Receptor-mediated adenylyl cyclase activation through XLαs, the extra-large variant of the stimulatory G protein α-subunit

Molecular Endocrinology

Volumn 16, Issue 8, 2002, Pages 1912-1919

  Bastepe, Murat ^a   Gunes, Yasemin ^a   Perez Villamil, Beatriz ^a   Hunzelman, Joy ^a   Weinstein, Lee S ^c   Jüppner, Harald ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; COMPLEMENTARY DNA; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; PARATHYROID HORMONE RECEPTOR; THYROTROPIN RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CELL SURFACE RECEPTOR; GNAS PROTEIN, MOUSE; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; NERVE PROTEIN; RECOMBINANT PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; EMBRYO; ENZYME ACTIVATION; EXON; GENE EXPRESSION; GENE MUTATION; HORMONE RECEPTOR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; ALTERNATIVE RNA SPLICING; ANIMAL; CELL LINE; CHEMISTRY; GENETIC TRANSFECTION; GENETIC VARIABILITY; GENETICS; METABOLISM; MOUSE MUTANT;

ADENYLATE CYCLASE; ALTERNATIVE SPLICING; ANIMAL; CELL LINE; ENZYME ACTIVATION; EXONS; G-PROTEIN, STIMULATORY GS; HETEROTRIMERIC GTP-BINDING PROTEINS; MICE; MICE, KNOCKOUT; PROMOTER REGIONS (GENETICS); RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, CELL SURFACE; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RECEPTORS, PARATHYROID HORMONE; RECEPTORS, THYROTROPIN; RECOMBINANT PROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; VARIATION (GENETICS); ANIMALS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; NERVE TISSUE PROTEINS;

ANIMALIA; MURINAE;

EID: 0036020511     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2002-0054     Document Type: Article

References (40)

1. Introduction to G-protein-coupled signal transduction and human disease
2. Endocrine manifestations of stimulatory G protein α-subunit mutations and the role of genomic imprinting
3. Parental origin of transcription from the human GNAS1 gene
4. The human GNAS1 gene is imprinted and encodes distinct paternally and biallelically expressed G proteins
5. sα gene
6. Imprinting of the G(s)α gene GNAS1 in the pathogenesis of acromegaly
7. A cluster of oppositely imprinted transcripts at the Gnas locus in the distal imprinting region of mouse chromosome 2
8. XLαs is a new type of G protein
9. Characterization of the extra-large G protein α-subunit XLαs. I. Tissue distribution and subcellular localization
10. Analysis of the GNAS1 gene in Albright's hereditary osteodystrophy
11. Hypoparathyroidism and pseudohypoparathyroidism
12. Rapid GDP release from Gs in patients with gain and loss of function
13. Paternally inherited inactivating mutations of the GNAS1 gene in progressive osseous heteroplasia
14. GNAS1 lesions in pseudohypoparathyroidism la and lc: Genotype phenotype relationship and evidence of the maternal transmission of the hormonal resistance
15. How receptors talk to trimeric G proteins
16. Crystal structure of the adenylyl cyclase activator Gsα
17. Characterization of the extra-large G protein α-subunit XLαs. II. Signal transduction properties
18. Molecular properties of the PTH/PTHrP receptor
19. Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs α stimulate adenylate cyclase
20. RGS-PX1, a GAP for GαS and sorting nexin in vesicular trafficking
21. Splice variants of the α subunit of the G protein Gs activate both adenylyl cyclase and calcium channels
22. Src tyrosine kinase is a novel direct effector of G proteins
23. Two overlapping reading frames in a single exon encode interacting proteins - A novel way of gene usage
24. A proline-rich region and nearby cysteine residues target XLαs to the Golgi complex region
25. Tissue-specific expression of antisense and sense transcripts at the imprinted Gnas locus
26. Expression of the extra-large G protein α-subunit XLαs in neuroepithelial cells and young neurons during development of the rat nervous system
27. G αs transcripts are biallelically expressed in the human kidney cortex: Implications for pseudohypoparathyroidism type lb
28. Imprinting in Albright's hereditary osteodystrophy
29. Paternal vs maternal transmission of a stimulator G-protein α subunit knockout produces opposite effects on energy metabolism
30. Genetic variation of the extra-large stimulatory G protein α-subunit leads to Gs hyperfunction in platelets and is a risk factor for bleeding
31. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol triphosphates and increases intracellular free calcium
32. Paternal uniparental isodisomy of chromosome 20q (patUPD20q)-and the resulting changes in GNAS1 methylation - As a plausible cause of pseudohypoparathyroidism
33. Residues in the membrane-spanning and extracellular regions of the parathyroid hormone (PTH)-2 receptor determine signaling selectivity for PTH and PTH-related peptide
34. Bidirectional imprinting of a single gene: GNAS1 encodes maternally, paternally, and biallelically derived proteins
35. Identification of a methylation imprint mark within the mouse gnas locus
36. Differential expression of novel Gs α signal transduction protein cDNA species
37. sα mRNA
38. An imprinted antisense transcript at the human GNAS1 locus
39. An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus