Reduction of O-linked N-acetylglucosamine-modified assembly protein-3 in Alzheimer's disease

Journal of Neuroscience

Volumn 18, Issue 7, 1998, Pages 2399-2411

  Yao, Pamela J ^a   Coleman, Paul D ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; Clathrin assembly protein AP 3; Galatosyltransferase labeling; N acetylglucosamine; Neurofibrillary tangles; O linked glycosylation; Phosphorylation

Indexed keywords

CELL PROTEIN; CLATHRIN ASSEMBLY PROTEIN 3; GALACTOSYLTRANSFERASE; N ACETYLGLUCOSAMINE; TAU PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; GLYCOSYLATION; HUMAN; HUMAN TISSUE; MOLECULAR DYNAMICS; NERVE CELL DEGENERATION; NEUROFIBRILLARY TANGLE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING;

EID: 0032053969     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-07-02399.1998     Document Type: Article

References (59)

1. Ahle S, Ungewickell E (1986) Purification and properties of a new clath- rin assembly protein. EMBO J 5:3143-3149.
2. Ahle S, Eichelsbacher U, Ungewickell E (1988) Structural relationships between clathrin assembly proteins from the Golgi and the plasma membrane. EMBO J 7:919-929.
3. Alzheimer A (1907) Uber eine eigenartige Erkrangkung der Himrinde. All Z Psychiatr 64:146-148.
4. Arnold CS, Johnson GVW, Cole RN, Dong DLY, Lee M, Hart GW (1996) The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine. J Biol Chem 271:28741-28744.
5. Arriagada PV, Growdon JH, Medley-Whyte T, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimers disease. Neurology 42:631-639.
6. Beyer TA, Sadler JE, Rearick JI, Paulson JC Hill RL (1981) Glycosyl- transferase and their use in assessing oligosaccaride structure and structure-function relationship. Adv Enzymol Relat Areas Mol Biol 52:23-175.
7. Blum H, Beier H, Gross HJ (1987) Improved silver staining of plant proteins, RNA, and DNA in polyacrylamide gels. Electrophoresis 8:93-99.
8. Braak H, Braak E (1995) Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 16:271-284.
9. Braak H, Braak E, Bohl J, Lang W (1989) Alzheimers disease: amyloid plaques in the cerebellum. J Neurol Sci 93:277-287.
10. Bramblett GT, Goedert M, Jakes R, Merrick SE, Trojanowski JO, Lee VMY (1993) Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 10:1089-1099.
11. Callahan LM, Coleman PD (1995) Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease. Neurobiol Aging 16:311-314.
12. Chou CF, Omary MB (1993) Mitotic arrest-associated enhancement of O-linked glycosylation and phosphorylation of human keratin 8 and 18. J Biol Chem 268:4465-4472.
13. Chou CF, Omary MB (1994) Mitotic arrest with anti-microtubule agents or okadaic acid is associated with increased glycoprotein terminal GlcNAc's. J Cell Sci 107:1833-1843.
14. Chou CF, Smith AJ, Omary MB (1992) Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18. J Biol Chem 267: 3901-3906.
15. Dong DLY, Hart GW (1994) Purification and characterization of an O-GlcNAc selective N-Acetyl-β-D-glucosaminidase from rat spleen cytosol. J Biol Chem 269:19321-19330.
16. Dong DLY, Xu ZS, Chevrier MR, Cotter RJ, Cleveland DW, Hart GW (1993) Glycosylation of mammalian neurofilaments. J Biol Chem 268:16679-16687.
17. Goedert M (1993) Tau protein and the neurofibrillary pathology of Alzheimer's disease. Trends Neurosci 16:460-465.
18. Greenberg SG, Davies P (1990) A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis. Proc Natl Acad Sci USA 87:5827-5831.
19. Griffith LS, Schmitz B (1995) O-linked N-acetylglucosamine is upregulated in Alzheimer brains. Biochem Biophys Res Commun 213:424-431.
20. Haltiwanger RS, Philipsberg GA (1997) Mitotic arrest with nocodazole induces selective changes in the level of O-linked N-acetylglucosamine and accumulation of incompletely processed TV-glycans on proteins from HT29 cells. J Biol Chem 272:8752-8758.
21. Haltiwanger RS, Blomberg MA, Hart GW (1992) Glycosylation of nuclear and cytoplasmic proteins. J Biol Chem 267:9005-9013.
22. Haltiwanger RS, Busby S, Grove K, Li S, Mason D, Medina L, Moloney D, Philipsberg G, Scartozzi R (1997) O-glycosylation of nuclear and cytoplasmic proteins: regulation analogous to phosphorylation? Biochem Biophys Res Commun 231:237-242.
23. Han I, Kudlow JE (1997) Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility. Mol Cell Biol 17:2550-2558.
24. Harlow E, Lane D (1988) Antibodies - a laboratory manual, pp 421-510. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
25. Hart GW, Greis KD, Dong LY, Blomberg MA, Chou TY, Jiang MS, Roquemore EP, Snow DM, Kreppel LK, Cole RN (1995) O-linked TV-acetylglucosamine: the "yin-yang" of Ser/Thr phosphorylation? Adv Exp Med Biol 376:115-123.
26. Kearse KP, Hart GW (1991) Lymphocyte activation induces rapid changes in nuclear and cytoplasmic glycoroteins. Proc Natl Acad Sci USA 88:1701-1705.
27. Keen JH, Black MM (1986) The phosphorylation of coated membrane protein in intact neuron. J Cell Biol 102:1325-1333.
