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Volumn 42, Issue 2, 2015, Pages 125-138

Overview of clinically approved oral antidiabetic agents for the treatment of type 2 diabetes mellitus

Author keywords

Biguanide; Dipeptidyl peptidase 4; Metformin; Sulphonylurea; Type 2 diabetes mellitus

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ALDOSE REDUCTASE INHIBITOR; ALPHA GLUCOSIDASE INHIBITOR; AMYLIN RECEPTOR AGONIST; ANOREXIGENIC AGENT; BIGUANIDE DERIVATIVE; BROMOCRIPTINE; DOPAMINE 2 RECEPTOR STIMULATING AGENT; G PROTEIN COUPLED RECEPTOR; GLITAZAR DERIVATIVE; GLITAZONE DERIVATIVE; GLUCOSIDASE; METFORMIN; ORAL ANTIDIABETIC AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PROTEIN SERINE THREONINE KINASE; SODIUM GLUCOSE COTRANSPORTER INHIBITOR; SULFONYLUREA DERIVATIVE; TRANSCRIPTION FACTOR; VOLTAGE GATED POTASSIUM CHANNEL; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL;

EID: 84920870211     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/1440-1681.12332     Document Type: Article
Times cited : (56)

References (100)
  • 1
    • 84872836127 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus in 2012. Optimal management of T2DM remains elusive
    • Holman RR. Type 2 diabetes mellitus in 2012. Optimal management of T2DM remains elusive. Nat. Rev. Endocrinol. 2013; 9: 67-8.
    • (2013) Nat. Rev. Endocrinol. , vol.9 , pp. 67-68
    • Holman, R.R.1
  • 2
    • 84874184400 scopus 로고    scopus 로고
    • A review of the efficacy and safety of oral antidiabetic drugs
    • Stein SA, Lamos EM, Davis SN. A review of the efficacy and safety of oral antidiabetic drugs. Expert Opin. Drug Saf. 2013; 12: 153-75.
    • (2013) Expert Opin. Drug Saf. , vol.12 , pp. 153-175
    • Stein, S.A.1    Lamos, E.M.2    Davis, S.N.3
  • 3
    • 0035544952 scopus 로고    scopus 로고
    • Aldose reductase inhibitors
    • Oka M, Kato N. Aldose reductase inhibitors. J. Enzyme Inhib. 2001; 16: 465-73.
    • (2001) J. Enzyme Inhib. , vol.16 , pp. 465-473
    • Oka, M.1    Kato, N.2
  • 4
    • 0021323690 scopus 로고
    • N-[5-(Trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]-N-methylglycine (tolrestat), a potent, orally active aldose reductase inhibitor
    • Sestanj K, Bellini F, Fung S et al. N-[5-(Trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]-N-methylglycine (tolrestat), a potent, orally active aldose reductase inhibitor. J. Med. Chem. 1984; 27: 255-6.
    • (1984) J. Med. Chem. , vol.27 , pp. 255-256
    • Sestanj, K.1    Bellini, F.2    Fung, S.3
  • 5
    • 0031039903 scopus 로고    scopus 로고
    • Worldwide pharmacovigilance systems and tolrestat withdrawal
    • Foppiano M, Lombardo G. Worldwide pharmacovigilance systems and tolrestat withdrawal. Lancet 1997; 349: 399-400.
    • (1997) Lancet , vol.349 , pp. 399-400
    • Foppiano, M.1    Lombardo, G.2
  • 6
    • 0034845679 scopus 로고    scopus 로고
    • Amylin receptor agonists: A novel pharmacological approach in the management of insulin-treated diabetes mellitus
    • Nyholm B, Brock B, Orskov L, Schmitz O. Amylin receptor agonists: A novel pharmacological approach in the management of insulin-treated diabetes mellitus. Expert Opin. Investig. Drugs 2001; 10: 1641-52.
    • (2001) Expert Opin. Investig. Drugs , vol.10 , pp. 1641-1652
    • Nyholm, B.1    Brock, B.2    Orskov, L.3    Schmitz, O.4
  • 7
    • 84859721063 scopus 로고    scopus 로고
    • DPP-4 inhibitors in the management of type 2 diabetes: A critical review of head-to-head trials
    • Scheen AJ. DPP-4 inhibitors in the management of type 2 diabetes: A critical review of head-to-head trials. Diabetes Metab. 2012; 38: 89-101.
    • (2012) Diabetes Metab. , vol.38 , pp. 89-101
    • Scheen, A.J.1
  • 8
    • 84869998632 scopus 로고    scopus 로고
    • Dapagliflozin: A review of its use in type 2 diabetes mellitus
    • Plosker GL. Dapagliflozin: A review of its use in type 2 diabetes mellitus. Drugs 2012; 72: 2289-312.
    • (2012) Drugs , vol.72 , pp. 2289-2312
    • Plosker, G.L.1
  • 9
    • 84865661999 scopus 로고    scopus 로고
    • Linagliptin. A review of its use in the management of type 2 diabetes mellitus
    • Deeks ED. Linagliptin. A review of its use in the management of type 2 diabetes mellitus. Drugs 2012; 72: 1793-824.
