Human interleukin-23 receptor antagonists derived from an albumin-binding domain scaffold inhibit IL-23-dependent ex vivo expansion of IL-17-producing T-cells

Proteins: Structure, Function and Bioinformatics

Volumn 82, Issue 6, 2014, Pages 975-989

  Kuchař, Milan ^a   Vaňková, Lucie ^a   Petroková, Hana ^a   Černý, Jiří ^a   Osička, Radim ^b   Pelák, Ondřej ^c   Šípová, Hana ^d   Schneider, Bohdan ^a   Homola, Jiří ^d   Šebo, Peter ^a,b   Kalina, Tomáš ^c   Malý, Petr ^a  

^a INSTITUTE OF BIOTECHNOLOGY   (Czech Republic)

^b INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^c UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

^d INSTITUTE OF PHOTONICS AND ELECTRONICS   (Czech Republic)

Author keywords

Combinatorial library; Cytokine; Engineered binding protein; Protein scaffold; Psoriasis; Ribosome display

Indexed keywords

BACTERIAL PROTEIN; BINDING PROTEIN; CYTOKINE RECEPTOR ANTAGONIST; IMMUNOGLOBULIN G; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR; INTERLEUKIN 23 RECEPTOR ANTAGONIST; LIGAND; PROTEIN G; PROTEIN P19; PROTEIN VARIANT; RECOMBINANT PROTEIN; REX BINDER; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; IGG FC-BINDING PROTEIN, STREPTOCOCCUS; IL23R PROTEIN, HUMAN; IMMUNOLOGIC FACTOR; INTERLEUKIN RECEPTOR; PEPTIDE FRAGMENT; PROTEIN BINDING;

ALBUMIN BINDING DOMAIN; ARTICLE; BINDING AFFINITY; CD4+ T LYMPHOCYTE; CELL SURFACE; CHIMERA; COMBINATORIAL LIBRARY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; STREPTOCOCCUS; SURFACE PLASMON RESONANCE; T LYMPHOCYTE; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; BINDING COMPETITION; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; JURKAT CELL LINE; K562 CELL LINE; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; SEQUENCE HOMOLOGY; TH17 CELL;

AMINO ACID SEQUENCE; ANTI-INFLAMMATORY AGENTS; BACTERIAL PROTEINS; BINDING, COMPETITIVE; DRUG EVALUATION, PRECLINICAL; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-23; JURKAT CELLS; K562 CELLS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING; RECEPTORS, INTERLEUKIN; SEQUENCE HOMOLOGY, AMINO ACID; TH17 CELLS;

EID: 84900813603     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24472     Document Type: Article

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