Vitamin D and DBP: The free hormone hypothesis revisited

Journal of Steroid Biochemistry and Molecular Biology

Volumn 144, Issue PART A, 2014, Pages 132-137

  Chun, Rene F ^a   Peercy, Bradford E ^b   Orwoll, Eric S ^c   Nielson, Carrie M ^c   Adams, John S ^a   Hewison, Martin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Bioavailable; Free hormone; Intracrine; Megalin; Vitamin D; Vitamin D binding protein

Indexed keywords

25 HYDROXYVITAMIN D; MEGALIN; OXYGENASE; VITAMIN D; VITAMIN D BINDING PROTEIN; ALBUMIN; CALCITRIOL;

BINDING AFFINITY; BONE DISEASE; BONE MINERALIZATION; DIET RESTRICTION; DIFFUSION; ENDOCYTOSIS; HUMAN; INTERNALIZATION; KIDNEY TUBULE CELL; KNOCKOUT MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; REVIEW; VITAMIN BLOOD LEVEL; VITAMIN METABOLISM; CIRCULATION; CONFERENCE PAPER; PROTEIN BLOOD LEVEL; VITAMIN D DEFICIENCY;

BIOAVAILABLE; FREE HORMONE; INTRACRINE; MEGALIN; VITAMIN D; VITAMIN D BINDING PROTEIN;

ANIMALS; HUMANS; VITAMIN D; VITAMIN D DEFICIENCY; VITAMIN D-BINDING PROTEIN;

EID: 84906790959     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2013.09.012     Document Type: Review

References (54)

