Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits

European Journal of Immunology

Volumn 29, Issue 6, 1999, Pages 2007-2013

  Wang, Xin ^a   Wilkinson, Victoria L ^a   Podlaski, Frank J ^a   Wu, Chang You ^a   Stern, Alvin S ^a   Presky, David H ^a   Magram, Jeanne ^a,b  

^a HOFFMANN LA ROCHE INC   (United States)

^b Cadus Pharmaceutical Corporation   (United States)

Author keywords

Binding; IL 12 p40 homodimer; Receptor

Indexed keywords

CONCANAVALIN A; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BINDING SITE; LYMPHOBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; SPLEEN CELL;

ANIMALS; B-LYMPHOCYTES; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; CONCANAVALIN A; DIMERIZATION; INTERLEUKIN-12; KINETICS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; PROTEIN CONFORMATION; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; RECOMBINANT PROTEINS;

EID: 0032991684     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199906)29:06<2007::AID-IMMU2007>3.0.CO;2-0     Document Type: Article

References (34)

1. Trinchieri, G., Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 1995. 13: 251-276.
2. Gately, M. K., Renzetti, L. M., Magram, J., Stern, A., Adorini, L., Gubler, U. and Presky, D. H., The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 1998. 16: 495-521.
3. Chua, A. O., Chizzonite, R., Desai, B. B., Truitt, T. P., Nunes, P., Minetti, L. J., Warrier, R. R., Presky, D. H., Levine, J. F. and Gately, M. K., Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. J. Immunol. 1994. 153: 128-136.
4. Presky, D. H., Yang, H., Minetti, L. J., Chua, A. O., Nabavi, N., Wu, C.-Y., Gately, M. K. and Gubler, U., A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA 1996. 93: 14002-14007.
5. Stahl, N. and Yancopoulos, G. D., The alphas, betas, and kinases of cytokine receptor complexes. Cell 1993. 74: 587-590.
6. Chua, A. O., Wilkinson, V. L., Presky, D. H. and Gubler, U., Cloning and characterization of a mouse IL-12 receptor-beta component. J. Immunol. 1995. 155: 4286-4294.
7. Wilkinson, V. L., Carvajal, D., Minetti, L. J., Chua, A. O., Gubler, U., Gately, M. K. and Presky, D. H., Functional characterization of mouse IL-12 receptors. J. Allergy Clin. Immunol. 1996. 99: S52.
8. Mattner, F., Fischer, S., Guckes, S., Jin, S., Kaulen, H., Schmitt, E., Rude, E. and Germann, T., The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. Eur. J. Immunol. 1993. 23: 2202-2208.
9. Ling, P., Gately, M. K., Gubler, U., Stern, A. S., Lin, P., Hollfelder, K., Su, C., Pan, Y.-C. and Hakimi, J., Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J. Immunol. 1995. 154: 116-127.
10. Gillessen, S., Carvajal, D., Ling, P., Podlaski, F. J., Stremlo, D. L., Familletti, P. C., Gubler, U., Presky, D. H., Stern, A. S. and Gately, M. K., Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur. J. Immunol. 1995. 25: 200-206.
11. Nickbarg, E. B., Vath, J. E., Pittman, D. D., Leonard, J. E., Waldburger, K. E. and Bond, M. D., Structural characterization of the recombinant p40 heavy chain subunit monomer and homodimer of murine IL-12. Bioorganic Chem. 1995. 23: 380-396.
12. Gately, M. K., Carvajal, O. M., Connaughton, S. E., Gillessen, S., Warrier, R. R., Kolinsky, K. D., Wilkinson, V. A., Dwyer, C. M., Higgins, J., G. F., Podlaski, F. J., Faherty, D. A., Familletti, P. C., Stern, A. S. and Presky, D. H., Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo. Ann. N. Y. Acad. Sci. 1996. 795: 1-12.
13. Heinzel, F. P., Hujer, A. M., Ahmed, F. N. and Rerko, R. M., In vivo production and function of IL-12 p40 homodimers. J. Immunol. 1997. 158: 4381-4388.
14. Podlaski, F. J., Nanduri, V. B., Hulmes, J. D., Pan, Y.-C. E., Levin, W., Danho, W., Chizzonite, R., Gately, M. K. and Stern, A. S., Molecular characterization of interleukin 12. Arch. Biochem. Biophys. 1992. 294: 230-237.
