TRIB3 alters endoplasmic reticulum stress-induced β-cell apoptosis via the NF-κB pathway

Metabolism: Clinical and Experimental

Volumn 63, Issue 6, 2014, Pages 822-830

  Fang, Ni ^a,b   Zhang, Wenjian ^a   Xu, Shiqing ^a   Lin, Hua ^a   Wang, Zai ^a   Liu, Honglin ^a   Fang, Qing ^a   Li, Chenghui ^a   Peng, Liang ^a   Lou, Jinning ^a,b  

^a CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^b GRADUATE SCHOOL OF PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Apoptosis; ER stress; NF B; TRIB3; Cell

Indexed keywords

CASPASE 3; CASPASE 7; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; PHOSPHOTRANSFERASE; SMALL INTERFERING RNA; STREPTOZOCIN; THAPSIGARGIN; TRIBBLES HOMOLOG 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; GENE OVEREXPRESSION; GENE SILENCING; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INS 1 CELL LINE; INSULIN RELEASE; KIDNEY CAPSULE; MOUSE; NICK END LABELING; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; UPREGULATION;

APOPTOSIS; ER STRESS; NF-ΚB; TRIB3; Β-CELL;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE PROTEINS; DIABETES MELLITUS, EXPERIMENTAL; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITORS; FEMALE; GENE KNOCKDOWN TECHNIQUES; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INSULIN-SECRETING CELLS; MICE; MICE, NUDE; NF-KAPPA B; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STREPTOZOCIN; THAPSIGARGIN; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84901191194     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2014.03.003     Document Type: Article

References (34)