    • (2012) Drugs , vol.72 , pp. 1793-1824
    • Deeks, E.D.1
  • 12
    • 84858141351 scopus 로고    scopus 로고
    • Liraglutide: From clinical trials to clinical practice
    • Gough SC. Liraglutide: From clinical trials to clinical practice. Diabetes Obes. Metab. 2012; 14 (Suppl. 2): 33-40.
    • (2012) Diabetes Obes. Metab. , vol.14 , pp. 33-40
    • Gough, S.C.1
  • 13
    • 84877301983 scopus 로고    scopus 로고
    • Amylin uncovered: A review on the polypeptide responsible for type II diabetes
    • Pillay K, Govender P. Amylin uncovered: A review on the polypeptide responsible for type II diabetes. Biomed. Res. Int. 2013; 2013: 826706.
    • (2013) Biomed. Res. Int. , vol.2013 , pp. 826706
    • Pillay, K.1    Govender, P.2
  • 14
    • 77952952796 scopus 로고    scopus 로고
    • Adjunct therapy for type 1 diabetes mellitus
    • Lebovitz HE. Adjunct therapy for type 1 diabetes mellitus. Nat. Rev. Endocrinol. 2010; 6: 326-34.
    • (2010) Nat. Rev. Endocrinol. , vol.6 , pp. 326-334
    • Lebovitz, H.E.1
  • 15
    • 0038102668 scopus 로고    scopus 로고
    • Pramlintide for the treatment of diabetes mellitus
    • Kleppinger EL, Vivian EM. Pramlintide for the treatment of diabetes mellitus. Ann. Pharmacother. 2003; 37: 1082-9.
    • (2003) Ann. Pharmacother. , vol.37 , pp. 1082-1089
    • Kleppinger, E.L.1    Vivian, E.M.2
  • 16
    • 79956109928 scopus 로고    scopus 로고
    • Pramlintide and the treatment of diabetes: A review of the data since its introduction
    • Younk LM, Mikeladze M, Davis SN. Pramlintide and the treatment of diabetes: A review of the data since its introduction. Expert Opin. Pharmacother. 2011; 12: 1439-51.
    • (2011) Expert Opin. Pharmacother. , vol.12 , pp. 1439-1451
    • Younk, L.M.1    Mikeladze, M.2    Davis, S.N.3
  • 17
    • 0036329452 scopus 로고    scopus 로고
    • Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: From metabolic fluxes to gene expression
    • Kohl C, Ravel D, Girard J, Pegorier JP. Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: From metabolic fluxes to gene expression. Diabetes 2002; 51: 2363-8.
    • (2002) Diabetes , vol.51 , pp. 2363-2368
    • Kohl, C.1    Ravel, D.2    Girard, J.3    Pegorier, J.P.4
  • 18
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998; 352: 854-65.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 19
    • 84875126739 scopus 로고    scopus 로고
    • Antidiabetic agents: Past, present and future
    • Mehanna A. Antidiabetic agents: Past, present and future. Future Med. Chem. 2013; 5: 411-30.
    • (2013) Future Med. Chem. , vol.5 , pp. 411-430
    • Mehanna, A.1
  • 20
    • 84873707522 scopus 로고    scopus 로고
    • Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
    • Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ. Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature 2013; 494: 256-60.
    • (2013) Nature , vol.494 , pp. 256-260
    • Miller, R.A.1    Chu, Q.2    Xie, J.3    Foretz, M.4    Viollet, B.5    Birnbaum, M.J.6
  • 22
    • 84875738351 scopus 로고    scopus 로고
    • Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism
    • Cabreiro F, Au C, Leung KY et al. Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 2013; 153: 228-39.
    • (2013) Cell , vol.153 , pp. 228-239
    • Cabreiro, F.1    Au, C.2    Leung, K.Y.3
  • 23
    • 0038727578 scopus 로고    scopus 로고
    • Kinetics of plasma and erythrocyte metformin after acute administration in healthy subjects
    • Robert F, Fendri S, Hary L, Lacroix C, Andrejak M, Lalau JD. Kinetics of plasma and erythrocyte metformin after acute administration in healthy subjects. Diabetes Metab. 2003; 29: 279-83.
    • (2003) Diabetes Metab. , vol.29 , pp. 279-283
    • Robert, F.1    Fendri, S.2    Hary, L.3    Lacroix, C.4    Andrejak, M.5    Lalau, J.D.6
  • 24
    • 84855850294 scopus 로고    scopus 로고
    • Bile acid sequestrants: More than simple resins
    • Out C, Groen AK, Brufau G. Bile acid sequestrants: More than simple resins. Curr. Opin. Lipidol. 2012; 23: 43-55.
    • (2012) Curr. Opin. Lipidol. , vol.23 , pp. 43-55
    • Out, C.1    Groen, A.K.2    Brufau, G.3
  • 25
    • 84857716618 scopus 로고    scopus 로고
    • Role of bile acid sequestrants in the treatment of type 2 diabetes
    • Takebayashi K, Aso Y, Inukai T. Role of bile acid sequestrants in the treatment of type 2 diabetes. World J. Diabetes 2010; 1: 146-52.
    • (2010) World J. Diabetes , vol.1 , pp. 146-152
    • Takebayashi, K.1    Aso, Y.2    Inukai, T.3
  • 26
  • 27
    • 84859977229 scopus 로고    scopus 로고
    • Comparison of metformin and insulin versus insulin alone for type 2 diabetes. Systematic review of randomised clinical trials with meta-analyses and trial sequential analyses
    • Hemmingsen B, Christensen LL, Wetterslev J et al. Comparison of metformin and insulin versus insulin alone for type 2 diabetes. Systematic review of randomised clinical trials with meta-analyses and trial sequential analyses. BMJ 2012; 344: e1771.
    • (2012) BMJ , vol.344 , pp. e1771
    • Hemmingsen, B.1    Christensen, L.L.2    Wetterslev, J.3
  • 28
    • 84867071091 scopus 로고    scopus 로고
    • An update in incretin-based therapy. A focus on glucagon-like peptide-1 receptor agonists
    • Edwards KL, Stapleton M, Weis J, Irons BK. An update in incretin-based therapy. A focus on glucagon-like peptide-1 receptor agonists. Diabetes Technol. Ther. 2012; 14: 951-67.
    • (2012) Diabetes Technol. Ther. , vol.14 , pp. 951-967
    • Edwards, K.L.1    Stapleton, M.2    Weis, J.3    Irons, B.K.4
  • 31
    • 84879133253 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus: A review of direct comparisons of efficacy, safety and patient satisfaction
    • Russell S. Incretin-based therapies for type 2 diabetes mellitus: A review of direct comparisons of efficacy, safety and patient satisfaction. Int. J. Clin. Pharm. 2013; 35: 159-72.
    • (2013) Int. J. Clin. Pharm. , vol.35 , pp. 159-172
    • Russell, S.1
  • 33
    • 77958579813 scopus 로고    scopus 로고
    • Bromocriptine: Old drug, new formulation and new indication
    • Holt RI, Barnett AH, Bailey CJ. Bromocriptine: Old drug, new formulation and new indication. Diabetes Obes. Metab. 2010; 12: 1048-57.
    • (2010) Diabetes Obes. Metab. , vol.12 , pp. 1048-1057
    • Holt, R.I.1    Barnett, A.H.2    Bailey, C.J.3
  • 34
    • 0038007567 scopus 로고    scopus 로고
    • Modulation of monoaminergic neural circuits. Potential for the treatment of type 2 diabetes mellitus
    • Pijl H, Edo AM. Modulation of monoaminergic neural circuits. Potential for the treatment of type 2 diabetes mellitus. Treat. Endocrinol. 2002; 1: 71-8.
    • (2002) Treat. Endocrinol. , vol.1 , pp. 71-78
    • Pijl, H.1    Edo, A.M.2
  • 36
    • 84869752516 scopus 로고    scopus 로고
    • α-Glucosidase inhibitors and their use in clinical practice
    • Derosa G, Maffioli P. α-Glucosidase inhibitors and their use in clinical practice. Arch. Med. Sci. 2012; 8: 899-906.
    • (2012) Arch. Med. Sci. , vol.8 , pp. 899-906
    • Derosa, G.1    Maffioli, P.2
  • 37
    • 57349160286 scopus 로고    scopus 로고
    • Medical management of hyperglycaemia in type 2 diabetes mellitus. A consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB et al. Medical management of hyperglycaemia in type 2 diabetes mellitus. A consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 2009; 52: 17-30.
    • (2009) Diabetologia , vol.52 , pp. 17-30
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 38
    • 84874610030 scopus 로고    scopus 로고
    • Synthesis of novel triterpene and N-allylated/N-alkylated niacin hybrids as alpha-glucosidase inhibitors
    • Narender T, Madhur G, Jaiswal N et al. Synthesis of novel triterpene and N-allylated/N-alkylated niacin hybrids as alpha-glucosidase inhibitors. Eur. J. Med. Chem. 2013; 63: 162-9.
    • (2013) Eur. J. Med. Chem. , vol.63 , pp. 162-169
    • Narender, T.1    Madhur, G.2    Jaiswal, N.3
  • 39
    • 84871093044 scopus 로고    scopus 로고
    • Taspoglutide, a once-weekly glucagon-like peptide 1 analogue, vs. insulin glargine titrated to target in patients with Type 2 diabetes: An open-label randomized trial
    • Nauck M, Horton E, Andjelkovic M et al. Taspoglutide, a once-weekly glucagon-like peptide 1 analogue, vs. insulin glargine titrated to target in patients with Type 2 diabetes: An open-label randomized trial. Diabet. Med. 2013; 30: 109-13.