1. M. Orchinik, N. Hastings, D. Witt, and B.S. McEwen High-affinity binding of corticosterone to mammalian neuronal membranes: possible role of corticosteroid binding globulin Journal of Steroid Biochemistry and Molecular Biology 60 3-4 1997 229 236
2. M.S. Khan, D.J. Hryb, G.A. Hashim, N.A. Romas, and W. Rosner Delineation and synthesis of the membrane receptor-binding domain of sex hormone-binding globulin Journal of Biological Chemistry 265 30 1990 18362 18365
3. G.L. Hammond Potential functions of plasma steroid-binding proteins Trends in Endocrinology and Metabolism: TEM 6 9-10 1995 298 304
4. W. Rosner, D.J. Hryb, M.S. Khan, A.M. Nakhla, and N.A. Romas Androgen and estrogen signaling at the cell membrane via G-proteins and cyclic adenosine monophosphate Steroids 64 1-2 1999 100 106
5. W. Rosner, D.J. Hryb, M.S. Khan, A.M. Nakhla, and N.A. Romas Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane Journal of Steroid Biochemistry and Molecular Biology 69 1-6 1999 481 485
6. N. Yamamoto, and V.R. Naraparaju Role of vitamin D3-binding protein in activation of mouse macrophages Journal of Immunology 157 4 1996 1744 1749
7. J.M. Sanger et al. Disruption of microfilament organization in living nonmuscle cells by microinjection of plasma vitamin D-binding protein or DNase I Proceedings of the National Academy of Sciences of the United States of America 87 14 1990 5474 5478
8. D. Zehnder et al. Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase Journal of Clinical Endocrinology and Metabolism 86 2 2001 888 894
9. M. Hewison Vitamin D and the intracrinology of innate immunity Molecular and Cellular Endocrinology 321 2 2010 103 111
10. M. Hewison et al. Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease Journal of Steroid Biochemistry and Molecular Biology 103 3-5 2007 316 321
11. J.S. Adams, and M. Hewison Update in vitamin D Journal of Clinical Endocrinology and Metabolism 95 2 2010 471 478
12. N.E. Cooke, and J.G. Haddad Vitamin D binding protein (Gc-globulin) Endocrine Reviews 10 3 1989 294 307
13. D.D. Bikle, E. Gee, B. Halloran, and J.G. Haddad Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease Journal of Clinical Investigation 74 6 1984 1966 1971
14. R. Bouillon, F.A. Van Assche, H. Van Baelen, W. Heyns, and P. De Moor Influence of the vitamin D-binding protein on the serum concentration of 1,25-dihydroxyvitamin D3. Significance of the free 1,25-dihydroxyvitamin D3 concentration Journal of Clinical Investigation 67 3 1981 589 596
15. C.M. Mendel The free hormone hypothesis: A physiologically based mathematical model Endocrine Reviews 10 3 1989 232 274
16. G.L. Hammond Access of reproductive steroids to target tissues Obstetrics and Gynecology Clinics of North America 29 3 2002 411 423
17. R. Vieth Simple method for determining specific binding capacity of vitamin D-binding protein and its use to calculate the concentration of "free" 1,25-dihydroxyvitamin D Clinical Chemistry 40 3 1994 435 441
18. S.K. Moestrup, and P.J. Verroust Megalin- and cubilin-mediated endocytosis of protein-bound vitamins, lipids, and hormones in polarized epithelia Annual Review of Nutrition 21 2001 407 428
19. E.I. Christensen, and H. Birn Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule. American journal of physiology Renal Physiology 280 4 2001 F562 F573
20. A. Nykjaer et al. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3 Cell 96 4 1999 507 515
21. A. Nykjaer et al. Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3) Proceedings of the National Academy of Sciences of the United States of America 98 24 2001 13895 13900
22. S.M. Morris, M.D. Tallquist, C.O. Rock, and J.A. Cooper Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport EMBO Journal 21 7 2002 1555 1564
23. S. Lundgren et al. Tissue distribution of human gp330/megalin, a putative Ca(2+)-sensing protein Journal of Histochemistry and Cytochemistry 45 3 1997 383 392
24. M.J. Rowling, C.M. Kemmis, D.A. Taffany, and J. Welsh Megalin-mediated endocytosis of vitamin D binding protein correlates with 25- hydroxycholecalciferol actions in human mammary cells Journal of Nutrition 136 11 2006 2754 2759
25. T.M. Chlon, D.A. Taffany, J. Welsh, and M.J. Rowling Retinoids modulate expression of the endocytic partners megalin, cubilin, and disabled-2 and uptake of vitamin D-binding protein in human mammary cells Journal of Nutrition 138 7 2008 1323 1328
26. M. van Driel et al. Evidence for auto/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 20 13 2006 2417 2419
27. G.J. Atkins et al. Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha, 25-dihydroxyvitamin D3 Bone 40 6 2007 1517 1528
28. F.F. Safadi et al. Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein Journal of Clinical Investigation 103 2 1999 239 251
29. L.A. Zella, N.K. Shevde, B.W. Hollis, N.E. Cooke, and J.W. Pike Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo Endocrinology 149 7 2008 3656 3667
30. C. Esteban et al. Receptor-mediated uptake and processing of vitamin D-binding protein in human B-lymphoid cells Journal of Biological Chemistry 267 14 1992 10177 10183
31. M. Petrini, R.M. Galbraith, D.L. Emerson, A.E. Nel, and P. Arnaud Structural studies of T lymphocyte Fc receptors. Association of Gc protein with IgG binding to Fc gamma Journal of Biological Chemistry 260 3 1985 1804 1810
32. P.T. Liu et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response Science 311 5768 2006 1770 1773
33. J.S. Adams et al. Vitamin d-directed rheostatic regulation of monocyte antibacterial responses Journal of Immunology 182 7 2009 4289 4295
34. R.F. Chun et al. Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxyvitamin D Journal of Clinical Endocrinology and Metabolism 95 7 2010 3368 3376
35. L.E. Jeffery et al. Availability of 25-hydroxyvitamin D3 to APCs controls the balance between regulatory and inflammatory T cell responses Journal of Immunology 189 11 2012 5155 5164
36. D.D. Bikle et al. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein Journal of Clinical Endocrinology and Metabolism 63 4 1986 954 959
37. C.E. Powe et al. Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research 26 7 2011 1609 1616
38. I. Bhan et al. Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients Kidney International 82 1 2012 84 89
39. D.D. Bikle, B.P. Halloran, E. Gee, E. Ryzen, and J.G. Haddad Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitamin D levels Journal of Clinical Investigation 78 3 1986 748 752
40. F.M.S.L. Rosmalen, E.G. Harbers, G.T. Mayer, and G.H. Parsons An Immunoassay for free 25-hydroxyvitamin D Journal of Bone and Mineral Research 26 Suppl. 2011 197
41. D.D. Bikle, P.K. Siiteri, E. Ryzen, and J.G. Haddad Serum protein binding of 1,25-dihydroxyvitamin D: A reevaluation by direct measurement of free metabolite levels Journal of Clinical Endocrinology and Metabolism 61 5 1985 969 975
42. J.F. Dunn Computer simulation of vitamin D transport Annals of the New York Academy of Sciences 538 1988 69 76
43. J. Hirschfled, B. Jonsson, and M R Immune electrophoretic demonstration of qualitative differences in human sera and their relation to the haptoglobins Acta Pathologica Microbiologica 47 1959 160 168
44. J. Arnaud, and J. Constans Affinity differences for vitamin D metabolites associated with the genetic isoforms of the human serum carrier protein (DBP) Human Genetics 92 2 1993 183 188
45. R. Bouillon, H. van Baelen, and P. de Moor Comparative study of the affinity of the serum vitamin D-binding protein Journal of Steroid Biochemistry 13 9 1980 1029 1034
46. A.L. Lauridsen, P. Vestergaard, and E. Nexo Mean serum concentration of vitamin D-binding protein (Gc globulin) is related to the Gc phenotype in women Clinical Chemistry 47 4 2001 753 756
47. M.I. Kamboh, and R.E. Ferrell Ethnic variation in vitamin D-binding protein (GC): A review of isoelectric focusing studies in human populations Human Genetics 72 4 1986 281 293
48. R.F. Chun, B.E. Peercy, J.S. Adams, and M. Hewison Vitamin D binding protein and monocyte response to 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D: analysis by mathematical modeling PloS One 7 1 2012 e30773
49. Z. Dastani et al. In healthy adults, biological activity of vitamin D, as assessed by serum PTH, is largely independent of DBP concentrations Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research 2013
50. M.R. Denburg et al. Vitamin D bioavailability and catabolism in pediatric chronic kidney disease Pediatric Nephrology 28 9 2013 1843 1853
51. S.J. Weinstein et al. Impact of circulating vitamin D binding protein levels on the association between 25-hydroxyvitamin D and pancreatic cancer risk: A nested case-control study Cancer Research 72 5 2012 1190 1198
52. T.O. Carpenter et al. Vitamin D binding protein is a key determinant of 25-hydroxyvitamin D levels in infants and toddlers Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research 28 1 2013 213 221
53. P. Glendenning, G.T. Chew, C.A. Inderjeeth, M. Taranto, and W.D. Fraser Calculated free and bioavailable vitamin D metabolite concentrations in vitamin D-deficient hip fracture patients after supplementation with cholecalciferol and ergocalciferol Bone 56 2 2013 271 275
54. R. Bouillon, D.Z. Xiang, R. Convents, and H. Van Baelen Polyunsaturated fatty acids decrease the apparent affinity of vitamin D metabolites for human vitamin D-binding protein Journal of Steroid Biochemistry and Molecular Biology 42 8 1992 855 861