O-GlcNAcylation promotes non-amyloidogenic processing of amyloid-β protein precursor via inhibition of endocytosis from the plasma membrane

Journal of Alzheimer's Disease

Volumn 44, Issue 1, 2015, Pages 261-275

  Chun, Yoon Sun ^a   Park, Yurim ^a   Oh, Hyun Geun ^a   Kim, Tae Wan ^b   Yang, Hyun Ok ^c   Park, Myoung Kyu ^a   Chung, Sungkwon ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b NewYork Presbyterian Hospital   (United States)

^c Korea Institute of Science and Technology   (South Korea)

Author keywords

Alzheimer's disease; Amyloid protein precursor; Endocytosis; O GlcNAcylation

Indexed keywords

ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; BETA N ACETYLGLUCOSAMINE; BETA SECRETASE; N ACETYLGLUCOSAMINE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; CARBAMIC ACID DERIVATIVE; CLATHRIN; N ACETYLGLUCOSAMINYLTRANSFERASE; N-ACETYLGLUCOSAMINONO-1,5-LACTONE O-(PHENYLCARBAMOYL)OXIME; O-GLCNAC TRANSFERASE; OXIME; SECRETASE;

ACYLATION; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ENDOCYTOSIS; FEMALE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN PROCESSING; TRANS GOLGI NETWORK; ANALOGS AND DERIVATIVES; ANIMAL; CHO CELL LINE; CRICETULUS; DOSE RESPONSE; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; HELA CELL LINE; METABOLISM; MUTATION; PROTEIN TRANSPORT; TIME;

ACETYLGLUCOSAMINE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL MEMBRANE; CHO CELLS; CLATHRIN; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCYTOSIS; HELA CELLS; HUMANS; MUTATION; N-ACETYLGLUCOSAMINYLTRANSFERASES; OXIMES; PHENYLCARBAMATES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; TIME FACTORS; TRANSFECTION;

EID: 84920813745     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-140096     Document Type: Article

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