    • (2013) Diabet. Med. , vol.30 , pp. 109-113
    • Nauck, M.1    Horton, E.2    Andjelkovic, M.3
  • 41
    • 84856104937 scopus 로고    scopus 로고
    • Repaglinide: A review of its use in type 2 diabetes mellitus
    • Scott LJ. Repaglinide: A review of its use in type 2 diabetes mellitus. Drugs 2012; 72: 249-72.
    • (2012) Drugs , vol.72 , pp. 249-272
    • Scott, L.J.1
  • 42
    • 38149009549 scopus 로고    scopus 로고
    • A review of nateglinide in the management of patients with type 2 diabetes
    • Tentolouris N, Voulgari C, Katsilambros N. A review of nateglinide in the management of patients with type 2 diabetes. Vasc. Health Risk Manag. 2007; 3: 797-807.
    • (2007) Vasc. Health Risk Manag. , vol.3 , pp. 797-807
    • Tentolouris, N.1    Voulgari, C.2    Katsilambros, N.3
  • 43
    • 0034864434 scopus 로고    scopus 로고
    • Nateglinide: A new rapid-acting insulinotropic agent
    • Hanif W, Kumar S. Nateglinide: A new rapid-acting insulinotropic agent. Expert Opin. Pharmacother. 2001; 2: 1027-31.
    • (2001) Expert Opin. Pharmacother. , vol.2 , pp. 1027-1031
    • Hanif, W.1    Kumar, S.2
  • 46
    • 84908339916 scopus 로고    scopus 로고
    • SGLT-2 inhibitors as second-line therapy in type 2 diabetes
    • Tahrani AA. SGLT-2 inhibitors as second-line therapy in type 2 diabetes. Lancet Diabetes Endocrinol. 2014; 2: 678-9.
    • (2014) Lancet Diabetes Endocrinol. , vol.2 , pp. 678-679
    • Tahrani, A.A.1
  • 47
    • 84884125716 scopus 로고    scopus 로고
    • SGLT2 inhibitors for diabetes: Turning symptoms into therapy
    • Diamant M, Morsink LM. SGLT2 inhibitors for diabetes: Turning symptoms into therapy. Lancet 2013; 382: 917-8.
    • (2013) Lancet , vol.382 , pp. 917-918
    • Diamant, M.1    Morsink, L.M.2
  • 48
    • 77956319973 scopus 로고    scopus 로고
    • Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus
    • Nomura S, Sakamaki S, Hongu M et al. Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus. J. Med. Chem. 2010; 53: 6355-60.
    • (2010) J. Med. Chem. , vol.53 , pp. 6355-6360
    • Nomura, S.1    Sakamaki, S.2    Hongu, M.3
  • 49
    • 84879496400 scopus 로고    scopus 로고
    • Canagliflozin: First global approval
    • Elkinson S, Scott LJ. Canagliflozin: First global approval. Drugs 2013; 73: 979-88.
    • (2013) Drugs , vol.73 , pp. 979-988
    • Elkinson, S.1    Scott, L.J.2
  • 50
    • 84880000540 scopus 로고    scopus 로고
    • Canagliflozin for the treatment of type 2 diabetes
    • Babu A. Canagliflozin for the treatment of type 2 diabetes. Drugs Today 2013; 49: 363-76.
    • (2013) Drugs Today , vol.49 , pp. 363-376
    • Babu, A.1
  • 51
    • 77953801665 scopus 로고    scopus 로고
    • Multiple-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy overweight and obese subjects: A randomized double-blind study
    • Hussey EK, Dobbins RL, Stoltz RR et al. Multiple-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy overweight and obese subjects: A randomized double-blind study. J. Clin. Pharmacol. 2010; 50: 636-46.
    • (2010) J. Clin. Pharmacol. , vol.50 , pp. 636-646
    • Hussey, E.K.1    Dobbins, R.L.2    Stoltz, R.R.3
  • 52
    • 77953734934 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy volunteers and patients with type 2 diabetes mellitus
    • Hussey EK, Clark RV, Amin DM et al. Single-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy volunteers and patients with type 2 diabetes mellitus. J. Clin. Pharmacol. 2010; 50: 623-35.
    • (2010) J. Clin. Pharmacol. , vol.50 , pp. 623-635
    • Hussey, E.K.1    Clark, R.V.2    Amin, D.M.3
  • 53
    • 84877922239 scopus 로고    scopus 로고
    • Ipragliflozin and other sodium-glucose cotransporter-2 (SGLT2) inhibitors in the treatment of type 2 diabetes: Preclinical and clinical data
    • Kurosaki E, Ogasawara H. Ipragliflozin and other sodium-glucose cotransporter-2 (SGLT2) inhibitors in the treatment of type 2 diabetes: Preclinical and clinical data. Pharmacol. Ther. 2013; 139: 51-9.
    • (2013) Pharmacol. Ther. , vol.139 , pp. 51-59
    • Kurosaki, E.1    Ogasawara, H.2
  • 54
    • 84860492610 scopus 로고    scopus 로고
    • Discovery of ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus
    • Imamura M, Nakanishi K, Suzuki T et al. Discovery of ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus. Bioorg. Med. Chem. 2012; 20: 3263-79.
    • (2012) Bioorg. Med. Chem. , vol.20 , pp. 3263-3279
    • Imamura, M.1    Nakanishi, K.2    Suzuki, T.3
  • 55
    • 80155181454 scopus 로고    scopus 로고
    • Effect of ipragliflozin (ASP1941), a novel selective sodium-dependent glucose co-transporter 2 inhibitor, on urinary glucose excretion in healthy subjects
    • Veltkamp SA, Kadokura T, Krauwinkel WJ, Smulders RA. Effect of ipragliflozin (ASP1941), a novel selective sodium-dependent glucose co-transporter 2 inhibitor, on urinary glucose excretion in healthy subjects. Clin. Drug Invest. 2011; 31: 839-51.
    • (2011) Clin. Drug Invest. , vol.31 , pp. 839-851
    • Veltkamp, S.A.1    Kadokura, T.2    Krauwinkel, W.J.3    Smulders, R.A.4
  • 56
    • 82455213037 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and pharmacodynamic profiles of ipragliflozin (ASP1941), a novel and selective inhibitor of sodium-dependent glucose co-transporter 2, in patients with type 2 diabetes mellitus
    • Schwartz SL, Akinlade B, Klasen S, Kowalski D, Zhang W, Wilpshaar W. Safety, pharmacokinetic, and pharmacodynamic profiles of ipragliflozin (ASP1941), a novel and selective inhibitor of sodium-dependent glucose co-transporter 2, in patients with type 2 diabetes mellitus. Diabetes Technol. Ther. 2011; 13: 1219-27.
    • (2011) Diabetes Technol. Ther. , vol.13 , pp. 1219-1227
    • Schwartz, S.L.1    Akinlade, B.2    Klasen, S.3    Kowalski, D.4    Zhang, W.5    Wilpshaar, W.6
  • 57
    • 84876899238 scopus 로고    scopus 로고
    • Active- and placebo-controlled dose-finding study to assess the efficacy, safety, and tolerability of multiple doses of ipragliflozin in patients with type 2 diabetes mellitus
    • Fonseca VA, Ferrannini E, Wilding JP et al. Active- and placebo-controlled dose-finding study to assess the efficacy, safety, and tolerability of multiple doses of ipragliflozin in patients with type 2 diabetes mellitus. J. Diabetes Complicat. 2013; 27: 268-73.
    • (2013) J. Diabetes Complicat. , vol.27 , pp. 268-273
    • Fonseca, V.A.1    Ferrannini, E.2    Wilding, J.P.3
  • 58
    • 84892478812 scopus 로고    scopus 로고
    • Pharmacokinetics, safety and tolerability of empagliflozin, a sodium glucose cotransporter 2 inhibitor, in patients with hepatic impairment
    • Macha S, Rose P, Mattheus M et al. Pharmacokinetics, safety and tolerability of empagliflozin, a sodium glucose cotransporter 2 inhibitor, in patients with hepatic impairment. Diabetes Obes. Metab. 2013; 16: 118-23.
    • (2013) Diabetes Obes. Metab. , vol.16 , pp. 118-123
    • Macha, S.1    Rose, P.2    Mattheus, M.3
  • 59
    • 84892477577 scopus 로고    scopus 로고
    • Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: A 24-week, randomized, placebo-controlled trial
    • Kovacs CS, Seshiah V, Swallow R et al. Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: A 24-week, randomized, placebo-controlled trial. Diabetes Obes. Metab. 2013; 16: 147-58.
    • (2013) Diabetes Obes. Metab. , vol.16 , pp. 147-158
    • Kovacs, C.S.1    Seshiah, V.2    Swallow, R.3
  • 60
    • 84879795546 scopus 로고    scopus 로고
    • A Phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes
    • Ferrannini E, Seman L, Seewaldt-Becker E, Hantel S, Pinnetti S, Woerle HJ. A Phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes. Diabetes Obes. Metab. 2013; 15: 721-8.
    • (2013) Diabetes Obes. Metab. , vol.15 , pp. 721-728
    • Ferrannini, E.1    Seman, L.2    Seewaldt-Becker, E.3    Hantel, S.4    Pinnetti, S.5    Woerle, H.J.6
  • 62
    • 0032788372 scopus 로고    scopus 로고
    • Molecular biology of adenosine triphosphate-sensitive potassium channels
    • Aguilar-Bryan L, Bryan J. Molecular biology of adenosine triphosphate-sensitive potassium channels. Endocr. Rev. 1999; 20: 101-35.
    • (1999) Endocr. Rev. , vol.20 , pp. 101-135
    • Aguilar-Bryan, L.1    Bryan, J.2
  • 64
    • 33645322386 scopus 로고    scopus 로고
    • ATP channels as molecular sensors of cellular metabolism
    • ATP channels as molecular sensors of cellular metabolism. Nature 2006; 440: 470-6.
