, Exler J, Harnly JM, Holden JM, Holick MF, et al,. Analyzing vitamin D in foods and supplements: methodologic challenges. Am J Clin Nutr. 2008; 88: 554S-7S.
61. Sorensen IM, Joner G, Jenum PA, Eskild A, Torjesen PA, Stene LC,. Maternal serum levels of 25-hydroxy-vitamin d during pregnancy and risk of type 1 diabetes in the offspring. Diabetes. 2012; 61: 175-8.
62. Hoang MT, Defina LF, Willis BL, Leonard DS, Weiner MF, Brown ES,. Association between low serum 25-hydroxyvitamin D and depression in a large sample of healthy adults: the Cooper Center longitudinal study. Mayo Clin Proc. 2011; 86: 1050-5.
63. Parker G, Brotchie H,. 'D' for depression: any role for vitamin D?'Food for Thought' II. Acta Psychiatr Scand. 2011; 124: 243-9.
64. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, et al,. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010; 376: 180-8.
65. Ahn J, Yu K, Stolzenberg-Solomon R, McCullough ML, Gallicchio L, Jacobs EJ, et al,. Genome-wide association study of circulating vitamin D levels. Hum Mol Genet. 2010; 19: 2739-45.
66. Hypponen E, Berry DJ, Wjst M, Power C,. Serum 25-hydroxyvitamin D and IgE-a significant but nonlinear relationship. Allergy. 2009; 64: 613-20.
67. Engelman CD, Meyers KJ, Ziegler JT, Taylor KD, Palmer ND, Haffner SM, et al,. Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS family study. J Steroid Biochem Mol Biol. 2010; 122: 186-92.
68. Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, Burrell A, et al,. A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Res. 2010; 20: 1352-60.
69. Berry D, Hypponen E,. Determinants of vitamin D status: focus on genetic variations. Curr Opin Nephrol Hypertens. 2011; 20: 331-6.
70. Ramos-Lopez E, Kahles H, Weber S, Kukic A, Penna-Martinez M, Badenhoop K, et al,. Gestational diabetes mellitus and vitamin D deficiency: genetic contribution of CYP27B1 and CYP2R1 polymorphisms. Diabetes Obes Metab. 2008; 10: 683-5.
71. Aslani S, Hossein-Nezhad A, Mirzaei K, Maghbooli Z, Afshar AN, Karimi F,. VDR FokI polymorphism and its potential role in the pathogenesis of gestational diabetes mellitus and its complications. Gynecol Endocrinol. 2011; 27: 1065-60.
72. Lai JK, Lucas RM, Banks E, Ponsonby AL,. Variability in vitamin D assays impairs clinical assessment of vitamin D status. Intern Med J. 2011.
73. Christesen HT, Elvander C, Lamont RF, Jørgensen JS,. The impact of vitamin D in pregnancy on extraskeletal health in children: a systematic review. Acta Obstet Gynecol Scand. 2012; 91: 1368-80