Dipeptidyl peptidase-4 inhibitor, vildagliptin, inhibits pancreatic beta cell apoptosis in association with its effects suppressing endoplasmic reticulum stress in db/db mice

Metabolism: Clinical and Experimental

Volumn 64, Issue 2, 2015, Pages 226-235

  Wu, Yan Ju ^a   Guo, Xin ^a   Li, Chun Jun ^a   Li, Dai Qing ^a   Zhang, Jie ^a   Yang, Yiping ^a   Kong, Yan ^a   Guo, Hang ^a   Liu, De Min ^a   Chen, Li Ming ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Endoplasmic reticulum; Type 2 diabetes; Vildagliptin

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CASPASE 3; CCAAT ENHANCER BINDING PROTEIN; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HEMOGLOBIN A1C; INSULIN; VILDAGLIPTIN; ADAMANTANE; ATF4 PROTEIN, MOUSE; CASP3 PROTEIN, MOUSE; CELL CYCLE PROTEIN; DDIT3 PROTEIN, MOUSE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; NITRILE; PYRROLIDINE DERIVATIVE; TRB3 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATF 4 GENE; BODY WEIGHT; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; EVALUATION STUDY; GENE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; MALE; MOUSE; NICK END LABELING; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRIB3 GENE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; GENETICS; HYPERGLYCEMIA; METABOLISM; MUTANT MOUSE STRAIN; PATHOLOGY; RANDOMIZATION;

ACTIVATING TRANSCRIPTION FACTOR 4; ADAMANTANE; ANIMALS; APOPTOSIS; CASPASE 3; CELL CYCLE PROTEINS; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; DIABETES MELLITUS, TYPE 2; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DOWN-REGULATION; ENDOPLASMIC RETICULUM STRESS; HYPERGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE, MUTANT STRAINS; NITRILES; PYRROLIDINES; RANDOM ALLOCATION; TRANSCRIPTION FACTOR CHOP;

EID: 84920606469     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2014.08.006     Document Type: Article

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