    • (2006) Nature , vol.440 , pp. 470-476
    • Nichols, C.G.1
  • 66
    • 84872760095 scopus 로고    scopus 로고
    • Cardiovascular effects of anti-diabetic medications in type 2 diabetes mellitus
    • Singh S, Bhat J, Wang PH. Cardiovascular effects of anti-diabetic medications in type 2 diabetes mellitus. Curr. Cardiol. Rep. 2013; 15: 327.
    • (2013) Curr. Cardiol. Rep. , vol.15 , pp. 327
    • Singh, S.1    Bhat, J.2    Wang, P.H.3
  • 67
    • 0035431321 scopus 로고    scopus 로고
    • Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242: Ligand selectivity and agonist activation in the PPAR family
    • Cronet P, Petersen JF, Folmer R et al. Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242: Ligand selectivity and agonist activation in the PPAR family. Structure 2001; 9: 699-706.
    • (2001) Structure , vol.9 , pp. 699-706
    • Cronet, P.1    Petersen, J.F.2    Folmer, R.3
  • 68
    • 84877329207 scopus 로고    scopus 로고
    • PPARgamma signaling and metabolism: The good, the bad and the future
    • Ahmadian M, Suh JM, Hah N et al. PPARgamma signaling and metabolism: The good, the bad and the future. Nat. Med. 2013; 19: 557-66.
    • (2013) Nat. Med. , vol.19 , pp. 557-566
    • Ahmadian, M.1    Suh, J.M.2    Hah, N.3
  • 69
    • 33644766913 scopus 로고    scopus 로고
    • PPARdelta regulates glucose metabolism and insulin sensitivity
    • Lee CH, Olson P, Hevener A et al. PPARdelta regulates glucose metabolism and insulin sensitivity. Proc. Natl Acad. Sci. USA 2006; 103: 3444-9.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 3444-3449
    • Lee, C.H.1    Olson, P.2    Hevener, A.3
  • 70
    • 84878520008 scopus 로고    scopus 로고
    • Rivoglitazone. A new thiazolidinedione for the treatment of type 2 diabetes mellitus
    • Koffarnus RL, Wargo KA, Phillippe HM. Rivoglitazone. A new thiazolidinedione for the treatment of type 2 diabetes mellitus. Ann. Pharmacother. 2013; 47: 877-85.
    • (2013) Ann. Pharmacother. , vol.47 , pp. 877-885
    • Koffarnus, R.L.1    Wargo, K.A.2    Phillippe, H.M.3
  • 72
    • 79955586140 scopus 로고    scopus 로고
    • Dual acting and pan-PPAR activators as potential anti-diabetic therapies
    • Heald M, Cawthorne MA. Dual acting and pan-PPAR activators as potential anti-diabetic therapies. Handb. Exp. Pharmacol. 2011; 203: 35-51.
    • (2011) Handb. Exp. Pharmacol. , vol.203 , pp. 35-51
    • Heald, M.1    Cawthorne, M.A.2
  • 73
    • 84886402812 scopus 로고    scopus 로고
    • Pharmacokinetics, safety, and tolerability of saroglitazar (ZYH1), a predominantly PPARα agonist with moderate PPARγ agonist activity in healthy human subjects
    • Jani RH, Kansagra K, Jain MR, Patel H. Pharmacokinetics, safety, and tolerability of saroglitazar (ZYH1), a predominantly PPARα agonist with moderate PPARγ agonist activity in healthy human subjects. Clin. Drug Invest. 2013; 33: 809-16.
    • (2013) Clin. Drug Invest. , vol.33 , pp. 809-816
    • Jani, R.H.1    Kansagra, K.2    Jain, M.R.3    Patel, H.4
  • 74
    • 0034604225 scopus 로고    scopus 로고
    • Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease
    • Bezafibrate Infarction Prevention (BIP) Study. Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease. Circulation 2000; 102: 21-7.
    • (2000) Circulation , vol.102 , pp. 21-27
  • 75
    • 53249119324 scopus 로고    scopus 로고
    • Bezafibrate, a peroxisome proliferator-activated receptors agonist, decreases body temperature and enhances electroencephalogram delta-oscillation during sleep in mice
    • Chikahisa S, Tominaga K, Kawai T et al. Bezafibrate, a peroxisome proliferator-activated receptors agonist, decreases body temperature and enhances electroencephalogram delta-oscillation during sleep in mice. Endocrinology 2008; 149: 5262-71.
    • (2008) Endocrinology , vol.149 , pp. 5262-5271
    • Chikahisa, S.1    Tominaga, K.2    Kawai, T.3
  • 76
    • 41649083174 scopus 로고    scopus 로고
    • Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor alogliptin: A randomized, double-blind, placebo-controlled, multiple-dose study in adult patients with type 2 diabetes
    • Covington P, Christopher R, Davenport M et al. Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor alogliptin: A randomized, double-blind, placebo-controlled, multiple-dose study in adult patients with type 2 diabetes. Clin. Ther. 2008; 30: 499-512.
