Variomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation

Journal of Biological Chemistry

Volumn 290, Issue 2, 2015, Pages 889-903

  Bill, Anke ^a   Popa, M Oana ^a   Van Diepen, Michiel T ^a   Gutierrez, Abraham ^c   Lilley, Sarah ^a   Velkova, Maria ^a   Acheson, Kathryn ^a   Choudhury, Hedaythul ^a   Renaud, Nicole A ^c   Auld, Douglas S ^a   Gosling, Martin ^a   Groot Kormelink, Paul J ^b   Gaither, L Alex ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; CHLORINE COMPOUNDS;

CHANNEL ACTIVATION; CHLORIDE CHANNELS; FUNCTIONAL CHARACTERISTICS; INTRACELLULAR TRAFFICKING; PHYSIOLOGICAL PROCESS; RANDOM MUTAGENESIS; STRUCTURE-FUNCTION RELATIONSHIP; VOLTAGE SENSITIVITY;

CALCIUM;

CALCIUM ACTIVATED CHLORIDE CHANNEL; CALCIUM ACTIVATED CHLORIDE CHANNEL ANO1; UNCLASSIFIED DRUG; ANO1 PROTEIN, HUMAN; CHLORIDE CHANNEL; ION CHANNEL; TUMOR PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BIOINFORMATICS; CALCIUM BINDING; CELLULAR DISTRIBUTION; CHANNEL GATING; CONTROLLED STUDY; EMBRYO; GENOMICS; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MEMBRANE POTENTIAL; NEXT GENERATION SEQUENCING; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; REENTRANT LOOP; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VARIOMICS; VOLTAGE CLAMP TECHNIQUE; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; GENETICS; HEK293 CELL LINE; METABOLISM; PROTEIN CONFORMATION;

ANIMALS; CHLORIDE CHANNELS; CHO CELLS; CRICETULUS; HEK293 CELLS; HUMANS; ION CHANNELS; MUTAGENESIS, SITE-DIRECTED; NEOPLASM PROTEINS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84920904077     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.618140     Document Type: Article

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