Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 23, 2011, Pages 9420-9424

  Van Eps, Ned ^a   Preininger, Anita M ^b   Alexander, Nathan ^c   Kaya, Ali I ^b   Meier, Scott ^b   Meiler, Jens ^c   Hamm, Heidi E ^b   Hubbell, Wayne L ^a  

^a JULES STEIN EYE INSTITUTE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY   (United States)

Author keywords

Signal transduction; Structural polymorphism

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; NUCLEOTIDE; PROTEIN SUBUNIT;

ALPHA CHAIN; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CROSS LINKING; ELECTRON; ESCAPE BEHAVIOR; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR AFFINITY; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; SPIN LABELING;

AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; CROSS-LINKING REAGENTS; ELECTRON SPIN RESONANCE SPECTROSCOPY; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEINS; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, G-PROTEIN-COUPLED; RHODOPSIN; SPIN LABELS;

EID: 79959343623     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1105810108     Document Type: Article

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