Sequence-dependent internalization of aggregating peptides

Journal of Biological Chemistry

Volumn 290, Issue 1, 2015, Pages 242-258

  Couceiro, José R ^a,b   Gallardo, Rodrigo ^a,b   De Smet, Frederik ^a,b   De Baets, Greet ^a,b   Baatsen, Pieter ^a,b   Annaert, Wim ^b   Roose, Kenny ^a,c   Saelens, Xavier ^a,c   Schymkowitz, Joost ^a,b   Rousseau, Frederic ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; ANTIGEN-ANTIBODY REACTIONS; COMPLEX NETWORKS; MACHINERY; MOLECULAR BIOLOGY; PEPTIDES; PROTEINS;

AGGREGATION PROCESS; AGGREGATION PROPENSITY; BIOPHYSICAL PROPERTIES; COMPETING MECHANISMS; ENDOSOMAL COMPARTMENTS; INTERCONNECTED NETWORK; MEMBRANE REMODELING; SEQUENCE-DEPENDENT;

AGGREGATES;

HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; MESSENGER RNA; PEPTIDE; PEPTIDE INF12; PEPTIDE INF36; PEPTIDE PEPL; PEPTIDE PEPS; UNCLASSIFIED DRUG; 5 (N ETHYL N ISOPROPYL)AMILORIDE; AMILORIDE; CYTOCHALASIN D; DNA BINDING PROTEIN; HEAT SHOCK TRANSCRIPTION FACTOR; HYDRAZONE DERIVATIVE; MEVINOLIN; N'-(3,4-DIHYDROXYBENZYLIDENE)-3-HYDROXY-2-NAPHTHAHYDRAZIDE; PROTEIN AGGREGATE; PROTEIN BINDING; TRANSCRIPTION FACTOR;

AGGREGATION PROPENSITY; AMINO ACID SEQUENCE; ARTICLE; CELL PHAGOCYTOSIS; CELL STRUCTURE; CELL SURFACE; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CHEMICAL PARAMETERS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSKELETAL REORGANIZATION; ENDOCYTOSIS; ENDOSOMAL SWELLING; ENDOSOME; FLUID PHASE ENDOCYTOSIS; GENE EXPRESSION; HEK293 CELL LINE; IN VITRO STUDY; INTERNALIZATION; INTRACELLULAR SIGNALING; ISOELECTRIC POINT; LYSOSOME; MEMBRANE REMODELING; MOLECULAR DYNAMICS; PARTICLE SIZE; PEPTIDE AGGREGATION; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; STATIC ELECTRICITY; TRANSMISSION ELECTRON MICROSCOPY; ACTIN FILAMENT; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG EFFECTS; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; PH; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACTIN CYTOSKELETON; AMILORIDE; AMINO ACID SEQUENCE; CYTOCHALASIN D; DNA-BINDING PROTEINS; ENDOCYTOSIS; ENDOSOMES; HEK293 CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; HYDRAZONES; HYDROGEN-ION CONCENTRATION; KINETICS; LOVASTATIN; LYSOSOMES; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN AGGREGATES; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN TRANSPORT; PROTEOLYSIS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

EID: 84920540570     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.586636     Document Type: Article

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