Treatment with extracellular HSP70/HSC70 protein can reduce polyglutamine toxicity and aggregation

Journal of Neurochemistry

Volumn 94, Issue 3, 2005, Pages 597-606

  Novoselova, Tatiana V ^a   Margulis, Boris A ^a   Novoselov, Sergey S ^a   Sapozhnikov, Alexander M ^b   Van Der Spuy, Jacqueline ^c   Cheetham, Michael E ^c   Guzhova, Irina V ^a  

^a INSTITUTE OF CYTOLOGY   (Russian Federation)

^b SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Apoptosis; Chaperone; HSP70; Huntingtin; Neuroblastoma; Polyglutamine

Indexed keywords

BIOTIN; CASPASE; GREEN FLUORESCENT PROTEIN; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 70; HUNTINGTIN; POLYGLUTAMINE;

APOPTOSIS; ARTICLE; BIOTINYLATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; IMMUNOBLOTTING; INCUBATION TIME; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; TRINUCLEOTIDE REPEAT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CATTLE; CELL AGGREGATION; CELL COUNT; CELL LINE, TUMOR; CELL SIZE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME INHIBITORS; FLOW CYTOMETRY; GREEN FLUORESCENT PROTEINS; HSC70 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INDOLES; MICROSCOPY, CONFOCAL; NEUROBLASTOMA; PEPTIDES; STAUROSPORINE; TIME FACTORS; TRANSFECTION; TRINUCLEOTIDE REPEAT EXPANSION;

ANIMALIA; BOVINAE;

EID: 23244452271     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03119.x     Document Type: Article

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