    • (2008) Clin. Ther. , vol.30 , pp. 499-512
    • Covington, P.1    Christopher, R.2    Davenport, M.3
  • 77
    • 84880320337 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in subjects with type 2 diabetes mellitus
    • Devineni D, Curtin CR, Polidori D et al. Pharmacokinetics and pharmacodynamics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in subjects with type 2 diabetes mellitus. J. Clin. Pharmacol. 2013; 53: 601-10.
    • (2013) J. Clin. Pharmacol. , vol.53 , pp. 601-610
    • Devineni, D.1    Curtin, C.R.2    Polidori, D.3
  • 78
    • 84873080743 scopus 로고    scopus 로고
    • Effects of rifampin and mefenamic acid on the pharmacokinetics and pharmacodynamics of dapagliflozin
    • Kasichayanula S, Liu X, Griffen SC, Lacreta FP, Boulton DW. Effects of rifampin and mefenamic acid on the pharmacokinetics and pharmacodynamics of dapagliflozin. Diabetes Obes. Metab. 2013; 15: 280-3.
    • (2013) Diabetes Obes. Metab. , vol.15 , pp. 280-283
    • Kasichayanula, S.1    Liu, X.2    Griffen, S.C.3    Lacreta, F.P.4    Boulton, D.W.5
  • 79
    • 84872111344 scopus 로고    scopus 로고
    • Pharmacokinetics of empagliflozin, a sodium glucose cotransporter-2 (SGLT-2) inhibitor, coadministered with sitagliptin in healthy volunteers
    • Brand T, Macha S, Mattheus M, Pinnetti S, Woerle HJ. Pharmacokinetics of empagliflozin, a sodium glucose cotransporter-2 (SGLT-2) inhibitor, coadministered with sitagliptin in healthy volunteers. Adv. Ther. 2012; 29: 889-99.
    • (2012) Adv. Ther. , vol.29 , pp. 889-899
    • Brand, T.1    Macha, S.2    Mattheus, M.3    Pinnetti, S.4    Woerle, H.J.5
  • 80
    • 84878947970 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks' treatment with empagliflozin once daily in patients with type 2 diabetes
    • Heise T, Seewaldt-Becker E, Macha S et al. Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks' treatment with empagliflozin once daily in patients with type 2 diabetes. Diabetes Obes. Metab. 2013; 15: 613-21.
    • (2013) Diabetes Obes. Metab. , vol.15 , pp. 613-621
    • Heise, T.1    Seewaldt-Becker, E.2    Macha, S.3
  • 81
    • 42949097094 scopus 로고    scopus 로고
    • Epalrestat. An aldose reductase inhibitor for the treatment of diabetic neuropathy
    • Ramirez MA, Borja NL. Epalrestat. An aldose reductase inhibitor for the treatment of diabetic neuropathy. Pharmacotherapy 2008; 28: 646-55.
    • (2008) Pharmacotherapy , vol.28 , pp. 646-655
    • Ramirez, M.A.1    Borja, N.L.2
  • 82
    • 0025341533 scopus 로고
    • Pharmacokinetic and pharmacodynamic studies of glibenclamide in non-insulin dependent diabetes mellitus
    • Coppack SW, Lant AF, McIntosh CS, Rodgers AV. Pharmacokinetic and pharmacodynamic studies of glibenclamide in non-insulin dependent diabetes mellitus. Br. J. Clin. Pharmacol. 1990; 29: 673-84.
    • (1990) Br. J. Clin. Pharmacol. , vol.29 , pp. 673-684
    • Coppack, S.W.1    Lant, A.F.2    McIntosh, C.S.3    Rodgers, A.V.4
  • 83
    • 0034020162 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of gliclazide in Caucasians and Australian Aborigines with type 2 diabetes
    • Davis TM, Daly F, Walsh JP et al. Pharmacokinetics and pharmacodynamics of gliclazide in Caucasians and Australian Aborigines with type 2 diabetes. Br. J. Clin. Pharmacol. 2000; 49: 223-30.
    • (2000) Br. J. Clin. Pharmacol. , vol.49 , pp. 223-230
    • Davis, T.M.1    Daly, F.2    Walsh, J.P.3
  • 84
    • 34548688661 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of glimepiride in type 2 diabetic patients. Compared effects of once- versus twice-daily dosing
    • Matsuki M, Matsuda M, Kohara K et al. Pharmacokinetics and pharmacodynamics of glimepiride in type 2 diabetic patients. Compared effects of once- versus twice-daily dosing. Endocr. J. 2007; 54: 571-6.
    • (2007) Endocr. J. , vol.54 , pp. 571-576
    • Matsuki, M.1    Matsuda, M.2    Kohara, K.3
  • 87
    • 0030959861 scopus 로고    scopus 로고
    • Duration of action and pharmacokinetics of the oral antidiabetic drug gliquidone in patients with non-insulin-dependent (type 2) diabetes mellitus
    • von Nicolai H, Brickl R, Eschey H et al. Duration of action and pharmacokinetics of the oral antidiabetic drug gliquidone in patients with non-insulin-dependent (type 2) diabetes mellitus. Arzneimittelforschung 1997; 47: 247-52.