15. D'Andrea, A., Rengaraju, M., Valiante, N. M., Chehimi, J., Kubin, M., Aste, M., Chan, S. H., Kobayashi, M., Young, D., Nickbarg, E., Chizzonite, R., Wolf, S. F. and Trinchieri, G., Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 1992. 176: 1387-1398.
16. Chen, L., Chen, D., Block, E., O'Donnell, M., Kufe, D. W. and Clinton, S. K., Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12p40 subunit homodimer. J. Immunol. 1997. 159: 351-359.
17. 2. Diabetologia 1997. 40: 641-646.
18. Piccotti, J. R., Chan, S. Y., Goodman, R. E., Magram, J., Eichwald, E. J. and Bishop, D. K., IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity. J. Immunol. 1996. 157: 1951-1957,
19. Yoshimoto, T., Wang, C.-R., Yoneto, T., Waki, S., Sunaga, S., Komagata, Y., Mitsuyama, M., Miyazaki, J. and Nariuchi, H., A pathogenic role of IL-12 in blood-stage murine malaria lethal strain Plasmodium berghei NK65 infection. J. Immunol, 160: 5500-5505.
20. Presky, D. H., Minetti, L. J., Gillessen, S., Gubler, U., Chizzonite, R., Stern, A. S. and Gately, M. K., Evidence for multiple sites of interaction between IL-12 and its receptor. Ann. N. Y. Acad. Sci. 1996. 795: 390-393.
21. Presky, D. H., Minetti, L. J., Gillessen, S., Wilkinson, V. L., Wu, C.-Y., Gubler, U., Chizzonite, R. and Gately, M. K., Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex. J. Immunol. 1998. 160: 2174-2179.
22. Magram, J., Sfarra, J., Connaughton, S., Faherty, D., Warrier, R., Carvajal, D., Wu, C.-Y., Stewart, C., Sarmiento, U. and Gately, M. K., IL-12-deficient mice are defective but not devoid of type 1 cytokine responses. Ann. N. Y. Acad. Sci. 1996. 795: 60-70.
23. Magram, J., Connaughton, S. E., Warrier, R. R., Carvajal, D. M., Wu, C.-Y., Ferrante, J., Stewart, C., Sarmiento, U., Faherty, D. A. and Gately, M. K., IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 1996. 4: 471-481.
24. + IFN-gamma-producing cells. J. Immunol. 1997. 158: 643-648.
25. Piccotti, J. R., Li, K., Chan, S. Y., Ferrante, J., Magram, J., Eichwald, E. J. and Bishop, K. D., Alloantigen-reactive Th1 development in IL-12-deficient mice. J. Immunol. 160: 1132-1138.
26. Bette, M., Jin, S.-C., Germann, T., Schafer, M. K.-H., Weihe, E., Rude, E. and Fleischer, B., Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ. Eur. J. Immunol. 1994. 24: 2435-2440.
27. Wu, C.-Y., Warrier, R. R., Carvajal, D. M., Chua, A. O., Minetti, L. J., Chizzonite, R., Mongini, P. K. A., Stern, A. S., Gubler, U., Presky, D. H. and Gately, M. K., Biological function and distribution of human interleukin-12 receptor β chain. Eur. J. Immunol. 1996. 26: 345-350.
28. Benjamin, D., Sharma, V., Kubin, M., Klein, J. L., Sartori, A., Holliday, J. and Trinchieri, G., IL-12 expression in AIDS-related lymphoma B cell lines. J. Immunol. 1996. 156: 1626-1637.
29. Metzger, D. W., Vogel, L. A., Van Cleave, V. H., Lester, T. L. and Buchanan, J. M., The effects of IL12 on B-cell subset function. Res. Immunol. 1995. 146: 499-505.
30. Vogel, L. A., Showe, L. C., Lester, T. L., McNutt, R. M., Van Cleave, V. H. and Metzger, D. W., Direct binding of IL-12 to human and murine B lymphocytes. Int. Immunol. 1996. 8: 1955-1962.
31. Gately, M. K., Warrier, R. R., Honasoge, S., Carvajal, D. M., Faherty, D. A., Connaughton, S. E., Anderson, T. M., Sarmiento, U., Hubbard, B. R. and Murphy, M., Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo. Int. Immunol. 1994. 6: 157-167.
32. Chizzonite, R., Truitt, T., Desai, B. B., Nunes, P., Podlaski, F. J., Stern, A. S. and Gately, M. K., IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts. J. Immunol. 1992. 148: 3117-3124.
33. McPherson, G. A., Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. J. Pharmacol. Methods 1985. 14: 213-228.
34. Scatchard, G., The attractions of proteins for small molecules and ions. Ann. N. Y. Acad. Sci. 1949. 51: 660-672.