Distinct subunit pairing criteria within the heterodimeric IL-12 cytokine family

Molecular Immunology

Volumn 51, Issue 2, 2012, Pages 234-244

  Jones, Lindsay L ^a   Chaturvedi, Vandana ^a   Uyttenhove, Catherine ^b   Van Snick, Jacques ^b   Vignali, Dario A A ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Belgium)

Author keywords

Cytokines; IL 12; IL 27; IL 35; Structure

Indexed keywords

CELL PROTEIN; HETERODIMER; INTERLEUKIN 12; INTERLEUKIN 27; INTERLEUKIN 35; PROTEIN EBI3; PROTEIN P35; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DIMERIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; SCREENING TEST; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; DIMERIZATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P35; INTERLEUKINS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN SUBUNITS; RECEPTORS, CYTOKINE; SEQUENCE ALIGNMENT; SPECIES SPECIFICITY;

EID: 84860363633     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2012.03.025     Document Type: Article

References (40)

1. Ahern P.P., Schiering C., Buonocore S., McGeachy M.J., Cua D.J., Maloy K.J., Powrie F. Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity 2010, 33:279-288.
2. Awasthi A., Carrier Y., Peron J.P., Bettelli E., Kamanaka M., Flavell R.A., Kuchroo V.K., Oukka M., Weiner H.L. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat. Immunol. 2007, 8:1380-1389.
3. Awasthi A., Kuchroo V.K. Th17 cells: from precursors to players in inflammation and infection. Int. Immunol. 2009, 21:489-498.
4. Boulanger M.J., Chow D.C., Brevnova E.E., Garcia K.C. Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science 2003, 300:2101-2104.
5. Bryson K., McGuffin L.J., Marsden R.L., Ward J.J., Sodhi J.S., Jones D.T. Protein structure prediction servers at University College London. Nucleic Acids Res. 2005, 33:W36-W38.
6. Chaturvedi V., Collison L.W., Guy C.S., Workman C.J., Vignali D.A. Cutting edge: human regulatory T cells require IL-35 to mediate suppression and infectious tolerance. J. Immunol. 2011, 186:6661-6666.
7. Collison L.W., Chaturvedi V., Henderson A.L., Giacomin P.R., Guy C., Bankoti J., Finkelstein D., Forbes K., Workman C.J., Brown S.A., Rehg J.E., Jones M.L., Ni H.T., Artis D., Turk M.J., Vignali D.A. IL-35-mediated induction of a potent regulatory T cell population. Nat. Immunol. 2010, 11:1093-1101.
8. Collison L.W., Delgoffe G.M., Guy C.S., Vignali K.M., Chaturvedi V., Fairweather D., Satoskar A.R., Garcia K.C., Hunter C.A., Drake C.G., Murray P.J., Vignali D.A.A. The composition and signaling of the IL-35 receptor are unconventional. Nat. Immunol. 2012, 13:290-299.
9. Collison L.W., Vignali D.A. Interleukin-35: odd one out or part of the family?. Immunol. Rev. 2008, 226:248-262.
10. Collison L.W., Workman C.J., Kuo T.T., Boyd K., Wang Y., Vignali K.M., Cross R., Sehy D., Blumberg R.S., Vignali D.A. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007, 450:566-569.
11. Cua D.J., Sherlock J., Chen Y., Murphy C.A., Joyce B., Seymour B., Lucian L., To W., Kwan S., Churakova T., Zurawski S., Wiekowski M., Lira S.A., Gorman D., Kastelein R.A., Sedgwick J.D. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003, 421:744-748.
12. Diveu C., McGeachy M.J., Boniface K., Stumhofer J.S., Sathe M., Joyce-Shaikh B., Chen Y., Tato C.M., McClanahan T.K., de Waal Malefyt R., Hunter C.A., Cua D.J., Kastelein R.A. IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J. Immunol. 2009, 182:5748-5756.
13. Egilmez N.K., Kilinc M.O. Tumor-resident CD8+ T-cell: the critical catalyst in IL-12-mediated reversal of tumor immune suppression. Arch. Immunol. Ther. Exp. (Warsz) 2010, 58:399-405.
14. Goujon M., McWilliam H., Li W., Valentin F., Squizzato S., Paern J., Lopez R. A new bioinformatics analysis tools framework at EMBL-EBI. Nucleic Acids Res. 2010, 38:W695-W699.
15. Halaby D.M., Poupon A., Mornon J. The immunoglobulin fold family: sequence analysis and 3D structure comparisons. Protein Eng. 1999, 12:563-571.
16. Hilton D.J., Watowich S.S., Katz L., Lodish H.F. Saturation mutagenesis of the WSXWS motif of the erythropoietin receptor. J. Biol. Chem. 1996, 271:4699-4708.
17. Huang C.H., Loo E.X., Kuo I.C., Soh G.H., Goh D.L., Lee B.W., Chua K.Y. Airway inflammation and IgE production induced by dust mite allergen-specific memory/effector Th2 cell line can be effectively attenuated by IL-35. J. Immunol. 2011, 187:462-471.
