Calcitriol downregulates TNF-α and IL-6 expression in cultured placental cells from preeclamptic women

Cytokine

Volumn 61, Issue 1, 2013, Pages 245-250

  Noyola Martínez, Nancy ^a,b   Díaz, Lorenza ^a   Avila, Euclides ^a   Halhali, Ali ^a   Larrea, Fernando ^a   Barrera, David ^a  

^a INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

IFN ; IL 1 ; Preeclampsia; Pregnancy; Vitamin D

Indexed keywords

CALCITRIOL; CHORIONIC GONADOTROPIN BETA SUBUNIT; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; AUTOCRINE EFFECT; CELL CULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GAMMA INTERFERON GENE; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN CHORIONIC GONADOTROPIN BETA SUBUNIT 5 GENE; INTERLEUKIN 1BETA GENE; INTERLEUKIN 6 GENE; NUCLEOTIDE SEQUENCE; PARACRINE SIGNALING; POLYMERASE CHAIN REACTION; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH1 CELL; TROPHOBLAST; TUMOR NECROSIS FACTOR ALPHA GENE;

EID: 84869868956     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2012.10.001     Document Type: Article

References (42)

1. Aquila S., Guido C., Perrotta I., Tripepi S., Nastro A., Ando S. Human sperm anatomy: ultrastructural localization of 1alpha,25-dihydroxyvitamin D receptor and its possible role in the human male gamete. J Anat 2008, 213:555-564.
2. Pospechova K., Rozehnal V., Stejskalova L., Vrzal R., Pospisilova N., Jamborova G., et al. Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma BeWo and JEG-3 cell lines. Mol Cell Endocrinol 2009, 299:178-187.
3. Kovacs C.S. Vitamin D In pregnancy and lactation: maternal, fetal, and neonatal outcomes from human and animal studies. Am J Clin Nutr 2008, 88:520S-528S.
4. Liu N.Q., Hewison M. Vitamin D, the placenta and pregnancy. Arch Biochem Biophys 2011, 523:37-47.
5. Halhali A., Figueras A.G., Diaz L., Avila E., Barrera D., Hernandez G., et al. Effects of calcitriol on calbindins gene expression and lipid peroxidation in human placenta. J Steroid Biochem Mol Biol 2010, 121:448-451.
6. Barrera D., Avila E., Hernandez G., Halhali A., Biruete B., Larrea F., et al. Estradiol and progesterone synthesis in human placenta is stimulated by calcitriol. J Steroid Biochem Mol Biol 2007, 103:529-532.
7. Barrera D., Avila E., Hernandez G., Mendez I., Gonzalez L., Halhali A., et al. Calcitriol affects hCG gene transcription in cultured human syncytiotrophoblasts. Reprod Biol Endocrinol 2008, 6:3.
8. Stephanou A., Ross R., Handwerger S. Regulation of human placental lactogen expression by 1,25-dihydroxyvitamin D3. Endocrinology 1994, 135:2651-2656.
9. Hewison M., Vitamin D. And the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am 2010, 39:365-379.
10. Liu N., Kaplan A.T., Low J., Nguyen L., Liu G.Y., Equils O., et al. Vitamin D induces innate antibacterial responses in human trophoblasts via an intracrine pathway. Biol Reprod 2009, 80:398-406.
11. Hayes C.E., Nashold F.E., Spach K.M., Pedersen L.B. The immunological functions of the vitamin D endocrine system. Cell Mol Biol (Noisy-le-grand) 2003, 49:277-300.
12. Grundmann M., von Versen-Hoynck F. Vitamin D - roles in women's reproductive health?. Reprod Biol Endocrinol 2011, 9:146.
13. Bodnar L.M., Catov J.M., Simhan H.N., Holick M.F., Powers R.W., Roberts J.M. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab 2007, 92:3517-3522.
14. Mulligan M.L., Felton S.K., Riek A.E., Bernal-Mizrachi C. Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol 2010, 202. 429 e1-9.
15. Ramma W., Ahmed A. Is inflammation the cause of pre-eclampsia?. Biochem Soc Trans 2011, 39:1619-1627.
16. Saito S., Shiozaki A., Nakashima A., Sakai M., Sasaki Y. The role of the immune system in preeclampsia. Mol Aspects Med 2007, 28:192-209.
17. Serin I.S., Kula M., Basbug M., Unluhizarci K., Gucer S., Tayyar M. Androgen levels of preeclamptic patients in the third trimester of pregnancy and six weeks after delivery. Acta Obstet Gynecol Scand 2001, 80:1009-1013.
18. Diaz L., Arranz C., Avila E., Halhali A., Vilchis F., Larrea F. Expression and activity of 25-hydroxyvitamin D-1 alpha-hydroxylase are restricted in cultures of human syncytiotrophoblast cells from preeclamptic pregnancies. J Clin Endocrinol Metab 2002, 87:3876-3882.
19. Tosun M., Celik H., Avci B., Yavuz E., Alper T., Malatyalioglu E. Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-alpha in normal pregnancies and in pregnancies complicated by preeclampsia. J Matern Fetal Neonatal Med 2010, 23:880-886.
