Genetic variants in CYP2R1, CYP24A1, and VDR modify the efficacy of vitamin D3 supplementation for increasing serum 25-hydroxyvitamin D levels in a randomized controlled trial

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 10, 2014, Pages E2133-E2137

  Barry, Elizabeth L ^a   Rees, Judy R ^a   Peacock, Janet L ^b   Mott, Leila A ^a   Amos, Christopher I ^a   Bostick, Roberd M ^c   Figueiredo, Jane C ^d   Ahnen, Dennis J ^e   Bresalier, Robert S ^f   Burke, Carol A ^g   Baron, John A ^a,h  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^c EMORY UNIVERSITY   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF TEXAS   (United States)

^g LERNER RESEARCH INSTITUTE   (United States)

^h UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; 7 DEHYDROCHOLESTEROL; CALCIUM CARBONATE; CALCIUM SENSING RECEPTOR; COLECALCIFEROL; COLECALCIFEROL 24 HYDROXYLASE; CYTOCHROME P450; CYTOCHROME P450 2R1; UNCLASSIFIED DRUG; VITAMIN D BINDING PROTEIN; VITAMIN D RECEPTOR; 25-HYDROXYVITAMIN D; CALCITRIOL RECEPTOR; CHOLESTANETRIOL 26 MONOOXYGENASE; CYP24A1 PROTEIN, HUMAN; CYP2R1 PROTEIN, HUMAN; VDR PROTEIN, HUMAN; VITAMIN D;

ADULT; AGED; ARTICLE; CASR GENE; COLORECTAL ADENOMA; CYP24A1 GENE; CYP2R1 GENE; DHCR7 GENE; DNA MODIFICATION; GC GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; SINGLE NUCLEOTIDE POLYMORPHISM; THERAPY EFFECT; VDR GENE; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; ANALOGS AND DERIVATIVES; BLOOD; CLINICAL TRIAL; CONTROLLED STUDY; DRUG RESISTANCE; FEMALE; GENETICS; MALE; MIDDLE AGED; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; STATISTICAL MODEL; TREATMENT OUTCOME; VITAMIN D DEFICIENCY;

AGED; CALCIUM CARBONATE; CHOLECALCIFEROL; CHOLESTANETRIOL 26-MONOOXYGENASE; DRUG RESISTANCE; FEMALE; GENETIC VARIATION; GENOTYPE; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CALCITRIOL; TREATMENT OUTCOME; VITAMIN D; VITAMIN D DEFICIENCY; VITAMIN D3 24-HYDROXYLASE;

EID: 84907654800     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-1389     Document Type: Article

References (12)

1. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266-281.
2. McGrath JJ, Saha S, Burne TH, Eyles DW. A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations. J Steroid Biochem Mol Biol. 2010;121:471-477.
3. Dastani Z, Li R, Richards B. Genetic regulation of vitamin D levels. Calcif Tissue Int. 2013;92:106-117.
4. Wang TJ, Zhang F, Richards JB, et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010;376:180-188.
5. Ahn J, Yu K, Stolzenberg-Solomon R, et al. Genome-wide association study of circulating vitamin D levels. Hum Mol Genet. 2010;19:2739-2745.
6. Vickers AJ, Altman DG. Statistics notes: analysing controlled trials with baseline and follow up measurements. BMJ. 2001;323:1123-1124.
7. Yao S, Zirpoli G, Bovbjerg DH, et al. Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study. Breast Cancer Res. 2012;14:R58.
8. Shen H, Bielak LF, Ferguson JF, et al. Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification. Arterioscler Thromb Vasc Biol. 2010;30:2648-2654.
9. Mondul AM, Shui IM, Yu K, et al. Genetic variation in the vitamin D pathway in relation to risk of prostate cancer-results from the breast and prostate cancer cohort consortium. Cancer Epidemiol Biomarkers Prev. 2013;22:688-696.
10. Levin GP, Robinson-Cohen C, de Boer IH, et al. Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes. JAMA. 2012;308:1898-1905.
11. Didriksen A, Grimnes G, Hutchinson MS, et al. The serum 25-hydroxy vitamin D response to vitamin D supplementation is related to genetic factors, BMI, and baseline levels. Eur J Endocrinol. 2013;169:559-567.
12. Fu L, Yun F, Oczak M, Wong BY, Vieth R, Cole DE. Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25 (OH) D] to vitamin D supplementation. Clin Biochem. 2009;42:1174-1177.