18. Jones L.L., Vignali D.A. Molecular interactions within the IL-6/IL-12 cytokine/receptor superfamily. Immunol. Res. 2011.
19. Larkin M.A., Blackshields G., Brown N.P., Chenna R., McGettigan P.A., McWilliam H., Valentin F., Wallace I.M., Wilm A., Lopez R., Thompson J.D., Gibson T.J., Higgins D.G. Clustal W and Clustal X version 2.0. Bioinformatics 2007, 23:2947-2948.
20. Li T., Robert E.I., van Breugel P.C., Strubin M., Zheng N. A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat. Struct. Mol. Biol. 2010, 17:105-111.
21. Lupardus P.J., Garcia K.C. The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12. J. Mol. Biol. 2008, 382:931-941.
22. McGeachy M.J., Chen Y., Tato C.M., Laurence A., Joyce-Shaikh B., Blumenschein W.M., McClanahan T.K., O'Shea J.J., Cua D.J. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat. Immunol. 2009, 10:314-324.
23. Neufert C., Becker C., Wirtz S., Fantini M.C., Weigmann B., Galle P.R., Neurath M.F. IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1. Eur. J. Immunol. 2007, 37:1809-1816.
24. Niedbala W., Wei X.Q., Cai B., Hueber A.J., Leung B.P., McInnes I.B., Liew F.Y. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur. J. Immunol. 2007, 37:3021-3029.
25. Oppmann B., Lesley R., Blom B., Timans J.C., Xu Y., Hunte B., Vega F., Yu N., Wang J., Singh K., Zonin F., Vaisberg E., Churakova T., Liu M., Gorman D., Wagner J., Zurawski S., Liu Y., Abrams J.S., Moore K.W., Rennick D., de Waal-Malefyt R., Hannum C., Bazan J.F., Kastelein R.A. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000, 13:715-725.
26. Pflanz S., Timans J.C., Cheung J., Rosales R., Kanzler H., Gilbert J., Hibbert L., Churakova T., Travis M., Vaisberg E., Blumenschein W.M., Mattson J.D., Wagner J.L., To W., Zurawski S., McClanahan T.K., Gorman D.M., Bazan J.F., de Waal Malefyt R., Rennick D., Kastelein R.A. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 2002, 16:779-790.
27. Rousseau F., Basset L., Froger J., Dinguirard N., Chevalier S., Gascan H. IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:19420-19425.
28. Rousseau F., Chevalier S., Guillet C., Ravon E., Diveu C., Froger J., Barbier F., Grimaud L., Gascan H. Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain. J. Biol. Chem. 2008, 283:30341-30350.
29. Shimozato O., Sato A., Kawamura K., Chiyo M., Ma G., Li Q., Tagawa M. The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses. Immunology 2009, 128:e816-e825.
30. Stern L.J., Brown J.H., Jardetzky T.S., Gorga J.C., Urban R.G., Strominger J.L., Wiley D.C. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 1994, 368:215-221.
31. Stern L.J., Wiley D.C. Antigenic peptide binding by class I and class II histocompatibility proteins. Structure 1994, 2:245-251.
32. Stumhofer J.S., Tait E.D., Quinn W.J., Hosken N., Spudy B., Goenka R., Fielding C.A., O'Hara A.C., Chen Y., Jones M.L., Saris C.J., Rose-John S., Cua D.J., Jones S.A., Elloso M.M., Grotzinger J., Cancro M.P., Levin S.D., Hunter C.A. A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nat. Immunol. 2010, 11:1119-1126.
33. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 2003, 3:133-146.
34. Tripp C.S., Kanagawa O., Unanue E.R. Secondary response to Listeria infection requires IFN-gamma but is partially independent of IL-12. J. Immunol. 1995, 155:3427-3432.
35. Uyttenhove C., Marillier R.G., Tacchini-Cottier F., Charmoy M., Caspi R.R., Damsker J.M., Goriely S., Su D., Van Damme J., Struyf S., Opdenakker G., Van Snick J. Amine-reactive OVA multimers for auto-vaccination against cytokines and other mediators: perspectives illustrated for GCP-2 in L. major infection. J. Leukoc. Biol. 2011, 89:1001-1007.
36. Villarino A.V., Stumhofer J.S., Saris C.J., Kastelein R.A., de Sauvage F.J., Hunter C.A. IL-27 limits IL-2 production during Th1 differentiation. J. Immunol. 2006, 176:237-247.
37. Wang X., Lupardus P., Laporte S.L., Garcia K.C. Structural biology of shared cytokine receptors. Annu. Rev. Immunol. 2009, 27:29-60.
38. Watford W.T., Moriguchi M., Morinobu A., O'Shea J.J. The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine Growth Factor Rev. 2003, 14:361-368.
39. Yoon C., Johnston S.C., Tang J., Stahl M., Tobin J.F., Somers W.S. Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12. EMBO J. 2000, 19:3530-3541.
40. Zandian M., Mott K.R., Allen S.J., Dumitrascu O., Kuo J.Z., Ghiasi H. Use of cytokine immunotherapy to block CNS demyelination induced by a recombinant HSV-1 expressing IL-2. Gene Ther. 2011, 18:734-742.