High throughput mutagenesis for identification of residues regulating human prostacyclin (hIP) receptor

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Bill, Anke ^a   Rosethorne, Elizabeth M ^a   Kent, Toby C ^a   Fawcett, Lindsay ^a   Burchell, Lynn ^a   Van Diepen, Michiel T ^a   Marelli, Anthony ^b   Batalov, Sergey ^b   Miraglia, Loren ^b   Orth, Anthony P ^b   Renaud, Nicole A ^a   Charlton, Steven J ^a   Gosling, Martin ^a   Gaither, L Alex ^a   Groot Kormelink, Paul J ^a,c  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PROSTACYCLIN RECEPTOR; AMINO ACID; HYDROXYLAMINE; PROSTAGLANDIN RECEPTOR; PTGIR PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ARTICLE; CELL SURFACE; CHEMICAL MUTAGENESIS; CODON; CONTROLLED STUDY; DNA SEQUENCE; GENE LIBRARY; GENETIC CODE; HIGH THROUGHPUT MUTAGENESIS; MUTAGENESIS; MUTATION RATE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SITE DIRECTED MUTAGENESIS; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; COMPUTER SIMULATION; GENETICS; HEK293 CELL LINE; HIGH THROUGHPUT SEQUENCING; HUMAN; MUTATION;

AMINO ACIDS; COMPUTER SIMULATION; HEK293 CELLS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; HYDROXYLAMINE; MUTAGENESIS; MUTATION; MUTATION RATE; POLYMERASE CHAIN REACTION; RECEPTORS, PROSTAGLANDIN;

EID: 84902332585     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097973     Document Type: Article

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