Non-canonical interleukin 23 receptor complex assembly: P40 protein recruits interleukin 12 receptor β1 via site II and induces P19/interleukin 23 receptor interaction via site III

Journal of Biological Chemistry

Volumn 290, Issue 1, 2015, Pages 359-370

  Schröder, Jutta ^a   Moll, Jens M ^a   Baran, Paul ^a   Grötzinger, Joachim ^b   Scheller, Jürgen ^a   Floss, Doreen M ^a  

^a Department of Orthopedic Surgery   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; PROTEINS;

BINDING MODES; COMPLEX FORMATIONS; CYTOKINES; EXPERIMENTAL VALIDATIONS; FUSION PROTEINS; INTERLEUKIN-12; RECEPTOR COMPLEX; RECEPTOR INTERACTION;

BINDING SITES;

HYBRID PROTEIN; INTERLEUKIN 12 RECEPTOR BETA1; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR; PROTEIN P19; PROTEIN P40; PROTEIN P40 DOMAIN 2 DOMAIN 3 PROTEIN P19 FUSION PROTEIN; UNCLASSIFIED DRUG; IL23R PROTEIN, HUMAN; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 12P40; INTERLEUKIN RECEPTOR; PROTEIN BINDING;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; DIMERIZATION; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; ANIMAL; CELL LINE; CHEMISTRY; CHLOROCEBUS AETHIOPS; CHO CELL LINE; COS CELL LINE; CRICETULUS; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; MOLECULAR MODEL; MOUSE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

ANIMALS; BINDING SITES; CELL LINE; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETULUS; GENE EXPRESSION; HUMANS; INTERLEUKIN-12 RECEPTOR BETA 1 SUBUNIT; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-23; MICE; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; RECOMBINANT FUSION PROTEINS;

EID: 84920693940     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.617597     Document Type: Article

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