28. Kelly WG, Dahmus ME, Hart GW (1993) RNA polymerase II is a glycoprotein. J Biol Chem 268:10416-10424.
29. Khachaturian ZS (1985) Diagnosis of Alzheimer's disease. Arch Neurol 42:1097-1105.
30. Kohtz DS. Puszkin S (1988) A neuronal protein (NP185) associated with clathrin-coated vesicles. J Biol Chem 263:7418-7425.
31. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
32. Lafer EM, Womack M, Zhao X, Prasad K, Augustine GJ (1997) Microinjection of the clathrin assembly domain of AP-3 enhances synaptic transmission at the squid giant synapse. Soc Neurosci Abstr 23:361.
33. Ledesma MD, Bonay P, Colaco C, Avila J (1994) Analysis of microtubule-associated protein tau glycation in paired helical filaments. J Biol Chem 269:21614-21619.
34. Lindner R. Ungewickell E (1992) Clathrin-associated proteins of bovine brain coated vesicles. J Biol Chem 267:16567-16573.
35. Lindwall G, Cole RD (1984) The purification of tau protein and the occurrence of two phosphorylation states of tau in brain. J Biol Chem 259:12241-12245.
36. Masliah E, Terry RD, DeTeresa RM, Hansen LA (1989) Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease. Neurosci Lett 103:234-239.
37. Maycox PR, Link E, Reetz A, Morris SA, Jahn R (1992) Clathrin- coated vesicles in nervous tissue are involved primarily in synaptic vesicle recycling. J Cell Biol 118:1379-1388.
38. Monsigny M, Roche AC, Sene C, Maget-Dana R, Delmotte F (1980) Sugar-lectin interactions: how does wheat-germ agglutinin bind sialoglycoconjugates? Eur J Biochem 104:147-153.
39. Morrison JH, Hof PR (1997) Life and death of neurons in the aging brain. Science 278:412-419.
40. Murphy DB (1991) Purification of tubulin and tau from chicken erythrocytes: tubulin isotypes and mechanisms of microtubule assembly. Methods Enzymol 196:235-246.
41. Murphy JE, Pleasure IT, Puszkin S, Prasad K, Keen JH (1991) Clathrin assembly protein AP-3. J Biol Chem 266:4401-4408.
42. Murphy JE, Hanover JA, Froehlich M, DuBois G, Keen JH (1994) Clathrin assembly protein AP-3 is phosphorylated and glycosylated on the 50 kDa structure domain. J Biol Chem 269:21346-21352.
43. O'Farrell PH (1975) High resolution two-dimensional electrophoresis of proteins J Biol Chem 250:4007-4021.
44. Plummer TH, Tarentino AL (1981) Facile cleavage of complex oligosaccharides from glycopeptides by almond emulsin peptide: N-glycosidase. J Biol Chem 256:10243-10246.
45. Regeur L, Jensen GB, Pakkenberg H, Evans SM, Pakkenberg B (1994) No global neocortical nerve cell loss in brains from patients with senile dementia of Alzheimer's type. Neurobiol Aging 15:347-352.
46. Roquemore EP, Chou TY, Hart GW (1994) Detection of O-linked N-acetylglucosamine on cytoplasmic and nuclear proteins. Methods Enzymol 230:443-461.
47. Scheff SW, Price DA (1993) Synapse loss in the temporal lobe in Alzheimer's disease. Ann Neurol 33:190-199.
48. Scheff SW, DeKosky ST, Price DA (1990) Quantitative assessment of conical synatic density in Alzheimer's disease. Neurobiol Aging 11:29-37.
49. Smith MA, Sayre LM, Monnier VM, Perry G (1995) Radical ageing in Alzheimer's disease. Trends Neurosci 18:172-176.
50. Sousa R, Tannery NH, Lafer EM (1990) Two new monoclonal antibodies provide immunohistochemical evidence for the unique biochemical similarity of the mouse globus pallidus, entopeduncular nucleus and substantia nigra pars reticulata. Neuroscience 34:403-410.
51. Tomlinson BE, Blessed G, Roth M (1970) Observations on the brains of demented old people. J Neurol Sci 11:205-242.
52. Torres CR, Hart GW (1984) Topography and polypeptide distribution of terminal W-acetyl-glucosamine residues on the surfaces of intact lymphocytes. J Biol Chem 259:3308-3317.
53. Travelyan WE, Procter, DP, Harrison JS (1950) Detection of sugars on paper chromatograms. Nature 166:3901-3906.
54. Turner JR, Tartakoff AM, Greenspan NS (1990) Cytologic assessment of nuclear and cytoplasmic O-linked N-acetylglucosamine distribution by using anti-streptococcal monoclonal antibodies. Proc Natl Acad Sci USA 87:5608-5612.
55. Wallenfels B (1979) Developmental and mutational changes of glycoproteins in the mouse neuronal retina: studies with bovine galactosyltransferase. Proc Natl Acad Sci USA 76:3223-3227.
56. Wang JZ, Grundke-Iqbal I, Iqbal K (1996) Glycosylation of microtubule- associated protein tau: an abnormal posttranslational modification in Alzheimer's disease. Nat Med 2:871-875.
57. Ye W, Lafer EM (1995) Bacterially expressed F1-20/AP-3 assembles clathrin into cages with a narrow size distribution: implications for the regulation of quantal size during neurotransmission. J Neurosci Res 41:15-26.
58. Zhou S, Tannery NH, Yang J, Puszkin S, Lafer EM (1993) The synapse- specific phosphoprotein F1-20 is identical to the clathrin assembly protein AP-3. J Biol Chem 269:12655-12662.
59. Zinn AB, Plantner JJ, Carlson DM (1977) Nature of linkages between protein core and oligosaccharides. In: The glycoconjugates (Horowitz MI, Pigman W, eds), pp 69-85. New York: Academic.