Synthesis of novel triterpene and N-allylated/N-alkylated niacin hybrids as α-glucosidase inhibitors

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 162-169

  Narender, Tadigoppula ^a   Madhur, Gaurav ^a   Jaiswal, Natasha ^a   Agrawal, Manali ^a   Maurya, Chandan K ^a   Rahuja, Neha ^a   Srivastava, Arvind K ^a   Tamrakar, Akhilesh K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Amyrin acetate; Glucosidase inhibitor; Lupeol; Niacin; Triterpene niacin hybrids

Indexed keywords

1 (3 METHYLBUT 2 ENYL) 3 [(4,4,6A,6B,8A,11,12,14B OCTAMETHYL 1,2,3,4,4A,5,6, 6A,6B,7,8,8A,9,10,11,12,12A,14,14A,14B ICOSAHYDROPICEN 3 YLOXY)CARBONYL]PYRIDINIUM BROMIDE; 1 [(3,7 DIMETHYLOCTA 2,6 DIENYL) 3A,5A,5B,8,8,11A HEXAMETHYL 1 (PROP 1 2 YL)ICOSAHYDRO 1H CYCLOPENTA[A]CHRYSEN 9 YLOXY)CARBONYL]PYRIDINIUM BROMIDE; 1 DOCOSYL 3 [(3A,5A,5B,8,8,11A HEXAMETHYL 1 (PROP 1 EN 2 YL)ICOSAHYDRO 1H CYCLOPENTA[A]CHRYSEN 9 YLOXY)CARBONYL]PYRIDINIUM BROMIDE; 1 DODECYL 3 [(4,4,6A,6B,8A,11,12,14B OCTAMETHYL 1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,14, 14A,14B ICOSAHYDROPICEN 3 YLOXY)CARBONYL]PYRIDINIUM BROMIDE; 1 HEXADECYL 3 [(4,4,6A,6B,8A,11,12,14B OCTAMETHYL 1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,14,14A,14B ICOSAHYDROPICEN 3-YLOXY)CARBONYL]PYRIDINIUM BROMIDE; 1 ICOSYL 3 [(4,4,6A,6B,8A,11,12,14B OCTAMETHYL 1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,14,14A,14B ICOSAHYDROPICEN 3-YLOXY)CARBONYL]PYRIDINIUM BROMIDE; 1 OCTADECYL 3 [(4,4,6A,6B,8A,11,12,14B OCTAMETHYL 1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,14,14A,14B ICOSAHYDROPICEN 3-YLOXY)CARBONYL]PYRIDINIUM BROMIDE; 3A,5A,5B,8,8,11A HEXAMETHYL 1 (PROP 1 EN 2 YL) 2,3,3A,4,5,5A,5B,6,7,7A,8,9, 10,11,11A,11B,12,13B-OCTADECAHYDRO 1H CYCLOPENTA[A]CHRYSEN 9 YL NICOTINATE; 4,4,6A,6B,8A,11,12,14B OCTAMETHYL 1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A, 14,14A,14B ICOSAHYDROPICEN 3 OL; 4,4,6A,6B,8A,11,12,14B OCTAMETHYL 1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,14,14A,14B ICOSAHYDROPICEN 3 YL NICOTINATE; ACARBOSE; ALPHA AMYRIN; ALPHA GLUCOSIDASE INHIBITOR; ANTIDIABETIC AGENT; LUPEOL; NICOTINIC ACID DERIVATIVE; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; NONHUMAN; RAT; STREPTOZOCIN DIABETES;

ALPHA-GLUCOSIDASES; ANIMALS; BLOOD GLUCOSE; CIRCULAR DICHROISM; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; HYPOGLYCEMIC AGENTS; KINETICS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NIACIN; RATS; TREATMENT OUTCOME; TRITERPENES;

EID: 84874610030     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.01.053     Document Type: Article

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