    • (1997) Arzneimittelforschung , vol.47 , pp. 247-252
    • von Nicolai, H.1    Brickl, R.2    Eschey, H.3
  • 88
    • 84861683713 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of linagliptin
    • Graefe-Mody U, Retlich S, Friedrich C. Clinical pharmacokinetics and pharmacodynamics of linagliptin. Clin. Pharmacokinet. 2012; 51: 411-27.
    • (2012) Clin. Pharmacokinet. , vol.51 , pp. 411-427
    • Graefe-Mody, U.1    Retlich, S.2    Friedrich, C.3
  • 89
    • 84882575562 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic evaluation of linagliptin in African American patients with type 2 diabetes mellitus
    • Friedrich C, Glund S, Lionetti D et al. Pharmacokinetic and pharmacodynamic evaluation of linagliptin in African American patients with type 2 diabetes mellitus. Br. J. Clin. Pharmacol. 2013; 76: 445-54.
    • (2013) Br. J. Clin. Pharmacol. , vol.76 , pp. 445-454
    • Friedrich, C.1    Glund, S.2    Lionetti, D.3
  • 90
    • 84880645404 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and pharmacodynamics of remogliflozin etabonate, a novel SGLT2 inhibitor, and metformin when co-administered in subjects with type 2 diabetes mellitus
    • Hussey EK, Kapur A, O'Connor-Semmes R et al. Safety, pharmacokinetics and pharmacodynamics of remogliflozin etabonate, a novel SGLT2 inhibitor, and metformin when co-administered in subjects with type 2 diabetes mellitus. BMC Pharmacol. Toxicol. 2013; 14: 25.
    • (2013) BMC Pharmacol. Toxicol. , vol.14 , pp. 25
    • Hussey, E.K.1    Kapur, A.2    O'Connor-Semmes, R.3
  • 91
    • 84856351738 scopus 로고    scopus 로고
    • The effects of food on the pharmacokinetics of mitiglinide tablets in healthy volunteers and a novel mass-spectrometric (UPLC-MS/MS) method for such studies
    • Zhang J, Cai LJ, Peng WX, Zhu RH, Yang J, Zhang QZ. The effects of food on the pharmacokinetics of mitiglinide tablets in healthy volunteers and a novel mass-spectrometric (UPLC-MS/MS) method for such studies. J. Clin. Pharm. Ther. 2012; 37: 95-9.
    • (2012) J. Clin. Pharm. Ther. , vol.37 , pp. 95-99
    • Zhang, J.1    Cai, L.J.2    Peng, W.X.3    Zhu, R.H.4    Yang, J.5    Zhang, Q.Z.6
  • 92
    • 0035064201 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of nateglinide in humans
    • Weaver ML, Orwig BA, Rodriguez LC et al. Pharmacokinetics and metabolism of nateglinide in humans. Drug Metab. Dispos. 2001; 29: 415-21.
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 415-421
    • Weaver, M.L.1    Orwig, B.A.2    Rodriguez, L.C.3
  • 94
    • 67650076664 scopus 로고    scopus 로고
    • Ranirestat for the management of diabetic sensorimotor polyneuropathy
    • Bril V, Hirose T, Tomioka S, Buchanan R; Ranirestat Study Group. Ranirestat for the management of diabetic sensorimotor polyneuropathy. Diabetes Care 2009; 32: 1256-60.
    • (2009) Diabetes Care , vol.32 , pp. 1256-1260
    • Bril, V.1    Hirose, T.2    Tomioka, S.3    Buchanan, R.4
  • 95
    • 0033911580 scopus 로고    scopus 로고
    • Absorption, disposition, and metabolism of rosiglitazone, a potent thiazolidinedione insulin sensitizer, in humans
    • Cox PJ, Ryan DA, Hollis FJ et al. Absorption, disposition, and metabolism of rosiglitazone, a potent thiazolidinedione insulin sensitizer, in humans. Drug Metab. Dispos. 2000; 28: 772-80.
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 772-780
    • Cox, P.J.1    Ryan, D.A.2    Hollis, F.J.3
  • 96
    • 0023270547 scopus 로고
    • Sorbinil pharmacokinetics in male and female elderly volunteers
    • Scott AK, Webster J, Petrie JC. Sorbinil pharmacokinetics in male and female elderly volunteers. Br. J. Clin. Pharmacol. 1987; 23: 495-7.
    • (1987) Br. J. Clin. Pharmacol. , vol.23 , pp. 495-497
    • Scott, A.K.1    Webster, J.2    Petrie, J.C.3
  • 99
    • 34447120048 scopus 로고    scopus 로고
    • Effect of renal insufficiency on the pharmacokinetics of sitagliptin, a dipeptidyl peptidase-4 inhibitor
    • Bergman AJ, Cote J, Yi B et al. Effect of renal insufficiency on the pharmacokinetics of sitagliptin, a dipeptidyl peptidase-4 inhibitor. Diabetes Care 2007; 30: 1862-4.
    • (2007) Diabetes Care , vol.30 , pp. 1862-1864
    • Bergman, A.J.1    Cote, J.2    Yi, B.3


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