Glucagon-like peptide-1 protects human islets against cytokine-mediated β-cell dysfunction and death: A proteomic study of the pathways involved

Journal of Proteome Research

Volumn 12, Issue 9, 2013, Pages 4193-4206

  Rondas, Dieter ^a   Bugliani, Marco ^b   D'Hertog, Wannes ^a   Lage, Kasper ^c,d,e   Masini, Mathilde ^b   Waelkens, Etienne ^f   Marchetti, Piero ^b   Mathieu, Chantal ^a   Overbergh, Lut ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF PISA   (Italy)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

Author keywords

2D DIGE; cytokines; GLP 1; human islets; protein interaction networks; Type 1 diabetes

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CHAPERONE; CYTOKINE; GAMMA INTERFERON; GLUCAGON LIKE PEPTIDE 1; HEAT SHOCK PROTEIN; INSULIN; INTERLEUKIN 1BETA; LIVER RECEPTOR HOMOLOG 1;

ACTIN FILAMENT; ADULT; AGED; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; FEMALE; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN METABOLISM; PROTEIN MODIFICATION; PROTEIN SYNTHESIS; PROTEOMICS; SEX RATIO; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS;

ADULT; AGED; APOPTOSIS; CELLS, CULTURED; CYTOSKELETON; DIABETES MELLITUS; FEMALE; GLUCAGON-LIKE PEPTIDE 1; HUMANS; INSULIN; INSULIN-SECRETING CELLS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; ISLETS OF LANGERHANS; MALE; MIDDLE AGED; PROTEIN INTERACTION MAPS; PROTEOLYSIS; PROTEOME; PROTEOMICS; RNA, TRANSFER; SECRETORY VESICLES;

EID: 84883755895     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr400527q     Document Type: Article

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