1. I. Marhfour, X.M. Lopez, and D. Lefkaditis et al. Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes Diabetologia 55 9 2012 2417 2420
2. U. Karunakaran, H.J. Kim, and J.Y. Kim et al. Guards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetes Exp Diabetes Res 2012 2012 639762
3. M. Cnop, N. Welsh, and J.C. Jonas et al. Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes Diabetes 54 2005 S97 S107
4. S.H. Back, S.W. Kang, and J. Han et al. Endoplasmic reticulum stress in the β-cell pathogenesis of type 2 diabetes Exp Diabetes Res 2012 2012 618396
5. J. Liu, X. Wu, and J.L. Franklin et al. Mammalian tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistance J Physiol Endocrinol Metab 298 3 2010 E565 E576
6. C.A. Corcoran, X. Luo, and Q. He et al. Genotoxic and endoplasmic reticulum stresses differentially regulate TRB3 expression Cancer Biol Ther 4 10 2005 1063 1067
7. S. Prudente, G. Sesti, and A. Pandolfi et al. The mammalian tribbles homolog trib3, glucose homeostasis, and cardiovascular diseases Endocr Rev 33 4 2012 526 546
8. C.W. Liew, J. Bochenski, and D. Kawamori et al. The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse β cells J Clin Invest 120 8 2010 2876 2888
9. D.A. Cunha, M. Igoillo-Esteve, and E.N. Gurzov et al. Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis Diabetes 61 11 2012 2763 2775
10. R.K. Humphrey, C.J. Newcomb, and S.M. Yu et al. Mixed lineage kinase-3 stabilizes and functionally cooperates with tribbles-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells J Biol Chem 285 29 2010 22426 22436
11. C.R. Bromati, C. Lellis-Santos, and T.S. Yamanaka et al. UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression Am J Physiol Regul Integr Comp Physiol 300 1 2011 R92 R100
12. S.P. Duggan, F.M. Behan, and M. Kirca et al. An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, downregulated in Barrett's oesophagus, which regulates NF-κB activation and cytokine levels Carcinogenesis 31 5 2010 936 945
13. M. Wu, L.G. Xu, and Z. Zhai et al. Sink is a p65-interacting negative regulator of NF-κB -dependent transcription J Biol Chem 278 29 2003 27072 27079
14. B. Qian, H. Wang, and X. Men et al. TRIB3 is implicated in glucotoxicity- and oestrogen receptor-stress-induced β-cell apoptosis J Endocrinol 199 2008 407 416
15. J. Duprez, and J.C. Jonas Role of activating transcription factor 3 in low glucose- and thapsigargin-induced apoptosis in cultured mouse islets Biochem Biophys Res Commun 415 2011 294 299
16. L. Peng, X. Men, and W. Zhang et al. Involvement of dynamin-related protein 1 in free fatty acid-induced INS-1-derived cell apoptosis PLoS ONE 7 2012 e49258
17. S.E. Kahn, R.L. Hull, and K.M. Utzschneider Mechanisms linking obesity to insulin resistance and type 2 diabetes Nature 444 7121 2006 840 846
18. Y. Zhou, E. Zhang, and C. Berggreen et al. Survival of pancreatic beta cells is partly controlled by a TCF7l2-p53-p53INP1-dependent pathway Hum Mol Genet 21 1 2012 196 207
19. X. Men, H. Wang, and M. Li et al. Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis Int J Biochem Cell Biol 41 4 2009 879 890
20. M.F. Tonnesen, L.G. Grunnet, and J. Friberg et al. Inhibition of nuclear factor-κB or bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells Endocrinology 150 9 2009 4094 4103
21. B. Andrew, and A. Luke Oxidative stress and nuclear factor-κB activation Biochem Pharmacol 59 2000 13 23
22. J.E. Nicoletti-Carvalho, T.C. Nogueira, and R. Gorjao et al. UPR-mediated TRIB3 expression correlates with reduced AKT phosphorylation and inability of interleukin 6 to overcome palmitate-induced apoptosis in RINm5F cells J Endocrinol 206 2 2010 183 193
23. P.T. Hoang, P. Park, and L.J. Cobb et al. The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice Metabolism 59 2010 343 349
24. K. Shimizu, S. Takahama, and Y. Endo et al. Stress-inducible caspase substrate TRB3 promotes nuclear translocation of procaspase-3 PLoS ONE 7 8 2012 e42721
25. A.J. Bowers, S. Scully, and J.F. Boylan SKIP3, a novel drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia Oncogene 22 18 2003 2823 2835
26. N. Ohoka, S. Yoshii, and T. Hattori et al. TRB3, a novel er stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death EMBO J 24 6 2005 1243 1255
27. R. Schwarzer, S. Dames, and D. Tondera et al. TRB3 is a PI 3-kinase dependent indicator for nutrient starvation Cell Signal 18 6 2006 899 909
28. D. Ord, K. Meerits, and T. Ord TRB3 protects cells against the growth inhibitory and cytotoxic effect of atf4 Exp Cell Res 313 16 2007 3556 3567
29. C.G. Zou, X.Z. Cao, and Y.S. Zhao et al. The molecular mechanism of endoplasmic reticulum stress-induced apoptosis in PC-12 neuronal cells: the protective effect of insulin-like growth factor I Endocrinology 150 1 2009 277 285
30. V.B. Wali, S.V. Bachawal, and P.W. Sylvester Endoplasmic reticulum stress mediates gamma-tocotrienol-induced apoptosis in mammary tumor cells Apoptosis 14 11 2009 1366 1377
31. C. Jousse, C. Deval, and A.C. Maurin et al. TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway J Biol Chem 282 2007 15851 15861
32. H. Heimberg, Y. Heremans, and C. Jobin et al. Inhibition of cytokine-induced NF-κB activation by adenovirus-mediated expression of a NF-κB super-repressor prevents β-cell apoptosis Diabetes 50 10 2001 2219 2224
33. B.R. Zhou, J.A. Zhang, and Q. Zhang et al. Palmitic acid induces production of proinflammatory cytokines interleukin-6, interleukin-1β, and tumor necrosis factor-α via a NF-κB-dependent mechanism in HaCaT keratinocytes Mediators Inflamm 2013 2013 530429
34. S. Norlin, U. Ahlgren, and H. Edlund Nuclear factor-κB activity in β-cells is required for glucose-stimulated insulin secretion Diabetes 54 1 2005 125 132