20. Szarka A., Rigo J., Lazar L., Beko G., Molvarec A. Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array. BMC Immunol 2010, 11:59.
21. Kalinderis M., Papanikolaou A., Kalinderi K., Ioannidou E., Giannoulis C., Karagiannis V., et al. Elevated serum levels of interleukin-6, interleukin-1beta and human chorionic gonadotropin in pre-eclampsia. Am J Reprod Immunol 2011, 66:468-475.
22. Stephanou A., Handwerger S. Interleukin-6 stimulates placental lactogen expression by human trophoblast cells. Endocrinology 1994, 135:719-723.
23. Steele G.L., Currie W.D., Leung E.H., Yuen B.H., Leung P.C. Rapid stimulation of human chorionic gonadotropin secretion by interleukin-1 beta from perifused first trimester trophoblast. J Clin Endocrinol Metab 1992, 75:783-788.
24. Haider S., Knofler M. Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. Placenta 2009, 30:111-123.
25. LaMarca B.D., Ryan M.J., Gilbert J.S., Murphy S.R., Granger J.P. Inflammatory cytokines in the pathophysiology of hypertension during preeclampsia. Curr Hypertens Rep 2007, 9:480-485.
26. Diaz L., Noyola-Martinez N., Barrera D., Hernandez G., Avila E., Halhali A., et al. Calcitriol inhibits TNF-alpha-induced inflammatory cytokines in human trophoblasts. J Reprod Immunol 2009, 81:17-24.
27. Evans K.N., Nguyen L., Chan J., Innes B.A., Bulmer J.N., Kilby M.D., et al. Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells. Biol Reprod 2006, 75:816-822.
28. Baeke F., Takiishi T., Korf H., Gysemans C., Mathieu C. Vitamin D: modulator of the immune system. Curr Opin Pharmacol 2010, 10:482-496.
29. Kliman H.J., Nestler J.E., Sermasi E., Sanger J.M., Strauss J.F. Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology 1986, 118:1567-1582.
30. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987, 162:156-159.
31. Crocker I.P., Tansinda D.M., Baker P.N. Altered cell kinetics in cultured placental villous explants in pregnancies complicated by pre-eclampsia and intrauterine growth restriction. J Pathol 2004, 204:11-18.
32. Stephanou A., Myatt L., Eis A.L., Sarlis N., Jikihara H., Handwerger S. Ontogeny of the expression and regulation of interleukin-6 (IL-6) and IL-1 mRNAs by human trophoblast cells during differentiation in vitro. J Endocrinol 1995, 147:487-496.
33. Munno I., Chiechi L.M., Lacedra G., Berardesca C., Patimo C., Marcuccio L., et al. Evaluation of nonspecific immunity and plasma levels of interferon-gamma, interleukin-6 and tumor necrosis factor-alpha in preeclampsia. Immunopharm Immunot 1999, 21:551-564.
34. Rinehart B.K., Terrone D.A., Lagoo-Deenadayalan S., Barber W.H., Hale E.A., Martin J.N., et al. Expression of the placental cytokines tumor necrosis factor alpha, interleukin 1beta, and interleukin 10 is increased in preeclampsia. Am J Obstet Gynecol 1999, 181:915-920.
35. Avila E., Diaz L., Barrera D., Halhali A., Mendez I., Gonzalez L., et al. Regulation of Vitamin D hydroxylases gene expression by 1,25-dihydroxyvitamin D3 and cyclic AMP in cultured human syncytiotrophoblasts. J Steroid Biochem Mol Biol 2007, 103:90-96.
36. Santhanam U., Avila C., Romero R., Viguet H., Ida N., Sakurai S., et al. Cytokines in normal and abnormal parturition: elevated amniotic fluid interleukin-6 levels in women with premature rupture of membranes associated with intrauterine infection. Cytokine 1991, 3:155-163.
37. Erzen B., Sabovic M., Sebestjen M., Keber I., Poredos P. Interleukin-6 correlates with endothelial dysfunction in young post-myocardial infarction patients. Cardiology 2007, 107:111-116.
38. Sharma A., Satyam A., Sharma J.B. Leptin, IL-10 and inflammatory markers (TNF-alpha, IL-6 and IL-8) in pre-eclamptic, normotensive pregnant and healthy non-pregnant women. Am J Reprod Immunol 2007, 58:21-30.
39. Freundlich M., Quiroz Y., Zhang Z., Zhang Y., Bravo Y., Weisinger J.R., et al. Suppression of renin-angiotensin gene expression in the kidney by paricalcitol. Kidney Int 2008, 74:1394-1402.
40. Eleftheriadis T., Antoniadi G., Liakopoulos V., Kartsios C., Stefanidis I., Galaktidou G. Paricalcitol reduces basal and lipopolysaccharide-induced (LPS) TNF-alpha and IL-8 production by human peripheral blood mononuclear cells. Int Urol Nephrol 2010, 42:181-185.
41. Li Y.C., Kong J., Wei M., Chen Z.F., Liu S.Q., Cao L.P. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002, 110:229-238.
42. Dong J, Wong SL, Lau CW, Lee HK, Ng CF, Zhang L, Yao X, Chen ZY, Vanhoutte PM, Huang Y. Cal citriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress. Eur Heart J. http://dx.doi.org/10.1093/eurheartj/ehr459.